Comparing Somatostatin Analogs in the Treatment of Advanced Gastroenteropancreatic Neuroendocrine Tumors
Conclusions: Overall, there was no difference in PFS between octreotide LAR and somatuline depot for pts with well-differentiated, metastatic GEP-NETs. A prospective study is worth designing selecting for G.Oncology (Source: Oncology)
Source: Oncology - January 25, 2022 Category: Cancer & Oncology Source Type: research
Pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone syndrome: a case report and 5-year follow-up
Endocr J. 2021 Oct 9. doi: 10.1507/endocrj.EJ21-0297. Online ahead of print.ABSTRACTPancreatic neuroendocrine tumors (P-NETs) secreting ectopic adrenocorticotropic hormones (ACTH) are rare and often delayed in diagnosis due to their atypical clinical characteristics. Here, we describe a case of P-NET in the pancreatic tail. The tumor had metastasized to the liver and secreted gastrin and ACTH. A 60-year-old female patient was diagnosed with gastrinoma in the pancreatic tail with liver metastases in 2015. After 3 months, the patient presented refractory hypokalemia and thyroid dysfunction. The final diagnosis was P-NET with...
Source: Endocrine Journal - October 11, 2021 Category: Endocrinology Authors: Mao Zheng Li Chen Xiaomin Nie Dong Wang Jie Zhu Wei Wang An Ren Shandong Ye Source Type: research
Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour
We report a rare case of a liver metastatic G1 low-grade NET of the intestine that induced hypercortisolism after surgical resection. A 50-year-old man was admitted for an intestinal obstruction caused by a tumour of the intestine. Paraneoplastic Cushing syndrome was diagnosed more than a year later following the appearance of cushingoid symptoms, despite stable disease according to RECIST criteria but chromogranin A increase. Ketoconazole and sandostatin medical treatment and liver chemoembolization never managed to control the hypercortisolism unlike the bilateral adrenalectomy. The identification and effective managemen...
Source: Case Reports in Oncology - September 23, 2021 Category: Cancer & Oncology Source Type: research
Octreotide acetate combined with somatostatin upregulates miR-1291 and downregulates miR-331-3p in patients with cirrhosis and upper gastrointestinal bleeding
CONCLUSION: OA + SS therapy is safe and effective for the treatment of patients with cirrhosis and UGIB.PMID:34540125 | PMC:PMC8430138 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - September 20, 2021 Category: Research Authors: Xiaodong Liu Xiaohui Guo Hu Zhou Source Type: research
