County-level Variation in Use of Surgery and Cancer-specific Survival for Stage I-II Pancreatic Adenocarcinoma
Objective: The aim of the study was to describe county-level variation in use of surgery for stage I-II pancreatic ductal adenocarcinoma (PDAC) and the association between county surgery rates and cancer-specific survival (CSS). Background: The degree of small geographic area variation in use of surgery for stage I-II PDAC and the association between area surgery rates and CSS remain incompletely defined. Methods: This is a retrospective cohort study of patients aged 18 to 80 years in the 2007 to 2015 Surveillance, Epidemiology, and End Results database with stage I-II PDAC without contraindications to su...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Metastatic Potential and Survival of Duodenal and Pancreatic Tumors in Multiple Endocrine Neoplasia Type 1: A GTE and AFCE Cohort Study (Groupe d’étude des Tumeurs Endocrines and Association Francophone de Chirurgie Endocrinienne)
Conclusions: DP-NETs of 2 cm in size or more, regardless of the associated secretion, should be removed to prevent metastasis and increase survival. Surgery for gastrinoma remains debatable. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma: International Multicenter Cohort Study
Conclusions: Independent predictors of OS in resected ampullary cancer were N-stage, perineural invasion, and adjuvant chemotherapy. N-stage was the only predictor of DFS. These findings improve predicting survival and recurrence after resection of ampullary adenocarcinoma. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases
Objective: The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). Background: Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies. Methods: We identified 396 patients with primary colorectal cancer and known somatic mutation status by next-generation sequencing who underwent hepatectomy for CLM (2005–2015). Survival after hepatectomy in patients with double mutation of APC and PIK3CA and others was analyzed. Pr...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Females Are More Resistant to Ischemia-Reperfusion-induced Intestinal Injury Than Males: A Human Study
Conclusion: The human female small intestine seems less susceptible to IR-induced tissue injury than the male small intestine. Recognition of such differences could lead to the development of novel therapeutic strategies to reduce IR-associated morbidity and mortality. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Neoadjuvant Radiotherapy Versus Surgery Alone for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors: A Prospective Multicenter Stratified Randomized Trial
Objective: The aim of this study was to compare stage II/III rectal cancers with or without high-risk factors, and evaluate the effect of neoadjuvant radiotherapy (NRT) in these 2 cohorts. Background: NRT is often used in stage II/III rectal cancers to improve local control, while not affecting overall survival. However, good-quality surgery without NRT may also achieve good local control in selected patients. Methods: According to risk-stratification criteria and clinical staging, consecutive eligible participants of stage II/III rectal cancer were preoperatively classified into patients with (high-risk)...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women
Conclusions: Bariatric surgery was associated with a reduced risk of breast cancer among severely obese women. These findings have significant public health relevance because the prevalence of obesity continues to rise, and few modifiable breast cancer risk factors have been identified, especially for premenopausal women. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Patient Behaviors and Characteristics Related to Weight Regain After Roux-en-Y Gastric Bypass: A Multicenter Prospective Cohort Study
Objective: To identify patient behaviors and characteristics related to weight regain after Roux-en-Y gastric bypass surgery (RYGB). Background: There is considerable variation in the magnitude of weight regain after RYGB, highlighting the importance of patient-level factors. Methods: A prospective cohort study of adults who underwent bariatric surgery in 6 US cities between 2006 and 2009 included presurgery, and 6-month and annual assessments for up to 7 years. Of 1573 eligible participants, 1278 (81%) with adequate follow-up were included (80% female, median age 46 years, median body mass index 46 kg/...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Influence of Preoperative Oropharyngeal Microflora on the Occurrence of Postoperative Pneumonia and Survival in Patients Undergoing Esophagectomy for Esophageal Cancer
This study included 675 patients who underwent esophagectomy between 2007 and 2014. Saliva samples from the oropharynx were collected 2 days before the operation. There were 442 patients with indigenous flora (Ind group) and 233 with allopatric flora. Among the patients with allopatric flora, 140 had antibiotic-sensitive microbes only (Allo-S group) while 93 had different types of antibiotic-resistant microbes (Allo-R group). We investigated the correlation between the types of oropharyngeal microflora and the incidence of postoperative complications as well as long-term outcomes. Results: Sixteen microbes could be ...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Tumor Long-interspersed Nucleotide Element-1 Methylation Level and Immune Response to Esophageal Cancer
Conclusions: Tumor LINE-1 hypomethylation level is associated with a diminished peritumoral lymphocytic reaction, providing impetus for further investigations on potential interactive roles of tumor LINE-1 hypomethylation and host immunity in esophageal cancer development. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Recertification Exam Performance in General Surgery is Associated With Subsequent Loss of License Actions
Conclusions: Failing the first recertification exam attempt was associated with a greater rate of subsequent loss-of-license actions. These results suggest that demonstrating sufficient surgical knowledge is a significant predictor of future loss-of-license actions. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Video-based Learning in Surgery: Establishing Surgeon Engagement and Utilization of Variable-duration Videos
Objective: To measure surgeon engagement and preferred video duration in a video-based learning program for nerve surgery. Background: Educational videos can improve, standardize, and democratize best practices in surgery. To improve care internationally, educators must optimize their videos for learning. However, surgeon engagement and optimal video duration remain undefined. Methods: A YouTube channel and a video-based learning website, PASSIO Education (passioeducation.com), were examined from 2011 to 2017. We assessed views, geographic location, audience engagement (average percent of video watched), ...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Concordance Between Registry and Administrative Data in the Determination of Comorbidity: A Multi-institutional Study
Objective: To characterize agreement between administrative and registry data in the determination of patient-level comorbidities. Background: Previous research finds poor agreement between these 2 types of data in the determination of outcomes. We hypothesized that concordance between administrative and registry data would also be poor. Methods: A cohort of inpatient operations (length of stay 1 day or greater) was obtained from a consortium of 8 hospitals. Within each hospital, National Surgical Quality Improvement Program (NSQIP) data were merged with intra-institutional inpatient administrative data. ...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Recalibration and External Validation of the Risk Analysis Index: A Surgical Frailty Assessment Tool
Objective and Background: The Risk Analysis Index (RAI) predicts 30-, 180-, and 365-day mortality based on variables constitutive of frailty. Initially validated, in a single-center Veteran hospital, we sought to improve model performance by recalibrating the RAI in a large, veteran surgical registry, and to externally validate it in both a national surgical registry and a cohort of surgical patients for whom RAI was measured prospectively before surgery. Methods: The RAI was recalibrated among development and confirmation samples within the Veterans Affairs Surgical Quality Improvement Program (VASQIP; 2010&nda...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

