Comment on “Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen
Conclusion: This study provides maiden evidence that chronic S. aureus biofilm infection in wounds results in impaired granulation tissue collagen leading to compromised wound tissue biomechanics. Clinically, such compromise in tissue repair is likely to increase wound recidivism. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Factors Associated With Long-term Outcomes After Injury: Results of the Functional Outcomes and Recovery After Trauma Emergencies (FORTE) Multicenter Cohort Study
Conclusion: The long-term sequelae of trauma are more significant than previously expected. Collection of postdischarge outcomes identified patient factors, such as female sex and low education, associated with worse recovery. This suggests that social support systems are potentially at the core of recovery rather than traditional measures of injury severity. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Evolving Practice Patterns of Academic Endocrine Surgeons: A Cross-sectional Analysis of the Faculty Practice Solutions Center Database 2014 to 2017
Conclusions: Although endocrine surgeons perform a high-volume of endocrine-specific operations, practice patterns are heterogeneous and suggest that most surgeons have to grow their endocrine-specific practice over time. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Reappraising the Concept of Conditional Survival After Pancreatectomy for Ductal Adenocarcinoma: A Bi-institutional Analysis
Conclusion: This paper provides new information on how prognosis following pancreatectomy for PDAC evolves over time, adjusting for the time the patient already survived, and for the patient's present disease status relative to recurrence. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma
Conclusions: Plasma miR-181a-5p is a specific biomarker for monitoring FOLFIRINOX response. Decline in plasma miR-181a-5p and CA19-9 levels is associated with better prognosis after FOLFIRINOX and may be useful for guiding therapeutic choices and surgical exploration. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Multicenter Study of Age, Frailty, and Waitlist Mortality Among Liver Transplant Candidates
Objective: To determine if the association of frailty and waitlist mortality varies by candidate age. Background: Frailty, a construct developed in geriatrics, is a state of decreased physiologic reserve, and is associated with mortality while awaiting liver transplantation (LT). However, older candidates have high comorbidity burden and less physiologic reserve, so the relationship between frailty and waitlist mortality may vary by candidate age. Methods: We studied adults listed for LT at 2 transplant centers. The liver frailty index (grip strength, chair stands, balance) was measured at evaluation, with frailty ...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Shadows Behind Using Simple Risk Models in Selection of Hepatocellular Carcinoma Patients for Liver Transplantation
Objective: To assess the potential influence of replacing Milan criteria with simple risk scores on outcomes of hepatocellular carcinoma (HCC) patients undergoing liver transplantation. Summary Background Data: Several risk scores combining morphological and biological features were recently proposed for precise selection of HCC patients for transplantation. Methods: This retrospective study included 282 HCC liver transplant recipients. Recurrence-free survival (RFS), the primary outcome measure, was evaluated according to Metroticket 2.0 model and French AFP model with Milan criteria serving as benchmark. Results...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Textbook Outcomes Among Medicare Patients Undergoing Hepatopancreatic Surgery
Conclusions: Less than one-half of Medicare patients achieved a TO following hepatopancreatic procedures with a wide variation in the rates of TO among hospitals. There was a discrepancy in Medicare payments for patients who achieved a TO versus patients who did not. TO could be useful for the public reporting of patient level hospital performance and hospital variation. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Colorectal Surgical Site Infection Prevention Kits Prior to Elective Colectomy Improve Outcomes
