The Effects of Octreotide Acetate on Spinal Cord Ischemia/Reperfusion Injury

In this study, we investigate the possible neuroprotective effects of a strong antioxidant, free radical scavenger; octreotide acetate on a rabbit spinal ischemia/reperfusion (I/R) injury model. A total of 18 rabbits were divided into 3 groups of 6 rabbits each, as follows: group 1 (n=6) sham, laparotomy only; group 2 (n=6) I/R group; group 3 (n=6) I/R+ octreotide group. I/R was established in groups 2 and 3. All rabbits were followed up neurologically for 24 hours. After 24 hours, the rabbits were killed and spinal cord tissue samples examined. Neurological examinations score, tissue malondialdehyde (MDA), glutathione peroxidase (GPx), xanthine oxidase (XO), tissue nitrite and nitrate levels and myeloperoxidase (MPO) levels, neuronal and glial degeneration, and apoptosis. Neurological examinations scores were significantly better in the treatment group than I/R group (P
Source: Neurosurgery Quarterly - Category: Neurosurgery Tags: Original Articles Source Type: research