Sentinel Lymph Node Mapping in Breast Cancer Patients Through Fluorescent Imaging Using Indocyanine Green: The INFLUENCE Trial
Conclusions:
ICG-fluorescence showed a higher (S)LN detection rate than 99mTc-nanocoilloid, and equal detection rate for pathological (S)LNs. ICG-fluorescence may be used as a safe and effective alternative to 99mTc-nanocoilloid for SLNB in patients with early-stage breast cancer. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Evaluating the Role of Circulating MicroRNAs to Aid Therapeutic Decision Making for Neoadjuvant Chemotherapy in Breast Cancer: A Prospective, Multicenter Clinical Trial
Conclusions:
This study illustrates the potential value of circulatory miRNA measurement in predicting response to NAC. Further interrogation of these findings may see miRNAs personalize therapeutic decision-making for patients undergoing NAC for early breast cancer. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Identification of an EMT-related Gene Signature Predicting Recurrence in Stage II/III Colorectal Cancer: A Retrospective Study in 1780 Patients
Objective:
To identify a prognostic significant gene signature for predicting colorectal cancer (CRC) recurrence.
Background:
Traditional prognostic risk assessment in stage II/III CRC patients remains controversial. Epithelial-mesenchymal transition is thought to be closely related to the malignant progression of tumors. Thus, it is promising to establish a prognostic model based on epithelial-mesenchymal transition–related gene (ERG) signature.
Materials and Methods:
We retrospectively analyzed transcriptome profiles and clinical information of 1780 stage II/III CRC patients from 15 public datasets. C...
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
A Breakthrough Improvement Collaborative Significantly Reduces Hospital Stay After Elective Colectomy for Cancer Across a Healthcare System
Conclusions:
A peer-constructed improvement collaborative effectively increases adherence to an ERAS protocol in individual hospitals. Across time, length of stay and postoperative complications decreased significantly, and a dose-response relationship was observed. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Long-Term Oncological Outcomes After Colorectal Anastomotic Leakage: A Retrospective Dutch Population-based Study
Conclusion:
AL has a stage-dependent negative impact on survival in both CC and RC, but no independent association with disease recurrence. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Sex Disparities in Outcomes Following Major Liver Surgery: New Powers of Estrogen?
Aim:
To explore potential sex differences in outcomes and regenerative parameters post major hepatectomies.
Background:
Although controversial, sex differences in liver regeneration have been reported for animals. Whether sex disparity exists in human liver regeneration is unknown.
Methods:
Data from consecutive hepatectomy patients (55 females, 67 males) and from the international ALPPS (Associating-Liver-Partition-and-Portal-vein-ligation-for-Staged-hepatectomy, a two stage hepatectomy) registry (449 females, 729 males) were analyzed. Endpoints were severe morbidity (≥3b Clavien-Dindo grades), Model f...
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liver Transplantation
Conclusions:
HepatoPredict outperforms conventional clinical-pathologic selection criteria (Milan, UCSF), providing superior prognostic information. Accurately identifying which patients most likely benefit from LT enables an objective stratification of waiting lists and information-based allocation of optimal versus suboptimal organs. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Novel Benchmark Values for Redo Liver Transplantation: Does the Outcome Justify the Effort?
Conclusion:
This study shows that redo-LT achieves good outcome when looking at benchmark scenarios. However, this figure changes in high-risk redo-LT, as for example in PNF. This analysis objectifies for the first-time results and efforts for redo-LT and can serve as a basis for discussion about the use of scarce resources. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Ex Vivo Liver Resection and Autotransplantation: Should It be Used More Frequently?
Conclusions:
Ex vivo resection utilizes techniques commonly practiced in partial liver transplantation, and we demonstrate relatively favorable outcomes in our large collective experience. Therefore, we propose that more liberal use of this technique may benefit selected patients in centers experienced with partial liver transplantation. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
Objective:
To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons.
Background:
Transplantation for PHC is used with reluctance in many centers and even contraindicated in several countries. Although benchmark values for LT are available, there is a lack of specific data on LT performed for PHC.
Methods:
PHC patients considered for LT after Mayo-like protocol were analyzed in 17 reference centers in 2 continents over the recent 5-year period (2014–2018). The minimum follow-up was 1 year. Benchmark patients were defined a...
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Living Donor Liver Transplantation With Augmented Venous Outflow and Splenectomy: A Promised Land for Small Left Lobe Grafts
Objective:
Living donor liver transplantation (LDLT) using small grafts, especially left lobe grafts (H1234-MHV) (LLG), continues to be a challenge due to small-for-size syndrome (SFSS). We herein demonstrate that with surgical modifications, outcomes with small grafts can be improved.
Methods:
Between 2012 and 2020, we performed 130 adult LDLT using 61 (47%) LLG (H1234-MHV) in a single Enterprise. The median graft-to-recipient weight ratio was 0.84%, with graft-to-recipient weight ratio (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Management of Pathogenic CDH1 Variant Carriers Within the FREGAT Network: A Multicentric Retrospective Study
Conclusions:
Among pCDH1vc, index cases carry a dismal prognosis. The risk of cancer among patients undergoing PTG remained high and unpredictable and has to be balanced with the morbidity and functional consequence of PTG. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Poorly Cohesive Gastric Cancers Showing the Transcriptomic Hallmarks of Epithelial-Mesenchymal Transition Behave Aggressively
Conclusion:
integrated genomic and transcriptomic analysis suggest the existence of 4 molecular subtypes of PC GC with prognostic significance where EMT features are associated with a worse outcome. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Gastric Bypass Resolves Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Low-BMI Patients: A Prospective Cohort Study
This study assesses the impact of Roux-en-Y gastric bypass (RYGB) on MAFLD in a prototypical cohort outside the guidelines for obesity surgery.
Methods:
Twenty patients were enrolled in this prospective, single-arm trial investigating the effects of RYGB on advanced metabolic disease (DRKS00004605). Inclusion criteria were an insulin-dependent type 2 diabetes, body mass index of 25 to 35 kg/m2, glucagon-stimulated C-peptide of>1.5 ng/mL, glycated hemoglobin>7%, and age 18 to 70 years. A RYGB with intraoperative liver biopsies and follow-up liver biopsies 3 years later was performed. Steatohepatitis was assessed by...
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
Recurrent Disease After Esophageal Cancer Surgery: A Substudy of The Dutch Nationwide Ivory Study
Conclusions:
This study provides important prognostic information assisting in the surveillance and counseling of patients after curatively intended esophageal cancer surgery. Nearly half the patients developed recurrent disease, with limited prospects of survival. The risk of recurrence was higher in patients with a higher tumor stage, nonradical resection and positive lymph node harvest. (Source: Annals of Surgery)
Source: Annals of Surgery - October 15, 2022 Category: Surgery Tags: ESA Paper Source Type: research
