PI3K Inhibition Modestly Extends Life in Mice
Long term treatment of mice that results in a modest extension of life span, such as the example here involving inhibition of a subunit of PI3K, is unlikely to be interesting as a basis for human medicine to target aging. Life span is more plastic in short-lived mammals in response to altered metabolic states. Of the known approaches to slowing aging where one can compare humans and mice directly, there is no large extension of life in humans. The most interesting approaches to aging are those that can be applied very intermittently later in life, and which repair damage or enhance function sufficiently well for even one t...
Source: Fight Aging! - February 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mesenchymal Stem Cell Exosomes to Treat Disc Degeneration
First generation stem cell therapies involve sourcing immune privileged cells from sources such as umbilical cord blood, or a patient's own cells from fat tissue or similar, expanding the cells in culture, and then injecting them. Only minimal modifications are permitted to cells prior to transplantation in the US, before it would be classed as a therapy that must go through the IND process with the FDA for specific approval. Outside the US, in the medical tourism market, a range of approaches are undertaken with the goal of altering cultured cell behavior to improve patient outcomes. Unfortunately very little of this is b...
Source: Fight Aging! - January 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Osteopontin Plays Diverse Roles in Degenerative Aging
Osteopontin levels are higher in blood samples taken from older people than in those taken from young people. It is a component of the senescence-associated secretory phenotype (SASP) produced by senescent cells, disruptive to tissue function. Osteopontin acts as a regulator in a number of tissues, and appears to be relevant to the age-related decline, such as of hematopoiesis and muscle function. Here, researchers review what is known of the role of osteopontin in aging.
Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is expressed both intracellularly and extracellularly in variou...
Source: Fight Aging! - January 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Communication Between Blood and Brain in Aging and Rejuvenation
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are interested in how changes in the blood signaling environment might be involved. While research initially focused on factors in young blood that are reduced in old blood, it is increasingly thought that the important mechanism is a dilution of harmful factors carried in the old bloodstream. This has led to a few studies of plasma transfer and dilution in humans, and at least one company attempting to determine the optimal dose and protocol to make...
Source: Fight Aging! - January 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senescent Cells Degrade Intestinal Stem Cell Function
Senescent cells are constantly created and destroyed in all tissues of the body throughout life, but the number present at any given time increases with age, in large part because the immune system ceases to clear senescent cells as efficiently as it should. Senescent cells secrete pro-growth, pro-inflammatory factors that are useful in the short term, such as during wound healing, or to draw attention to potentially cancerous cells. When kept up for the long term, however, the signaling of senescent cells is highly disruptive to tissue structure and function. The example given here, of disrupted intestinal stem cell funct...
Source: Fight Aging! - January 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senotherapeutics Will Reduce the Side-Effects of Cancer Radiotherapy
Treatment with radiation to kill cancerous cells results in an increased burden of senescent cells, both in and around the tumor. This is a fair trade-off; a senescent cancerous cell may be harmful in and of itself, but it is a good deal less harmful in the long run than an active cancer cell. Unfortunately senescent cells produce pro-growth, pro-inflammatory signaling that is disruptive of tissue function, raises the risk of suffering a range of age-related conditions, and increases the risk of both reoccurrence of the treated cancer and the development of later unrelated cancers.
Thus given the work taking place o...
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Discussing the Hallmarks of Aging in the Context of Alzheimer's Disease
This article will focus on the primary aging hallmarks as these are interconnected with other aging characteristics and are at the base of the hierarchical order of aging features, and have been shown to be related to AD. It is an attempt to improve our understanding of the pathological mechanisms of AD to find potential therapeutic approaches and diagnostic tools.
Link: https://doi.org/10.7150/thno.79535 (Source: Fight Aging!)
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fecal Microbiota Transplant From Young to Old Mice Reduces Inflammation and Improves Hematopoiesis
In this study, we performed fecal microbiota transplantation (FMT) from young mice to aged mice and observed significant increment in lymphoid differentiation and decrease in myeloid differentiation in aged recipient mice. Further, FMT from young mice rejuvenated aged HSCs with enhanced short-term and long-term hematopoietic repopulation capacity. Mechanistically, single-cell RNA sequencing deciphered that FMT from young mice mitigated inflammatory signals, upregulated FoxO signaling pathway and promoted lymphoid differentiation of HSCs during aging. Finally, integrated microbiome and metabolome analyses uncovered that FMT...
Source: Fight Aging! - January 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Method of Inducing Epigenetic Aging via Damage to DNA
You may recall the work linking DNA double strand break repair to epigenetic changes characteristic of aging. Repeated cycles of this repair cause some form of depletion of necessary factors or other disarray in the mechanisms controlling gene expression. This is a compelling way to link random DNA damage, largely occurring in parts of the genome that are inactive in any given cell, largely occurring in cells that will not go on to divide many times, and occurring in completely different locations from cell to cell, to a consistent, characteristic aspect of aging. Beyond the question of cancer risk, the only other compelli...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Quantifying the Ability of Fasting and Exercise to Increase BDNF Expression
Upregulation of BDNF is a useful goal, as it produces greater neurogenesis in the brain. Neurogenesis, the production of new neurons from neural stem cells, and their integration into neural circuits, is important in memory, learning, and the resilience of the brain to damage and aging. Increased levels of BDNF may also improve metabolism and reduce inflammation in brain tissue. BDNF levels decline with age, but evidence suggests that BDNF expression can be boosted via calorie restriction and exercise. Researchers here compare these approaches for effectiveness, finding that short bursts of high intensity exercise produce ...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
More on the Work of the Longevity Escape Velocity Foundation
The Longevity Escape Velocity Foundation (LEVF) is initially working to assess combinations of approaches to the treatment of aging, to assess the degree to which mouse life span is affected. Aging consists of many distinct mechanisms, and comprehensive rejuvenation will require a diverse package of therapies. Yet the research and development community undertakes little work on combined treatments. Here, the Lifespan.io team talks to Aubrey de Grey about some of the details of the work presently under way.
We are obviously very excited about LEVF's robust mouse rejuvenation (RMR) project. Could you walk our reader...
Source: Fight Aging! - January 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Proposal to Accelerate Progress Towards Human Rejuvenation
Here find the first draft of a proposal regarding the best way forward at the present time to accelerate progress towards the development of diverse, effective rejuvenation therapies. The key is to use philanthropic funding to (a) prove efficacy in low-cost clinical trials, and then (b) market that data to ensure physician adoption of the first working rejuvenation therapies. A PDF version of this draft also exists.
Executive Summary
1. Aging is by far the greatest cause of human morbidity and mortality.
2. Rejuvenation therapies that will greatly reduce unnecessary late life suffering and death ar...
Source: Fight Aging! - January 13, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