Introduction: Patient compliance with preoperative mechanical and antibiotic bowel preparation, skin washes, carbohydrate loading, and avoidance of fasting are key components of successful colorectal ERAS and surgical site infection (SSI)-reduction programs. In July 2016, we began a quality improvement project distributing a free SSI Prevention Kit (SSIPK) containing patient instructions, mechanical and oral bowel preparation, chlorhexidine washes, and carbohydrate drink to all patients scheduled for elective colectomy, with the goal of improving patient compliance and rates of SSI. Methods: This was a prospective dat...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Unconventional Role for Gastric Volume in the Response to Bariatric Surgery for Both Weight Loss and Glucose Lowering
Conclusions: The data suggest a minimum threshold volume of the residual stomach that is necessary to induce sustained weight loss. Although all gastric volume interventions increased the GLP-1 response, none of the interventions, except VSG, significantly improved glucose tolerance. In conclusion, if weight loss is the primary goal of surgical intervention, significant volume reduction is required, and this most likely requires excising gastric tissue. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Reporting National Outcomes After Esophagectomy and Gastrectomy According to the Esophageal Complications Consensus Group (ECCG)
Conclusions: Reporting complications according to the ECCG platform is feasible in the Netherlands and facilitates international benchmarking. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Quantitative Assessment of Blood Flow in the Gastric Conduit With Thermal Imaging for Esophageal Reconstruction
Objective: The study's primary aim was to evaluate the effectiveness of thermal imaging (TI) and its secondary aim was to compare TI and indocyanine green (ICG) fluorescence angiography, with respect to the evaluation of the viability of the gastric conduit. Summary Background Data: The optimal method for evaluating perfusion in the gastric conduit for esophageal reconstruction has not been established. Methods: We reviewed the prospectively collected data of 263 patients who had undergone esophagectomy with gastric conduit reconstruction. TI was used in all patients. ICG fluorescence was concomitantly used in 24 p...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Classifying Preoperative Opioid Use for Surgical Care
Objective: We characterized patterns of preoperative opioid use in patients undergoing elective surgery to identify the relationship between preoperative use and subsequent opioid fill after surgery. Background: Preoperative opioid use is common, and varies by dose, recency, duration, and continuity of fills. To date, there is little evidence to guide postoperative prescribing need based on prior opioid use. Methods: We analyzed claims data from Clinformatics DataMart Database for patients aged 18 to 64 years undergoing major and minor surgery between 2008 and 2015. Preoperative use was defined as any opioid prescr...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Multi-institution Evaluation of Adherence to Comprehensive Postoperative VTE Chemoprophylaxis
Conclusions: In contrast to SCIP-VTE-2, our novel quality measure unmasked VTE chemoprophylaxis failures in 18% of colectomies. Most failures were due to patient refusals or ordering errors. Hospitals should focus improvement efforts on ensuring patients receive VTE prophylaxis throughout their entire hospitalization. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Local Referral of High-risk Patients to High-quality Hospitals: Surgical Outcomes, Cost Savings, and Travel Burdens
Conclusions: Complication rates and Medicare payments are significantly lower for high-risk patients treated at local high-quality hospitals. This suggests triaging high-risk patients to local high-quality hospitals within small geographic areas may serve as a template for improving the value of surgical care. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Patterns of Postoperative Visits Among Medicare Fee-for-service Beneficiaries
Conclusions: The proportion of expected postoperative visits that were provided is low. These results support the need for a reassessment of payment for surgical procedures. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

