Response to the Comment on “Objective Evidence of Reflux Control After Magnetic Sphincter Augmentation: One Year Results From a Post Approval Study”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Comment on “Objective Evidence of Reflux Control After Magnetic Sphincter Augmentation: 1 Year Results From a Post Approval Study”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: LETTERS TO THE EDITOR Source Type: research

Patient, Surgeon, and Health Care Worker Safety during the COVID-19 Pandemic: Erratum
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ERRATUM Source Type: research

Invited Commentary on “A Novel and Generic Workflow of Indocyanine Green Perfusion Assessment Integrating Standardization and Quantification Towards Clinical Implementation”
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

A Novel and Generic Workflow of Indocyanine Green Perfusion Assessment Integrating Standardization and Quantification Toward Clinical Implementation
Conclusion: WISQ needs prospective validation in larger series and may eventually support clinical decision-making to predict and prevent postoperative organ function impairment in a large and varied surgical population. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

First in Man
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

“First in Man” Total Percutaneous Aortic Arch Repair With 3-Inner-branch Endografts: A Report of Two Cases
Conclusions: Our new truly minimally invasive approach demonstrates that it is possible to manage one of the most challenging treatments of aortic pathologies without any surgical incision. Further, evaluation and experience are required to confirm these promising results. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Is There a Role for Routine Specialty Palliative Care Consultation in Cancer Patients Undergoing Curative-Intent Surgery?
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Psychosocial Stress Before Major Oncologic Operations: A Qualitative Content Analysis of Palliative Care Provider Documentation
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

The Other Global Pandemic: Scientific Racism and the Normality Bias
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Stopping the Progression of Moral Injury: A Priority During Surgical Training
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Myths, Superstitions, and Popular Beliefs: Do They Still Impact Our Practice?
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Left Hepatic Trisectionectomy With Caudate Lobectomy: Demanding But Essential Routine Surgical Procedure for Perihilar Cholangiocarcinoma
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Is the Evidence for Thoracic Surgery of Early Stage Lung Cancer Adequate?
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Why So Many Formats When One Will Do? A Call for a Single Manuscript Submission Format
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Surgeons and Administrators Co-creating Value
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Asian Americans (AAPI) in Academic Surgery
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Perioperative Provider Safety in Low- and Middle-income Countries During the COVID-19 Pandemic: A Call for Renewed Investments in Resources and Training
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL PERSPECTIVES Source Type: research

Innovation and Tribulation in the History of Randomized Controlled Trials in Surgery
Despite persistent critiques of the rigor of surgical research, surgeons have actually pursued careful empirical studies for centuries. Their work has enriched not only surgical science but also the development of evidencebased medicine. From conducting landmark controlled trials, to using statistics, alternate patient allocation, randomization, and sham controls, surgeons have long embraced innovative trial approaches and played important roles in the development of key methods of RCTs. However, historical contexts unique to surgery have shaped the implementation of RCTs in this field. Unlike the history of pharmaceutical...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL RETROSPECTIVE Source Type: research

