A New Day for Parkinson ’s Disease Research Is Near
By STEVEN ZERCOLA
The U.S. Department of Health and Human Service (“HHS”) is responsible for a wide range of activities relating to medical and public health. It has 60,000 employees and a $1.7 trillion annual budget with approximately $140 billion for discretionary spending. For the past 13 years, HHS has been spearheading a National Plan for addressing Alzheimer’s disease – with some notable successes.
Given its resources, expertise and charter, HHS should launch a National Plan to cure Parkinson’s disease patterned after its approach on Alzheimer’s disease.
Legislation, or Not
The U.S. House of R...
Source: The Health Care Blog - February 6, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Drug discovery FDA Parkinson's Disease steve zecola Source Type: blogs
More Thought Needed on Causes versus Consequences in the Hallmarks of Aging
The hallmarks of aging are exactly that, hallmarks. They are not intended to be a list of causative mechanisms, though it appears that some people take it that way, particularly if it is supportive to their research and development program choices. Some of the hallmarks of aging overlap with the Strategies for Engineered Negligible Senescence (SENS) list of proposed causative mechanisms of aging, and the hallmarks paper itself clearly owes much to earlier SENS publications, as well as parallel proposals such as the Seven Pillars of Aging. It is important to target causes rather than consequences when it comes to aspects of...
Source: Fight Aging! - February 6, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making a Mouse that Exhibits Human Telomere Dynamics
Telomerase acts to extend telomeres, the repeated DNA sequences at the ends of chromosomes. With every cell division, some of the telomere repeats are lost. Cells with critically short telomeres become senescent or undergo programmed cell death, having reached the Hayflick limit on replication. Some cells employ telomerase to adjust the countdown of telomere length. In humans, only stem cells use telomerase. In other species, such as mice, telomerase is much more widely expressed. There has been some interest in the research community in upregulation of telomerase as a way to improve stem cell and tissue function in old ag...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
DEL-1 Upregulation Promotes Bone Regeneration in Aged Mice
Bone is constantly remodeled throughout life. The extracellular matrix making up bone tissue is continually broken down by osteoclast cells and built up by osteoblast cells. In youth, these activities are balanced. With aging, however, the activity of osteoclast cells progressively outweighs the activity of osteoblast cells. The consequence is an ever greater loss of bone mineral density leading to osteoporosis. This process is also found in the bone loss characteristic of advanced periodontitis. There are many contributing factors leading to the imbalance in bone remodeling, and it isn't all that clear as to which of them...
Source: Fight Aging! - February 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exosomes as a Treatment for Skin Aging
Much of the communication that takes place between cells takes the form of secretion and uptake of extracellular vesicles, small membrane-wrapped packages of diverse molecules. Vesicles are currently categorized by size, for lack of a better taxonomy, and exosomes are one of the better studied size classes. It appears to be the case that much of the benefit of first generation stem cell therapies is produced by the signaling generated by transplanted cells, and thus the research community has started to focus on the logistically easier approach of harvesting and using extracellular vesicles rather than transplanting the ce...
Source: Fight Aging! - January 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Continued Efforts to Produce Universal Pluripotent Stem Cells
Publicity materials here note a recent research initiative to produce pluripotent stem cell lines that will not be rejected when transplanted into other individuals, or even between species. This technological capability is necessary to the development of new forms of regenerative medicine, allowing the production of universal donor cells and tissues at reasonable cost. While the results sound impressive, it is worth noting that several large and well-funded pharma companies have been developing earlier, first generation versions of this technology for some years, accompanied by many smaller research groups and companies. ...
Source: Fight Aging! - January 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy
The primary focus of the Longevity Escape Velocity (LEV) Foundation is to demonstrate that therapies based on the repair of forms of underlying molecular damage that cause aging can be combined to produce greater rejuvenation. Research of recent years has demonstrated quite comprehensively that the alternative strategy for treating aging, to manipulate metabolism into a state in which aging occurs modestly more slowly, has so far produced therapies that largely cannot be combined. The combination of any two or more metabolic alterations, induced by supplements or other small molecules, that individually modestly slow aging...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chronic Inflammation and Mitochondrial Dysfunction Interact in the Production of Sarcopenia
Sarcopenia is the name given to the later stages of the characteristic loss of muscle mass and strength that occurs in every individual with aging, eventually leading to weakness and the state of frailty. There are many possible contributing mechanisms, and those mechanisms interact with one another. One important cause is loss of muscle stem cell activity, but this may be driven by any number of other aspects of aging. Another important contribution is dysfunction of neuromuscular junctions, as loss of innervation tends to have a negative impact on tissue maintenance. This again may be driven by any number of causative me...
Source: Fight Aging! - January 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
DNA G-Quadruplexes in Epigenetic Cell Aging
Researchers here describe a G-quadruplex-related mechanism operating across diverse species that contributes to epigenetic change following cell replication, leading to the Hayflick limit on replication and subsequent cell death or cell senescence. G-quadruplexes form in telomeric regions at the ends of chromosomes, and their contributions to genomic structure, epigenetics, and aging are far from fully understood.
Insofar as the mechanism described in this paper is operating in organismal aging, it is worth bearing in mind that aging is accompanied by a reduction in stem cell activity, meaning a reduced supply of re...
Source: Fight Aging! - January 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Flagellin Immunization Modestly Extends Life Span After Late-Life Administration in Mice
The immune system recognizes flagellin as foreign. Flagellin is the protein found in flagellae, the whip-like structures that bacteria use to move around. Attacking and destroying these bacteria is very much a part of the immune system's portfolio of normal activities. Thus immunization with flagellin provokes the immune system into greater activity and responsiveness in the short term, and it has been tested in humans as a vaccine adjuvant, intended to make the immune system respond more effectively to the vaccine delivered alongside flagellin. Interestingly, flagellin immunization also makes the immune system clear out h...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The 6 Most Exciting Medical Technology Breakthroughs Of Recent Years
Amidst the flurry of hyped technologies, it’s not easy to pinpoint which specific technological breakthroughs will have the most impact in the coming years.
Dr. Meskó, The Medical Futurist, reviews multiple reports, studies, and articles daily. Consequently, our days are filled with awe-inspiring developments. However, our aim here is to offer more than just a compilation of “wow, look how fascinating” stories.
To achieve this, we have selected technologies that:
Have undergone significant breakthroughs in recent years, be it in regulatory, technological, or scientific aspects
Are anticipate...
Source: The Medical Futurist - January 9, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health future Healthcare Source Type: blogs
