Demethylation-activated light-up dual-color RNA aptamersensor for label-free detection of multiple demethylases in lung tissues
Biosens Bioelectron. 2023 Dec 21;247:115966. doi: 10.1016/j.bios.2023.115966. Online ahead of print.ABSTRACTMethylation is one of the most prevalent epigenetic modifications in natural organisms, and the processes of methylation and demethylation are closely associated with cell growth, differentiation, gene transcription and expression. Abnormal methylation may lead to various human diseases including cancers. Simultaneous analysis of multiple DNA demethylases remains a huge challenge due to the requirement of diverse substrate probes and scarcity of proper signal transduction strategies. Herein, we propose a sensitive an...
Source: Biosensors and Bioelectronics - December 26, 2023 Category: Biotechnology Authors: Xiao-Wen Liu Ning-Ning Zhao Hui-Min Yuan Dong-Ling Li Meng Liu Chun-Yang Zhang Source Type: research
Investigation of pesticide residues level on commonly consumed leafy vegetables picked from the central market in Jeddah, Saudi Arabia
In conclusion, this study sheds light on the contamination levels of commonly consumed domestically produced and purchased leafy vegetables in the Central Market of Jeddah. To ensure food safety and the well-being of consumers, we strongly recommend enhanced scientific assessments and continued monitoring of pesticide usage in agricultural practices.PMID:38147241 | DOI:10.1007/s11356-023-31694-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - December 26, 2023 Category: Environmental Health Authors: Rawan S Almutiriy Afnan M Alnajeebi Manal E A Elhalwagy Omer A Thabet Fahad K Alenzi Mona M Aljadani Source Type: research
Demethylation-activated light-up dual-color RNA aptamersensor for label-free detection of multiple demethylases in lung tissues
Biosens Bioelectron. 2023 Dec 21;247:115966. doi: 10.1016/j.bios.2023.115966. Online ahead of print.ABSTRACTMethylation is one of the most prevalent epigenetic modifications in natural organisms, and the processes of methylation and demethylation are closely associated with cell growth, differentiation, gene transcription and expression. Abnormal methylation may lead to various human diseases including cancers. Simultaneous analysis of multiple DNA demethylases remains a huge challenge due to the requirement of diverse substrate probes and scarcity of proper signal transduction strategies. Herein, we propose a sensitive an...
Source: Biosensors and Bioelectronics - December 26, 2023 Category: Biotechnology Authors: Xiao-Wen Liu Ning-Ning Zhao Hui-Min Yuan Dong-Ling Li Meng Liu Chun-Yang Zhang Source Type: research
Genes, Vol. 15, Pages 36: Comparative Transcriptome Analysis of Gene Expression and Regulatory Characteristics Associated with Different Bolting Periods in Spinacia oleracea
In this study, 18 samples from three periods of bolting-tolerant spinach material 12S3 and bolting-susceptible material 12S4 were analyzed using RNA-seq on, resulting in 10,693 differentially expressed genes (DEGs). Functional enrichment and co-expression trend analysis indicated that most DEGs were enriched in the photoperiod pathway, the hormone signaling pathway, and the cutin, suberin, and wax biosynthetic pathways. According to the weighted gene co-expression network analysis (WGCNA), SpFT (SOV4g003400), SOV4g040250, and SpGASA1 (SOV6g017600) were likely to regulate bolting through the gibberellin and photoperiod path...
Source: Genes - December 26, 2023 Category: Genetics & Stem Cells Authors: Hao Wu Zhilong Zhang Zhiyuan Liu Qing Meng Zhaosheng Xu Helong Zhang Wei Qian Hongbing She Tags: Article Source Type: research
Validation of JCLIMB, SPINACH, and VQI Calculators for Prediction of Two Year Survival in Patients With Chronic Limb Threatening Ischaemia After Infra-inguinal Surgical or Endovascular Revascularisation
CONCLUSION: The JCLIMB, SPINACH, and VQI survival calculation models were useful, although the OS predicted by the VQI model appeared to be lower than the observed OS.PMID:38141957 | DOI:10.1016/j.ejvs.2023.12.023 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - December 23, 2023 Category: Surgery Authors: Koichi Morisaki Daisuke Matsuda Atsushi Guntan Shogo Kawanami Shinichiro Yoshino Kentaro Inoue Kenichi Honma Terutoshi Yamaoka Shinsuke Mii Tomoharu Yoshizumi Source Type: research
Pressmud Subdue Phytoremediation Indices in Lead-Contaminated Soils: A Human Health Perspective
In this study, graded levels of pressmud (0, 2.5, 5, 10 g/kg) were applied on lead imposed soil with different contamination levels (0, 100, 150, 300 mg/kg) and metal dynamics was studied in spinach crop. Experimental results showed that the addition of pressmud upto 10 mg/kg had decreased different phytoremediation indices in spinach crop. Whereas, increasing Pb level enhanced the indices' values, indicating accumulation of significant amount of Pb in spinach biomass. However, application of pressmud (upto 10 mg/kg) reduced the bioconcentration factor (BCF) from 0.182 to 0.136, transfer factor (TF) from 0.221 to 0.191, tr...
Source: Bulletin of Environmental Contamination and Toxicology - December 21, 2023 Category: Environmental Health Authors: M L Dotaniya M C Nagar Amita Sharma C K Dotaniya R K Doutaniya Source Type: research
Pressmud Subdue Phytoremediation Indices in Lead-Contaminated Soils: A Human Health Perspective
In this study, graded levels of pressmud (0, 2.5, 5, 10 g/kg) were applied on lead imposed soil with different contamination levels (0, 100, 150, 300 mg/kg) and metal dynamics was studied in spinach crop. Experimental results showed that the addition of pressmud upto 10 mg/kg had decreased different phytoremediation indices in spinach crop. Whereas, increasing Pb level enhanced the indices' values, indicating accumulation of significant amount of Pb in spinach biomass. However, application of pressmud (upto 10 mg/kg) reduced the bioconcentration factor (BCF) from 0.182 to 0.136, transfer factor (TF) from 0.221 to 0.191, tr...
Source: Bulletin of Environmental Contamination and Toxicology - December 21, 2023 Category: Environmental Health Authors: M L Dotaniya M C Nagar Amita Sharma C K Dotaniya R K Doutaniya Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Validation of JCLIMB, SPINACH, and VQI Calculators for Prediction of Two Year Survival in Patients With Chronic Limb Threatening Ischaemia After Infra-inguinal Surgical or Endovascular Revascularisation
This study aimed to evaluate three survival prediction models: the JAPAN Critical Limb Ischemia Database (JCLIMB), Surgical Reconstruction Versus Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH), and Vascular Quality Initiative (VQI) calculators. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - December 20, 2023 Category: Surgery Authors: Koichi Morisaki, Daisuke Matsuda, Atsushi Guntan, Shogo Kawanami, Shinichiro Yoshino, Kentaro Inoue, Kenichi Honma, Terutoshi Yamaoka, Shinsuke Mii, Tomoharu Yoshizumi Source Type: research
Selenium-rich food potentially useful to control mercury levels among Afro-Colombians: Towards an intercultural intervention
CONCLUSION: It is proposed that the banana juice, the pineapple colada, the borojó (Borojoa patinoi) sorbet, the cucas, and the enyucado are basic elements for a culturally acceptable intervention.PMID:38109141 | DOI:10.7705/biomedica.6981 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - December 18, 2023 Category: International Medicine & Public Health Authors: Sonia M D íaz Ruth Mari én Palma Edna M Gamboa Álvaro J Idrovo Source Type: research
