Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies
Publication date: 5 July 2016 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 500 Author(s): Qingze Fan, Feng Qi, Chunyu Miao, Hua Yue, Fangling Gong, Jie Wu, Guanghui Ma, Zhiguo Su Biodegradable polymeric particles have been widely used in the biomedical fields such as drug carriers, tissue engineering, and medical imaging. It has been recognized that the physical properties of particles, such as size and shape, have a profound influence on their functions. However, it is not easy to prepare non-spherical particles by the conventional emulsion-based method because the mi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - April 22, 2016 Category: Chemistry Source Type: research
Self-assembly of platinum nanochains using octreotide acetate template and their catalytic activity study
Publication date: 1 May 2016 Source:Materials Letters, Volume 170 Author(s): Zi Wang, Weili Xue, Xiaoning Zhao, Yanji Li, Zhiwei Liu, Faming Gao, Dawei Gao A facile method was reported for preparing self-assembly Pt nanochains (PtNCs) by using octreotide acetate (AOC) as template in aqueous environment at room temperature. The influence of pH values on the reaction system was examined, and other synthesis parameters were optimized in order to prepare AOC-templated Pt nanoparticle arrays with high electrocatalytic activities. AOC was found with diameters in the range of 50±5nm at pH 2.0/9.0, while the dia...
Source: Materials Letters - February 14, 2016 Category: Materials Science Source Type: research
Hepatectomy After Yttrium-90 (Y90) Radioembolization-Induced Liver Fibrosis
Abstract
An obese 55-year-old woman with nonalcoholic fatty liver disease presented 7 years after resection of a T3N1 ileal carcinoid tumor with an elevated chromogranin A, multifocal metastatic disease to the liver, and carcinoid syndrome. She underwent right hepatic artery yttrium-90 (Y90) radioembolization, followed a month later by selective Y90 treatment to segment IV. She then presented to our clinic 10 months later, remaining symptomatic with flushing, diarrhea, anxiety, myalgia, pain, and persistent night sweats despite Sandostatin administration. At least 11 tumors were identified in the right lo...
Source: Journal of Gastrointestinal Surgery - February 3, 2016 Category: Surgery Source Type: research
Transfusion free radical antegrade modular pancreaticosplenectomy of metastatic neuroendocrine tumor of the pancreas in Jehovah's Witness patient.
We present a case of successful bloodless multimodality therapy, which was performed for a JW. The patient was a 49-year-old woman and JW who had general weakness 7 days before admission. She was diagnosed with a pancreatic neuroendocrine tumor (PNET) with hepatic metastases. Transcatheter arterial chemoembolization and Sandostatin LAR injection were performed, and then she was given a transfusion-free Radical antegrade modular pancreatosplenectomy sequentially. We gave recombinant human erythropoietin and iron hydroxide sucrose complex daily for five days after surgery. She was discharged at postoperative day 12 without a...
Source: Annals of Surgical Treatment and Research - November 28, 2015 Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report
Conclusion:
The identification, characterization and follow-up of this rare cause of ectopic ACTH secretion is important in order to assess the long-term prognostic and management. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - November 26, 2015 Category: Endocrinology Authors: Diana PaunLavinia VijaEmilia StanAlexandra BanicaElena BobeicaDana TerzeaCatalina PoianaCorin BadiuSorin Paun Source Type: research
The Effects of Octreotide Acetate on Spinal Cord Ischemia/Reperfusion Injury
In this study, we investigate the possible neuroprotective effects of a strong antioxidant, free radical scavenger; octreotide acetate on a rabbit spinal ischemia/reperfusion (I/R) injury model. A total of 18 rabbits were divided into 3 groups of 6 rabbits each, as follows: group 1 (n=6) sham, laparotomy only; group 2 (n=6) I/R group; group 3 (n=6) I/R+ octreotide group. I/R was established in groups 2 and 3. All rabbits were followed up neurologically for 24 hours. After 24 hours, the rabbits were killed and spinal cord tissue samples examined. Neurological examinations score, tissue malondialdehyde (MDA), glutathione per...
Source: Neurosurgery Quarterly - November 1, 2015 Category: Neurosurgery Tags: Original Articles Source Type: research
Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction
Objectives: To characterize the gut hormone profile and determine the effect of satiety gut hormone blockade on food intake in disease-free postesophagectomy patients.
Background: Improved oncologic outcomes for esophageal cancer have resulted in increased survivorship and a focus on health-related quality of life. Anorexia and early satiety are common, but putative causative factors, in particular the gut-brain hormonal axis, have not been systematically studied.
Methods: In a double-blind, placebo-controlled, randomized crossover study, disease-free patients at least 1 year postresection and gastric conduit reconstructio...
