Association of Premature Menopause With Risk of Abdominal Aortic Aneurysm in the Women’s Health Initiative
Conclusions:
This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked. These results suggest an opportunity to develop strategies for better screening, risk reduction and stratification, and outcome improvement in the comprehensive vascular care of women. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Tumor Size, Histology, and Survival After Stereotactic Ablative Radiotherapy and Sublobar Resection in Node-negative Non-small Cell Lung Cancer
Conclusions:
In this National Cancer Database analysis, sublobar resection was associated with greater survival compared to SABR for lesions>6or 8 mm in patients with adenocarcinoma or squamous cell carcinoma; however, SABR was associated with similar survival compared to sublobar resection in patients with aggressive tumors including papillary and large cell histology. Histologic diagnosis in patients with even small tumors may enable better treatment selection in those who cannot tolerate lobectomy. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Sublobar Resection Versus Lobectomy for Early-Stage Pulmonary Carcinoid Tumors ≤3 cm in Size: A SEER Population-Based Study
This study aimed to determine the optimal surgical procedure for early-stage pulmonary carcinoids (PCs).
Background:
PCs, comprising typical carcinoids (TCs) and atypical carcinoids (ACs), are rare low-grade malignant tumors. We determine the optimal surgical management for early-stage PCs using data from the Surveillance, Epidemiology, and End Results registry.
Methods:
Clinical and survival data of patients with early-stage PC tumors with a diameter ≤3 cm were retrieved. The Kaplan-Meier method and logrank tests were used to assess the differences in overall survival (OS). Subgroup analyses were also perf...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Acute Kidney Injury in Deceased Organ Donors and Kidney Transplant Outcomes: A National Cohort Study Using a Novel Data Source
Objective:
The aim of this study was to determine graft function and survival for kidney transplants from deceased donors with acute kidney injury (AKI) that persists at the time of organ procurement.
Background:
Kidneys from donors with AKI are often discarded and may provide an opportunity to selectively expand the donor pool.
Methods:
Using Organ Procurement and Transplantation Network and DonorNet data, we studied adult kidney-only recipients between May 1, 2007 and December 31, 2016. DonorNet was used to characterize longitudinal creatinine trends and urine output. Donor AKI was defined using KDIGO g...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
The Impact of General Surgeons on Pediatric Surgical Practice in North Carolina: The Reality of Pediatric Surgical Care Delivery
Objective:
The aim of this study was to define the training background of the actual surgical workforce providing care to pediatric patients in North Carolina (NC).
Background:
Due to database limitations, pediatric surgical workforce studies have not included general surgeons (GS) who operate on children. Defining the role of GS in care delivery affects policy for clinical care and general and pediatric surgical training.
Methods:
We performed a retrospective review of the NC Hospital Discharge Database (2011–2017), including pediatric patients ( (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children With Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study
Conclusions:
Local recurrence occurs in one-quarter of children with chest wall sarcoma and is independent of tumor type. Scoliosis occurs in 13% of patients, but patient-reported quality of life is excellent. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Internal and External Validation of an Alcohol Biomarker for Screening in Trauma
Conclusion and Relevance: PEth alone proved to be the single best biomarker for screening of unhealthy alcohol use and performed better than existing screening systems with BAC. PEth may overcome existing screening barriers. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Outpatient Opioid Prescriptions are Associated With Future Substance Use Disorders and Overdose Following Adolescent Trauma
Conclusions:
Short-term outpatient opioid prescribing over the first few months of recovery had the largest effect on developing an SUD, while long-term prescription use over multiple years was associated with a future overdose. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS
Objectives:
Identify the metabolites that are increased in the plasma of severely injured patients that developed ARDS versus severely injured patients that did not, and assay if these increased metabolites prime pulmonary sequestration of neutrophils (PMNs) and induce pulmonary sequestration in an animal model of ARDS. We hypothesize that metabolic derangement due to advanced shock in critically injured patients leads to the PMNs, which serves as the first event in the ARDS. Summary of Background Data: Intracellular metabolites accumulate in the plasma of severely injured patients.
Methods:
Untargeted metabolom...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Out-of-Pocket Costs for Patients Undergoing Thyroid Surgery
Objective:
The aim of this study was to determine out-of-pocket costs (OOPC) in patients undergoing thyroidectomy for benign and malignant conditions in a commercially insured US population.
Summary Background Data:
Little is known about OOPC for thyroid surgery in the United States.
Methods:
Retrospective cohort study using claims of patients undergoing thyroidectomy from the IBM Watson Marketscan database from 2008 to 2017. OOPCs accrued from 90 days before surgery to 360 days after thyroid surgery were quantified. Costs were divided into expenditures for inpatient care, outpatient care and outpatient d...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Risk of Breast Cancer in Selected Women With Atypical Ductal Hyperplasia Who do not Undergo Surgical Excision
Conclusions:
Observation, rather than surgical excision, is safe in select women with ADH. National guidelines should consider observation for this select group of patients. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
De-implementation of Axillary Dissection in Women With Breast Cancer is Largely Driven By Site-level Contextual Effects
Conclusion:
Compared to known patient, tumor, and institutional factors, contextual effects had a higher contribution to the variation in cALND use. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
A Pretreatment Prognostic Score to Stratify Survival in Pancreatic Cancer
Conclusion:
The HELPP-score is a readily available prognostic tool based on pretreatment routine parameters to stratify survival in PDAC independently of resection status and pathological tumor stage. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
High-risk Pancreatic Anastomosis Versus Total Pancreatectomy After Pancreatoduodenectomy: Postoperative Outcomes and Quality of Life Analysis
Objective:
To evaluate TP as an alternative to PD in patients at high-risk for popf.
Background:
Outcomes of high-risk PD (HR-PD) and TP have never been compared.
Methods:
All patients who underwent PD or TP between July 2017 and December 2019 were identified. HR-PD was defined according to the alternative fistula risk score. Postoperative outcomes (primary endpoint), pancreatic insufficiency, and quality of life after 12 months of follow-up (QoL) were compared between HR-PD or planned PD intraoperatively converted to TP (C-TP).
Results:
A total of 566 patients underwent PD and 136 underwent TP dur...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
Gastric Venous Congestion After Total Pancreatectomy is Frequent and Dangerous
Objective:
The aim of this study was to determine the role of GVC in mortality after TP.
Background:
Data from a nationwide administrative database revealed that TP is associated with a 23% mortality rate in Germany.Methods: A total of 585 consecutive patients who had undergone TP (n = 514) or elective completion pancreatectomy (n = 71) between January 2015 and December 2019 were analyzed. Univariable and multivariable analyses were performed to identify risk factors for GVC and 90-day mortality. Results: GVC was observed in 163 patients (27.9%) requiring partial or total gastrectomy. Splenectomy (odds ratio 2.1...
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Original Articles Source Type: research
