Oxidative Stress and Inflammation in Aging Muscles

With advancing age, muscle tissue loses mass and strength, leading to sarcopenia and frailty. A range of mechanisms are thought to contribute to this progressive degeneration, but researchers here suggest that the preventative focus for muscle aging should be placed on ways to reduce oxidative stress and chronic inflammation. These two aspects of aging go hand in hand, linked by a number of different mechanisms, such as the level of damage and altered behavior of mitochondria in cells. Both oxidative stress and inflammation change cell behavior for the worse, and in muscle tissue it may be that reduced activity in the stem cell populations responsible for generating new somatic cells to replace losses are of greatest importance. With aging, the progressive loss of skeletal muscle will have negative effect on multiple physiological parameters, such as exercise, respiration, thermoregulation, and metabolic homeostasis. Accumulating evidence reveals that oxidative stress and inflammation are the main pathological characteristics of skeletal muscle during aging. Here, we focus on aging-related sarcopenia, summarize the relationship between aging and sarcopenia, and elaborate on aging-mediated oxidative stress and oxidative damage in skeletal muscle and its critical role in the occurrence and development of sarcopenia. In addition, we discuss the production of excessive reactive oxygen species (ROS) in aging skeletal muscle, which reduces the ability of skeletal mu...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs