LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy

The primary focus of the Longevity Escape Velocity (LEV) Foundation is to demonstrate that therapies based on the repair of forms of underlying molecular damage that cause aging can be combined to produce greater rejuvenation. Research of recent years has demonstrated quite comprehensively that the alternative strategy for treating aging, to manipulate metabolism into a state in which aging occurs modestly more slowly, has so far produced therapies that largely cannot be combined. The combination of any two or more metabolic alterations, induced by supplements or other small molecules, that individually modestly slow aging in animal models will likely result in no effect or even a modest acceleration of aging. The advocacy community might do well to use this as a teaching moment, to refocus efforts on the better path of damage repair. In this article the LEV Foundation staff discuss the use of senolytics to clear senescent cells in their combination studies in mice, and the relevance of this approach to the bigger picture of combined therapeutics to produce rejuvenation. Since aging is a condition caused by a number of interacting but quite different forms of molecular damage and disarray, it will require a panoply of different therapies to repair aged tissue. Reversing mitochondrial dysfunction, repairing stem cell populations, removing senescent cells, clearing intracellular and extracellular waste products, and so forth. Once widespread in the clinic, senolytic drug...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs