Reviewing the Potential of Extracellular Vesicles to Treat Degenerative Bone Conditions
First generation stem cell therapies, in which cells near entirely die following transplantation, cause benefits via changes in native cell behavior resulting from the signaling produced by the transplanted cells. Much of cell signaling is carried in extracellular vesicles, membrane-bound packages of various molecules. The types, contents, and circumstances of creation of extracellular vesicles are not fully understood, a work in progress. Harvesting these vesicles from specific cell types known to be beneficial when transplanted is a way to circumvent this lack of knowledge in the near term.
Degenerative bone dis...
Source: Fight Aging! - October 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Aging of the Ovaries
The ovaries, like the thymus, undergo a form of degenerative aging that occurs somewhat in advance of the aging of other parts of the body. It leads to the phenomenon of menopause and subsequent consequences to health and function, which, interestingly, is a feature of aging that is shared with only a few other mammalian species. That makes the ovaries and their surrounding tissues an interesting target for the development of ways to slow or reverse loss of function. Maintained ovarian function may prove to modestly slow aging in older women; it is a reasonable hypothesis and goal to pursue given what is known of the inter...
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Mesenchymal Stem Cells, a Target for Treating Age-Related Joint Disorders
Senescent cells accumulate in tissues throughout the body, and their collective signaling is pro-inflammatory to a significant degree. Focusing on cellular senescence in specific cell populations, such as stem cells or other critical cells in joint tissues, is a popular area of study. Adding senescent cells to a joint in mice produces degeneration, but specifically removing senescent cells from a joint using a locally injected senolytic drug doesn't reverse degeneration in humans. This suggests that the rest of the senescent cell population in the body can continue to provide enough signaling to the joint to maintain dysfu...
Source: Fight Aging! - October 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Research Organism Superheroes: Tardigrades
A 3D rendering of a tardigrade. Credit: iStock.
“Water bear” or “moss piglet”? No matter what you call them, tardigrades have secured the title of cutest invertebrate—at least in our book. They’re tiny creatures, averaging about the size of a grain of salt, so while you can spot them with the naked eye, using a microscope is the best way to see them. They earned their nickname of water bear and their official name (which comes from tardigradus, Latin for “slow walker”) because of the way they lumber slowly and deliberately on short, stubby legs.
They’re excellent research organism...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Tools and Techniques Cool Creatures Research Organisms Source Type: blogs
T Cell Exhaustion and the Role of Infections in Alzheimer's Disease
In this study we examined immune system alterations early in the progression to Alzheimer's disease (AD). We observed multiple changes across the peripheral innate and adaptive immune systems associated with amyloid and cognitive status within our aging cohort. In the innate immune system, we observed increased plasmacytoid and myeloid dendritic cells in amyloid positive participants, but these changes were particularly pronounced in those with mild cognitive impairment. We also observed a decrease in total natural killer cells with amyloid positivity. When the adaptive immune system was examined, we observed increases in ...
Source: Fight Aging! - October 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mechanisms of Disruptive Inflammation in the Aging of the Intestinal Barrier
The intestinal barrier becomes leaky with age, allowing microbes and unwanted metabolites in the gut access to the body, where they will produce chronic inflammation and other harmful consequences. Ironically, it may be increased inflammatory signaling in the intestinal epithelium that causes dysfunction of the intestinal barrier and then later widespread, greater inflammation. Researchers here explore some of this inflammatory signaling and its downstream consequences, focusing in on IFNγ and its effects on a variety of mechanisms relevant to tissue dysfunction in the intestine.
The influence of aging on intesti...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Disabling the Notch Pathway in Skeletal Stem Cells Greatly Improves Bone Density
Skeletal stem cells in the bone marrow produce cells responsible for creating bone tissue. Researchers here show that disabling the well-known notch pathway in these cells leads to a considerable increase in bone mineral density with age. This is a desirable outcome, slowing the onset of osteoporosis, a widespread condition of old age. Better ways to encourage greater deposition of bone extracellular matrix are much needed, given the only modest efficacy of present drugs used in the treatment of osteoporosis.
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce few...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is Known of the Mechanisms of Age-Related Hearing Loss
Hearing loss is prevalent in older individuals, either involving the destruction of sensory hair cells in the inner ear, or the axonal connections between those hair cells and the brain, or both. Hair cells do not normally regenerate to any great degree in adults, which has led to efforts to grow patient matched replacement cells, or reprogram native cells to convince them to produce new hair cells. Despite promising advances, it is not as yet a solved problem.
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Outsider's Popular Science View of the Longevity Industry and Academia
A brace of popular science articles on aging research were recently published at the Economist. Like many of these views from a distance written by journalists on the outside, peering into the field, one must assume that its existence is largely the result of the sizable investments made over the last two years into the development of therapies based on partial reprogramming. The Altos Labs funding in particular represented a meaningful fraction of all investment into biotech made that year. That tends to attract attention. From there, an investigator would notice an additional broad focus on cellular senescence, many comp...
Source: Fight Aging! - October 2, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Certain Type of Media Outlet that Chooses to Generate Confusion About Longevity Science
There is a certain type of media entity and journalist that really only cares about name dropping the wealthy and the famous, and has absolutely no interest in accuracy, education, understanding, factual conveyance of information, all of those pleasant things that make the world turn. Thus there will continue to be articles about ongoing intitiatives relating to aging, such as the one I'll reluctantly point out today, that are abysmal. This sort of article is abysmal because it actively, willfully conflates a whole set of very different activities with very different merits under one heading, while appealing to lowest comm...
Source: Fight Aging! - September 25, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
