Blood Tests for Alzheimer's Disease Continue to Look Promising
In recent years, data has shown correlations between specific blood biomarkers and Alzheimer's disease pathology in the brain, such as the burden of misfolded, aggregated amyloid-β. This has led to the development of a variety of blood tests for Alzheimer's disease, intended to replace the presently onerous testing that requires either expensive imaging or invasive analysis of cerebrospinal fluid. Alzheimer's disease develops slowly over time, a long period of raised amyloid-β levels in the brain setting the stage for later dysfunction. Early testing for the risk of later Alzheimer's disease enabled attempts to slow or e...
Source: Fight Aging! - March 6, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Catalase to Reduce Mitochondrial Oxidative Stress Does Not Reduce Cellular Senescence
Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now integrated into the cell. Mitochondria generate oxidative molecules as a consequence of the processes that generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. Those oxidative molecules cause damage, near all rapidly repaired. They also serve as signals, such as in the beneficial response to exercise. With aging, however, mitochondrial function becomes impaired and the degree of oxidative stress generated by the operation of mitochondria becomes harmful.
Researchers have in the...
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Maverick Or The Contrarian: Which Non-Conformist Are You? (M)
Study reveals society's stereotypes about those who go against the grain. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 5, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Personality subscribers-only Source Type: blogs
Home Health AI: Predicting Illness and Preventing Hospitalizations
The following is a guest article by Shveta Mangal, CEO at VitaWerks
In today’s rapidly evolving healthcare environment, the concept of home as an “extension of care” is gaining traction, ushering in a new era of patient-centered support. Traditionally, healthcare was confined to clinical settings, but with advancements in technology, particularly artificial intelligence (AI) and machine learning, the paradigm is shifting.
These cutting-edge technologies are now being harnessed to predict health issues before they escalate, revolutionizing home health care and paving the way for proactive interventions tha...
Source: EMR and HIPAA - March 5, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Healthcare at Home Home Health AI Home Health Care Home Healthcare Hospitalization Prevention Illness Prediction Source Type: blogs
RapidClaims Uses AI to Help US Healthcare Providers Address $250B in Denied Claims
RapidClaims Launches from Stealth with $3.1M Funding to Tackle the Core Issues Behind Claims Denial
Healthcare organizations are turning to automation with “revenue cycle management” to protect operating margins and the increasing claim denials from the payors. Every year, close to $265B in claims made by US healthcare organizations are denied because of the way claims are coded on payor documentation and delayed submissions are two chief reasons for the denials. Coding errors account for over 40% of claim denials, while untimely submissions contribute to 35% of denials; eligibility and prior authorization being some o...
Source: EMR and HIPAA - March 5, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Abhinay Vyas Ankit Jain Better Capital DeVC Dushyant Mishra Girish Mathrubootham Health IT Funding Health IT Fundings Health IT Investment Infinitus Jot Sarup Sahni Manav Garg Mass General Neon Source Type: blogs
Searching for a Causal Link Between Gut Microbiome Populations and Pace of Aging
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
Link: https://doi.org/10.3390/microorganisms12020370 (Source: Fight Aging!)
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Human Data on Epigenetic Age Following Senolytic Treatment
This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with DNAm measured at baseline, 3 months, and 6 months. The age range of these individuals that were considered in the first study analyses were between 43.0 and 86.6.
Significant increases in epigenetic age acceleration were observed in first-generation epigenetic clocks and mitotic clocks at 3 and 6 months, along with a notable decrease in telomere length. However, no significant differences...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Genome-Wide Genetic Association Study of Sleep Duration and Longevity
In this study, we firstly studied the genome-wide genetic association between four sleep behaviors (short sleep duration, long sleep duration, insomnia, and sleep chronotype) and lifespan using GWAS summary statistics, and both sleep duration time and insomnia were negatively correlated with lifespan. Then, two-sample Mendelian randomization (MR) and multivariable MR analyses were applied to explore the causal effects between sleep behaviors and lifespan.
