Development of a novel patient-reported measure for acromegaly: the Acro-TSQ
ConclusionsThe Acro-TSQ is a novel PRO, focused on both disease burden and impact of treatment; it was found to be comprehensive, clear, and relevant for patients with acromegaly receiving injectable SSA treatment. (Source: Pituitary)
Source: Pituitary - September 14, 2019 Category: Endocrinology Source Type: research
The Outcome of Primary Hepatic Neuroendocrine Tumors: A Single-Center Experience
ConclusionOur data suggest that the prognosis of the tumor seems favorable. Surgical resection is the curative treatment. TACE is a favorable option in unresectable tumors. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - September 12, 2019 Category: Gastroenterology Source Type: research
The Outcome of Primary hepatic neuroendocrine tumours: A Single-center experience
CONCLUSIONOur data suggest that the prognosis of the tumour seems favourable. Surgical resection is the curative treatment. TACE is a favourable option in unresectable tumours. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - August 17, 2019 Category: Gastroenterology Source Type: research
Pore change during degradation of octreotide acetate-loaded PLGA microspheres: The effect of polymer blends.
This study used PLGA 5050 4H (F-1), PLGA 5050 1A: PLGA 5050 4H = 3:7 (F-2) and PLGA 7525 1A: PLGA 5050 4H = 3:7 (F-3) as a carrier, respectively. Microspheres (MS) were obtained by O/W emulsion solvent evaporation technique and characterized by scanning electron microscopy (SEM), particle size, drug loading, fluorescence characteristics, and in vitro and in vivo release. Accelerated tests in vitro showed that the size and number of core pores significantly affected drug release in the first and second phases. After intramuscular administration, F-2 and F-3 showed effective blood concentration levels and their bioav...
Source: European Journal of Pharmaceutical Sciences - July 11, 2019 Category: Drugs & Pharmacology Authors: Wang T, Xue P, Wang A, Yin M, Han J, Tang S, Liang R Tags: Eur J Pharm Sci Source Type: research
Efficacy and safety of high-dose long-acting repeatable octreotide as monotherapy or in combination with pegvisomant or cabergoline in patients with acromegaly not adequately controlled by conventional regimens: Results of an open-label, multicenter study.
CONCLUSION: These data demonstrate that high-dose Sandostatin LAR as monotherapy or in combination with pegvisomant or cabergoline is a feasible salvage option in patients with pituitary adenomas not adequately controlled on conventional SSA regimens. PMID: 31274183 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 5, 2019 Category: Endocrinology Authors: Colao A, Zgliczyński W, Komorowski J, Kos-Kudła B, Tabarin A, Kerlan V, Minuto FM, Scaroni C, Bolanowski M Tags: Endokrynol Pol Source Type: research
Proton Oriented- “Smart Depot” for Responsive Release of Ca 2+ to Inhibit Peptide Acylation in PLGA Microspheres
ConclusionsWith the presence of the smart Ca2+ depot (Ca3(PO4)2) in the microspheres, a sustainable and long-term inhibition of peptide acylation was achieved. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 4, 2019 Category: Drugs & Pharmacology Source Type: research
Control of octreotide release from silk fibroin microspheres
Publication date: September 2019Source: Materials Science and Engineering: C, Volume 102Author(s): He Gong, Jing Wang, Jue Zhang, Jianbing Wu, Zhaozhu Zheng, Xusheng Xie, David L. Kaplan, Gang Li, Xiaoqin WangAbstractPoly(d,l-lactide-co-glycolide) (PLGA) microspheres have been used as an injectable depot for prolonged release of octreotide (Sandostatin LAR®), a peptide drug for the treatment of acromegaly and gastrointestinal tumors. However, acylation and incomplete release of the encapsulated octreotide, as well as acidic degradation product-induced inflammation are the major challenges hampering widespread clinical ...
Source: Materials Science and Engineering: C - May 11, 2019 Category: Materials Science Source Type: research
Effect of inner pH on peptide acylation within PLGA microspheres.
Abstract Polymer degradation within the controlled-release depots comprising of lactide and glycolide (PLGA) forms an acidic microenvironment, in which severe acylation of the peptide by the polymer degradation products takes place. The aim of this study was to make out the role of the inner μpH on peptide acylation within the microspheres and how could it influence the reaction. The effects of pH on the acylation reaction within microspheres were composed of two aspects. Firstly, the inherent effect of pH on the acylation reaction itself was figured out: with the pH environment going up from acid to neutral, a...