The Carbon Footprint of Surgical Operations: A Systematic Review
Conclusions: Future research should focus on optimizing the carbon footprint of operating theatres through streamlining operations, expanding assessments to other surgical contexts, and determining ways to reduce the footprint through targeting carbon hotspots. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: REVIEW PAPERS Source Type: research

Detecting the Near Infrared Autofluorescence of the Human Parathyroid: Hype or Opportunity?
Conclusions: Because NIRAF-based identification of PG is noninvasive and label-free, the popularity of this approach has considerably surged. As the present limitations of various technologies capable of NIRAF detection are identified, we anticipate that newer device iterations will continue to be developed enhancing the current merits of these modalities to aid surgeons in identifying and preserving PGs. However, more concrete and long-term outcome studies with these modalities are essential to determine the impact of this technique on patient outcome and actual cost-benefits. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: REVIEW PAPERS Source Type: research

The Effect of Perioperative Music on Medication Requirement and Hospital Length of Stay: A Meta-analysis
This study was registered with PROSPERO (CRD42018093140) and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Results: The literature search yielded 2414 articles, 55 studies (N = 4968 patients) were included. Perioperative music significantly reduced postoperative opioid requirement (pooled SMD −0.31 [95% CI −0.45 to −0.16], P (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: META-ANALYSIS Source Type: research

Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900)
Conclusion: A primary open strategy by cut-down of the cephalic vein, if necessary enhanced by a modified Seldinger technique, reduces the frequency of pneumothorax or haemothorax after central venous port implantation significantly compared with a closed strategy by primary puncture of the subclavian vein without routine sonographic guidance. Therefore, open surgical cut-down should be the reference standard for port implantation in comparable cohorts. Trial Registration: German Clinical Trials Register DRKS 00004900. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