Source: Annals of Surgery - October 25, 2015 Category: Surgery Tags: Papers of the 22nd Annual ESA Meeting Source Type: research
Possible role of TGF β1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine
Discussion Based on the current literature and our previous experiences, we can state that IPT are an aberrant secondary immunological process possibly induced by excessive TGF β1 and not a neoplasia. Nevertheless, the tumorous behavior points to a continuity between inflammation and neoplasia. Differential diagnoses and the potential molecular pathogenesis are further discussed. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 18, 2015 Category: Pathology Source Type: research
Possible role of TGF β- 1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine
Discussion Based on the current literature and our previous experiences, we can state that IPT are an aberrant secondary immunological process possibly induced by excessive TGF- β 1 and not a neoplasia. Nevertheless, the tumorous behavior points to a continuity between inflammation and neoplasia. Differential diagnoses and the potential molecular pathogenesis are further discussed. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 14, 2015 Category: Pathology Source Type: research
Abstract A01: Exploring phosphatase and tensin homolog (PTEN) loss as a potential predictive marker for response to everolimus in patients with pancreatic neuroendocrine tumors (PNETs)
Conclusion: The index case for this study had a PTEN deletion and had a partial response to treatment and prolonged disease control for 2 years with everolimus. Testing is ongoing in additional cases to determine if there is a consistent correlation between PTEN loss by FISH and PFS.Citation Format: Moh'd Khushman, Joyce Slingerland, Yao-Shan Fan, Monica Garcia-Buitrago, Ernesto Bustinza, Maria Restrepo, Daniel Sussman, Caio Rocha-Lima, Peter Hosein. Exploring phosphatase and tensin homolog (PTEN) loss as a potential predictive marker for response to everolimus in patients with pancreatic neuroendocrine tumors (PNETs). [ab...
Source: Molecular Cancer Therapeutics - July 6, 2015 Category: Cancer & Oncology Authors: Khushman, M., Slingerland, J., Fan, Y.-S., Garcia-Buitrago, M., Bustinza, E., Restrepo, M., Sussman, D., Rocha-Lima, C., Hosein, P. Tags: Clinical Data with PI3K and mTOR Inhibitors: Poster Presentations - Proffered Abstracts Source Type: research
A rapid hydrolysis method and DABS-Cl derivatization for complete amino acid analysis of octreotide acetate by reversed phase HPLC.
Abstract
Octreotide as a synthetic cyclic octapeptide is a somatostatin analog with longer half-life and more selectivity for inhibition of the growth hormone. The acetate salt of octreotide is currently used for medical treatment of somatostatin-related disorders such as endocrine and carcinoid tumors, acromegaly, and gigantism. Octreotide contains both cysteine and tryptophan residues which make the hydrolysis part of its amino acid analysis procedure very challenging. The current paper introduces a fast and additive-free method which preserves tryptophan and cysteine residues during the hydrolysis. Usin...
Source: Amino Acids - May 23, 2015 Category: Biochemistry Authors: Akhlaghi Y, Ghaffari S, Attar H, Alamir Hoor A Tags: Amino Acids Source Type: research
A high-efficiency, low-toxicity, phospholipids-based phase separation gel for long-term delivery of peptides.
Abstract
Peptide and protein drugs are currently under rapid development attributed to their high potency and efficacy in therapy. Their successful delivery, however, is highly limited by their short half-life, fast degradation and rapid clearance. Here, we present a high content phospholipids-based phase separation gel (PPSG), which is readily injectable due to its low initial viscosity and can rapidly transform into an in situ implant after injection upon exposure to an aqueous environment. A selected model peptide, octreotide acetate, is loaded into PPSG and achieves sustained release profiles for one m...
Source: Biomaterials - February 13, 2015 Category: Materials Science Authors: Zhang T, Peng Q, San FY, Luo JW, Wang MX, Wu WQ, Gong T, Zhang ZR Tags: Biomaterials Source Type: research
Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis
In this study, we further evaluated rhIL-1Ra in the treatment of CIM induced by different chemoagents and their combination. Normal as well as tumor-bearing mice were administered oxaliplatin (L-OHP), 5-fluorouracil, or their combination to induce intestinal mucositis and mortality. rhIL-1Ra administered after the chemotherapy, but not after the onset of diarrhea, significantly improved mouse survival, attenuated body weight loss, and reduced the incidence, severity, and duration of diarrhea. Histological examination showed that rhIL-1Ra-treated mice had a relatively intact mucosa structure, more proliferating crypt cells,...
Source: Anti-Cancer Drugs - November 27, 2014 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Poor pregnancy outcome after octreotide treatment during pregnancy for familial hyperinsulinemic hypoglycemia: a case report
Conclusion:
In a woman with late familial hyperinsulinemic hypoglycemia octreotide was given during the first four pregnancies resulting in 2 cases of early termination of pregnancy on parental request and 2 cases of inappropriate fetal growth and unviable outcome. The following two pregnancies treated with diet only had a successful outcome. (Source: BMC Research Notes)
Source: BMC Research Notes - November 17, 2014 Category: Research Authors: Gitte SkajaaElisabeth MathiesenElisabeth IyoreHenning Beck-NielsenEspen Jimenez¿SolemPeter Damm Source Type: research
Treatment with octreotide in patients with well-differentiated neuroendocrine tumors of the ileum: prognostic stratification with Ga-68-DOTA-TATE positron emission tomography.
Authors: Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR
Abstract
We investigated the use of Ga-68-DOTA-Tyr3-octreotate (Ga-68-DOTA-TATE) positron emission tomography (PET) and standardized uptake values (SUVs) to predict the effectiveness of treatment with the somatostatin analogue octreotide acetate (Sandostatin LAR) in patients with neuroendocrine tumors (NETs). Thirty patients with well-differentiated NETs of the ileum (grades G1 and G2) were studied with Ga-68-DOTA-TATE. The average SUV of a 50% isocontour volume of interest covering the lesion with maximum upt...
Source: Molecular Imaging - November 15, 2014 Category: Radiology Tags: Mol Imaging Source Type: research