Source: European Journal of Pharmaceutical Sciences - April 16, 2019 Category: Drugs & Pharmacology Authors: Liu J, Xu Y, Wang Y, Ren H, Meng Z, Liu K, Liu Z, Huang H, Li X Tags: Eur J Pharm Sci Source Type: research
03:09 PM Abstract No. 24 Catheter-directed gastric artery embolization with octreotide acetate loaded PLA/PLGA (poly[lactide-co-glycolide] acid) microspheres with slow sustained-release properties suppresses the plasma concentration of ghrelin, which results in weight loss
The objective of the present work was to formulate slow- and sustained-release octreotide acetate-loaded PLA/PLGA (polylactide)(poly (Lactic-co- Glycolic) acid) microspheres and prospectively test the effects of catheter-directed gastric artery administration of these microspheres on plasma ghrelin levels and body weight in swine. Octreotide is a long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. In the GI system it inhibits secretin, gastrin, vasoactive intestinal peptide, motilin and ghrelin. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - February 23, 2019 Category: Radiology Authors: F. Nurili, T. Acar, S. Derman, A. Bas, I. Caymaz, S. Ozkanli, H. Cakiroglu, I. Yurdaisik, O. Aras Tags: Scientific Session 3: Not Your Run-of-the-Mill Embolization Source Type: research
Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors.
Authors: Di Giacinto P, Rota F, Rizza L, Campana D, Isidori A, Lania A, Lenzi A, Zuppi P, Baldelli R Abstract Background. Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index. The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate. The PROMID trial assesses the effect of octreotide LAR on the tumor growth in patients with well-differentiated metastatic midgut NETs. The CLARINET trial evaluates the effects of lanreotide in patients with nonf...
Source: International Journal of Endocrinology - August 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Utility of Somatostatin receptor-targeted imaging with Ga-68 DOTATATE PET/MRI in the management of progressive meningiomas
1844Aim: Utility of Somatostatin receptor-targeted imaging with Ga-68 DOTATATE PET/MRI in the management of progressive meningiomas Meningiomas are the most common type of intracranial tumors. Although these brain tumors are generally benign, some of these could be very aggressive which require extensive surgery followed by radiotherapy. Treating such refractory meningiomas could be extremely challenging. Various treatment protocols are in vogue such as cytotoxic chemotherapy and targeted therapies. One such relatively newer targeted therapy option employs sandostatin, a somatostatin analog that specifically targets somato...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Mertel, K., Mohammadi, S., Nguyen, N., Mountz, J., Muthukrishnan, A. Tags: Technologist Poster Session Source Type: research
Total pancreatic necrosis after organophosphate intoxication
AbstractCases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodi...
Source: Frontiers of Medicine - May 18, 2018 Category: General Medicine Source Type: research
Metastatic neuroendocrine pancreatic tumor - Case report.
Discussion.As a group, well-differentiated gastroenteropancreatic NETs are generally indolent malignancies with prolonged natural history. Intermediate-grade NETs have a slightly worse prognosis than low-grade tumors. Abbreviations: NETs - neuroendocrine tumors, NEC - neuroendocrine carcinoma, CT - computed tomography, MRI - magnetic resonance imaging, DM - diabetes mellitus, WHO - World Health Organisation, HCV - hepatitis C virus, CEA - carcinoembryonic antigen, AFP - alpha-fetoprotein, 5-HIAA - 5-Hydroxyindoleacetic acid, IHC - immunohistochemistry, EUS - endoscopic ultrasonography, EUS FNA - endoscopic ultrasonography ...
Source: Journal of Medicine and Life - April 27, 2018 Category: General Medicine Tags: J Med Life Source Type: research
Relative Bioavailability of a Single 4-mg Dose of Somatropin Administered by Subcutaneous Injection or by Needle-free Device and Coadministered With the Growth Hormone Inhibitor Octreotide Acetate in Healthy Adult Subjects.
