Assessing Epigenetic Age Acceleration as a Predictor of Age-Related Morbidity and Mortality
This study uses data from 3,581 Health and Retirement Study (HRS) participants to examine the relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality.
We examine whether recent improvements to these scores, using principal component (PC)-based measures designed to remove some of the technical noise and unreliability in measurement, improve the predictive capability of these measures. We also examine how well DNAm-based measures perform against well-known predictors of health outcomes such as demographics, socioeconomic status (SES)...
Source: Fight Aging! - March 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Early Life Physical Fitness Correlates with Lesser Degrees of Atherosclerosis in Later Life
Lifestyle choices related to physical fitness have an impact on many aspects of degenerative aging. As noted here, the pace at which atherosclerosis develops is one of these aspects. Atherosclerosis is the buildup of fatty deposits in blood vessel wall tissue. Those deposits grow into atheromas that ultimately rupture to produce stroke and heart attack. It is the largest single cause of human mortality. Atherosclerosis is a dysfunction of cholesterol transport and the innate immune cells known as macrophages that are responsible for clearing excess cholesterol from blood vessel walls. Over a full lifetime of exposure, life...
Source: Fight Aging! - March 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Are AI Clinical Protocols A Dobb-ist Trojan Horse?
By MIKE MAGEE
For most loyalist Americans at the turn of the 19th century, Justice John Marshall Harlan’s decision in Jacobson v. Massachusetts (1905). was a “slam dunk.” In it, he elected to force a reluctant Methodist minister in Massachusetts to undergo Smallpox vaccination during a regional epidemic or pay a fine.
Justice Harlan wrote at the time: “Real liberty for all could not exist under the operation of a principle which recognizes the right of each individual person to use his own, whether in respect of his person or his property, regardless of the injury that may be done to others.”
What could ...
Source: The Health Care Blog - March 1, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Abortion AI Dobbs Forced Sterilization Mike Magee racial bias SCOTUS Vaccination Source Type: blogs
Radiology ’ s Next Phase: Real-Time Collaboration Leading the Way
The following is a guest article by Vivian Liu, COO at Braid Health
One thing in healthcare remains constant: the need for answers. This is why radiology is a pillar of our healthcare system because, without a diagnosis, there is no treatment.
In today’s digital age, people want things to be fast, convenient, and reliable. The same is true in healthcare. Patients seek fast, crystal-clear answers to their issues.
In the last 5–10 years, substantial innovations in imaging, particularly through deep learning methods of image classification, have emerged. A noteworthy development is the augmentation of radiology with A...
Source: EMR and HIPAA - February 29, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Communication and Patient Experience Health IT Company Healthcare IT Braid Health Diagnostic Delivery Radiology Radiology AI Radiology IT Real-Time Collaboration Real-Time Radiology teleradiology Turnaround Time Source Type: blogs
Unlearn Raises $50 Million Series C to Optimize Clinical Research With AI-Powered Digital Twin Technology
Using Novel Digital Twins of Clinical Trial Participants, Unlearn is Accelerating Clinical Research to Help Bring New Treatments to Patients Sooner
Unlearn, an AI company creating digital twins of clinical trial participants that enable smaller, faster studies, today announced a $50M Series C round led by Altimeter Capital, joined by returning investors Radical Ventures, Wittington Ventures, Mubadala Capital, Epic Ventures, and Necessary Venture Capital. This round of funding was secured to propel the company’s mission to advance AI to eliminate trial and error in medicine by investing in its people, data, engineering ca...
Source: EMR and HIPAA - February 29, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 8VC Altimeter Capital Charles Fisher DCVC DCVC Bio Epic Ventures Health IT Funding Health IT Fundings Health IT Investment Insight Partners Mubadala Capital Necessary Venture Capital Pauline Yang Source Type: blogs
Particulate Air Pollution Correlates with Risk of Alzheimer's Disease
Researchers here use data on air pollution from a single US metropolitan area to show a correlation with Alzheimer's disease risk. Air pollution is shown to increase chronic inflammation via the interaction of particulates with lung tissue, and inflammation is an important component of the onset and progression of neurodegenerative conditions such as Alzheimer's disease. That said, the researchers were primarily interested in traffic as a source of particulate air pollution, and one might think that this introduces a correlation with wealth, given the usual distribution of cost of living versus proximity to major flows of ...
Source: Fight Aging! - February 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why Don't Biotech Investors Run Replication Studies Before Investing?
Ichor Life Sciences is one of the earliest longevity industry companies, an interesting mix of contract research organization (CRO), biotech working on several different therapeutics, and investor in very early stage biotech startups. One of the Ichor co-founders here offers an interesting, though possibly biased perspective on how investors should behave in the biotech space. Inside companies, every new development program in the biotech industry starts with an attempt to replicate the research results that form the basis for the program, even given the existence of detailed, published papers and a coven of accessible res...
Source: Fight Aging! - February 28, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Amie Fornah Sankoh Achieves a Scientific Dream
Credit: LinkedIn.
