Targeting the Aging of the Immune System in the Context of Frailty
The immune system declines into a state of incapacity (immunosenescence) and chronic inflammation (inflammaging) with advancing age. Unresolved inflammatory signaling is disruptive of tissue function in many ways, from reduced stem cell activity to pathologically altered somatic cell behavior. It is thought to be important in the declining muscle mass and strength that contributes to age-related frailty. Thus addressing immune aging is a significant and important target in the treatment of aging as a whole.
Frailty is a highly prevalent geriatric syndrome that has attracted significant attention from physicians an...
Source: Fight Aging! - November 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
First Generation Stem Cell and Exosome Therapies Promote Neurogenesis
First generation stem cell transplants have not as yet produced the reliably improved regeneration that was hoped for, but they do suppress chronic inflammation for some months. This effect is mediated by cell signaling on the part of the transplanted cells in the short time that they survive after transplantation. Much of that signaling is carried by exosomes and other classes of extracellular vesicle, and hence similar outcomes result from therapies based on delivery of exosomes harvested from cultured stem cells.
One of the effects of the unresolved inflammatory signaling characteristic of aging is a suppression ...
Source: Fight Aging! - November 24, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Where Does Diabetes Technology Stand In 2022?
Diabetes management went through a radical transformation in the last years due to technology: the diabetes patient community found a strong voice online, continuous glucose monitors are taking the place of finger pricks, digital patches and insulin pumps make the dosage of insulin more predictable, and connected devices promise the era of artificial pancreas real soon. We looked around where diabetes technology stands today and what could we expect in the next 5-10 years.
The diabetes community and digital health tech companies pushing for change
Diabetes continues to affect the lives of millions around the globe. A...
Source: The Medical Futurist - November 22, 2022 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine community diabetes digital digital health patient technology artificial pancreas blood diabetes management insulin diabetic health management blood sugar Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reprogramming Alone is Not Sufficient
Epigenetic reprogramming is a process of exposing cells to the Yamanaka factors for a long enough period of time to shift their epigenome towards that found in youthful tissues, but not for so long as to cause any meaningful number of them to change state into pluripotent stem cells. It is an attempt to reproduce aspects of the cellular rejuvenation that occurs in the initial stages of embryogenesis, without harming the functional specialization of the cells so altered. It works surprisingly well in animal studies, considering all of the very reasonable a priori objections as to why we should believe that such an embryonic...
Source: Fight Aging! - November 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Better Understanding the Outcome of Destroying and Rebuilding the Immune System
The use of chemotherapy to destroy as much of the peripheral immune system as possible, followed by some form of stem cell transplant to rebuild it, has been used for some years as a way to treat multiple sclerosis. In this autoimmune condition, the problem resides in the immune memory, and getting rid of that memory is the solution. The only approach currently demonstrated to work is this somewhat drastic treatment, and the balance of risk and cost means that it is only used for severe diseases such as multiple sclerosis. But in principle, clearance and restoration of the immune system could solve a great many of the issu...
Source: Fight Aging! - November 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Does the Gut Microbiome Contribute to Frailty via Oxidative Stress?
The challenge in understanding degenerative aging is at this point less a matter of identifying mechanisms, and more a matter of establishing which of the many mechanisms involved in every specific aspect of aging are actually important. Cellular biochemistry is a complex interconnected web, and it is very hard to make changes to just one mechanism in isolation, so as to establish exactly its contribution. Now that biotechnology has advanced to the point at which near every biological mechanism is a viable target for intervention, it matters whether or not the research and development communities focus on the right targets...
Source: Fight Aging! - November 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Potential for Epigenetic Rejuvenation
Epigenetic change occurs with age, altering cellular behavior for the worse. Epigenetic reprogramming, via approaches derived from the use of Yamanaka factors to produce induced pluripotent stem cells, offers the potential to reset cell behavior in order to restore a more youthful tissue function. In mice, this is producing promising results. It remains an open question as to how age-related epigenetic change relates to fundamental causes of aging. It appears to be a far downstream consequence of underlying damage and dysfunction, but more recent work suggests that it may be an immediate consequence of stochastic DNA damag...
Source: Fight Aging! - November 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Danger Alert: A.I. Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of A.I. text generators around the web, offering more or less the same.
You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever
Isn’t it amazing? Writing a good text takes effort, so outsourcing it to A.I. could save us a ton of time in researching and crafting content.
Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it ...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs
Danger Alert: AI Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of AI text generators around the web, offering more or less the same.
You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever
Isn’t it amazing? Writing a good text takes effort, so outsourcing it to AI could save us a ton of time in researching and crafting content.
Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it is l...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reprogramming to Improve Stem Cell Function Synergizes with Senescent Cell Clearance in Flies
Rejuvenation will be achieved in humans by combinations of therapies, provided periodically over time. Each individual therapy will in some way address one of the forms of cell and tissue damage that accumulate to cause the pathologies of aging. There are numerous independent sources of such damage, however. It is the case that the various types of accumulating damage, and the far greater variety of dysfunctions caused by that damage, will interact with one another to make outcomes worse than they would have been alone. Nonetheless, very different forms of rejuvenation therapy will be required to repair each of the very di...
Source: Fight Aging! - November 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reprogramming as an Approach to Reduce T Cell Exhaustion
T cell exhaustion occurs following repeated stimulation, such as when faced with a growing cancer or persistent viral infection. It manifests as a progressive loss of function, the T cells no longer attacking pathogens or errant cells. Finding a way to minimize this phenomenon would assist in a range of conditions, such as by improving the outcome of T cell immunotherapies targeting cancer, and might help improve the aged immune system, in which T cell exhaustion is also observed. Here, the use of partial reprogramming is suggested as an approach to achieve this goal. In partial reprogramming, cells are exposed to the fact...
Source: Fight Aging! - October 31, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metaboli...
Source: Fight Aging! - October 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
