Smallpox, an ancient term for various infectious diseases: the dreaded Smallpox, the almost unknown Alastrim, the Mpox
Conclusion: The recent human cases of Mpox have prompted greater surveillance and research into the biology of MPXV and other closely related poxviruses. Studies have focused on the natural history of the virus, its transmission, pathogenesis, host interactions and evolution, and on the development of drugs and vaccines to prevent its spread. (Source: Journal of Preventive Medicine and Hygiene)
Source: Journal of Preventive Medicine and Hygiene - August 1, 2023 Category: International Medicine & Public Health Authors: Davide Orsini, Mariano Martini, Masoud Behzadifar, Nicola Luigi Bragazzi Source Type: research
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for the Re-emerging Human Monkeypox Virus
J Microbiol Biotechnol. 2023 Jul 25;33(12):1-7. doi: 10.4014/jmb.2306.06033. Online ahead of print.ABSTRACTMonkeypox (Mpox) virus, a member of the Poxviridae family, causes a severe illness similar to smallpox, which is characterized by symptoms such as high fever, rash, and pustules. Human-to-human transmission cases have been reported but remained low since the first recorded case of human infection occurred in the Congo in 1970. Recently, Mpox has re-emerged, leading to an alarming surge in infections worldwide since 2022, originating in the United Kingdom. Consequently, the World Health Organization (WHO) officially de...
Source: Journal of Microbiology and Biotechnology - July 31, 2023 Category: Biotechnology Authors: Wooseong Lee Yu-Jin Kim Su Jin Lee Dae-Gyun Ahn Seong-Jun Kim Source Type: research
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for the Re-emerging Human Monkeypox Virus
J Microbiol Biotechnol. 2023 Jul 25;33(12):1-7. doi: 10.4014/jmb.2306.06033. Online ahead of print.ABSTRACTMonkeypox (Mpox) virus, a member of the Poxviridae family, causes a severe illness similar to smallpox, which is characterized by symptoms such as high fever, rash, and pustules. Human-to-human transmission cases have been reported but remained low since the first recorded case of human infection occurred in the Congo in 1970. Recently, Mpox has re-emerged, leading to an alarming surge in infections worldwide since 2022, originating in the United Kingdom. Consequently, the World Health Organization (WHO) officially de...
Source: Journal of Microbiology and Biotechnology - July 31, 2023 Category: Biotechnology Authors: Wooseong Lee Yu-Jin Kim Su Jin Lee Dae-Gyun Ahn Seong-Jun Kim Source Type: research
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for the Re-emerging Human Monkeypox Virus
J Microbiol Biotechnol. 2023 Jul 25;33(8):1-7. doi: 10.4014/jmb.2306.06033. Online ahead of print.ABSTRACTMonkeypox (Mpox) virus, a member of the Poxviridae family, causes a severe illness similar to smallpox, which is characterized by symptoms such as high fever, rash, and pustules. Human-to-human transmission cases have been reported but remained low since the first recorded case of human infection occurred in the Congo in 1970. Recently, Mpox has re-emerged, leading to an alarming surge in infections worldwide since 2022, originating in the United Kingdom. Consequently, the World Health Organization (WHO) officially dec...
Source: Journal of Microbiology and Biotechnology - July 31, 2023 Category: Biotechnology Authors: Wooseong Lee Yu-Jin Kim Su Jin Lee Dae-Gyun Ahn Seong-Jun Kim Source Type: research
Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine
In this study, a potentially universal DNA vaccine candidate against mpox based on conserved epitopes was designed and its efficacy was evaluated via an immunoinformatics approach. The vaccine candidate demonstrated potent humoral and cellular immune responses in silico, indicating the potential efficacy in vivo and the need for further research. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 21, 2023 Category: Microbiology Source Type: research
The prospective outcome of the monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology
A new threat to global health re-emerged with monkeypox’s advent in early 2022. As of November 10, 2022, nearly 80,000 confirmed cases had been reported worldwide, with most of them coming from places where the disease is not common. There were 53 fatalities, with 40 occurring in areas that had never before recorded monkeypox and the remaining 13 appearing in the regions that had previously reported the disease. Preliminary genetic data suggest that the 2022 monkeypox virus is part of the West African clade; the virus can be transmitted from person to person through direct interaction with lesions during sexual activity....
