GSE261214 High-throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella During Stress and Infection- Barseq1 (NonSPI2, InSPI2, InSPI2Mg, M9glucose)
Contributors : Benjamin X Wang ; Denise M MonackSeries Type : OtherOrganism : Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 ; Salmonella enterica subsp. enterica serovar Typhi str. Ty2 ; Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 ; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74Salmonella enterica is comprised of genetically distinct “serovars”, that together provide an intriguing model for exploring the genetic basis of pathogen evolution. While the genomes of numerous Salmonella isolates with broad variations in host range and human disease manifes...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Other Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 Salmonella enterica subsp. enterica serovar Source Type: research
Testusterol, a new sterol of the sponge species < em > Xestospongia testudinaria < /em > from Phu Quoc island, Vietnam
Nat Prod Res. 2024 Apr 11:1-9. doi: 10.1080/14786419.2024.2340757. Online ahead of print.ABSTRACTA new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical structures were elucidated based on extensive spectroscopic analyses (1D, 2D NMR, ESIMS and HRESIMS) and comparison with published data. The results of in vitro test (utilizing brine shrimp Artemia salina LEACH) showed that three extracts ethanol, dichloromethane, and ethanol/water, significantly inhibited Artemia salina with LC50 values ...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Phuong Vu Luu Hien Minh Nguyen Phuc Minh Phan An Duy Vo Huong Lien Ton-Nu Source Type: research
Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research
Testusterol, a new sterol of the sponge species < em > Xestospongia testudinaria < /em > from Phu Quoc island, Vietnam
Nat Prod Res. 2024 Apr 11:1-9. doi: 10.1080/14786419.2024.2340757. Online ahead of print.ABSTRACTA new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical structures were elucidated based on extensive spectroscopic analyses (1D, 2D NMR, ESIMS and HRESIMS) and comparison with published data. The results of in vitro test (utilizing brine shrimp Artemia salina LEACH) showed that three extracts ethanol, dichloromethane, and ethanol/water, significantly inhibited Artemia salina with LC50 values ...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Phuong Vu Luu Hien Minh Nguyen Phuc Minh Phan An Duy Vo Huong Lien Ton-Nu Source Type: research
Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research
GSE263108 Hysteresis of IL-10R primes solid tumour microenvironment for bacterial immunotherapy
Contributors : Yan Wang ; Yichuan Xiao ; Chenli Liu ; Zhiguang ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHysteresis, a ubiquitous phenomenon in nonlinear systems, plays a vital role in diverse scientific disciplines. Here, we demonstrated the presence of hysteresis in the expression of interleukin-10 receptor (IL-10R) within the tumour microenvironment (TME) during bacterial immunotherapy. The engineered Salmonella enterica, administered intravenously, exhibited remarkable efficacy in multiple tumour types, effectively eliminating tumours and preventing recurrence and m...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Recent development of oral vaccines (Review)
Exp Ther Med. 2024 Mar 22;27(5):223. doi: 10.3892/etm.2024.12511. eCollection 2024 May.ABSTRACTOral immunization can elicit an effective immune response and immune tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via the gastrointestinal mucosa offers superior immune effects and compliance, as well as simplicity and convenience, making it a more optimal route for immunization. At present, various oral vaccine delivery systems exist. Certain modified bacteria, such as Salmonella, Escherichia coli and particularly Lactobacillus, are considered promising carriers for oral...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Ying Liu Dominic Man-Kit Lam Mei Luan Wenfu Zheng Hao Ai Source Type: research
Dendritic cell targeting peptide plus Salmonella FliCd flagellin fused outer membrane protein H (OmpH) demonstrated increased efficacy against infections caused by different Pasteurella multocida serogroups in mouse models
