Melatonin Ameliorates Sevoflurane Anesthesia-Induced Deficits in Learning and Memory of Aged Mice Through Nrf2 Signaling Related Ferroptosis
Rejuvenation Research, Ahead of Print. (Source: Rejuvenation Research)
Source: Rejuvenation Research - February 6, 2024 Category: Genetics & Stem Cells Authors: Honghu Ni Yijia Chen Yongxiang Xie Source Type: research
Cerebral oxygenation saturation in childhood: difference by age and comparison of two cerebral oximetry algorithms
In this study, we aimed to assess and compare rSO2 levels in pediatric patients of different age groups undergoing non-cardiac surgery. We used two oximeters, tNIRS-1, which uses time-resolved spectroscopy, and conventional INVOS 5100C. Seventy-eight children —26 infants, 26 toddlers, and 26 schoolchildren—undergoing non-cardiac surgery were included. We investigated the differences in the rSO2 levels among the age groups and the correlation between the models and physiological factors influencing the rSO2 values. rSO2 measured by INVOS 5100C was significantly lower in infants than those in other patients. rSO2 measure...
Source: Journal of Clinical Monitoring and Computing - February 4, 2024 Category: Information Technology Source Type: research
Sevoflurane Postconditioning Protects From an Early Neurological Deficit After Subarachnoid Hemorrhage: Results of a Randomized Laboratory Study in Rats
CONCLUSIONS: Sevoflurane postconditioning improves survival by 23% (SAH-sevoflurane versus SAH-propofol). The sevoflurane intervention could attenuate the early neurologic deficit, while the long-term outcome was similar across the groups. A higher vascular density close to the SAH area in the propofol group was not associated with improved outcomes.PMID:38259181 | DOI:10.1213/ANE.0000000000006829 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - January 23, 2024 Category: Anesthesiology Authors: Laurent Morax Beatrice Beck-Schimmer Jonah Neff Mattia Mueller Renata Flury-Frei Martin Schl äpfer Source Type: research
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice
Transl Res. 2024 Jan 19:S1931-5244(24)00017-3. doi: 10.1016/j.trsl.2024.01.007. Online ahead of print.ABSTRACTProlonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting genetic material. Nevertheless, the specific mechanisms by which miRNAs in ADEs contribute to sevoflurane-in...
Source: Translational Research : the journal of laboratory and clinical medicine - January 21, 2024 Category: Laboratory Medicine Authors: Junhua Li Hui Xu Kun Zhang Yafang Liu Cong Zeng Yanni Fu Yujuan Li Source Type: research
Retraction notice to "Inhibition of miR-495-3p ameliorated sevoflurane induced damage through BDNF/ERK/CREB signaling pathways in HT22 cells" [Transplant Immunology, Volume75, December 2022, 101708]
Transpl Immunol. 2024 Jan 18:101992. doi: 10.1016/j.trim.2024.101992. Online ahead of print.NO ABSTRACTPMID:38242727 | DOI:10.1016/j.trim.2024.101992 (Source: Transplant Immunology)
Source: Transplant Immunology - January 19, 2024 Category: Transplant Surgery Authors: Xiaomei Chen Chongyi Li Rui Zeng Ling Qiu Jianhang Huang Ning Wang Xia Ren Xingwu Lin Source Type: research
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice
Prolonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting genetic material. Nevertheless, the specific mechanisms by which miRNAs in ADEs contribute to sevoflurane-induced cognitive deficit are currently unknown. (Source: Translational Research)
Source: Translational Research - January 18, 2024 Category: Research Authors: Junhua Li, Hui Xu, Kun Zhang, Yafang Liu, Cong Zeng, Yanni Fu, Yujuan Li Source Type: research
The halothane era in pediatric anesthesia: The convergence of a cardiac depressant anesthetic with the immature myocardium of infancy
Paediatr Anaesth. 2024 Jan 17. doi: 10.1111/pan.14840. Online ahead of print.ABSTRACTIntroduced in the late 1950s, halothane became the anesthetic of choice for inhalational induction of children for over 40 years. Halothane enjoyed a generally favorable safety record during its time, but its cardiac contractility depressant effect-well tolerated by most age groups-was profoundly heightened in neonates and infants, leading to increased incidences of hypotension and cardiac arrest. The neonatal myocardium is immature and is characterized by poor ventricular compliance, poor contractility due to fewer contractile elements, i...
Source: Paediatric Anaesthesia - January 17, 2024 Category: Anesthesiology Authors: Robert H Friesen Source Type: research
Effects of propofol versus sevoflurane on surgical field visibility during arthroscopic rotator cuff repair: a randomized trial
During arthroscopic rotator cuff repair (ARCR), clear surgical field visibility (SFV) is the basis of successful surgery, but the choice of anesthesia maintenance drugs may have different effects on SFV. In th... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - January 17, 2024 Category: Anesthesiology Authors: Wenchao Yin, Chenzhu Yin, Wencan Wang, Rao Peng, Li Su and Peiyu Li Tags: Research Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
