Immunotherapeutic Properties of Dexmedetomidine on Pain Management and Cardiovascular Function in Videolaparoscopic Cholecystectomies: A Randomized, Two-Arm, Double-Blinded, Placebo-Controlled Trial
CONCLUSIONS: Dexmedetomidine provided anti-inflammatory activity, sympatholytic effect and analgesia with cardiovascular safety. It reinforces the therapeutic nature of highly selective α2-adrenergic agonists when combined within anesthetic interventions.PMID:38383315 | DOI:10.1177/15533506241234591 (Source: Surgical Innovation)
Source: Surgical Innovation - February 21, 2024 Category: Surgery Authors: Gustavo Nascimento Silva Virna Guedes Brand ão Marcelo Vaz Perez Sandoval Lage Sobrinho Jo ão Gabriel de Cerqueira Campos Villardi Priscilla Mendon ça do Sacramento Luiz Claudio Pereira Ribeiro Rossano Kepler Alvim Fiorelli Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis
CONCLUSIONS: LRG induced autophagy activation can maintain cell homeostasis and promote cell survival by blocking the apoptotic pathway. LRG could improve Sev-induced POCD via activating autophagy, inhibiting apoptosis, and regulating AMPK/mTOR signaling pathway. This study provides a novel therapeutic strategy for the prevention and treatment of POCD.PMID:38364258 | DOI:10.18632/aging.205558 (Source: Aging)
Source: Aging - February 16, 2024 Category: Biomedical Science Authors: Ying Hu Haijin Huang Yao Jiang Jingling Zhang Yang Zhang Ying Tian Qin Zhang Source Type: research
Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis
CONCLUSIONS: LRG induced autophagy activation can maintain cell homeostasis and promote cell survival by blocking the apoptotic pathway. LRG could improve Sev-induced POCD via activating autophagy, inhibiting apoptosis, and regulating AMPK/mTOR signaling pathway. This study provides a novel therapeutic strategy for the prevention and treatment of POCD.PMID:38364258 | DOI:10.18632/aging.205558 (Source: Aging)
Source: Aging - February 16, 2024 Category: Biomedical Science Authors: Ying Hu Haijin Huang Yao Jiang Jingling Zhang Yang Zhang Ying Tian Qin Zhang Source Type: research
Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis
CONCLUSIONS: LRG induced autophagy activation can maintain cell homeostasis and promote cell survival by blocking the apoptotic pathway. LRG could improve Sev-induced POCD via activating autophagy, inhibiting apoptosis, and regulating AMPK/mTOR signaling pathway. This study provides a novel therapeutic strategy for the prevention and treatment of POCD.PMID:38364258 | DOI:10.18632/aging.205558 (Source: Aging)
Source: Aging - February 16, 2024 Category: Biomedical Science Authors: Ying Hu Haijin Huang Yao Jiang Jingling Zhang Yang Zhang Ying Tian Qin Zhang Source Type: research
Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes
This study was undertaken to compare the effects of sevoflurane and propofol anesthesia on perioperative hemodynamics and perioperative adverse cardiovascular events (PACE) in elderly patients with diabetes undergoing general anesthesia for noncardiac surgery.METHODS: According to the random number table (n = 40), 80 patients with diabetes undergoing noncardiac general anesthesia were divided into a control group and an observation group. In the control group, the patients were given propofol 4 to 6 mg/(kg·h), continuously pumped to maintain anesthesia. In the observation group, the patients were given maintained concentr...
Source: Clinical Therapeutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Liling Jia Hongfeng Li Tuping Li Source Type: research
Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes
This study was undertaken to compare the effects of sevoflurane and propofol anesthesia on perioperative hemodynamics and perioperative adverse cardiovascular events (PACE) in elderly patients with diabetes undergoing general anesthesia for noncardiac surgery.METHODS: According to the random number table (n = 40), 80 patients with diabetes undergoing noncardiac general anesthesia were divided into a control group and an observation group. In the control group, the patients were given propofol 4 to 6 mg/(kg·h), continuously pumped to maintain anesthesia. In the observation group, the patients were given maintained concentr...
