Allostatic Load as a Correlate of Aging
Allostatic load is the concept of wear and tear on the body that emerges from stresses via overactivation of the neuroendocrine system. Causative stresses can range from starvation to psychological stress to a high burden of age-related dysfunction. At some point reactions to stress that are compensatory tip over into being themselves damaging. Thus one could expect allostatic load to correlate with degenerative aging and risk of mortality to at least some degree. In practice, however, there is little agreement on how to measure allostatic load, particularly in human patients, which makes it hard to compare results from st...
Source: Fight Aging! - February 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The power of nutrition in cancer prevention
In its annual cancer statistics report released this week, the American Cancer Society (ACS) predicted over 2 million new cancer cases and over 600,000 cancer deaths in the United States in 2024. The ACS cites decreased smoking rates, earlier detection, and improved treatments as the primary reasons for decreased death rates from cancer in recent decades. Missing
Read more…
The power of nutrition in cancer prevention originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 13, 2024 Category: General Medicine Authors: Dr. Roxanne Becker Tags: Conditions Nutrition Source Type: blogs
Putting West Virginia Students on the Path to Scientific Careers
Credit: NIGMS.
Two NIGMS-funded programs are teaming up to shape the future of science and technology in West Virginia (WV). One engages high school students in science, technology, engineering, math, and medicine (STEM+M); introduces them to research; and provides direct access to college through tuition waivers. In the other program, undergraduate students are paired with a researcher at their institution for a paid internship—an important step toward a career in science.
The Health Sciences & Technology Academy
“We liken our students to rosebuds. As they grow, you see them blossom into self-confident lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 31, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education SEPA Training Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantifying the Effects of Time Spent Sitting on Mortality
The study noted here provides an interesting addition to the debate over whether time spent sitting is harmful to health independently of its contribution to time spent being sedentary. Time spent sitting increases mortality, while time spent active or undertaking exercise decreases mortality. The results of this large epidemiological study quantify how much additional exercise is required to mitigate the mortality increase resulting from time spent sitting. The results also have the look of common sense at the end of the day; the intuition that one should compensate for a desk job with additional exercise outside work tur...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A man in his 30s with chest pain. How was he managed? What if they had used the Queen of Hearts?
Written by Pendell MeyersA man in his late 30s with history of hypertension, tobacco use, and obesity presented to the Emergency Department for acute chest pain which started approximately 3 hours prior to arrival, in the setting of a very stressful situation. The pain radiated down both arms, 10/10 in severity. He stated it did not feel like his prior episodes of reflux. Vitals were within normal limits except some hypertension. Triage ECG:And here she explains her assessment:The ECG was read as simply " No ST elevation. " Which is true.The initial high sensitivity troponin I returned at around 3300 ng/L. No repeat E...
Source: Dr. Smith's ECG Blog - January 20, 2024 Category: Cardiology Authors: Pendell Source Type: blogs
The Future Of Cognitive Health: This Is How Digital Health Can Help
According to this study, digital healthcare technologies offer ways to manage and slow down the progression of conditions like dementia and mild cognitive impairment. However, choosing the right technology is difficult because there’s no comprehensive review that covers the various types of digital technology for cognitive impairment, including their effects and limitations.
The goal of the study was to identify different types of digital health technologies used for dementia and mild cognitive impairment and evaluate how the results are measured and aligned with their intended purposes.
A total of 13...
Source: The Medical Futurist - January 16, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF cognitive health Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
National Academies Replaces Big Alcohol-Conflicted Researcher on Review Panel with Another Big Alcohol-Conflicted Researcher
Just over one month ago, Ireported that the National Academies had appointed to their newly formedexpert committee to review the health effects of alcohol
two scientists who were principal investigators of a research grant
funded by the alcohol industry to the tune of $67 million (Dr. Eric Rimm and Dr. Kenneth Mukamal). AfterNew York Times reporter Roni Rabin exposed these conflicts of interest in anarticle, the National Academies announced that it had pulled both Dr. Rimm and Dr. Mukamal from the panel and would replace them.The National Academies recently announced the replacement panelists, and one of them is Dr. Luc ...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - January 5, 2024 Category: Addiction Source Type: blogs
Air Pollution Implicated as a Contributing Cause of Numerous Age-Related Conditions
A compelling range of evidence links greater particulate air pollution to a greater incidence of age-related disease and mortality. The primary mechanism is considered to be induction of chronic inflammation via the interaction of particulates with lung tissue. Constant, unresolved inflammatory signaling is disruptive to cell and tissue function throughout the body, accelerating the onset and progression of all of the most common disabling and ultimately fatal age-related conditions.
Growing evidence suggests that exposure to fine particulate matter (PM2.5) may reduce life expectancy; however, the causal pathways ...
Source: Fight Aging! - January 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
2024 Prediction: Society Will Arrive at an Inflection Point in AI Advancement
By MIKE MAGEE
For my parents, March, 1965 was a banner month. First, that was the month that NASA launched the Gemini program, unleashing “transformative capabilities and cutting-edge technologies that paved the way for not only Apollo, but the achievements of the space shuttle, building the International Space Station and setting the stage for human exploration of Mars.” It also was the last month that either of them took a puff of their favored cigarette brand – L&M’s.
They are long gone, but the words “Gemini” and the L’s and the M’s have taken on new meaning and relevance now six decades l...
Source: The Health Care Blog - December 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Google LLM Microsoft Mike Magee Source Type: blogs
poem
Train StationThe game ofLifedidn ’t age well. No one plays it anymore. Half the pieces are missing. Half the family’s dead. Its gilded suburbia a Potemkin sham. Fake money all gone. Besides, it ' s too much like real life. Insurance premiums going up, escrow shortages. Estate taxes on the bachelor uncle everyone hated so he left it all to you. When life itself is just a game, the game itself stops being any fun.Riskis more of the same. A strategy distilled down to the heaviest gas. Domination, manipulation. Betrayal and degradation. But it ’s all just roll of the dice luck. And much less fun when there’s abso...
Source: Buckeye Surgeon - December 27, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An ECG with only «marginal» change
DISCUSSION: This case nicely illustrates how subtle OMI changes really can be. The Queen of Hearts AI model did not identify OMI in the initial ECG.Below is the QoH explainability for the limb leads of the ECG #2 (left part of the image) and limb leads of ECG #3 (right side of the image). The sets of six limb leads are put next to each other for comparison. I ' ve excluded the precordial leads as they didn ' t add much information in this case. You can look at each leads and compare the two ECGs. You then can appreciate the dynamic change and see what parts of the waveform the QoH identifies as ischemic findings....
Source: Dr. Smith's ECG Blog - December 15, 2023 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
This article was originally published on The Conversation.
News in Context:
Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
What are cognitive abilities and how to boost them?
The post Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 14, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimer’s biological Brain-Fitness cognition cognitive engagement cognitive-abilities cognitive-reserve dementia depression exercise inflammation lifestyle neuroplasticity optimize cognition Stress Source Type: blogs