This study evaluated the relative bioavailability of somatropin delivered with a needle-free device compared with traditional SC injection. METHODS: In this randomized, single-dose, crossover study, healthy adults aged 18 to 35 years received single 4-mg doses of somatropin via a needle-free device or SC injection, along with octreotide to suppress endogenous growth hormone production. Blood samples were analyzed for serum somatropin and insulin-like growth factor-1 (IGF-1) concentrations over 24 hours after somatropin dosing. Pharmacokinetic and pharmacodynamic parameters were evaluated by using noncompartmental meth...
Source: Clinical Therapeutics - April 23, 2018 Category: Drugs & Pharmacology Authors: Brimhall DB, Petri N, D'Angelo P Tags: Clin Ther Source Type: research
Long-Acting Somatostatin Analog Therapy Differentially Alters 68Ga-DOTATATE Uptake in Normal Tissues Compared with Primary Tumors and Metastatic Lesions
Conclusion: Long-acting octreotide treatment diminished 68Ga-DOTATATE uptake in the liver, spleen, and thyroid but did not compromise tracer uptake in residual primary tumor and metastatic lesions. These findings have a direct impact on the interpretation of 68Ga-DOTATATE PET/CT scans. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Ayati, N., Lee, S. T., Zakavi, R., Pathmaraj, K., Al-Qatawna, L., Poon, A., Scott, A. M. Tags: Clinical Source Type: research
The LARO-MEN1 study: a longitudinal clinical experience with octreotide Long-Acting Release in patients with Multiple Endocrine Neoplasia type 1 Syndrome.
Authors: Cioppi F, Cianferotti L, Masi L, Giusti F, Brandi ML Abstract Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumoral syndrome, featured by a combination of neoplasms of various endocrine and nonendocrine tissues. Approximately 33% of MEN1-related deaths are due to the malignant behaviour of well-differentiated neuroendocrine tumors (NETs), for which a preventive surgical treatment is not feasible. Somatostatin analogues (SSA) have been employed in the treatment of NETs in the stage of advanced or metastatic disease, in order to control the growth and secretion of tumor lesions. A longitudi...
Source: Clinical Cases in Mineral and Bone Metabolism - December 22, 2017 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Impact of 68 Ga-DOTA-Peptide PET/CT on the Management of Gastrointestinal Neuroendocrine Tumour (GI-NET): Malaysian National Referral Centre Experience
Conclusions68Ga-DOTA-peptide PET/CT has a significant impact on management decisions in GI-NET patients as it can provide additional information on occult metastasis/equivocal lesions and supply the clinician an opportunity to select patients for targeted therapy. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 8, 2017 Category: Nuclear Medicine Source Type: research
Quantitative determination and validation of octreotide acetate using (1) H-NMR spectroscopy with internal standard method.
We presented a validated (1) H quantitative nuclear magnetic resonance ((1) H-qNMR) method for assay of octreotide acetate (OCT-Ac), a kind of cyclic octopeptide. Deuterium oxide was used to remove the undesired exchangeable peaks, which was referred to as proton exchange, in order to make the quantitative signals isolated in the crowded spectrum of the peptide and ensure precise quantitative analysis. Gemcitabine hydrochloride was chosen as the suitable internal standard (IS). Experimental conditions, including relaxation delay time,the numbers of scans and pulse angle were optimized first. Then method validation was carr...
Source: Magnetic Resonance in Chemistry : MRC - September 15, 2017 Category: Chemistry Authors: Yu C, Zhang Q, Xu PY, Bai Y, Shen WB, Di B, Su MX Tags: Magn Reson Chem Source Type: research
Telotristat Ethyl (Xermelo) for Carcinoid Syndrome Diarrhea
Date: July 17, 2017 Issue #: 1525Summary: The FDA has approved telotristat ethyl (Xermelo– Lexicon), a tryptophan hydroxylase inhibitor, for use in combination with a somatostatin analog (SSA) for treatment of carcinoid syndrome diarrhea inadequately controlled with SSA therapy alone. Telotristat ethyl is the first oral drug to be approved in the US for this indication. (Source: The Medical Letter)
Source: The Medical Letter - July 10, 2017 Category: Drugs & Pharmacology Authors: admin Tags: lanreotide octreotide Sandostatin Somatuline Autogel Somatuline Depot Telotristat ethyl Xermelo Source Type: research
Conservative management of postoperative chylous fistula with octreotide and peripheral total parenteral nutrition.
