Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial
Objective: The aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP). Summary Background Data: The impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown. Methods: We conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of deat...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIAL Source Type: research

A Prospective US National Trauma Center Study of Firearm Injury Survivors Weapon Carriage and Posttraumatic Stress Disorder Symptoms
Objective: To describe the demographic, injury-related, and mental health characteristics of firearm injury patients and trace firearm weapon carriage and PTSD symptoms over the year after injury. Summary and Background Data: Based on the increasing incidence of firearm injury and need for novel injury prevention strategies, hospital-based violence intervention programs are being implemented in US trauma centers. There is limited data on the long-term outcomes and risk behaviors of firearm injury survivors to guide this work. Methods: We conducted a secondary analysis of a pragmatic 25-trauma center rando...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Optimal Pancreatic Surgery: Are We Making Progress in North America?
Objective: Our aims were to assess North American trends in the management of patients undergoing pancreatoduodenectomy (PD) and distal pancreatectomy (DP), and to quantify the delivery of optimal pancreatic surgery. Background: Morbidity after pancreatectomy remains unacceptably high. Recent literature suggests that composite measures may more accurately define surgical quality. Methods: The 2013 to 2017 American College of Surgeons National Surgical Quality Improvement Program Participant Use Files were queried to identify patients undergoing PD (N = 16,222) and DP (N = 7946). Patient, process, procedur...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Incidence and Risk Factors of Postoperative Mortality and Morbidity After Elective Versus Emergent Abdominal Surgery in a National Sample of 8193 Patients With Cirrhosis
Conclusions: Accurate preoperative risk assessments in patients with cirrhosis should account for cirrhosis severity, comorbidities, type of procedure, and whether the procedure is emergent versus elective. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Hospital and Surgeon Selection for Medicare Beneficiaries With Stage II/III Rectal Cancer: The Role of Rurality, Distance to Care, and Colonoscopy Provider
Objective: To determine factors associated with rectal cancer surgery performed at high-volume hospitals (HVHs) and by high-volume surgeons (HVSs), including the roles of rurality and diagnostic colonoscopy provider characteristics. Summary of Background Data: Although higher-volume hospitals/surgeons often achieve superior surgical outcomes, many rectal cancer resections are performed by lower-volume hospitals/surgeons, especially among rural populations. Methods: Patients age 66+ diagnosed from 2007 to 2011 with stage II/III primary rectal adenocarcinoma were selected from surveillance, epidemiology, an...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Perioperative Risks of Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass Among Patients With Chronic Kidney Disease: A Review of the MBSAQIP Database
Conclusions: Among well-matched cohorts of RYGB and sleeve gastrectomy patients, incidence of primary outcomes were similar. Among secondary outcomes, only acute kidney injury was statistically-significantly higher among RYGB patients; however, the E-value for this difference was small and relatively weak confounder(s) could abrogate the statistical difference. The perception that RYGB has prohibitively-high perioperative risks among CKD patients is disputable and operative selection should be weighed on patient candidacy and anticipated long-term benefit. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Value of Lymphadenectomy in Patients Receiving Neoadjuvant Therapy for Esophageal Adenocarcinoma
Conclusions: Worldwide data for adenocarcinoma of the esophagus and esophagogastric junction demonstrate that lymphadenectomy during esophagectomy is a valuable component of neoadjuvant therapy. Survival is maximized when an optimum range of nodes is resected. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Medicare Advantage Networks and Access to High-volume Cancer Surgery Hospitals
Conclusions: The study identifies lack of high-volume hospital coverage in MA health plans as a major detriment in regionalization of cancer surgery impacting at least a third of older Americans. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Timing of Preoperative Antibiotic Prophylaxis and Surgical Site Infection: TAPAS, An Observational Cohort Study
Conclusions: For SAP with short infusion time no clear superior timing interval within the 60-minute interval before incision could be identified in this cohort. We were unable to reproduce differences in SSI risk found in earlier studies. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Changes in Hospital-acquired Conditions and Mortality Associated With the Hospital-acquired Condition Reduction Program
Conclusions and Relevance: Although hospital-acquired conditions targeted under the HACRP declined at a greater rate after the program was announced, 30-day mortality was unchanged. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Outcomes of Subtotal Parathyroidectomy Versus Total Parathyroidectomy With Autotransplantation for Tertiary Hyperparathyroidism: Multi-institutional Study
Conclusions: To our knowledge, this is the largest multi-center study that compared different approaches for managing tertiary HPT. Showing that STPX is the better modality in patients diagnosed with tertiary HPT and had kidney transplants avoiding the risk of hypoparathyroidism. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis
Conclusions: Persistent elevations of PICS biomarkers in the CCI and Zubrod 4/5 cohorts and their improved prediction of Zubrod 4/5 validate that PICS plays a role in CCI pathobiology. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

De-escalation of Endocrine Therapy in Early Hormone Receptor-positive Breast Cancer: When Is Local Treatment Enough?
