Long-term Outcomes of Parenchyma-sparing and Oncologic Resections in Patients With Nonfunctional Pancreatic Neuroendocrine Tumors
Introduction:
The role of parenchyma-sparing resections (PSR) and lymph node dissection in small ( (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms
Conclusions:
Here we provide the first comprehensive evaluation of single-cell composition of the abdominal aortic wall and reveal how the gene expression landscape is altered in human AAAs. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Nationwide Management of Trauma in Child Abuse: Exploring the Racial, Ethnic, and Socioeconomic Disparities
Conclusions:
Significant racial, ethnic, and socioeconomic disparities exist in the nationwide management of child abuse. Further studies are strongly warranted to understand contributing factors and possible strategies to address them.
Level of Evidence:
Level III—therapeutic/care management. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Lack of Workplace Support for Obstetric Health Concerns is Associated With Major Pregnancy Complications: A National Study of US Female Surgeons
Conclusions:
Lack of workplace support for reduction in clinical duties is associated with adverse obstetric outcomes for surgeons. This is a modifiable workplace obstacle that deters surgeons from acting to optimize their infant’s and their own health. To ensure the health of expectant surgeons, departmental policies should support reduction of clinical workload in an equitable manner without creating financial penalties, requiring payback for missed call duties, or overburdening colleagues. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Evaluation of Fontan-associated Liver Disease and Ethnic Disparities in Long-term Survivors of the Fontan Procedure: A Population-based Study
Conclusions:
In this population-based analysis of long-term outcomes post-Fontan, Hispanic ethnicity was associated with increased all-cause mortality. Further, the prevalence of FALD is underrecognized, but our data confirms that its incidence increases with age. FALD is associated with late mortality but excellent posttransplant survival. This emphasizes the need for FALD-specific liver surveillance strategies in patients post-Fontan. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
A Novel Nonantibiotic Gut-directed Strategy to Prevent Surgical Site Infections
Conclusions:
A nonantibiotic phosphate-rich polymer, Pi-PEG, added to the drinking water of mice prevents SSIs and may represent a more sustainable approach in lieu of the current trend of greater sterility and the use of more powerful and broader antibiotic coverage. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Mental Health Care Following Firearm and Motor Vehicle-related Injuries: Differences Impacting Our Treatment Strategies
Objective:
To compare new mental health diagnoses (NMHD) in children after a firearm injury versus following a motor vehicle collision (MVC).
Background:
A knowledge gap exists regarding childhood mental health diagnoses following firearm injuries, notably in comparison to other forms of traumatic injury.
Methods:
We utilized Medicaid MarketScan claims (2010–2016) to conduct a matched case-control study of children ages 3 to 17 years. Children with firearm injuries were matched with up to 3 children with MVC injuries. Severity was determined by injury severity score and emergency department disposition....
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Pancreatic Cancer Patient-derived Organoids Can Predict Response to Neoadjuvant Chemotherapy
Conclusion:
Herein we report a large single-institution organoid biobank, including ethnic minority samples. The ability to establish PDOs from chemotherapy-naive and post-NAT tissue enables longitudinal PDO generation to assess dynamic chemotherapy sensitivity profiling. PDOs can be rapidly screened and further development of rapid screening may aid in the initial stratification of patients to the most active NAT regimen. (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Intraportal Islet Autotransplantation Independently Improves Quality of Life After Total Pancreatectomy in Patients With Chronic Refractory Pancreatitis
Objective:
To determine if islet autotransplantation (IAT) independently improves the quality of life (QoL) in patients after total pancreatectomy and islet autotransplantation (TP-IAT).
Background:
TP-IAT is increasingly being used for intractable chronic pancreatitis. However, the impact of IAT on long-term islet function and QoL is unclear.
Methods:
TP-IAT patients at our center>1 year after TP-IAT with ≥1 Short Form-36 QoL measure were included. Patients were classified as insulin-independent or insulin-dependent, and as having islet graft function or failure by C-peptide. The associations of insuli...
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
Translational Epidemiology: An Integrative Approach to Determine the Interplay Between Genetic Ancestry and Neighborhood Socioeconomic Status on Triple Negative Breast Cancer
Conclusions:
In this translational epidemiologic study of genetic ancestry and nSES on BC subtype, we discovered associations between increasing WA ancestry, low nSES, and higher rates of TNBC compared to other BC subtypes. Moreover, on admixture mapping, specific chromosomal segments were associated with WA ancestry and TNBC, independent of nSES. However, on multinomial logistic regression adjusting for WA ancestry, women from low nSES were more likely to have TNBC, independent of genetic ancestry. These findings highlight the complex nature of TNBC and the importance of studying potential gene-environment interaction...
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
The Kidney Transplant Equity Index: Improving Racial and Ethnic Minority Access to Transplantation
Objectives:
To develop a scalable metric which quantifies kidney transplant (KT) centers’ performance providing equitable access to KT for minority patients, based on the individualized prelisting prevalence of end-stage renal disease (ESRD).
Background:
Racial and ethnic disparities for access to transplant in patients with ESRD are well described; however, variation in care among KT centers remains unknown. Furthermore, no mechanism exists that quantifies how well a KT center provides equitable access to KT for minority patients with ESRD.
Methods:
From 2013 to 2018, custom datasets from the United St...
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research
History Worth Remembering: Lessons for Today Learned From a Period and Ongoing Process in American History Called Reconstruction
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Presidential Address Source Type: research
Multiinstitutional Validation Study of Cyst Fluid Protein Biomarkers in Patients With Cystic Lesions of the Pancreas
Conclusions:
This prospective study of patients with unknown cyst pathology further demonstrates the importance of cyst fluid protein analysis in the preoperative identification of patients with high-risk IPMN. Longer follow-up is necessary to determine if this model will be useful in clinical practice. (Source: Annals of Surgery)
Source: Annals of Surgery - July 30, 2022 Category: Surgery Tags: Brief Clinical Reports Source Type: research
Updated Alternative Fistula Risk Score (ua-FRS) to Include Minimally Invasive Pancreatoduodenectomy: Pan-European Validation
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - July 15, 2022 Category: Surgery Tags: Erratum Source Type: research
Response to “Why Gastric Bypass Might Not be a Good Choice for Type-2 Diabetes Treatment”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - July 15, 2022 Category: Surgery Tags: Letters to the Editor Source Type: research
