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Infectious Disease: Parasitic Diseases
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Total 27724 results found since Jan 2013.
Epidemiological, serological, and entomological aspects of visceral leishmaniasis (VL) in suspected new VL foci in Bangladesh
Acta Trop. 2023 Sep 14:107021. doi: 10.1016/j.actatropica.2023.107021. Online ahead of print.ABSTRACTThe study aimed to explore epidemiological, serological, and entomological aspects of visceral leishmaniasis (VL) in suspected new VL foci and assess the knowledge, attitude, and practices of the community living in the alleged new VL foci. The study investigated new visceral leishmaniasis (VL) cases reported between 2019 and 2020 in four sub-districts (Dharmapasha, Hakimpur, Islampur and Savar) where we tested 560 members using the rK39 rapid test and conducted vector collections in six neighbouring houses of the index cas...
Source: Acta Tropica - September 16, 2023 Category: Infectious Diseases Authors: Debashis Ghosh Md Utba Rashid Soumik Kha Sagar Md Rasel Uddin Shomik Maruf Prakash Ghosh Rajashree Chowdhury Md Abu Rahat Md Nazmul Islam M M Aktaruzzaman Abu Nayeem Mohammad Sohel Megha Raj Banjara Axel Kroeger Abraham Aseffa Dinesh Mondal Source Type: research
Both C57BL/KsJ (H2 < sup > d < /sup > haplotype) and CB10-H2 (H2 < sup > b < /sup > haplotype) mice are highly susceptible to congenital toxoplasmosis
In conclusion, the high IFN-γ and TNF serum levels observed in C57BL/KsJ (H2d) and CB10-H2 (H2b) mice were involved in the poor pregnancy outcomes in congenital toxoplasmosis. In addition, the higher IFN-γ, IL-6 and TNF levels detected in C57BL/KsJ in relation to CB10-H2 mice on 8dP/8dI seem to be related to the genetic background of C57BL/6J mice that may have contributed to the worse pregnancy outcome in this mouse lineage.PMID:37716667 | DOI:10.1016/j.actatropica.2023.107022
Source: Acta Tropica - September 16, 2023 Category: Infectious Diseases Authors: Loyane Bertagnolli Coutinho M ário Cézar de Oliveira Ester Cristina Borges Araujo Fl ávia Batista Ferreira França Marcos Paulo Oliveira Almeida Yusmaris Cariaco Paulo Czarnewski Neide Maria Silva Source Type: research
Conditional expression of NanoLuc luciferase through a multimodular system offers rapid detection of antimalarial drug activity
Exp Parasitol. 2023 Sep 14:108620. doi: 10.1016/j.exppara.2023.108620. Online ahead of print.ABSTRACTConditional gene expression is a powerful tool to investigate putative vaccine and drug targets, especially in a haploid organism such as Plasmodium falciparum. Inducible systems based on regulation of either transcription, translation, protein or mRNA stability, among others, allow switching on an off the expression of any desired gene causing specific gain or loss of function phenotypes. However, those systems can be cumbersome involving the construction of large plasmids and generation of multiple transgenic parasite lin...
Source: Experimental Parasitology - September 16, 2023 Category: Parasitology Authors: Caroline Lima Ignasi B Verdaguer Gerhard Wunderlich Alejandro M Katzin Brendan S Crabb Paul R Gilson Mauro F Azevedo Source Type: research
Critical interdependencies between Plasmodium nutrient flux and drugs
Trends Parasitol. 2023 Sep 14:S1471-4922(23)00212-X. doi: 10.1016/j.pt.2023.08.008. Online ahead of print.ABSTRACTNutrient import and waste efflux are critical dependencies for intracellular Plasmodium falciparum parasites. Nutrient transport proteins are often lineage specific and can provide unique targets for antimalarial drug development. P. falciparum nutrient transport pathways can be a double-edged sword for the parasite, not only mediating the import of nutrients and excretion of waste products but also providing an access route for drugs. Here we briefly summarise the nutrient acquisition pathways of intracellular...
Source: Trends in Parasitology - September 16, 2023 Category: Parasitology Authors: Isabelle G Henshall Tobias Spielmann Source Type: research
Phytoconstituents from < em > Turraea obtusifolia < /em > and their antiplasmodial activity
Nat Prod Res. 2023 Sep 15:1-13. doi: 10.1080/14786419.2023.2255921. Online ahead of print.ABSTRACTThree new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC50 value of 3.47 µg/mL (4.57 µM), nymania 1 (4) showed a weak activity (IC50 13.36 µg/mL (19.40 µM)) and the r...
Source: Natural Product Research - September 15, 2023 Category: Biochemistry Authors: Sephora Mutombo Mianda Phanankosi Moyo Suzan Maboane Lyn-Mari é Birkholtz Vinesh J Maharaj Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Phytoconstituents from < em > Turraea obtusifolia < /em > and their antiplasmodial activity
Nat Prod Res. 2023 Sep 15:1-13. doi: 10.1080/14786419.2023.2255921. Online ahead of print.ABSTRACTThree new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC50 value of 3.47 µg/mL (4.57 µM), nymania 1 (4) showed a weak activity (IC50 13.36 µg/mL (19.40 µM)) and the r...