A Novel Method to Improve Perfusion of Ex Vivo Pumped Human Kidneys
Conclusions: S-Nitrosylation therapy restored the microcirculation and thus improved overall organ perfusion. Inclusion of ENO in the renal preservation solution holds promise to increase the number and quality of kidneys available for transplant. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Pneumonectomy for Pediatric Tumors—a Pediatric Surgical Oncology Research Collaborative Study
Objective: To describe utilization and long-term outcomes of pneumonectomy in children and adolescents with cancer. Summary Background Data: Pneumonectomy in adults is associated with significant morbidity and mortality. Little is known about the indications and outcomes of pneumonectomy for pediatric tumors. Methods: The Pediatric Surgical Oncology Research Collaborative (PSORC) identified pediatric patients (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Abdominal Drainage at Appendectomy for Complicated Appendicitis in Children: A Propensity-matched Comparative Study
Objective: The aim of the study was to investigate the effect of abdominal drainage at appendectomy for complicated appendicitis in children. Summary of Background Data: Although an abdominal drain placement at appendectomy is an option for reducing or preventing postoperative infectious complication, there is controversy regarding its effect for complicated appendicitis. Method: The study used the data on appendectomies for complicated appendicitis in children (≤15 years old) that were operated in 2015 and registered in the National Clinical Database, a nationwide surgical database in Japan. One-to-tw...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Optimizing Surveillance and Re-intervention Strategy Following Elective Endovascular Repair of Abdominal Aortic Aneurysms
Conclusions: All alternative strategies improved clinical benefits compared with the EVAR-1 trial. Further work is needed regarding the cost and accuracy of primary care ultrasound, and the potential impact of these strategies in the comparison with OR. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Is Immediate Lymphatic Reconstruction Cost-effective?
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars: A Prospective Study of Objective and Subjective Outcomes
Objective: The aim of this study is to determine objective and subjective changes in mature hypertrophic burn scars treated with a fractional ablative carbon dioxide (CO2) laser. Background: Fractional CO2 laser treatment has been reported to improve burn scars, with increasing clinical use despite a paucity of controlled, prospective clinical studies using objective measures of improvement. Methods: A multicenter, site-controlled, prospective open-label study was conducted from 2013 to 2016. Objective and patient-reported outcome measures were documented at baseline, at each monthly laser treatment, and ...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Impact of Socioeconomic Deprivation on Clinical Outcomes for Pancreatic Adenocarcinoma at a High-volume Cancer Center: A Retrospective Cohort Analysis
Conclusions: Although nearly one-quarter of curative-intent surgery patients were from high SED neighborhoods, this factor was not associated with measures of treatment quality or survival. These observations suggest that treatment at a high-volume cancer center employing a standardized clinical pathway may in part address socioeconomic disparities in pancreatic cancer. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Significance of Examined Lymph Node Number in Accurate Staging and Long-term Survival in Resected Stage I–II Pancreatic Cancer—More is Better? A Large International Population-based Cohort Study
Conclusions: In stage I to II PaC, more ELNs are associated with more precise nodal staging, which might largely explain the survival association. Our observational study does not suggest causality, and does not encourage more extended lymphadenectomy before further randomized evidence is obtained. Our results robustly conclude 11 ELNs as the minimal and suggest 19 ELNs as the optimal cut-points, for evaluating quality of lymph node examination and possibly for stratifying postoperative prognosis. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Tradition Versus Value: Is There Utility in Protocolized Postoperative Laboratory Testing After Elective Colorectal Surgery?
Conclusions: Routine POD 1 lab tests after elective colorectal surgery are rarely abnormal, and they even less frequently require active intervention beyond rechecking. This results in increased resource utilization and cost of care without appreciable impact on clinical care, and is not cost-effective. Protocolized POD 1 laboratory testing should be replaced with clinically-based criteria to trigger serum laboratory investigations. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Predictive Value of Endoscopic Features for a Complete Response After Chemoradiotherapy for Rectal Cancer
Conclusions: More than 70% of the patients with a luminal CR after neoadjuvant treatment for rectal cancer can be identified by endoscopy at ±9 weeks. Together with findings on digital rectal examination (DRE) and magnetic resonance imaging, specific endoscopic features can be used to select patients for an extended observation period to select for organ preservation. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries
Objective: We aimed to clarify the long-term risk development of EAC after antireflux surgery. Summary of Background Data: Gastroesophageal reflux disease (GERD) increases EAC risk, but whether antireflux surgery prevents EAC is uncertain. Methods: Multinational, population-based cohort study including individuals with GERD from all 5 Nordic countries in 1964–2014. First, EAC risk after antireflux surgery in the cohort was compared with the corresponding background population by calculating standardized incidence ratios (SIRs) with 95% confidence intervals (95% CIs). Second, multivariable Cox propor...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Quality of Life After Caustic Ingestion
Objective: The aim of the study was to evaluate long-term QOL after caustic ingestion. Background: Caustic ingestion strongly affects patient's QOL but data on the topic is scarce in the literature. Methods: QOL evaluation was conducted in survivors from a large cohort of patients with caustic injuries. QOL was assessed using the EORTC QLQ-OG25 module, the SF12v2 score, and the hospital anxiety and depression scale questionnaire. One hundred thirty-four patients (59 men, median age 43) completed the survey; 72 (54%) patients underwent emergency digestive resection and in 99 (74%) patients underwent esopha...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Current and Projected Financial Burden of Emergency General Surgery for Adults in Scotland's Single Payer Healthcare System: A Cost Analysis of Hospital Admissions
Conclusions: The future financial burden of EGS in Scotland is projected to increase moderately between 2016 and 2041. This is in sharp contrast to previous studies from settings such as the United States. However, if no further reductions in LOS or cost per bed day are made, especially for elderly patients, the cost of EGS will rise dramatically. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Preoperative Statin Use and 90-Day Mortality After Noncardiac Surgery: A Hospital Registry Study
Objective: The aim of this study was to investigate the association between preadmission statin use and 90-day mortality after planned elective noncardiac surgery in adult patients. Summary Background Data: Statin therapy is known to have pleiotropic effects, which improve the outcomes of various diseases. However, the effect of perioperative statin therapy on postoperative mortality remains controversial. Methods: This retrospective cohort study analyzed the medical records of adult patients who were admitted to a single tertiary academic hospital for elective noncardiac surgery between January 2012 and ...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Survival After Robotic-assisted Prostatectomy for Localized Prostate Cancer: An Epidemiologic Study
Backgrounds: To determine the potential survival benefit associated with robotic-assisted laparoscopic prostatectomy (RALP) compared to open radical prostatectomy (ORP) for prostate cancer. Summary of Background Data: RALP has become the dominant surgical approach for localized disease in the absence of randomized clinical evidence and despite of the factor that RALP is more expensive than ORP. Methods: We performed a cohort study involving patients who underwent RALP and ORP for localized prostate cancer at the Commission on Cancer- accredited hospitals in the United States. Overall survival was analyzed...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Implementation and Evaluation of Quality Improvement Training in Surgery: A Systematic Review
Conclusions: The evidence suggests that surgical QI training can focus on any well-established QI technique, provided it is done through a combination of didactic teaching and practical application. True effectiveness and extent of impact of QI training remain unclear, due to methodological weaknesses and inconsistent reporting. Conduct of larger-scale educational QI studies across multiple institutions can advance the field. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: REVIEW PAPER Source Type: research

