Stem Cell Derived Extracellular Vesicles Reduce Epigenetic Age in Mice
As a strategy, the measurement of epigenetic age to assess the outcome of therapy intended to slow or reverse aging has its issues. Since it remains unknown as to how near all of the epigenetic marks on the genome are caused by the underlying processes of aging, it is quite possible that any given epigenetic clock will underestimate or overestimate the effects of a given approach to therapy, based on the choice and weighting of epigenetic marks used in the clock. It is suspected that the existing clocks are strongly influenced by only some of the mechanisms of aging.
Thus the assessment epigenetic age in a study of ...
Source: Fight Aging! - October 27, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Age of Metabolomics
Obtaining enormous amounts of data on the human metabolome now costs little. Databases of metabolomic data available for analysis have become vast, and continue to grow. Productive analysis trails far behind the production of data, unfortunately, as is true for all of the omics technologies. In this paper, researchers discuss the present state of metabolomic knowledge in the context of aging, and the path forward to producing useful understanding from this deluge of human data, contributing perhaps to the better development of treatments for aging.
Aging is a fundamental part of the human experience, and it has lo...
Source: Fight Aging! - October 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Oxidative Stress and Inflammation in Aging Muscles
With advancing age, muscle tissue loses mass and strength, leading to sarcopenia and frailty. A range of mechanisms are thought to contribute to this progressive degeneration, but researchers here suggest that the preventative focus for muscle aging should be placed on ways to reduce oxidative stress and chronic inflammation. These two aspects of aging go hand in hand, linked by a number of different mechanisms, such as the level of damage and altered behavior of mitochondria in cells. Both oxidative stress and inflammation change cell behavior for the worse, and in muscle tissue it may be that reduced activity in the stem...
Source: Fight Aging! - October 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Burden of Somatic Mutation with Age
Mutational damage occurs constantly to nuclear DNA throughout life. Little of that damage goes unrepaired, and little of the lasting breakage occurs in active parts of the genome. Where mutations go unrepaired in active parts of the genome, little of that occurs in important genes. Where it does occur in important genes, that only matters to the extent that (a) the mutation can spread, and (b) the mutation is potentially cancerous. Comparatively few cells in the body have the capacity to create many descendant cells through replication, as the Hayflick limit ensures that near all cells are limited in the number of times th...
Source: Fight Aging! - October 24, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Subpopulation of Thymic Cells Can Restore Function to an Aged Thymus
You may recall that researchers have shown that endothelial progenitor cells can restore function to an atrophied thymus. Here, researchers identify a particular subset of functional cells in the thymus that can achieve the same result. The thymus loses active tissue with age, and this loss is a major contribution to the age-related decline of the immune system. The thymus is where thymocytes, created in the bone marrow, mature into new T cells of the adaptive immune system. Absent this supply of T cell reinforcements, the immune system becomes ever more crowded, year after year, with dysfunctional, broken cells. Restoring...
Source: Fight Aging! - October 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
