The Outcome of Primary Hepatic Neuroendocrine Tumors: A Single-Center Experience
ConclusionOur data suggest that the prognosis of the tumor seems favorable. Surgical resection is the curative treatment. TACE is a favorable option in unresectable tumors. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - September 12, 2019 Category: Gastroenterology Source Type: research
The Outcome of Primary hepatic neuroendocrine tumours: A Single-center experience
CONCLUSIONOur data suggest that the prognosis of the tumour seems favourable. Surgical resection is the curative treatment. TACE is a favourable option in unresectable tumours. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - August 17, 2019 Category: Gastroenterology Source Type: research
Pore change during degradation of octreotide acetate-loaded PLGA microspheres: The effect of polymer blends.
This study used PLGA 5050 4H (F-1), PLGA 5050 1A: PLGA 5050 4H = 3:7 (F-2) and PLGA 7525 1A: PLGA 5050 4H = 3:7 (F-3) as a carrier, respectively. Microspheres (MS) were obtained by O/W emulsion solvent evaporation technique and characterized by scanning electron microscopy (SEM), particle size, drug loading, fluorescence characteristics, and in vitro and in vivo release. Accelerated tests in vitro showed that the size and number of core pores significantly affected drug release in the first and second phases. After intramuscular administration, F-2 and F-3 showed effective blood concentration levels and their bioav...
Source: European Journal of Pharmaceutical Sciences - July 10, 2019 Category: Drugs & Pharmacology Authors: Wang T, Xue P, Wang A, Yin M, Han J, Tang S, Liang R Tags: Eur J Pharm Sci Source Type: research
Efficacy and safety of high-dose long-acting repeatable octreotide as monotherapy or in combination with pegvisomant or cabergoline in patients with acromegaly not adequately controlled by conventional regimens: Results of an open-label, multicenter study.
CONCLUSION: These data demonstrate that high-dose Sandostatin LAR as monotherapy or in combination with pegvisomant or cabergoline is a feasible salvage option in patients with pituitary adenomas not adequately controlled on conventional SSA regimens.
PMID: 31274183 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 4, 2019 Category: Endocrinology Authors: Colao A, Zgliczyński W, Komorowski J, Kos-Kudła B, Tabarin A, Kerlan V, Minuto FM, Scaroni C, Bolanowski M Tags: Endokrynol Pol Source Type: research
Proton Oriented- “Smart Depot” for Responsive Release of Ca 2+ to Inhibit Peptide Acylation in PLGA Microspheres
ConclusionsWith the presence of the smart Ca2+ depot (Ca3(PO4)2) in the microspheres, a sustainable and long-term inhibition of peptide acylation was achieved. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 3, 2019 Category: Drugs & Pharmacology Source Type: research
Control of octreotide release from silk fibroin microspheres
Publication date: September 2019Source: Materials Science and Engineering: C, Volume 102Author(s): He Gong, Jing Wang, Jue Zhang, Jianbing Wu, Zhaozhu Zheng, Xusheng Xie, David L. Kaplan, Gang Li, Xiaoqin WangAbstractPoly(d,l-lactide-co-glycolide) (PLGA) microspheres have been used as an injectable depot for prolonged release of octreotide (Sandostatin LAR®), a peptide drug for the treatment of acromegaly and gastrointestinal tumors. However, acylation and incomplete release of the encapsulated octreotide, as well as acidic degradation product-induced inflammation are the major challenges hampering widespread clinical app...
Source: Materials Science and Engineering: C - May 11, 2019 Category: Materials Science Source Type: research
Effect of inner pH on peptide acylation within PLGA microspheres.
Abstract
Polymer degradation within the controlled-release depots comprising of lactide and glycolide (PLGA) forms an acidic microenvironment, in which severe acylation of the peptide by the polymer degradation products takes place. The aim of this study was to make out the role of the inner μpH on peptide acylation within the microspheres and how could it influence the reaction. The effects of pH on the acylation reaction within microspheres were composed of two aspects. Firstly, the inherent effect of pH on the acylation reaction itself was figured out: with the pH environment going up from acid to neut...
Source: European Journal of Pharmaceutical Sciences - April 15, 2019 Category: Drugs & Pharmacology Authors: Liu J, Xu Y, Wang Y, Ren H, Meng Z, Liu K, Liu Z, Huang H, Li X Tags: Eur J Pharm Sci Source Type: research
03:09 PM Abstract No. 24 Catheter-directed gastric artery embolization with octreotide acetate loaded PLA/PLGA (poly[lactide-co-glycolide] acid) microspheres with slow sustained-release properties suppresses the plasma concentration of ghrelin, which results in weight loss
The objective of the present work was to formulate slow- and sustained-release octreotide acetate-loaded PLA/PLGA (polylactide)(poly (Lactic-co- Glycolic) acid) microspheres and prospectively test the effects of catheter-directed gastric artery administration of these microspheres on plasma ghrelin levels and body weight in swine. Octreotide is a long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. In the GI system it inhibits secretin, gastrin, vasoactive intestinal peptide, motilin and ghrelin. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - February 23, 2019 Category: Radiology Authors: F. Nurili, T. Acar, S. Derman, A. Bas, I. Caymaz, S. Ozkanli, H. Cakiroglu, I. Yurdaisik, O. Aras Tags: Scientific Session 3: Not Your Run-of-the-Mill Embolization Source Type: research
Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors.