“I wanted to give up so many times. Although I tried to remain positive, I never thought I’d be able to finish my Ph.D. But I made it, and I’m extremely proud of myself,” says Amie Fornah Sankoh, Ph.D., a research scientist with Dow Chemical Company who received NIGMS support as a graduate student.
Human and Plant Communication
Dr. Sankoh has loved science and mathematics since she was just a child growing up in Sierra Leone. When she was 3 years old, Dr. Sankoh became deaf from a childhood disease. Math, unlike other subjects, is very visual, which played a part in her interest in it. “...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 28, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Training Source Type: blogs
Wednesday Bible Study: Divine Right
Psalm 72 is one of those elevating the king to a kind of demigod status and extolling his power and glory. As I have said many times, the basic structure of Judean society, as was the norm throughout the region, was an alliance between a priestly caste and warrior kings, so that ' s what this is all about. But yes, it ' s weird that it ' s called a Psalm of Solomon, and concludes with " The prayers of David, son of Jesse, are ended. " It ' s doubly weird because many subsequent psalms are in fact ascribed to David. The likely explanation is that the Book of Psalms we have today is a compilation of several books, usually th...
Source: Stayin' Alive - February 28, 2024 Category: American Health Source Type: blogs
Aged Pancreatic Fibroblasts Secrete GDF-15, Encouraging Tumor Growth
Researchers here note one of a broad range of examples in which age-related changes in the state and behavior of non-cancerous cells results in a more hospitable environment for the growth of neighboring cancerous tissue. Cancer is an age-related condition not just because of increased damage to cells in older tissues, nor just because the immune system falters in its surveillance of potentially cancerous cells, but also due to other maladaptive changes that favor the metabolism and growth of some forms of cancerous cells.
A new study provides clues as to why pancreatic cancer is more common and aggressive in olde...
Source: Fight Aging! - February 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
When it comes to Lepidoptera, plus ça change
An analysis of the genomes of more than 200 butterfly and moth, Lepidoptera, species reveals that genetic framework of what is ostensibly a very diverse group of insects, has remained remarkably stable since they diverged from their last common ancestor over 250 million years ago.
In a study published in the journal Nature Ecology and Evolution, shed new light on the evolutionary history and genetic structure of the Lepidoptera, which could help in conservation efforts for what is an incredibly important group of pollinators, food source for birds, bats, and other creatures, and a vital part of a healthy ecosystem and env...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 28, 2024 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs
Trial By Error: An Interview with Neuroscientist Michael VanElzakker about the Just-Published and Long-Awaited NIH Study
By David Tuller, DrPH So, okay…The big enchilada from the US National Institutes of Health’s seven-year, $8-million, under-recruited and over-hyped study—”Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome”–was published last week in Nature Communications. It would be fair to describe the ensuing public debate over this massive text-and-data dump as spirited. (NIH press release here; … Trial By Error: An Interview with Neuroscientist Michael VanElzakker about the Just-Published and Long-Awaited NIH Study Read More » (Source: virology blog)
Source: virology blog - February 28, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized effort preference NIH vanElzakker Source Type: blogs
An Update on Progress Towards Treating Atherosclerosis at Cyclarity
Today I'll point out an interview with one of the Cyclarity Therapeutics founders, illustrative of the degree to which biotech companies are at the mercy of regulators once they arrive at the clinical stage of development. Cyclarity, formerly Underdog Pharmaceuticals, is a spin-out from the SENS Research Foundation, an organization that aims to clear roadblocks in the translational research needed for the production of rejuvenation therapies. The program that led to Cyclarity was focused on finding a way to clear 7-ketocholesterol from the body. 7-ketocholesterol is a form of oxidized cholesterol, created as a result of ox...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Bonus Features, ViVE Edition – February 27, 2024 – GE and Biofourmis collaborating on care at home, DeepScribe and AWS Health Scribe partnering, plus 20 other stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
This edition is a special dispatch from the first days of ViVE 2024. There have been a lot of new research reports, products, and partnerships announced in Los Angeles. We wanted to try and cover as many announcements for the He...
Source: EMR and HIPAA - February 27, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT 2morrow AvaSure AWS HealthScribe Axil Health Biofourmis Cancer Moonshot CenTrak Clearstep Health Coeus Health CPSI DeepScribe Dolbey Froedtert & the Medical College of Wisconsin GE Healthcare Healthcare IT Today Source Type: blogs
Higher Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation Noted After Spinal Cord Injury
There are several factors which increase the risk of cardiovascular disease in survivors of spinal cord injury. They have a greater prevalence of obesity, dyslipidemia, metabolic syndrome and diabetes mellitus. Energy expenditure is lesser both due to lack of motor function and lack of opportunities to engage in physical activity. Autonomic dysfunction caused by spinal cord injury is associated with abnormalities in blood pressure, heart rate variability, arrhythmias and blunted cardiovascular response to exercise which can limit the capacity to perform physical activity [1].
A recent large study from Korea compared over 5...
Source: Cardiophile MD - February 27, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