National Quality Forum Guidelines for Evaluating the Scientific Acceptability of Risk-adjusted Clinical Outcome Measures: A Report From the National Quality Forum Scientific Methods Panel
Quality measurement is at the heart of efforts to achieve high-quality surgical and medical care at a lower cost. Without accurate quality measures, it is not possible to appropriately align incentives with quality. The aim of these National Quality Forum (NQF) guidelines is to provide measure developers and other stakeholders with guidance on the standards used by the NQF to evaluate the scientific acceptability of performance measures. Using a methodologically rigorous and transparent process for evaluating health care quality measures is the best insurance that alternative payment plans will truly reward and promote hig...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: REVIEW PAPER Source Type: research

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Objective: To define the impact of perioperative treatment with probiotics or synbiotics on postoperative outcome in patients undergoing abdominal surgery. Background: Postoperative surgical infection accounts for a third of all cases of sepsis, and is a leading cause of morbidity and mortality. Probiotics, prebiotics, and synbiotics (preparations that combine probiotics and prebiotics) are nutritional adjuncts that are emerging as novel therapeutic modalities for preventing surgical infections. However, current evidence on their effects is conflicting. Methods: A comprehensive search of the PubMed, Embase, and WHO...
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: META-ANALYSIS Source Type: research

Nonoperative Treatment Versus Appendectomy for Acute Nonperforated Appendicitis in Children: Five-year Follow Up of a Randomized Controlled Pilot Trial
Conclusions: At 5 years of follow-up 46% of children treated with antibiotics for acute nonperforated appendicitis had undergone an appendectomy, although acute appendicitis was only histologically confirmed in 4/24 (17%). Treatment with antibiotics seems to be safe in the intermediate-term; none of the children previously treated nonoperatively re-presented with complicated appendicitis. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

Health-related Quality of Life Following Hybrid Minimally Invasive Versus Open Esophagectomy for Patients With Esophageal Cancer, Analysis of a Multicenter, Open-label, Randomized Phase III Controlled Trial: The MIRO Trial
Conclusions: Esophagectomy has substantial effects upon short-term HRQOL. These effects for some specific parameters are, however, reduced with HMIE, with persistent differences up to 2 years, and maybe mediated by a reduction in postoperative complications. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

Too Much Surgery: Overcoming Barriers to Deimplementation of Low-value Surgery
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Using Positive Psychology to Optimize Patient-centered Surgical Care
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Responsibilities and Expectations: Considerations of Disclosure of Overlapping Operations
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

The Emergence of Robotic-assisted Breast Surgery: Proceed With Caution
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Consensus Statement on Robotic Mastectomy—Expert Panel From International Endoscopic and Robotic Breast Surgery Symposium (IERBS) 2019
Conclusion: Robotic mastectomy is a promising technique and could well be the future of minimally invasive breast surgery whereas proving to be safe and feasible. The first consensus statement on robotic mastectomy from an international panel of experts serves as an extremely important milestone and provides recommendations for breast surgeons keen to embark on this technique. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Pancreatic Cancer: A Time to Change
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Postoperative Chemotherapy Benefits Patients Who Received Preoperative Therapy and Pancreatectomy for Pancreatic Adenocarcinoma
Conclusions: Despite being administered more frequently to patients with poor prognostic factors, postoperative chemotherapy after preoperative therapy and pancreatectomy for PDAC was of clinical benefit. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Perpetuation of Inequity: Disproportionate Penalties to Minority-serving and Safety-net Hospitals Under Another Medicare Value-based Payment Model
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Medicare's Hospital Acquired Condition Reduction Program Disproportionately Affects Minority-serving Hospitals: Variation by Race, Socioeconomic Status, and Disproportionate Share Hospital Payment Receipt
Conclusions: Minority-serving hospitals are being disproportionately penalized by the HACRP. As the program continues to develop, efforts are needed to identify and protect patients in vulnerable institutions to ensure that disparities do not increase. (Source: Annals of Surgery)
Source: Annals of Surgery - May 22, 2020 Category: Surgery Tags: FEATURES Source Type: research

Response to the Comment on “Epidural Analgesia (TEA) vs. IV-PCA After Open Liver Surgery”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Comment on “Epidural Analgesia (TEA) vs. IV-PCA After Open Liver Surgery”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Response to the Comment on “Postoperative Opioid Prescribing and Pain”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Comment on “Postoperative Opioid Prescribing and Pain”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Response to the Comment on“Survival Following Liver Transplantation for Patients With Non-resectable Liver Only Colorectal Metastases”: What if those Lesions Are Gone?
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Comment on “Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases”: Shaking the Coconut Tree
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Response to the Comment on “Somatostatin as Inflow Modulator in Liver-transplant Recipients With Severe Portal Hypertension: A Randomized Trial”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Comment on “Somatostatin as Inflow Modulator in Liver-transplant Recipients With Severe Portal Hypertension—A Randomized Trial”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Surprise Billing: Need for Comprehensive Risk Protection Programs
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

