Clinical Cases in Mineral and Bone Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The effect of strontium chloride on human periodontal ligament stem cells.
In this study, we have isolated a clonal finite cell line derived from human periodontal ligament (PDL) in order to assess whether and in which way different doses of SrCl2 (from 0.5 to 500 μg/ml) can influence both the proliferation and the mineralization process, for future application in oral diseases. PDL cells were cloned by dilution plating technique and characterized by FACS. Cell proliferation analysis and mineralization were performed by [3H]-thymidine incorporation and spectrofluorometric assay. Results have evidenced that the higher SrCl2 concentrations tested, from 25 to 500 μg/ml, have increased the prolifer...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Lower limbs heterometry correction in patients with osteoporosis and increased risk of falls.
Authors: Pratelli E, Alito A, Zanella C, Busi L, Mangone G, Scarselli M, Pasquetti P
Abstract
Osteoporotic fractures are associated with a significant increase in morbidity, mortality and medical costs. There is also a strong link between fractures and increased mortality. Among effective measures for the prevention of falls, instability treatment surely plays a crucial role. Several factors contribute to instability, many of which are ageing-related: visual spatial deficit, strength reduction, weight imbalance with COP lateralization sometimes favoured by LLD (leg length discrepancy). It seems useful to d...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Grafting and fixation of proximal humeral aseptic non union: a prospective case series.
Conclusions: Surgical techniques that increase mechanical stability, while incorporating bone biology, are effective aids for treating problematic fractural patterns.
PMID: 29354157 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Effect of combined treatment with focused mechano-acoustic vibration and pharmacological therapy on bone mineral density and muscle strength in post-menopausal women.
Conclusion: Hence, the combined treatment with focused mechano-acoustic vibration and pharmacological therapy has a beneficial effect on BMD and T-score as well as on the muscle strength and quality of life of osteoporotic subjects.
PMID: 29354158 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Hypothyrodism as a risk factor of periodontitis and its relation with vitamin D deficiency: mini-review of literature and a case report.
Conclusions: Injectabe vitamin D is an adjunctive treatment modality that needs to be discovered in another way. It may provide further solutions for the periodontal regeneration problem. Clinical studies with large sample sizes and long term follow up are needed.
PMID: 29354159 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Surgical treatment of neglected hip fracture in children with cerebral palsy: case report and review of the literature.
Conclusion: To early diagnose this fractures, it is mandatory to perform a comprehensive clinical and radiological evaluation including also a second level imaging. The use of cannulated screws with cancellous bone graft and MSCs is a viable treatment option in these patients.
PMID: 29354160 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Atypical femur fractures: a distinctive tract of adult hypophosphatasia.
Authors: Marini F, Brandi ML
Abstract
Hypophosphatasia (HPP) is a congenital, rare and heterogeneous bone disorder, characterized by a deficit of calcified tissue mineralization, leading to skeletal deformities and osteomalacia in adults, rickets in infants and children, and fragility fractures and premature loss of dentition in children and adults. The disease is caused by a reduced or absent expression and activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, derived from inactivating mutations of the alkaline phosphatase (ALPL) gene. Six different clinical variants have been reported...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Pitfalls in interpreting interventional studies for osteoporosis.
In this report, we are highlighting two issues of utmost importance for correctly interpreting interventional studies for osteoporosis. One issue is the bone remodelling transient (BRT). It refers to a transient change in bone mineral density (BMD) by any agent that reduces remodeling space temporarily. This change is, however, not sustained for a long period and can be misinterpreted as a true gain in bone mass. The second issue is difference between calcium balance and bone balance. Calcium balance is the difference between the amount of calcium ingested in a day and the amount of calcium lost in that day. Recommendation...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Secondary aneurysmal bone cyst in McCune-Albright syndrome.
We present a 28-year-old female with McCune-Albright syndrome. She experienced precocious puberty at age 3 months. In childhood, she experienced multiple long bone fractures, facial deformity and progressive visual and hearing impairment. One year ago, she experienced a painful, gradually enlarging bone lesion involving the right ilium, pubic and ischial bone with groundglass appearance, septa, marginal sclerosis, endosteal scalloping and blow-out expansion resulting in localized thinning of the cortex. CT-guided needle biopsy of the pelvic lesion showed aneurysmal bone cyst. Selective arterial embolization was recommended...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Actual reason for bone fractures in the case of a patient followed-up with the osteogenesis imperfecta: Gaucher's Disease.