The Comparative Efficacy of Chlorhexidine Gluconate and Povidone-iodine Antiseptics for the Prevention of Infection in Clean Surgery: A Systematic Review and Network Meta-analysis
Conclusions: Alcoholic formulations of 4%–5% CHG seem to be safe and twice as effective as PVI (alcoholic or aqueous solutions) in preventing infection after clean surgery in adults. Our findings concur with the literature on contaminated and clean-contaminated surgery, and endorse guidelines worldwide which advocate the use of alcoholic CHG for preoperative skin antisepsis. Registration: PROSPERO ID CRD42018113001. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: META ANALYSIS Source Type: research

Effect of Denonvilliers’ Fascia Preservation Versus Resection During Laparoscopic Total Mesorectal Excision on Postoperative Urogenital Function of Male Rectal Cancer Patients: Initial Results of Chinese PUF-01 Randomized Clinical Trial
Conclusions: DVF preservation during L-TME revealed protective effects on postoperative urogenital function, and could be a better choice for male rectal cancer patients with specific staging and location. Trial registration number: NCT02435758. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

Multicenter Randomized Phase 2 Trial Comparing Chemoradiotherapy and Docetaxel Plus 5-Fluorouracil and Cisplatin Chemotherapy as Initial Induction Therapy for Subsequent Conversion Surgery in Patients With Clinical T4b Esophageal Cancer: Short-term Results
Conclusion: Upfront CRT was superior to upfront CT in terms of pathological effects and AEs. The Japan Registry of Clinical Trials (s051180164). (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

The University of Pennsylvania Medical School Commencement of 1889: Aequanimitas and the Agnew Clinic
Academic commencements ceremonies usually do not result in memorable occasions and once ended usually are forgotten. Not so for the University of Pennsylvania's School of Medicine commencement on May 1,1889, which was marked by an address by William Osler, the retirement of the renowned Professor of Surgery, D. Hayes Agnew, and the presentation to the University of Thomas Eakins’ remarkable masterpiece, “The Agnew Clinic.” Osler had been on the faculty of the University for 5 years and in his keynote address, Aequanimitas, he laid out 2 elements, imperturbability and equanimity, that he stated would &ldqu...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: SURGICAL RETROSPECTIVE Source Type: research