The Influence of Perioperative Fluid Therapy on N-terminal-pro-brain Natriuretic Peptide and the Association With Heart and Lung Complications in Patients Undergoing Colorectal Surgery: Secondary Results of a Clinical Randomized Assessor-blinded Multicenter Trial
Objective: To investigate the influence of intravenous (iv) fluid volumes on the secretion of N-terminal-pro-brain natriuretic peptide (NT-Pro-BNP) in colorectal surgical patients and its association with cardiopulmonary complications (CPC). In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC. Methods: Blood samples from patients enrolled in a previously published clinical randomized assessor-blinded multicenter trial were analyzed.1 Included were adult patients undergoing elective colorectal surgery with the American-Society-of-Anesthesiologists-scores of 1–3. Sam...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research

Ensuring Equal Access to Mentorship and Sponsorship for Surgeons Through Structured Team-based Mentoring
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 - SURGICAL PERSPECTIVES Source Type: research

Responding to Unexpected Crises – The Role of Surgical Leadership
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 - SURGICAL PERSPECTIVES Source Type: research

Defining Domains of Survivorship
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 - SURGICAL PERSPECTIVES Source Type: research

Ethics of Codes and Codes of Ethics: When Is It Ethical to Provide Cardiopulmonary Resuscitation During the COVID-19 Pandemic?
Conclusions: CPR is an intervention like any other, with attendant risks and benefits and with responsibility for the utilization of limited resources. Our ethical analysis advocates for a systematic approach to codes that respects the important ethical considerations in caring for the critically ill and facilitates patient-centered, evidence-based, and fair treatment to all. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 Source Type: research

Stereotactic Body Radiotherapy Versus Delayed Surgery for Early-stage Non-small-cell Lung Cancer
Conclusion: In this national analysis, for patients with stage IA NSCLC, extended delay of surgery was associated with improved survival when compared to early treatment with SBRT. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 Source Type: research

Yield of Screening for COVID-19 in Asymptomatic Patients Before Elective or Emergency Surgery Using Chest CT and RT-PCR (SCOUT): Multicenter Study
Conclusions: One in every 100 patients without COVID-19 symptoms tested positive for SARS-CoV-2 with RT-PCR; this yield increased in conjunction with community prevalence. The added value of chest CT was limited. Preoperative screening allowed us to take adequate precautions for SARS-CoV-2 positive patients in a surgical population, whereas negative patients needed only routine procedures. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: COVID-19 Source Type: research

Ethical Centralization of High-risk Surgery Requires Racial and Economic Justice
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE - SURGICAL PERSPECTIVES Source Type: research

Let Us Not Be Silent
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE - SURGICAL PERSPECTIVES Source Type: research

Eastern Association for the Surgery of Trauma Statement on Structural Racism, and the Deaths of George Floyd, Ahmaud Arbery, and Breonna Taylor
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE - SURGICAL PERSPECTIVES Source Type: research

Perceptions of Equity and Inclusion in Acute Care Surgery: From the #EAST4ALL Survey
Objectives and Background: The aim of this study was to characterize equity and inclusion in acute care surgery (ACS) with a survey to examine the demographics of ACS surgeons, the exclusionary or biased behaviors they witnessed and experienced, and where those behaviors happen. A major initiative of the Equity, Quality, and Inclusion in Trauma Surgery Practice Ad Hoc Task Force of the Eastern Association for the Surgery of Trauma was to characterize equity and inclusion in ACS. To do so, a survey was created with the above objectives. Methods: A cross-sectional, mixed-methods anonymous online survey was sent to...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE Source Type: research

Toward a Gender Neutral and Multicultural Meritocracy in Academic Surgery – No Better Time Than Now
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE Source Type: research

Benchmarking Accomplishments of Leaders in American Surgery and Justification for Enhancing Diversity and Inclusion
Conclusion: The ACS and ASA presidents’ CVs displayed unsurpassed scholastic achievement, and although not equivalent, both the AWS and the SBAS presidents had comparable attainment. These findings further substantiate that women and ethnic minority surgeons are deserving of additional national leadership consideration as organized medicine pursues a more diverse and reflective physician workforce. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: EQUITY AND SOCIAL JUSTICE Source Type: research

Laparoscopic Liver Transplantation: It's Time to Call for the Red Team!
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: FEATURES Source Type: research