Abstract Postoperative chylous fistula after neck dissection is an uncommon complication associated with significant patient morbidity. Octreotide acetate is a somatostatin analogue established in the treatment of chylothorax; however, its utility in the management of cervical chylous fistulae has not been fully evaluated. The investigators hypothesized that chylous fistula can be managed by a combination of octreotide and peripheral total parenteral nutrition (TPN). A retrospective review of cases compiled at our institution from 2009 to 2015 was conducted. Ten patients, all men, were identified as having a posto...
Source: Ear, Nose and Throat Journal - July 1, 2017 Category: ENT & OMF Authors: Chan JY, Wong EW, Ng SK, van Hasselt CA, Vlantis AC Tags: Ear Nose Throat J Source Type: research
Treatment with Octreotide in Patients with Well-Differentiated Neuroendocrine Tumors of the Ileum: Prognostic Stratification with Ga-68-DOTA-TATE Positron Emission Tomography.
Authors: Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR Abstract We investigated the use of Ga-68-DOTA-Tyr(3)-octreotate (Ga-68-DOTA-TATE) positron emission tomography (PET) and standardized uptake values (SUVs) to predict the effectiveness of treatment with the somatostatin analogue octreotide acetate (Sandostatin LAR) in patients with neuroendocrine tumors (NETs). Thirty patients with well-differentiated NETs of the ileum (grades G1 and G2) were studied with Ga-68-DOTA-TATE. The average SUV of a 50% isocontour volume of interest covering the lesion with maximum uptake (SU...
Source: Molecular Imaging - June 29, 2017 Category: Radiology Tags: Mol Imaging Source Type: research
Diagnostic performance of Ga-68 DOTATOC PET/CT in patients with Neuroendocrine tumors (NET)-Comparison with conventional imaging and impact on management.
Conclusion: Gallium-68-DOTA-TOC PET/CT is decidedly superior to existing conventional imaging methods for the evaluation of NETs and can have a significant impact on patient management. The impact of change in management on patients’ quality of life and survival will be further evaluated. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Gavane, S., Warner, R., Kim, M., Ghesani, M., Kostakoglu, L. Tags: Other Tumors Source Type: research
Clinical Effect of Somatostatin Analogue (Sandostatin) in Three Cases of Non-Malignant Enteropancreatic Disorders
We report three cases of different non-malignant gastrointestinal disorders in which long acting somatostatin analogue (Sandostatin) was successfully used. Case 1 A 39-year-old male (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - May 3, 2017 Category: Journals (General) Tags: ISSUE 1 Source Type: research
Tolerability and Biological Effects of Long-Acting Octreotide in Patients With Continuous Flow Left Ventricular Assist Devices
In conclusion, octreotide acetate LAR 20 mg depot injection was safe and effective in this population. (Source: ASAIO Journal)
Source: ASAIO Journal - May 1, 2017 Category: Medical Equipment Tags: Brief Communication Source Type: research
Micro-Flow Imaging as a quantitative tool to assess size and agglomeration of PLGA microparticles.
Abstract The purpose of this study was to explore the potential of flow imaging microscopy to measure particle size and agglomeration of poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles. The particle size distribution of pharmaceutical PLGA microparticle products is routinely determined with laser diffraction. In our study, we performed a unique side-by-side comparison between MFI 5100 (flow imaging microscopy) and Mastersizer 2000 (laser diffraction) for the particle size analysis of two commercial PLGA microparticle products, i.e., Risperdal Consta and Sandostatin LAR. Both techniques gave similar results...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 6, 2017 Category: Drugs & Pharmacology Authors: van Beers MM, Slooten C, Meulenaar J, Sediq AS, Verrijk R, Jiskoot W Tags: Eur J Pharm Biopharm Source Type: research
Evaluation of the efficacy of octreotide LAR in the treatment of Crohn's disease associated refractory diarrhea.
CONCLUSIONS: In this uncontrolled open-label study, octreotide appeared safe and effective in CD refractory diarrhea, in addition to CD treatments. It significantly improved the number of liquid or smooth stools, the HBI and the IBDQ. PMID: 28270045 [PubMed - in process] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 10, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Abstract IA18: Targeted polymeric nanoparticles: From academic innovations to clinical trials and lessons learned
A variety of organic and inorganic materials have been utilized to generate nanoparticles for drug delivery applications, including polymeric nanoparticles, dendrimers, nanoshells, liposomes, nucleic acid based nanoparticles, magnetic nanoparticles, and virus nanoparticles. The two most commonly used systems are polymeric nanoparticles and liposomes [1, 2]. Controlled release polymer technology has impacted virtually every branch of medicine, including ophthalmology, pulmonary, pain medicine, endocrinology, cardiology, orthopedics, immunology, neurology and dentistry, with several of these systems in clinical practice toda...