Source: Natural Product Research - September 15, 2023 Category: Biochemistry Authors: Sephora Mutombo Mianda Phanankosi Moyo Suzan Maboane Lyn-Mari é Birkholtz Vinesh J Maharaj Source Type: research
The question of the early diagnosis of asymptomatic and subpatent malaria in pregnancy: Implications for diagnostic tools in a malaria endemic area
CONCLUSIONS: Average age of enrolled women was 28.8 years and mean gestational age was 21.0 weeks. The parasite positivity rates were 4.3%, 8.8% and 25.0% for microscopy, mRDT and PCR at V1 and was 2.4%, 3.4% and 43.4% at delivery, respectively. Sensitivity for microscopy and mRDT was 11.2% and 30.3% respectively at V1, while specificity was 98.2% and 98.5%. At delivery, the sensitivity reduced to 1.6% and 4.9%; while specificity was 96.9% and 97.6% respectively. Only 2.3% cases correlated with all three diagnostic methods. Our data showed a decrease in sensitivity of the diagnostic methods as pregnancy progressed, which m...
Source: Reproductive Biology - September 15, 2023 Category: Reproduction Medicine Authors: G N Uyaiabasi A Olaleye C J Elikwu R I Funwei C Okangba A Adepoju A Akinyede O O Adeyemi O Walker Source Type: research
Identification and dynamics of novel scaffolds against < em > Enterococcus faecium < /em > serine hydroxymethyltransferase enzyme: a potential target for antibiotics development
J Biomol Struct Dyn. 2023 Sep 15:1-11. doi: 10.1080/07391102.2023.2257313. Online ahead of print.ABSTRACTSerine hydroxymethyltransferase enzyme is a significant player in purine, thymidylate, and L-serine biosynthesis and has been tagged as a potential target for cancer, viruses, and parasites. However, this enzyme as an anti-bacterial druggable target has not been explored much. Herein, in this work, different computational chemistry and biophysics techniques were applied to identify potential computational predicted inhibitory molecules against Enterococcus faecium serine hydroxymethyltransferase enzyme. By structure bas...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Hassan H Alhassan Yasir S Alruwaili Sami I Alzarea Muharib Alruwaili Omar Awad Alsaidan Abdulaziz Ibrahim Alzarea Emad Manni Muhammad Tahir Ul Qamar Source Type: research
Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913165219. Online ahead of print.ABSTRACTMalaria is a devastating infectious disease that affects large swathes of human populations across the planet's tropical regions. It is caused by parasites of the genus Plasmodium, with Plasmodium falciparum being responsible for the most lethal form of the disease. During the intraerythrocytic stage in the human hosts, malaria parasites multiply and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine proteases, falcipains 2 and 3 (FP-2 and FP-3). Due to their role as major hemoglobinases, FP-2 and...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Jorge Enrique Hern ández González Emir Salas-Sarduy Lilian Hern ández Alvarez Pedro A Valiente Raghuvir K Arni Pedro G Pascutti Source Type: research
Tapeworms (cestoda: ophiotaenia) from the northern cottonmouth (agkistrodon piscivorus)
J Parasitol. 2023 Oct 1;109(5):464-479. doi: 10.1645/23-32.ABSTRACTThe northern cottonmouth, Agkistrodon piscivorus (Lacépède, 1789) (Viperidae: Crotalinae), occurs in the southeastern United States and is one of the few semiaquatic vipers in the world. Three proteocephalid tapeworms of the genus OphiotaeniaLa Rue, 1911 (Cestoda), have been described from this venomous snake. A critical evaluation of type specimens and tapeworms recently collected from A. piscivorus has revealed that only 2 species, Ophiotaenia marenzelleri (Barrois, 1898) and Ophiotaenia grandisLa Rue, 1911 (new synonym Ophiotaenia agkistrodontis [Harwo...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Tom áš Scholz Alain de Chambrier Chris T McAllister Vasyl V Tkach Roman Kuchta Source Type: research
The first survey of bovine babesia species infecting yaks (bos grunniens) in mongolia
J Parasitol. 2023 Oct 1;109(5):480-485. doi: 10.1645/22-93.ABSTRACTYak (Bos grunniens) farming is an important part of Mongolia's livestock industry. Yaks survive in harsh mountain environments; provide meat, milk, and wool; and serve as a mode of transportation. In Mongolia, yaks are frequently raised alongside other livestock animals such as cattle, Bactrian camels, sheep, goats, and horses. Recently, we demonstrated that Babesia bovis, Babesia bigemina, and Babesia naoakii-parasites with the potential to cause clinical bovine babesiosis-infect not only cattle but also Bactrian camels in Mongolia. However, yaks have neve...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Davaajav Otgonsuren Punsantsogvoo Myagmarsuren Myagmar Zoljargal Believe Ahedor Thillaiampalam Sivakumar Banzragch Battur Badgar Battsetseg Naoaki Yokoyama Source Type: research
Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913165219. Online ahead of print.ABSTRACTMalaria is a devastating infectious disease that affects large swathes of human populations across the planet's tropical regions. It is caused by parasites of the genus Plasmodium, with Plasmodium falciparum being responsible for the most lethal form of the disease. During the intraerythrocytic stage in the human hosts, malaria parasites multiply and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine proteases, falcipains 2 and 3 (FP-2 and FP-3). Due to their role as major hemoglobinases, FP-2 and...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Jorge Enrique Hern ández González Emir Salas-Sarduy Lilian Hern ández Alvarez Pedro A Valiente Raghuvir K Arni Pedro G Pascutti Source Type: research