Laparoscopic Liver Transplantation: Dream or Reality? The First Step With Laparoscopic Explant Hepatectomy
Conclusions: This case study suggests that the hybrid approach may be feasible and safe in selected recipients. The decision to use this surgical approach should be made in transplant centers with significant expertise in both laparoscopic liver and pancreatic surgery. Further reducing the size of the abdominal incision is the next step, which may be achieved with the development of vascular anastomoses devices. (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: FEATURES Source Type: research

Excessive Opioid Prescribing After Surgery – A Uniquely American Problem
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: FEATURES Source Type: research

Opioids After Surgery in the United States Versus the Rest of the World: The International Patterns of Opioid Prescribing (iPOP) Multicenter Study
Objective: The International Patterns of Opioid Prescribing study compares postoperative opioid prescribing patterns in the United States (US) versus the rest of the world. Summary of Background Data: The US is in the middle of an unprecedented opioid epidemic. Diversion of unused opioids contributes to the opioid epidemic. Methods: Patients ≥16 years old undergoing appendectomy, cholecystectomy, or inguinal hernia repair in 14 hospitals from 8 countries during a 6-month period were included. Medical records were systematically reviewed to identify: (1) preoperative, intraoperative, and postoperative c...
Source: Annals of Surgery - November 30, 2020 Category: Surgery Tags: FEATURES Source Type: research

Prognostic Impact of Frozen Section Investigation and Extent of Proximal Safety Margin in Gastric Cancer Resection
Conclusion: In pT2-T4a gastric cancer, proximal margin of ≥3 cm plus frozen margin confirmation provides high oncological safety. In DG patients with R0-resection, proximal margin length does not correlate with survival or recurrence. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Pancreatic Inflammation and Proenzyme Activation Are Associated With Clinically Relevant Postoperative Pancreatic Fistulas After Pancreas Resection
Conclusions: Trypsinogen activation, increased cathepsin B activity and inflammation around the pancreato-enteric anastomosis on post operative day 1 are associated with subsequent clinically relevant POPFs after pancreatoduodenectomy. The parenchymal damage seems to be induced by placing sutures in the pancreatic parenchyma during pancreatic surgery. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors
Conclusions: mTOR-inhibitor treatment with sirolimus for ≥3 months improves outcomes in LT for HCC, especially in patients with AFP-evidence of higher tumor activity, advocating particularly for mTOR inhibitor use in this subgroup of patients. Clinical Trial Registration: EudraCT: 2005-005362-36 Clinicaltrials.gov: NCT00355862. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Centralization and Oncologic Training Reduce Postoperative Morbidity and Failure-to-rescue Rates After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: Study on a 10-year National French Practice
Objective: Evaluate at a national level the postoperative mortality (POM), major morbidity (MM) and failure-to-rescue (FTR) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) across time and according to hospital-volume. Background: CRS/HIPEC is an effective therapeutic strategy commonly used to treat peritoneal surface malignancies. However, this aggressive approach has the reputation to be associated with a high POM and MM. Methods: All patients treated with CRS/HIPEC between 2009 and 2018 in France were identified through a national medical database. Patients and perioperativ...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