Objective: To identify subgroups of hormone receptor-positive (HR+) breast cancer patients that might not benefit from adding endocrine therapy (ET) to their local treatment. Background: De-escalation in breast cancer treatment has included surgery, radiation, and chemotherapy and has often focused on older patient populations. Systemic ET has yet to be de-escalated, though it carries serious side-effects, decreasing quality of life over 5 to 10 years. We hypothesize the 21-gene recurrence score (RS) could identify subgroups of younger patients whose long-term survival is unaffected by adjuvant ET. Methods:...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Gastroesophageal Reflux Disease Outcomes After Vertical Sleeve Gastrectomy and Gastric Bypass
The objective of this study is to assess whether vertical sleeve gastrectomy (VSG) increases the incidence of gastroesophageal reflux disease (GERD), esophagitis and Barrett esophagus (BE) relative to patients undergoing Roux-en-Y gastric bypass (RYGB) in patients with and without preoperative GERD. Summary of Background Data: Concerns for potentiation of GERD, supported by multiple high-quality retrospective studies, have hindered greater adoption of the VSG. Methods: From the OptumLabs Data Warehouse, VSG and RYGB patients with ≥2 years enrollment were identified and matched by follow-up time. GERD [re...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

The Correlation Between Case Total Work Relative Value Unit, Operative Stress, and Patient Frailty: Retrospective Cohort Study
Conclusions: Surgeon reimbursement correlates with operative stress but not patient frailty. The total wRVU does not adequately reflect patient-specific factors that increase the physician workload required to render optimal care to complex patients. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Interleukin-10 Producing T Lymphocytes Attenuate Dermal Scarring
Conclusions: IL-10 producing T-lymphocytes, specifically Tr1, regulate inflammatory cell cytokine expression to promote HA-rich ECM deposition and attenuate fibrosis. Promoting IL-10 producing lymphocytes in wounds may be a therapeutic target to promote regenerative wound healing. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Participation in a Chronic Limb Threatening Ischemia Randomized Trial Is Inversely Correlated With Regional Amputation Rate in Limb Threatening Ischemia Patients
Conclusions: Amputation rate among Medicare CLI patients is inversely correlated with US BEST-CLI site distribution. Higher participation in clinical research, especially within large RCTs, may be a marker of optimal PAD management. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Optimal Timing of Administration of Direct-acting Antivirals for Patients With Hepatitis C-associated Hepatocellular Carcinoma Undergoing Liver Transplantation
Objective: To investigate the optimal timing of direct acting antiviral (DAA) administration in patients with hepatitis C-associated hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). Summary of Background Data: In patients with hepatitis C (HCV) associated HCC undergoing LT, the optimal timing of direct-acting antivirals (DAA) administration to achieve sustained virologic response (SVR) and improved oncologic outcomes remains a topic of much debate. Methods: The United States HCC LT Consortium (2015–2019) was reviewed for patients with primary HCV-associated HCC who underwent LT ...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Successful Implementation of Enhanced Recovery in Elective Colorectal Surgery is Variable and Dependent on the Local Environment
Objective: To evaluate local hospital success with enhanced recovery implementation as measured by colorectal surgery process measure (PM) compliance and characterize local environment factors associated with success within a contemporary quality improvement collaborative. Summary Background Data: Enhanced recovery programs (ERP) have proven an effective perioperative quality improvement strategy, but local variation in implementation can hinder patient outcome improvement. Methods: Individual hospitals participating in a national colorectal ERP quality improvement program were evaluated with quantitative...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Racial and Ethnic Bias Impact Perceptions of Surgeon Communication