Source: Cancer Research - January 16, 2017 Category: Cancer & Oncology Authors: Omid C. Farokhzad Tags: Drug Delivery and Nanomedicine Source Type: research
Bilateral Choroidal Metastases from Endobronchial Carcinoid Treated with Somatostatin Analogues.
CONCLUSION: Endobronchial carcinoid tumors have an indolent nature and long-term follow-up is recommended for early detection of metastases. Although treatment with somatostatin analogues rarely induces complete tumor regression, tumor stabilization and prevention of symptoms related to hormone secretion is achieved. This well-tolerated systemic treatment provides a worthy alternative treatment for choroidal metastasis compared to classic radiotherapy without any risk of radiation or laser-related visual loss. PMID: 27843513 [PubMed - in process] (Source: Open Ophthalmology Journal)
Source: Open Ophthalmology Journal - November 17, 2016 Category: Opthalmology Tags: Open Ophthalmol J Source Type: research
Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future
Acromegaly is a hormonal disorder that arises when the pituitary gland secretes excess growth hormone (GH), which in turn stimulates a concomitant increase in serum insulin-like growth factor 1 (IGF-1) levels. Gastroenteropancreatic neuroendocrine tumours (GEP-NET) constitute a heterogeneous group of tumours that can secrete serotonin and a variety of peptide hormones that may cause characteristic symptoms known as carcinoid syndrome or other symptoms and hormonal hypersecretion syndromes depending on the tumour’s site of origin. Current medical therapy for the treatment of acromegaly and GEP-NET involves the adminis...
Source: Endocrine-Related Cancer - November 2, 2016 Category: Endocrinology Authors: Oberg, K., Lamberts, S. W. J. Tags: Review Source Type: research
Pancreatic panniculitis associated with pancreatic carcinoma: A case report
Conclusion: Pancreatic panniculitis is a rare complication of pancreatic cancer. However, in the presence of a pancreatic mass, as in this case, clinicians should be aware that panniculitis may be the sentinel of pancreatic carcinoma. (Source: Medicine)
Source: Medicine - August 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
177Lu-Dotatate therapy for patients with metastatic gastrointestinal neuroendocrine tumors: How to prepare your practice for optimal administration.
Conclusions While planning for the provision of 177Lu-Dotatate treatment may pose challenging coordination and implementation of new workflows, proper departmental and institutional preparation has enabled high quality patient care and safe delivery of a novel therapy using an unsealed source within a nuclear medicine department setting that is addressing an unmet clinical need for this patient population. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 24, 2016 Category: Nuclear Medicine Authors: Abbott, A., Kuzuhara, Y., Jacene, H., Sakellis, C., Andersen, E., Hilton, N., Sommers, R., Chan, J. A., Kulke, M. H., Van den Abbeele, A. D. Tags: MTA I: Technologist Posters Source Type: research
Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies
Publication date: 5 July 2016 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 500 Author(s): Qingze Fan, Feng Qi, Chunyu Miao, Hua Yue, Fangling Gong, Jie Wu, Guanghui Ma, Zhiguo Su Biodegradable polymeric particles have been widely used in the biomedical fields such as drug carriers, tissue engineering, and medical imaging. It has been recognized that the physical properties of particles, such as size and shape, have a profound influence on their functions. However, it is not easy to prepare non-spherical particles by the conventional emulsion-based method because the minimization...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - April 23, 2016 Category: Chemistry Source Type: research
Self-assembly of platinum nanochains using octreotide acetate template and their catalytic activity study
Publication date: 1 May 2016 Source:Materials Letters, Volume 170 Author(s): Zi Wang, Weili Xue, Xiaoning Zhao, Yanji Li, Zhiwei Liu, Faming Gao, Dawei Gao A facile method was reported for preparing self-assembly Pt nanochains (PtNCs) by using octreotide acetate (AOC) as template in aqueous environment at room temperature. The influence of pH values on the reaction system was examined, and other synthesis parameters were optimized in order to prepare AOC-templated Pt nanoparticle arrays with high electrocatalytic activities. AOC was found with diameters in the range of 50±5nm at pH 2.0/9.0, while the diamet...