Authors: Di Giacinto P, Rota F, Rizza L, Campana D, Isidori A, Lania A, Lenzi A, Zuppi P, Baldelli R
Abstract
Background. Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index. The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate. The PROMID trial assesses the effect of octreotide LAR on the tumor growth in patients with well-differentiated metastatic midgut NETs. The CLARINET trial evaluates the effects of lanreotide in patients ...
Source: International Journal of Endocrinology - August 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Utility of Somatostatin receptor-targeted imaging with Ga-68 DOTATATE PET/MRI in the management of progressive meningiomas
1844Aim: Utility of Somatostatin receptor-targeted imaging with Ga-68 DOTATATE PET/MRI in the management of progressive meningiomas Meningiomas are the most common type of intracranial tumors. Although these brain tumors are generally benign, some of these could be very aggressive which require extensive surgery followed by radiotherapy. Treating such refractory meningiomas could be extremely challenging. Various treatment protocols are in vogue such as cytotoxic chemotherapy and targeted therapies. One such relatively newer targeted therapy option employs sandostatin, a somatostatin analog that specifically targets somato...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Mertel, K., Mohammadi, S., Nguyen, N., Mountz, J., Muthukrishnan, A. Tags: Technologist Poster Session Source Type: research
Total pancreatic necrosis after organophosphate intoxication
AbstractCases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodi...
Source: Frontiers of Medicine - May 18, 2018 Category: General Medicine Source Type: research
Metastatic neuroendocrine pancreatic tumor - Case report.
Discussion.As a group, well-differentiated gastroenteropancreatic NETs are generally indolent malignancies with prolonged natural history. Intermediate-grade NETs have a slightly worse prognosis than low-grade tumors. Abbreviations: NETs - neuroendocrine tumors, NEC - neuroendocrine carcinoma, CT - computed tomography, MRI - magnetic resonance imaging, DM - diabetes mellitus, WHO - World Health Organisation, HCV - hepatitis C virus, CEA - carcinoembryonic antigen, AFP - alpha-fetoprotein, 5-HIAA - 5-Hydroxyindoleacetic acid, IHC - immunohistochemistry, EUS - endoscopic ultrasonography, EUS FNA - endoscopic ultrasonography ...
Source: Journal of Medicine and Life - April 27, 2018 Category: General Medicine Tags: J Med Life Source Type: research
Relative Bioavailability of a Single 4-mg Dose of Somatropin Administered by Subcutaneous Injection or by Needle-free Device and Coadministered With the Growth Hormone Inhibitor Octreotide Acetate in Healthy Adult Subjects.
This study evaluated the relative bioavailability of somatropin delivered with a needle-free device compared with traditional SC injection.
METHODS: In this randomized, single-dose, crossover study, healthy adults aged 18 to 35 years received single 4-mg doses of somatropin via a needle-free device or SC injection, along with octreotide to suppress endogenous growth hormone production. Blood samples were analyzed for serum somatropin and insulin-like growth factor-1 (IGF-1) concentrations over 24 hours after somatropin dosing. Pharmacokinetic and pharmacodynamic parameters were evaluated by using noncompartmental m...
Source: Clinical Therapeutics - April 23, 2018 Category: Drugs & Pharmacology Authors: Brimhall DB, Petri N, D'Angelo P Tags: Clin Ther Source Type: research
Long-Acting Somatostatin Analog Therapy Differentially Alters 68Ga-DOTATATE Uptake in Normal Tissues Compared with Primary Tumors and Metastatic Lesions
Conclusion: Long-acting octreotide treatment diminished 68Ga-DOTATATE uptake in the liver, spleen, and thyroid but did not compromise tracer uptake in residual primary tumor and metastatic lesions. These findings have a direct impact on the interpretation of 68Ga-DOTATATE PET/CT scans. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Ayati, N., Lee, S. T., Zakavi, R., Pathmaraj, K., Al-Qatawna, L., Poon, A., Scott, A. M. Tags: Clinical Source Type: research
The LARO-MEN1 study: a longitudinal clinical experience with octreotide Long-Acting Release in patients with Multiple Endocrine Neoplasia type 1 Syndrome.
Authors: Cioppi F, Cianferotti L, Masi L, Giusti F, Brandi ML
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumoral syndrome, featured by a combination of neoplasms of various endocrine and nonendocrine tissues. Approximately 33% of MEN1-related deaths are due to the malignant behaviour of well-differentiated neuroendocrine tumors (NETs), for which a preventive surgical treatment is not feasible. Somatostatin analogues (SSA) have been employed in the treatment of NETs in the stage of advanced or metastatic disease, in order to control the growth and secretion of tumor lesions. A ...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