Objective: To evaluate patient satisfaction scores as a function of physician and patient race and sex. Background: Patient satisfaction is increasingly used as a surrogate for physician performance. How patient and surgeon race and ethnicity affect perceptions of surgeon communication and care is not widely explored. Methods: Press Ganey patient satisfaction surveys collected from January 2019 to September 2020 were studied. Multivariate logistic regressions were used to identify factors associated with favorable surgeon performance as a function of patient and surgeon demographics. Results: A tot...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Five Hundred Patients With Gut Malrotation: Thirty Years of Experience With the Introduction of a New Surgical Procedure
Objectives: Define clinical spectrum and long-term outcomes of gut malrotation. With new insights, an innovative procedure was introduced and predictive models were established. Methods: Over 30-years, 500 patients were managed at 2 institutions. Of these, 274 (55%) were children at time of diagnosis. At referral, 204 (41%) patients suffered midgut-loss and the remaining 296 (59%) had intact gut with a wide range of digestive symptoms. With midgut-loss, 189 (93%) patients underwent surgery with gut transplantation in 174 (92%) including 16 of 31 (16%) who had autologous gut reconstruction. Ladd's procedure was d...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Value Analysis of Methods of Inguinal Hernia Repair
Conclusions: Use of higher cost technology to repair inguinal hernias reduces value. Incremental health benefits must be realized to justify increased costs. We expect payors and patients will incorporate value into payment decisions. (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Age-related Opioid Exposure in Trauma: A Secondary Analysis of the Multimodal Analgesia Strategies for Trauma (MAST) Randomized Trial
Objective: Evaluate the effect of age on opioid consumption after traumatic injury. Summary Background Data: Older trauma patients receive fewer opioids due to decreased metabolism and increased complications, but adequacy of pain control is unknown. We hypothesized that older trauma patients require fewer opioids to achieve adequate pain control. Methods: A secondary analysis of the multimodal analgesia strategies for trauma Trial evaluating the effectiveness of 2 multimodal pain regimens in 1561 trauma patients aged 16 to 96 was performed. Older patients (≥55 years) were compared to younger patient...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Expanding the Donor Pool: First Use of Hepatitis B Virus Nat Positive Solid Organ Allografts Into Seronegative Recipients
Objectives: The aim of this study was to assess the 1-year safety and effectiveness of HBV Nucleic Acid Test positive (HBV NAT+) allografts in seronegative kidney transplant (KT) and liver transplant (LT) recipients. Summary Background Data: Despite an ongoing organ shortage, the utilization of HBV NAT+ allografts into seronegative recipients has not been investigated. Methods: From January 2017 to October 2020, a prospective cohort study was conducted among consecutive KT and LT recipients at a single institution. Primary endpoints were post-transplant HBV viremia, graft and patient survival. Results:...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

National Institutes of Health Career Development (K) Awards to Young Surgeons: An Academic Milestone or One-hit Wonder?
Objective: To assess contemporary trends in the National Institutes of Health (NIH) Career Development (K) Awards within the Departments of Surgery and its impact on the likelihood of achieving independent R01 grants. Background: The NIH provides K-type Career Development Awards to nurture young clinicians toward a productive academic career, thereby maintaining a pipeline of physician-scientists. However, the impact of K awards on career trajectory of surgeons remains unclear. Methods: The NIH grant data was queried for all new K08/K23 grants awarded to Departments of Surgery (1999–2019). Principal...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Chemotherapy Versus Chemotherapy Plus Chemoradiation as Neoadjuvant Therapy for Resectable Gastric Adenocarcinoma: A Multi-institutional Analysis
Objective: We compare neoadjuvant chemotherapy (CT) to neoadjuvant chemotherapy plus chemoradiation (CRT) for patients with gastric adenocarcinoma (GA). Summary of Background Data: The optimal neoadjuvant therapy regimen for resectable GA is not defined. Methods: Utilizing data from 2 high-volume cancer centers, we analyzed patients who underwent surgery for localized GA from 1/1/2000-12/31/2017. Standard CT regimens were used according to treatment period. We compared propensity matched cohorts based on age, sex, race, histology, and clinical stage. Results: Four-hundred five patients (age 62 &plu...