“Surprise” Out-of-network Billing in Orthopedic Surgery: Charges From Surprising Sources
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Mechanical Trauma and the Skin Immune System in Hand Transplant Rejection
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Trauma-induced Rejection in Vascularized Composite Allotransplantation
Vascularized composite allotransplantation (VCA) is a relatively new field in reconstructive medicine. Likely a result of the unique tissue composition of these allografts—including skin and often a bone marrow component—the immunology and rejection patterns do not always mimic those of the well-studied solid organ transplantations. While the number and type of VCAs performed is rapidly expanding, there is still much to be discovered and understood in the field. With more patients, new findings and patterns emerge and add to our understanding of VCA. Here, we present a case report of an upper extremity transpla...
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

A New Aortic Arch Inclusion Technique With Frozen Elephant Trunk for Type A Aortic Dissection
Conclusions: The aortic arch inclusion technique with FET provides a safe alternative for TAAD treatment, with satisfactory operative results. Short-term follow-up results are encouraging, and long-term outcomes need further evaluation. (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms
Objective: To compare outcomes of fenestrated (FEVAR) and open repairs of complex abdominal aortic aneurysms (cAAA). Background: FEVAR has emerged as an alternative to open surgery for treating cAAA, but direct comparisons are limited. Methods: We studied all repairs of intact or symptomatic cAAA in the Vascular Quality Initiative between 2012 and 2018, excluding chimney/snorkels and any devices implanted under Investigational Device Exemption studies. We compared open repairs, commercially available FEVAR devices and physician-modified endografts (PMEG) using inverse probability weighting. As a secondary analysis,...
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Development and Implications of an Evidence-based and Public Health-relevant Definition of Complicated Appendicitis in Children
Objective: To characterize the influence of intraoperative findings on complications and resource utilization as a means to establish an evidence-based and public health-relevant definition for complicated appendicitis. Summary of Background Data: Consensus is lacking surrounding the definition of complicated appendicitis in children. Establishment of a consensus definition may have implications for standardizing the reporting of clinical research data and for refining reimbursement guidelines. Methods: This was a retrospective cohort study of patients ages 3 to 18 years who underwent appendectomy from January 1, 2...
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

A Prospective Evaluation of the Utility of a Hybrid Operating Suite for Severely Injured Patients: Overstated or Underutilized?
Objective: The primary objective of this study was to evaluate the utility, clinical impact, and work flow of a new trauma hybrid operating theater. Summary Background Data: The potential utility and clinical benefit of hybrid operating theaters are increasingly postulated. Unfortunately, the clinical outcomes and efficiencies of these environments remain unclear. Methods: All severely injured patients who were transferred to the hybrid suite for emergent intervention between 2013 and 2017 were compared to consecutive prehybrid patients. Standard statistical methodology was employed (P (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Abdominal Hernia-Q: Development, Psychometric Evaluation, and Prospective Testing
Conclusions: Through patient involvement and rigorous, iterative psychometric evaluation, we have produced substantial data to suggest the validity and reliability of AHQ scores in measuring hernia-specific PRO. The AHQ advances the clinical management and treatment of patients with abdominal hernias by providing a more complete understanding of patient-defined outcomes. (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for the Occurrence of New Cancer in the Remnant Pancreas
Conclusions: Concomitant IPMN in PDAC is an independent predictive factor for the development of new PDAC in remnant pancreas. Cancer susceptibility of remnant pancreas after resection for PDAC concomitant with IPMN is probably due to an increased density of pancreatic intraepithelial neoplasia lesions. (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Pancreatectomy With Arterial Resection for Pancreatic Adenocarcinoma: How Can It Be Done Safely and With Which Outcomes?: A Single Institution's Experience With 118 Patients
Conclusion: In a specialized setting, P-AR for locally advanced pancreatic adenocarcinoma can be performed safely with limited mortality and morbidity. Negative resection margin and the absence of associated venous invasion might predict favorable long-term outcomes. (Source: Annals of Surgery)
Source: Annals of Surgery - April 17, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research