Source: Clinical Therapeutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Liling Jia Hongfeng Li Tuping Li Source Type: research
Sevoflurane causes cognitive impairment by inducing iron deficiency and inhibiting the proliferation of neural precursor cells in infant mice
CONCLUSION: The results from the present study demonstrated that Sev-induced iron deficiency might be a new mechanism of cognitive impairment caused by inhaled anesthetics in infant mice. Iron supplementation before anesthesia is an effective strategy to prevent cognitive impairment caused by Sev in infants.PMID:38334030 | PMC:PMC10853893 | DOI:10.1111/cns.14612 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Yong Zuo Jinhong Xie Xue Zhang Anand Thirupathi Xiaopeng Liu Di Zhang Jianhua Zhang Zhenhua Shi Source Type: research
Dysregulation of iron homeostasis and ferroptosis in sevoflurane and isoflurane associated perioperative neurocognitive disorders
CNS Neurosci Ther. 2024 Feb;30(2):e14553. doi: 10.1111/cns.14553.ABSTRACTIn recent years, sevoflurane and isoflurane are the most popular anesthetics in general anesthesia for their safe, rapid onset, and well tolerant. Nevertheless, many studies reported their neurotoxicity among pediatric and aged populations. This effect is usually manifested as cognitive impairment such as perioperative neurocognitive disorders. The wide application of sevoflurane and isoflurane during general anesthesia makes their safety a major health concern. Evidence indicates that iron dyshomeostasis and ferroptosis may establish a role in neurot...
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Mengrong Miao Yaqian Han Yangyang Wang Jie Wang Ruilou Zhu Yitian Yang Ningning Fu Ningning Li Mingyang Sun Jiaqiang Zhang Source Type: research
Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia ‑reperfusion injury in sevoflurane‑treated rats
Mol Med Rep. 2024 Mar;29(3):54. doi: 10.3892/mmr.2024.13178. Epub 2024 Feb 9.ABSTRACTThe aim of the present study was to examine the effect of fullerenol C60 on lung and kidney tissue in sevoflurane‑treated rats with lower extremity ischemia‑reperfusion (IR) injury. A total of 30 Wistar albino rats weighing 225‑275 g were used and were equally divided into five groups (n=6/group): i) Sham; ii) IR; iii) IR‑fullerenol C60 (IR‑FUL); iv) IR‑sevoflurane; and v) IR‑fullerenol C60‑sevoflurane (IR‑FUL‑SEVO). Fullerenol C60 was administered intraperitoneally prior to lower extremity IR induction and sevoflurane ...
Source: Molecular Medicine Reports - February 9, 2024 Category: Molecular Biology Authors: Ay şe Hande Arpaci Zeynep K öksal Zeynep Yi ğman Ay şegül Küçük Volkan Şivgin Mustafa Arslan Mustafa Kavut çu Saadet Özen Akarca Di Zakar Source Type: research
The effect of sevoflurane exposure on cell ‐type‐specific changes in the prefrontal cortex in young mice
This study focuses on investigating the impact of neonatal sevoflurane exposure on cell-type-specific alterations in the prefrontal cortex (PFC) of young mice. Neonatal mice were subjected to either control treatment (60% oxygen balanced with nitrogen) or sevoflurane anesthesia (3% sevoflurane in 60% oxygen balanced with nitrogen) for 2 hours on postnatal days (PNDs) 6, 8, and 10. Behavioral tests and single-nucleus RNA sequencing (snRNA-seq) of the PFC were conducted from PNDs 31 to 37. Mechanistic exploration included clustering analysis, identification of differentially expressed genes (DEGs), enrichment analyses, si...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Bao ‐Jian Zhao,
Shao‐Yong Song,
Wei‐Ming Zhao,
Han‐Bing Xu,
Ke Peng,
Xi‐Sheng Shan,
Qing‐Cai Chen,
Hong Liu,
Hua‐Yue Liu,
Fu‐Hai Ji Tags: ORIGINAL ARTICLE Source Type: research