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

A Public Health Approach to Prevent Firearm Related Injuries and Deaths
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - September 14, 2021 Category: Surgery Tags: PRESIDENTIAL FORUM Source Type: research

Not Just Bystanders: A Qualitative Study on the Vicarious Effects of Surgical Training on the Wellness of Support Persons for Trainees
Conclusions: The impact of surgical training can extend beyond trainees and can affect the wellness of their support persons who endure the effects of training alongside trainees. Programs should be aware of these effects and develop meaningful strategies to aid trainees and their support persons. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Poisson Probability of Failing to Meet Minimum Case Volumes in Pediatric Surgery Fellowships
Conclusions: There is significant risk of a fellow failing to meet case minimums in the ACGME system and the proposed ABS system. This probability is increased for the half of programs below median. If the ABS institutes case minimums as a requirement for certification in pediatric surgery, the current training paradigm may be impacted at some programs. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Successful Implementation of Unmanned Aircraft Use for Delivery of a Human Organ for Transplantation
Conclusions: Here, we completed the first successful delivery of a human organ using unmanned aircraft. This study brought together multidisciplinary resources to develop, build, and test the first organ drone system, through which we performed the first transplant of a drone transported kidney. These innovations could inform not just transplantation, but other areas of medicine requiring life-saving payload delivery as well. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Does Aggressive Variant Histology Without Invasive Features Predict Overall Survival in Papillary Thyroid Cancer?: A National Cancer Database Analysis
Objective: We aimed to clarify whether aggressive histology of papillary thyroid cancer (PTC) impacts overall survival (OS). Summary Background Data: Aggressive variants of PTC (AVPTC) are associated with invasive features. However, their behavior in the absence of these features is not well characterized. Methods: Patients treated from 2004 to 2015 for classic PTC (cPTC) or AVPTCs were identified from the National Cancer Database. Patients were further stratified based on presence of at least 1 invasive feature—extrathyroidal extension, multifocality, lymphovascular invasion, nodal or distant metas...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Racial and Ethnic Disparities in Breast Cancer Survival: Emergence of a Clinically Distinct Hispanic Black Population
Objective: To understand the impact of Black race on breast cancer (BC) presentation, treatment, and survival among Hispanics. Summary of Background Data: It is well-documented that non-Hispanic Blacks (NHB) present with late-stage disease, are less likely to complete treatment, and have worse survival compared to their non-Hispanic White (NHW) counterparts. However, no data evaluates whether this disparity extends to Hispanic Blacks (HB) and Hispanic Whites (HW). Given our location in Miami, gateway to Latin America and the Caribbean, we have the diversity to evaluate BC outcomes in HB and HW. Methods: R...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Oncologic Outcomes After Robotic Pancreatic Resections Are Not Inferior to Open Surgery
We examined the effect of surgical approach on receipt of adjuvant chemotherapy, complications, and overall survival after pancreatectomy. Methods: A single-institution retrospective review of all patients with PDAC who underwent robotic or open pancreatectomy from 2011 to 2016 with 24-month follow-up. Results: Four hundred fifty-six patients underwent resection: 226 robotic and 230 open. No significant difference was identified in major complications or receipt of adjuvant chemotherapy between robotic and open pancreatectomy, nor was approach an independent predictor of these outcomes. Robotic pancreatectomy...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Preoperative Risk Assessment for Loss of Independence Following Hepatic Resection in Elderly Patients: A Prospective Multicenter Study
Objective: To establish a preoperative risk assessment method for loss of independence after hepatic resection. Summary Background Data: Hepatic resection often results in loss of independence in preoperatively self-sufficient elderly people. Elderly patients should therefore be carefully selected for surgery. Methods: In this prospective, multicenter study, 347 independently-living patients aged ≥65 years, scheduled for hepatic resection, were divided into study (n = 232) and validation (n = 115) cohorts. We investigated the risk factors for postoperative loss of independence in the study cohort and v...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Early (2009–2017) Experience With Robot-assisted Cholecystectomy in New York State