Authors: Demirci U, Çizmecioglu A, Aydogdu I
Abstract
Gaucher's disease (GD) is a rare disease characterized by a β-glucocerebroside accumulation in the reticulo-endothelial system. Patients may refer to the clinic with complaints of bone pain, hepatosplenomegaly, anemia, thrombocytopenia, growth retardation, interstitial pulmonary disease, pulmonary hypertension, and skeletal disorders. Skeletal system involvement is observed commonly in Gaucher patients and a significant cause of morbidity. Our patient was followed for several years as a glass child - osteogenesis imperfecta and he had joint deformitie...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Calcitriol-mediated hypercalcemia secondary to granulomatous disease caused by soft-tissue filler injection: a case report.
Authors: Noreña JA, Niño CD, Gallego S, Builes-Barrera CA, Castro DC, Román-González A, Jimenez C
Abstract
Soft-tissue filler (STF) injections have been used worldwide for cosmetic reasons. In most cases, they are not approved by the United States Food and Drug Administration (FDA). Regulatory boards in Latin American countries do not allow the medical use of STF injections; however, these injections are still widely used. A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented. The reported case highlights the consequ...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Adult-onset hypophosphatasia diagnosed following bilateral atypical femoral fractures in a 55-year-old woman.
We report the case of a 55-year-old woman who presented to the emergency department having woken from sleep with right sided thigh swelling. Pelvic radiographs revealed bilateral atypical subtrochanteric femoral fractures (ASFFs). In the two years leading up to this admission, the patient had experienced gradually increasing pain and weakness in her legs which had resulted in a decrease in her mobility from fully mobile to bed-bound. During this time a neurologist had organised a magnetic-resonance imaging (MRI) scan of the brain and spine which was normal. There was no history of bisphosphonate (BP) use. Historical and ad...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Neonatal severe hyperparathyroidism secondary to a novel homozygous CASR gene mutation.
We present a case of a 2-month old girl with severe hypercalcemia and hyperparathyroidism. She was found to have a novel homozygous mutation in the acceptor splicing site of intron 4 (c.1378 -2A>G) of the calcium sensing receptor gene (CASR). This mutation causes frame shift deletion of exon 5 and insensitivity of CASR to calcium. The patient was treated with intravenous fluids, fruosemide, calcitonin, intravenous pamidronate and oral cinacalcet. She did not respond to medical treatment. Parathyroid gland imaging including ultrasound, MRI and sestamibi nuclear scan were not helpful in localizing the glands. Her symptoms...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Glomus tumor as a cause of oncogenic osteomalacia.
Authors: Dehghani M, Dabbaghmanesh MH, Khalafi-Nezhad A, Riazmontazer N, Dehghanian A, Vojdani R, Sasani M
Abstract
Many tumors that occasionally are benign in origin causes hypophosphatemic osteomalacia. Here we present a case of glomus tumor in a 59-year-old man with oncogenic osteomalacia. Diagnosis was made after observation of abnormal increase activity in octreotide scan. The magnetic resonance imaging showed a round lesion in left ankle joint. Surgical excision of tumor was curative and all symptoms and intractable hypophosphatemia improved after few weeks.
PMID: 29354168 [PubMed] (Source: C...
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
Femur shaft fracture following osteoid osteoma radiofrequency ablation.
Conclusion: Radiofrequency ablation is an effective and relatively safe technique in treating osteoid osteomas, however the physician should be aware of the fracture risk involved, consider mechanical and biologic factors of the bone prior to drilling, and be very conservative when recommending return to high level activity. In addition, a close follow-up should be carried on after the procedure in order to supervise bone remodeling.
PMID: 29354169 [PubMed] (Source: Clinical Cases in Mineral and Bone Metabolism)
Source: Clinical Cases in Mineral and Bone Metabolism - January 24, 2018 Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