Identifying a Basket of Surgical Procedures to Standardize Global Surgical Metrics: An International Delphi Study
Conclusions: This surgical basket facilitates a more standardized assessment of a country's surgical system. Further testing and refinement will likely be needed, but this basket can be used immediately to guide ongoing monitoring and evaluation of global surgery capacities to improve and strengthen surgery and anesthesia care. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Matched Pairs Comparison of an Enhanced Recovery Pathway Versus Conventional Management on Opioid Exposure and Pain Control in Patients Undergoing Lung Surgery
Objective: The aim of this study was to assess the effect of an enhanced recovery after surgery (ERAS) pathway on pain and opioid use following lung resection. Summary Background Data: A major component ERAS pathways is opioid-sparing analgesia; however, the effect on postoperative pain and opioid use in patients undergoing lung resection is unknown. Methods: Following implementation of an ERAS pathway for lung resection, 123 consecutive patients were identified. Patients were propensity-matched 1:1 with a group of consecutive patients (n = 907) undergoing lung resection before ERAS. Differences regarding...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Endovascular Repair of Blunt Thoracic Aortic Trauma is Associated With Increased Left Ventricular Mass, Hypertension, and Off-target Aortic Remodeling
Conclusions: TEVAR is associated with LV mass increase, development of hypertension, and accelerated expansile remodeling of the ascending aorta. Although younger trauma patients may adapt to these effects, these changes may be even more important in older patients with other aortic pathologies and diminished baseline cardiac function. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Inner Deliberations of Surgeons Treating Critically-ill Emergency General Surgery Patients: A Qualitative Analysis
Conclusions: This is the first study to explore how surgeons decide among management options for critically-ill EGS patients. Surgeons’ decision-making reflected a broad array of clinical, personal, and institutional variables. Effective interventions to ensure preference-sensitive care for EGS patients must address all of these variables. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Adrenalectomy for Secondary Malignancy: Patients, Outcomes, and Indications
Conclusions: Durable survival is observed in patients undergoing adrenal metastasectomy and should be considered for subjects with isolated adrenal metastases. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Global Macroeconomic Burden of Breast Cancer: Implications for Oncologic Surgery
Conclusions: The burden of disease and economic impact of breast cancer is intensifying in LMICs. Global efforts to improve access to surgical care for women with breast cancer could reduce mortality and mitigate the social and financial impact of this disease in LMICs. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Optimal Adjuvant Treatment Approach After Upfront Resection of Pancreatic Cancer: Revisiting the Role of Radiation Based on Pathologic Features
Objective: To identify the survival benefit of different adjuvant approaches and factors influencing their efficacy after upfront resection of pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: The optimal adjuvant approach for PDAC remains controversial. Methods: Patients from the National Cancer Database who underwent upfront PDAC resection from 2010 to 2014 were analyzed to determine clinical outcomes of different adjuvant treatment approaches, stratified according to pathologic characteristics. Factors associated with overall survival were identified with multivariable logistic regressi...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Multi-institutional Development and External Validation of a Nomogram to Predict Recurrence After Curative Resection of Pancreatic Neuroendocrine Tumors
Objective: To develop a nomogram estimating the probability of recurrence free at 5 years after resection for localized grade 1 (G1)/ grade 2 (G2) pancreatic neuroendocrine tumors (PanNETs). Background: Among patients undergoing resection of PanNETs, approximately 17% experience recurrence. It is not established which patients are at risk, with no consensus on optimal follow-up. Method: A multi-institutional database of patients with G1/G2 PanNETs treated at 2 institutions was used to develop a nomogram estimating the rate of freedom from recurrence at 5 years after curative resection. A second cohort...
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Safe Dissemination of Laparoscopic Liver Resection in 27,146 Cases Between 2011 and 2017 From the National Clinical Database of Japan
Conclusions: LLR has rapidly become widespread in Japan. Basic LLR is now a standard option, and advanced LLR, while not as common yet, has been increasing year by year. LLR has been safely developed with low mortality and complications rate relative to OLR. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

How to Handle Arterial Conduits in Liver Transplantation? Evidence From the First Multicenter Risk Analysis
Conclusion: When AC is required for rescue graft revascularization, the conduit placement site seems to be negligible and should follow the surgeon's preference. In this high-risk group, the study supports the concept of postoperative antiaggregation in LT requiring AC. (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Time to Surgery and Colon Cancer Survival in the United States
Purpose: Time to surgery (TTS) is of concern to patients diagnosed with cancer and their physicians. Controversy surrounds the impact of TTS on colon cancer survival. There are limited national data evaluating the association; thus, our aim was to estimate the overall survival (OS) impact from increasing TTS for patients with colon cancer. Methods: Using the National Cancer Data Base (NCDB), we assessed OS as a function of time between diagnosis and surgery by evaluating intervals encompassing (Source: Annals of Surgery)
Source: Annals of Surgery - November 23, 2021 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research