Objective: The aim of this study was to examine real-life patterns of care and patient outcomes associated with robot-assisted cholecystectomy (RAC) in New York State (NYS). Background: Although robotic assistance may offer some technological advantages, RACs are associated with higher procedural costs and longer operating times compared to traditional laparoscopic cholecystectomies (LCs). Evidence on long-term patient outcomes after RAC from large population-based datasets remains limited and inconsistent. Methods: Using NYS inpatient and ambulatory surgery data from the Statewide Planning and Research C...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Oncological Impact of High Vascular Tie After Surgery for Rectal Cancer: A Nationwide Cohort Study
Objective: The purpose of this study was to investigate the impact of tie level on oncological outcomes in rectal cancer surgery. Summary background data: Theoretically, a high tie of the inferior mesenteric artery could facilitate removal of apical node metastases and improve tumor staging accuracy. However, no appropriately sized randomized controlled trial exists and results from observational studies are not consistent. Methods: All stage I–III rectal cancer patients who underwent abdominal surgery with curative intention in 2007 to 2014 were identified and followed, using the Swedish Colorectal...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Risk of Severe Maternal Morbidity After Bariatric Surgery: Retrospective Cohort Study
Conclusions: Pregnant women with prior bariatric surgery have similar risks as nonobese women for most types of severe maternal morbidity, except for intensive care unit admission. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Do the 2018 Leapfrog Group Minimal Hospital and Surgeon Volume Thresholds for Esophagectomy Favor Specific Patient Demographics?
Objective: We examine how esophagectomy volume thresholds reflect outcomes relative to patient characteristics. Summary Background Data: Esophagectomy outcomes are associated with surgeon and hospital operative volumes, leading the Leapfrog Group to recommend minimum annual volume thresholds of 7 and 20 respectively. Methods: Patients undergoing esophagectomy for cancer were identified from the 2007–2013 New York and Florida Healthcare Cost and Utilization Project's State Inpatient Databases. Logit models adjusted for patient characteristics evaluated in-hospital mortality, complications, and prolon...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Effectiveness of Preoperative Iron Supplementation in Major Surgical Patients With Iron Deficiency: A Prospective Observational Study
Objective: To evaluate the effectiveness of routine intravenous iron in surgical patients with iron deficiency anemia (IDA). Background: Anemia is the most common medical disease in the world and is an independent risk factor for morbidity and mortality. Iron deficiency (ID) is the main cause for anemia and constitutes a potentially preventable condition with great impact on surgical outcome. Methods: In this prospective single-center observational study, surgical patients were screened for the presence of anemia and ID. Patients were assigned to 1 of 4 study groups: A− (no anemia); A−, ID+, T...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Dabigatran Reversal With Idarucizumab in Patients Requiring Urgent Surgery: A Subanalysis of the RE-VERSE AD Study
Conclusions: Idarucizumab facilitates management of patients requiring urgent procedures by providing rapid dabigatran reversal, and is the only agent of its class studied in surgical patients. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Physician Heal Thyself: A Call to Action for Prioritizing Trainee Health
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVE Source Type: research

Patient-reported Outcomes After Metabolic Surgery Versus Medical Therapy for Diabetes: Insights From the STAMPEDE Randomized Trial
Objective: The aim of this study was to investigate the long-term effects of medical and surgical treatments of type 2 diabetes mellitus (T2DM) on patient-reported outcomes (PROs). Background: Robust data on PROs from randomized trials comparing medical and surgical treatments for T2DM are lacking. Methods: The Surgical Treatment And Medications Potentially Eradicate Diabetes Efficiently (STAMPEDE) trial showed that 5 years after randomization, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) were superior to intensive medical therapy (IMT) alone in achieving glycemic control in patients with T...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Outcomes in Endoscopic and Operative Transgastric Pancreatic Debridement
Conclusions: Operative and endoscopic transgastric debridement achieve necrosis resolution with different temporal and procedural profiles. Clear multidisciplinary communication is essential to determine appropriate approach to individual necrotizing pancreatitis patients. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Patient Social Vulnerability and Hospital Community Racial/Ethnic Integration: Do All Patients Undergoing Pancreatectomy Receive the Same Care Across Hospitals?