The Impact of Hospital Volume on Failure to Rescue after Liver Resection for Hepatocellular Carcinoma: Analysis from the HE.RC.O.LE.S. Italian Registry
Conclusions: Risk of major complications and mortality was related with comorbidities, cirrhosis severity, and complexity of surgery. These factors were not correlated with FTR. Center's volume was the only independent predictor related with severe complications, mortality, and FTR. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Can Early Postoperative Complications Predict High Morbidity and Decrease Failure to Rescue Following Major Abdominal Surgery?
Objective: To assess whether specific patterns of early postoperative complications may predict overall severe morbidity after major surgery, warranting early escalation of care and prevention of failure to rescue. Summary of Background Data: It is unclear whether early postoperative complications predict a poor outcome. Detailed knowledge of the chronology and type of early complications after major surgery may alert clinicians when to expect higher risk for subsequent major negative events. Methods: All 90-day postoperative events following complex pancreas, liver, and rectal surgeries, and liver transplantation ...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Stratification of Major Hepatectomies According to Their Outcome: Analysis of 2212 Consecutive Open Resections in Patients Without Cirrhosis
Conclusions: The term “major hepatectomy” includes resections having heterogeneous outcome. Different MajHs can be stratified according to their mortality, severe morbidity, liver failure, and bile leak rates. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Liver Resection for Early Hepatocellular Carcinoma: Preoperative Predictors of Non Transplantable Recurrence and Implications for Treatment Allocation
Background and Aims: LR and LT are the standard curative options for early HCC. LT provides best long-term survival but is limited by organ shortage. LR, readily available, is hampered by high recurrence rates. Salvage liver transplantation is an efficient treatment of recurrences within criteria. The aim of the study was to identify preoperative predictors of non transplantable recurrence (NTR) to improve patient selection for upfront LR or LT at initial diagnosis. Study Design: Consecutive LR for transplantable HCC between 2000 and 2015 were studied. A prediction model for NTR based on preoperative variables was dev...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Adverse Biology in Adenocarcinoma of the Esophagus and Esophagogastric Junction Impacts Survival and Response to Neoadjuvant Therapy Independent of Anatomic Subtype
Objective: The aim of this study was to propose and test a novel adverse pathology classification in AEG. Background: Recent scientific advances show genomic and molecular concordance across all AEG types, suggesting a rationale for a biologic classification. We tested a 3-dimension adverse pathology classification across the entire junction and per Siewert anatomic subtype. Methods: Of 1625 patients with AEG, 650 underwent radical surgery, 55% post-neoadjuvant therapy (NeoT). Adverse features defined a priori were poor differentiation (PD), lymphatic invasion (LI), vascular invasion (VI), and perineural invasion (...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Incidence and Grading of Complications After Gastrectomy for Cancer Using the GASTRODATA Registry: A European Retrospective Observational Study
Conclusions: The use of a standardized platform to collect European data on perioperative complications revealed that gastrectomy for gastric cancer is still associated with heavy morbidity and mortality. Actions are needed to limit the incidence of, and to effectively treat, the most frequent and most lethal complications. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Risk Factors of Redo Surgery After Unilateral Focused Parathyroidectomy: Conclusions From a Comprehensive Nationwide Database of 13,247 Interventions Over 6 Years
Background: Surgical removal of hyperfunctional parathyroid gland is the definitive treatment for primary hyperparathyroidism (pHPT). Postoperative follow-up shows variability in persistent/recurrent disease rate throughout different centers. Objective: To evaluate the incidence of redo surgery after targeted parathyroidectomy for pHPT. Methods: We performed a nationwide retrospective cohort study on the “Programme de Medicalisation des Systemes d’Information,” the French administrative database that collects information on all healthcare facilities’ discharges. We extracted data from 2009 t...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients With Colorectal Liver Metastases
Objectives: To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS. Background: ALPPS is a two-stage hepatectomy variant that increases resection rates and R0 resection rates in patients with primarily unresectable CRLM as evidenced in a recent randomized controlled trial. Long-term oncologic results, however, are lacking. Methods: Cases in- and outside the International ALPPS Registry were collected and completed by direct contacts to ALPPS centers to secure a comprehensive cohort. Overall, cancer-specific (...
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

The ILLS Laparoscopic Liver Surgery Fellow Skills Curriculum
Conclusion: We here suggest a stepwise approach for training of hepatobiliary fellows in LLR. Based on the estimated complexity of the substeps and the size of the center, not every substep can be learned within 2 years. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Neoadjuvant Chemoradiotherapy Using Cisplatin and 5-Fluorouracil (PF) Versus Carboplatin and Paclitaxel (CROSS Regimen) for Esophageal Squamous Cell Carcinoma (ESCC): A Propensity Score-matched Study
Conclusions: There is no statistically difference in survival or clinicopathological outcome between both groups, but the trend favors PFRT. Prospective head-to-head comparison and novel strategies to improve the outcomes in resectable ESCC are warranted. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

Long-term Prognosis After Elective Abdominal Aortic Aneurysm Repair is Poor in Women and Men: The Challenges Remain
Conclusions: Changes in elective AAA management reduced short-term mortality, but failed to improve the profound long-term survival disadvantage of AAA patients. The persistent high (cardiovascular) mortality calls for further intensification of cardiovascular risk management, and a critical appraisal of the basis for the excess mortality of AAA patients. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research