Source: Materials Letters - February 14, 2016 Category: Materials Science Source Type: research
Hepatectomy After Yttrium-90 (Y90) Radioembolization-Induced Liver Fibrosis
Abstract An obese 55-year-old woman with nonalcoholic fatty liver disease presented 7 years after resection of a T3N1 ileal carcinoid tumor with an elevated chromogranin A, multifocal metastatic disease to the liver, and carcinoid syndrome. She underwent right hepatic artery yttrium-90 (Y90) radioembolization, followed a month later by selective Y90 treatment to segment IV. She then presented to our clinic 10 months later, remaining symptomatic with flushing, diarrhea, anxiety, myalgia, pain, and persistent night sweats despite Sandostatin administration. At least 11 tumors were identified in the right lobe of the...
Source: Journal of Gastrointestinal Surgery - February 3, 2016 Category: Surgery Source Type: research
Transfusion free radical antegrade modular pancreaticosplenectomy of metastatic neuroendocrine tumor of the pancreas in Jehovah's Witness patient.
We present a case of successful bloodless multimodality therapy, which was performed for a JW. The patient was a 49-year-old woman and JW who had general weakness 7 days before admission. She was diagnosed with a pancreatic neuroendocrine tumor (PNET) with hepatic metastases. Transcatheter arterial chemoembolization and Sandostatin LAR injection were performed, and then she was given a transfusion-free Radical antegrade modular pancreatosplenectomy sequentially. We gave recombinant human erythropoietin and iron hydroxide sucrose complex daily for five days after surgery. She was discharged at postoperative day 12 without a...
Source: Annals of Surgical Treatment and Research - November 28, 2015 Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report
Conclusion: The identification, characterization and follow-up of this rare cause of ectopic ACTH secretion is important in order to assess the long-term prognostic and management. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - November 26, 2015 Category: Endocrinology Authors: Diana PaunLavinia VijaEmilia StanAlexandra BanicaElena BobeicaDana TerzeaCatalina PoianaCorin BadiuSorin Paun Source Type: research
The Effects of Octreotide Acetate on Spinal Cord Ischemia/Reperfusion Injury
In this study, we investigate the possible neuroprotective effects of a strong antioxidant, free radical scavenger; octreotide acetate on a rabbit spinal ischemia/reperfusion (I/R) injury model. A total of 18 rabbits were divided into 3 groups of 6 rabbits each, as follows: group 1 (n=6) sham, laparotomy only; group 2 (n=6) I/R group; group 3 (n=6) I/R+ octreotide group. I/R was established in groups 2 and 3. All rabbits were followed up neurologically for 24 hours. After 24 hours, the rabbits were killed and spinal cord tissue samples examined. Neurological examinations score, tissue malondialdehyde (MDA), glutathione per...
Source: Neurosurgery Quarterly - November 1, 2015 Category: Neurosurgery Tags: Original Articles Source Type: research
Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction
Objectives: To characterize the gut hormone profile and determine the effect of satiety gut hormone blockade on food intake in disease-free postesophagectomy patients. Background: Improved oncologic outcomes for esophageal cancer have resulted in increased survivorship and a focus on health-related quality of life. Anorexia and early satiety are common, but putative causative factors, in particular the gut-brain hormonal axis, have not been systematically studied. Methods: In a double-blind, placebo-controlled, randomized crossover study, disease-free patients at least 1 year postresection and gastric conduit reconstructio...