In this study, we modified OmpH with dendritic cell targeting peptide (Depeps) and/or Salmonella FliCd flagellin, and expressed three types of recombinant proteins with the MBP tag (rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, rFliC-OmpH-MBP). Assessments in mouse models revealed that vaccination with rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, or rFliC-OmpH-MBP induced significant higher level of antibodies as well as IFN-γ and IL-4 in murine sera than vaccination with rOmpH-MBP (P < 0.5). Vaccination with the three modified proteins also provided increased protection (rDepeps-FliC-OmpH-MBP, 70 %; rDepeps-OmpH-MBP, 50 %; rFl...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Zihao Wang Mixue Wang Fei Wang Yajuan Luo Hanyuan Liu Zhanwei Zhu Xi Huang Lin Hua Huanchun Chen Bin Wu Zhong Peng Source Type: research
Salmonella Infection: a Real Threat
Eur J Vasc Endovasc Surg. 2024 Apr 5:S1078-5884(24)00287-9. doi: 10.1016/j.ejvs.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38583738 | DOI:10.1016/j.ejvs.2024.04.001 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 7, 2024 Category: Surgery Authors: Camil-Cassien Bamd é Eric Steinmetz Source Type: research
Dendritic cell targeting peptide plus Salmonella FliCd flagellin fused outer membrane protein H (OmpH) demonstrated increased efficacy against infections caused by different Pasteurella multocida serogroups in mouse models
In this study, we modified OmpH with dendritic cell targeting peptide (Depeps) and/or Salmonella FliCd flagellin, and expressed three types of recombinant proteins with the MBP tag (rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, rFliC-OmpH-MBP). Assessments in mouse models revealed that vaccination with rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, or rFliC-OmpH-MBP induced significant higher level of antibodies as well as IFN-γ and IL-4 in murine sera than vaccination with rOmpH-MBP (P < 0.5). Vaccination with the three modified proteins also provided increased protection (rDepeps-FliC-OmpH-MBP, 70 %; rDepeps-OmpH-MBP, 50 %; rFl...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Zihao Wang Mixue Wang Fei Wang Yajuan Luo Hanyuan Liu Zhanwei Zhu Xi Huang Lin Hua Huanchun Chen Bin Wu Zhong Peng Source Type: research
Salmonella Infection: a Real Threat
Eur J Vasc Endovasc Surg. 2024 Apr 5:S1078-5884(24)00287-9. doi: 10.1016/j.ejvs.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38583738 | DOI:10.1016/j.ejvs.2024.04.001 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 7, 2024 Category: Surgery Authors: Camil-Cassien Bamd é Eric Steinmetz Source Type: research
Dendritic cell targeting peptide plus Salmonella FliCd flagellin fused outer membrane protein H (OmpH) demonstrated increased efficacy against infections caused by different Pasteurella multocida serogroups in mouse models
In this study, we modified OmpH with dendritic cell targeting peptide (Depeps) and/or Salmonella FliCd flagellin, and expressed three types of recombinant proteins with the MBP tag (rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, rFliC-OmpH-MBP). Assessments in mouse models revealed that vaccination with rDepeps-FliC-OmpH-MBP, rDepeps-OmpH-MBP, or rFliC-OmpH-MBP induced significant higher level of antibodies as well as IFN-γ and IL-4 in murine sera than vaccination with rOmpH-MBP (P < 0.5). Vaccination with the three modified proteins also provided increased protection (rDepeps-FliC-OmpH-MBP, 70 %; rDepeps-OmpH-MBP, 50 %; rFl...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Zihao Wang Mixue Wang Fei Wang Yajuan Luo Hanyuan Liu Zhanwei Zhu Xi Huang Lin Hua Huanchun Chen Bin Wu Zhong Peng Source Type: research
Unusual Iliopsoas Abscess due to Salmonella typhi
Am J Trop Med Hyg. 2024 Apr 2:tpmd230833. doi: 10.4269/ajtmh.23-0833. Online ahead of print.NO ABSTRACTPMID:38579701 | DOI:10.4269/ajtmh.23-0833 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Harpreet Singh Deba Prasad Dhibhar Suresh Selvam Vishal Kumar Vikas Suri Ashish Bhalla Source Type: research
Unusual Iliopsoas Abscess due to Salmonella typhi
Am J Trop Med Hyg. 2024 Apr 2:tpmd230833. doi: 10.4269/ajtmh.23-0833. Online ahead of print.NO ABSTRACTPMID:38579701 | DOI:10.4269/ajtmh.23-0833 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 5, 2024 Category: Infectious Diseases Authors: Harpreet Singh Deba Prasad Dhibhar Suresh Selvam Vishal Kumar Vikas Suri Ashish Bhalla Source Type: research
Unusual Iliopsoas Abscess due to Salmonella typhi
Am J Trop Med Hyg. 2024 Apr 2:tpmd230833. doi: 10.4269/ajtmh.23-0833. Online ahead of print.NO ABSTRACTPMID:38579701 | DOI:10.4269/ajtmh.23-0833 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Harpreet Singh Deba Prasad Dhibhar Suresh Selvam Vishal Kumar Vikas Suri Ashish Bhalla Source Type: research