Conclusion: Patients with high social vulnerability who underwent pancreatectomy in hospitals located in communities with low racial/ethnic integration had the lowest chance to achieve an “optimal” TO. A focus on both patient- and community-level factors is needed to ensure optimal and equitable patient outcomes. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma
Background: No effective molecular targeted therapy has been established for SCC. We conducted a comprehensive study of SCC patients using RNA-sequencing and TCGA dataset to clarify the driver oncogene of SCC. Method: Forty-six samples of 23 patients were totally analyzed with RNA-sequencing. We then searched for candidate-oncogenes of SCC using the TCGA database. To identify candidate oncogenes, we used the following 2 criteria: (1) the genes of interest were overexpressed in tumor tissues of SCC patients in comparison to normal tissues; and (2) using an integrated mRNA expression and DNA copy number profiling ...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Midterm Outcomes of a Prospective, Nonrandomized Study to Evaluate Endovascular Repair of Complex Aortic Aneurysms Using Fenestrated-Branched Endografts
Conclusion: FB-EVAR is safe and effective for treatment of PRA and TAAAs with low rate of aortic-related mortality and aneurysm rupture on midterm follow-up. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Molecular Genomic Assessment Using a Blood-based mRNA Signature (NETest) is Cost-effective and Predicts Neuroendocrine Tumor Recurrence With 94% Accuracy
Introduction: Identification of residual disease after neuroendocrine tumor (NET) resection is critical for management. Post-surgery imaging is insensitive, expensive, and current biomarkers ineffective. We evaluated whether the NETest, a multigene liquid biopsy blood biomarker, correlated with surgical resection and could predict recurrence. Methods: Multicenter evaluation of NET resections over 24 months (n = 103): 47 pancreas, 26 small bowel, 26 lung, 2 appendix, 1 duodenum, 1 stomach. Surgery: R0 (83), R1/R2 (20). One millilitre of blood was collected at D0 and posroperative day (POD) 30. Transcript quanti...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Anti-C5 Antibody Tesidolumab Reduces Early Antibody-mediated Rejection and Prolongs Survival in Renal Xenotransplantation
Objective: Pig-to-primate renal xenotransplantation is plagued by early antibody-mediated graft loss which precludes clinical application of renal xenotransplantation. We evaluated whether temporary complement inhibition with anti-C5 antibody Tesidolumab could minimize the impact of early antibody-mediated rejection in rhesus monkeys receiving pig kidneys receiving costimulatory blockade-based immunosuppression. Methods: Double (Gal and Sda) and triple xenoantigen (Gal, Sda, and SLA I) pigs were created using CRISPR/Cas. Kidneys from DKO and TKO pigs were transplanted into rhesus monkeys that had the least react...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Outcomes of the First Virtual General Surgery Certifying Exam of the American Board of Surgery
Conclusions: The first virtual CE by the ABS was completed using available internet technology. There was high satisfaction, with the majority preferring the virtual platform. Compared to past in-person CEs, there was no difference in outcomes as measured by passing rates. These data suggest that expansion of the virtual CE may be desirable. (Source: Annals of Surgery)
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research

Failure to Rescue After Pancreatoduodenectomy: A Transatlantic Analysis
Objective: This analysis aimed to compare failure to rescue (FTR) after pancreatoduodenectomy across the Atlantic. Summary Background Data: FTR, or mortality after development of a major complication, is a quality metric originally created to compare hospital results. FTR has been studied in North American and Northern European patients undergoing pancreatoduodenectomy (PD). However, a direct comparison of FTR after PD between North America and Northern Europe has not been performed. Methods: Patients who underwent PD in North America, the Netherlands, Sweden and Germany (GAPASURG dataset) were identified...
Source: Annals of Surgery - August 20, 2021 Category: Surgery Tags: PAPERS OF THE 141ST ASA ANNUAL MEETING Source Type: research