Source: Annals of Surgery - October 25, 2015 Category: Surgery Tags: Papers of the 22nd Annual ESA Meeting Source Type: research
Possible role of TGF β1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine
Discussion Based on the current literature and our previous experiences, we can state that IPT are an aberrant secondary immunological process possibly induced by excessive TGF β1 and not a neoplasia. Nevertheless, the tumorous behavior points to a continuity between inflammation and neoplasia. Differential diagnoses and the potential molecular pathogenesis are further discussed. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 18, 2015 Category: Pathology Source Type: research
Possible role of TGF β- 1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine
Discussion Based on the current literature and our previous experiences, we can state that IPT are an aberrant secondary immunological process possibly induced by excessive TGF- β 1 and not a neoplasia. Nevertheless, the tumorous behavior points to a continuity between inflammation and neoplasia. Differential diagnoses and the potential molecular pathogenesis are further discussed. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 14, 2015 Category: Pathology Source Type: research
Abstract A01: Exploring phosphatase and tensin homolog (PTEN) loss as a potential predictive marker for response to everolimus in patients with pancreatic neuroendocrine tumors (PNETs)
Conclusion: The index case for this study had a PTEN deletion and had a partial response to treatment and prolonged disease control for 2 years with everolimus. Testing is ongoing in additional cases to determine if there is a consistent correlation between PTEN loss by FISH and PFS.Citation Format: Moh'd Khushman, Joyce Slingerland, Yao-Shan Fan, Monica Garcia-Buitrago, Ernesto Bustinza, Maria Restrepo, Daniel Sussman, Caio Rocha-Lima, Peter Hosein. Exploring phosphatase and tensin homolog (PTEN) loss as a potential predictive marker for response to everolimus in patients with pancreatic neuroendocrine tumors (PNETs). [ab...
Source: Molecular Cancer Therapeutics - July 6, 2015 Category: Cancer & Oncology Authors: Khushman, M., Slingerland, J., Fan, Y.-S., Garcia-Buitrago, M., Bustinza, E., Restrepo, M., Sussman, D., Rocha-Lima, C., Hosein, P. Tags: Clinical Data with PI3K and mTOR Inhibitors: Poster Presentations - Proffered Abstracts Source Type: research
A rapid hydrolysis method and DABS-Cl derivatization for complete amino acid analysis of octreotide acetate by reversed phase HPLC.
Abstract Octreotide as a synthetic cyclic octapeptide is a somatostatin analog with longer half-life and more selectivity for inhibition of the growth hormone. The acetate salt of octreotide is currently used for medical treatment of somatostatin-related disorders such as endocrine and carcinoid tumors, acromegaly, and gigantism. Octreotide contains both cysteine and tryptophan residues which make the hydrolysis part of its amino acid analysis procedure very challenging. The current paper introduces a fast and additive-free method which preserves tryptophan and cysteine residues during the hydrolysis. Using only 6...
Source: Amino Acids - May 23, 2015 Category: Biochemistry Authors: Akhlaghi Y, Ghaffari S, Attar H, Alamir Hoor A Tags: Amino Acids Source Type: research
A high-efficiency, low-toxicity, phospholipids-based phase separation gel for long-term delivery of peptides.
Abstract Peptide and protein drugs are currently under rapid development attributed to their high potency and efficacy in therapy. Their successful delivery, however, is highly limited by their short half-life, fast degradation and rapid clearance. Here, we present a high content phospholipids-based phase separation gel (PPSG), which is readily injectable due to its low initial viscosity and can rapidly transform into an in situ implant after injection upon exposure to an aqueous environment. A selected model peptide, octreotide acetate, is loaded into PPSG and achieves sustained release profiles for one month in ...
Source: Biomaterials - February 13, 2015 Category: Materials Science Authors: Zhang T, Peng Q, San FY, Luo JW, Wang MX, Wu WQ, Gong T, Zhang ZR Tags: Biomaterials Source Type: research
Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis
In this study, we further evaluated rhIL-1Ra in the treatment of CIM induced by different chemoagents and their combination. Normal as well as tumor-bearing mice were administered oxaliplatin (L-OHP), 5-fluorouracil, or their combination to induce intestinal mucositis and mortality. rhIL-1Ra administered after the chemotherapy, but not after the onset of diarrhea, significantly improved mouse survival, attenuated body weight loss, and reduced the incidence, severity, and duration of diarrhea. Histological examination showed that rhIL-1Ra-treated mice had a relatively intact mucosa structure, more proliferating crypt cells,...
Source: Anti-Cancer Drugs - November 27, 2014 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Poor pregnancy outcome after octreotide treatment during pregnancy for familial hyperinsulinemic hypoglycemia: a case report
Conclusion: In a woman with late familial hyperinsulinemic hypoglycemia octreotide was given during the first four pregnancies resulting in 2 cases of early termination of pregnancy on parental request and 2 cases of inappropriate fetal growth and unviable outcome. The following two pregnancies treated with diet only had a successful outcome. (Source: BMC Research Notes)
Source: BMC Research Notes - November 17, 2014 Category: Research Authors: Gitte SkajaaElisabeth MathiesenElisabeth IyoreHenning Beck-NielsenEspen Jimenez¿SolemPeter Damm Source Type: research
Treatment with octreotide in patients with well-differentiated neuroendocrine tumors of the ileum: prognostic stratification with Ga-68-DOTA-TATE positron emission tomography.