Source: Frontiers in cellular and infection microbiology - July 18, 2023 Category: Microbiology Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: American Family Physician - July 13, 2023 Category: Primary Care Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: Pain Physician - July 13, 2023 Category: Anesthesiology Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: American Family Physician - July 13, 2023 Category: Primary Care Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: American Family Physician - July 13, 2023 Category: Primary Care Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: American Family Physician - July 13, 2023 Category: Primary Care Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Mpox: Rapid Evidence Review
Am Fam Physician. 2023 Jul;108(1):78-83.ABSTRACTMpox (formerly monkeypox) is a DNA virus of the Orthopoxvirus genus, similar to smallpox. Although mpox was endemic to the Democratic Republic of the Congo and parts of Africa, increasing numbers of cases were reported worldwide in 2022. More than 30,000 cases have been reported in the United States, and worldwide 98% of cases are found in men who have sex with men. Transmission is primarily through contact with skin lesions. The rash of mpox is often vesiculopustular and may be localized to the anogenital region or distributed on the face, trunk, limbs, palms, and soles. Two...
Source: American Family Physician - July 13, 2023 Category: Primary Care Authors: Aaron Saguil Lindy Krebs Ulyee Choe Source Type: research
Viruses, Vol. 15, Pages 1533: Clinical Strategies and Therapeutics for Human Monkeypox Virus: A Revised Perspective on Recent Outbreaks
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Saikat Dewanjee
An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus Orthopoxviridae, a family of notorious smallpox viruses, and so it shares similar clinical pathophysiological features. The recent multicountry HMPX outbreak (May 2022 onwards) is recognized as an emerging global public health emergency by the World Health Organization, shunting its endemic status as opined over the past few decades. Re-emergence of HMPX raises concern to reassess the present clinical strategy and therapeutics as its outbreak e...
Source: Viruses - July 12, 2023 Category: Virology Authors: Nilanjan Ghosh Leena Chacko Jayalakshmi Vallamkondu Tanmoy Banerjee Chandrima Sarkar Birbal Singh Rajkumar Singh Kalra Jasvinder Singh Bhatti Ramesh Kandimalla Saikat Dewanjee Tags: Review Source Type: research
“Take” after LC16m8 for mpox
A 40-year-old male participant with no history of smallpox vaccination in a specified clinical trial on pre-exposure vaccination against mpox was inoculated with an attenuated live smallpox vaccine, LC16m8, in his left upper arm.[1] The inoculation site was erythematous after 1 day, papular after 3 days, blistering after 8 days, and pustular after 9 days. Crusting began at the center of the pustule on day 10 (Fig. 1). The rash reached its maximum diameter of 9 mm on day 12 (Fig. 2). On day 14, the entire area was covered with crusting, and the crusting had fallen off by day 28, leaving behind a small scar (day 56, Fig. (So...
Source: International Journal of Infectious Diseases - July 12, 2023 Category: Infectious Diseases Authors: Nobumasa Okumura, Masahiro Ishikane, Mugen Ujiie, Norio Ohmagari Tags: Medical Imagery Source Type: research
Summary of the National Advisory Committee on Immunization (NACI) Rapid Response-Interim guidance on the use of Imvamune in the context of monkeypox outbreaks in Canada
CONCLUSION: NACI has rapidly developed guidance on the use of Imvamune in Canada in the context of many uncertainties. Recommendations may be revisited as new evidence emerges.PMID:37426289 | PMC:PMC10324881 | DOI:10.14745/ccdr.v48i78a09 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - July 10, 2023 Category: Infectious Diseases Authors: April Killikelly Nicholas Brousseau Source Type: research