We found that genetically predicted short sleep duration was causally and negatively associated with lifespan in univariable and multivariable MR analyses, and thi...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Restriction of RNA Polymerase I Activity Extends Life in Nematode Worms
RNA Polymerase I (Pol I) is prominent in the regulatory systems managing the nutrient-driven tradeoff between growth and longevity. It is responsible for producing a sizable fraction of RNA, reading from gene sequences and assembling corresponding RNA molecules. As such, it is responsible for initiating some of the most energetically expensive processes in the cell, including translation of messenger RNA into proteins. Suppression of the production of proteins is a consequence of low calorie intake, an intervention known to slow aging, and researchers have shown that interfering in RNA synthesis can also extend life in sho...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
When the conventional algorithm diagnoses the ECG as COMPLETELY NORMAL, but there is in fact OMI, what does the Queen of Hearts PM Cardio AI app say? (with 10 case examples)
Conclusions Need Scrutiny.Proximal LAD Occlusion with STE in I and aVL, and hyperacute T-waves in V2-V6.Algorithm: Marquette 12 SL (GE)The Queen gets it rightCase 9 (prehospital and ED ECGs). Echocardiography, even (or especially) with Speckle Tracking, can get you in trouble. The ECG told the story. 30 yo woman with trapezius pain. HEART Pathway = 0. Computer " Normal " ECG. Reality: ECG is Diagnostic of LAD Occlusion.Prehospital ECG:There are hyperacute T-waves in V3-V5.The Queen gets it rightFirst ED ECG:Hyperacute T-waves persist. Called normal again! Algorithm: Veritas (on Mortara...
Source: Dr. Smith's ECG Blog - March 4, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
ACT plus exercise, vs exercise alone …
and what a shame there was no ACT alone group…
No secret here, I like ACT (Acceptance and Commitment Therapy) as an approach for living well with chronic pain. I like it for many reasons, but probably the most compelling ones are that the hierarchy between therapist and person living with pain is minimised (we’re both humans finding our way through life) and that it doesn’t require the person to delve into challenging or disputing thoughts – this in turn enhances adherence to the core elements of ACT: living a life aligned with what really matters to this person. People seem to find using ACT mor...
Source: HealthSkills Weblog - March 3, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: ACT - Acceptance & Commitment Therapy Chronic pain Pain conditions Physiotherapy Professional topics Psychology Research Science in practice pain management Therapeutic approaches Source Type: blogs
Bonus Features – March 3, 2024 – 75% of healthcare leaders expect widespread implementation of AI in 3 years, 78% of orgs lack knowledge on how to train employees to use AI, plus 18 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
Studies
Roughly 75% of healthcare leaders expect widespread implementation of AI within three years, according to a BRG survey. Additionally, 60% believe current AI regulations provide adequate safety measures.
While healthcare...
Source: EMR and HIPAA - March 3, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Amazon Web Services AnalyticsIQ Belong.life Berkeley Research Group Brand Engagement Network care.ai CharmHealth CHIME Deloitte Center for Health Solutions eClinicalWorks FHIR GE Healthcare Greenway Health hc1 Ins Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Answer to Case 739
Answer toParasite Case of the Week 739:Loa loamicrofilariaeThanks to everyone who wrote in with comments. We received a lot of different responses including some of the sheathed and unsheathed microfilariae. Therefore, this is a great time to review my approach to identifying microfilariae in blood specimens. You can also readthis articleI wrote with Blaine Mathison and Marc Couturier that provides a diagnostic algorithm for microfilariae in blood. In this algorithm, we recommend first measuring the length of the microfilariae. If they are small (<200 micrometers long), then it is likely to be one of theMansonella...
Source: Creepy Dreadful Wonderful Parasites - March 2, 2024 Category: Parasitology Source Type: blogs
What is Known of the Contribution of Cellular Senescence to Osteoporosis
The vast majority of senescent cells are produced when somatic cells reach the Hayflick limit to cell division, their telomeres shortened to a point at which they either self-destruct or enter the senescent state. Damage due to mutation or cytotoxic compounds can also induce senescence, as can the regenerative processes following injury. Senescent cells cease replication, become larger, and change their behavior in many other ways. Senescent cells secrete a pro-growth, pro-inflammatory mix of signals, the senescence-associated secretory phenotype (SASP), that attracts the attention of immune cells capable of destroying sen...
Source: Fight Aging! - March 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