Authors: Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR Abstract We investigated the use of Ga-68-DOTA-Tyr3-octreotate (Ga-68-DOTA-TATE) positron emission tomography (PET) and standardized uptake values (SUVs) to predict the effectiveness of treatment with the somatostatin analogue octreotide acetate (Sandostatin LAR) in patients with neuroendocrine tumors (NETs). Thirty patients with well-differentiated NETs of the ileum (grades G1 and G2) were studied with Ga-68-DOTA-TATE. The average SUV of a 50% isocontour volume of interest covering the lesion with maximum uptake (SUV ...
Source: Molecular Imaging - November 15, 2014 Category: Radiology Tags: Mol Imaging Source Type: research
Ms-24 * systemic treatment of meningiomas: is there a role for long-acting somatostatin?
CONCLUSION: Long acting somatostatin displays minor activity as salvage treatment for recurrent meningiomas after surgery and radiation therapy. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Soffietti, R., Magistrello, M., Trevisan, E., Bertero, L., Pellerino, A., Ruda, R. Tags: MENINGIOMA/VESTIBULAR SCHWANNOMA/SKULL BASE TUMORS/OTHER (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research
Delayed-Onset Chylous Ascites After a Living-Donor Liver Transplant: First Case Successfully Treated With Conservative Treatment?
We report a case of chylous ascites after a living-donor liver transplant that was diagnosed after 6 months of uneventful follow-up. Sirolimus was added to cyclosporine early (2 wk after the operation) owing to poor renal function and it was found to be high (> 22 ng/mL) when the chylous ascites occurred. The patient was treated with total parenteral nutrition in combination with Sandostatin and rapid tapering of sirolimus after the failed initial conservative treatment. Residual abdominal fullness after meals and lymphedema of the legs disappeared 1 month after discontinuing sirolimus. This is the first case of delayed...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - October 31, 2014 Category: Transplant Surgery Authors: Chen JH, Chang CM, Lu MC, Wei CK, Yin WY Tags: Exp Clin Transplant Source Type: research
1165TiP * NETTER-1: FIRST PIVOTAL PHASE III STUDY EVALUATING 177LU-DOTATATE IN MIDGUT NEUROENDOCRINE TUMOURS
Background: Currently, there is an unmet medical need for long-term effective treatment of inoperable, gastro-entero-pancreatic neuroendocrine tumours (GEPNETs). Patients having midgut neuroendocrine tumours (30-50% of all NETs) have very limited therapeutic options: the only registered products (i.e. somatostatin analogues, such as Octreotide®) are approved for symptomatic treatment, and all other potential treatments are either investigational, or off-label. Tumor-targeted peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA0-Tyr3-Octreotate (177Lu-DOTATATE) has been in use since 2000, with over several thous...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Lopera Sierra, M., Kwekkeboom, D., Mariani, M. F., Bodei, L., Santoro, P., Krenning, E. P. Tags: neuroendocrine & amp; endocrine tumours and cup Source Type: research
Effects of long‐acting somatostatin analogues on redox systems in rat lens in experimental diabetes
Summary The effects of long‐acting somatostatin analogues, angiopeptin (AGP) and Sandostatin (SMS), on the early decline in the lens content of glutathione (GSH), ATP and NADPH and increase in sorbitol were studied in STZ diabetic rats, and comparison was made with the effect of insulin. Three factors prompted this study: (i) the known increase in IGF‐1 in ocular tissue in diabetes and antagonistic effect of somatostatins, (ii) the known effect of IGF‐1 in increasing lens aldose reductase and (iii) the lack of effect of somatostatins on diabetic hyperglycaemia, the latter enabling a differentiation to be made between...
Source: International Journal of Experimental Pathology - March 6, 2014 Category: Pathology Authors: Sirilaksana Kunjara, A. Leslie Greenbaum, Milena Sochor, Allan Flyvbjerg, Henning Grønbaek, Patricia McLean Tags: Original Article Source Type: research