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Infectious Disease: Parasitic Diseases
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Phytoconstituents from < em > Turraea obtusifolia < /em > and their antiplasmodial activity
Nat Prod Res. 2023 Sep 15:1-13. doi: 10.1080/14786419.2023.2255921. Online ahead of print.ABSTRACTThree new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC50 value of 3.47 µg/mL (4.57 µM), nymania 1 (4) showed a weak activity (IC50 13.36 µg/mL (19.40 µM)) and the r...
Source: Natural Product Research - September 15, 2023 Category: Biochemistry Authors: Sephora Mutombo Mianda Phanankosi Moyo Suzan Maboane Lyn-Mari é Birkholtz Vinesh J Maharaj Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Tapeworms (cestoda: ophiotaenia) from the northern cottonmouth (agkistrodon piscivorus)
J Parasitol. 2023 Oct 1;109(5):464-479. doi: 10.1645/23-32.ABSTRACTThe northern cottonmouth, Agkistrodon piscivorus (Lacépède, 1789) (Viperidae: Crotalinae), occurs in the southeastern United States and is one of the few semiaquatic vipers in the world. Three proteocephalid tapeworms of the genus OphiotaeniaLa Rue, 1911 (Cestoda), have been described from this venomous snake. A critical evaluation of type specimens and tapeworms recently collected from A. piscivorus has revealed that only 2 species, Ophiotaenia marenzelleri (Barrois, 1898) and Ophiotaenia grandisLa Rue, 1911 (new synonym Ophiotaenia agkistrodontis [Harwo...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Tom áš Scholz Alain de Chambrier Chris T McAllister Vasyl V Tkach Roman Kuchta Source Type: research
The first survey of bovine babesia species infecting yaks (bos grunniens) in mongolia
J Parasitol. 2023 Oct 1;109(5):480-485. doi: 10.1645/22-93.ABSTRACTYak (Bos grunniens) farming is an important part of Mongolia's livestock industry. Yaks survive in harsh mountain environments; provide meat, milk, and wool; and serve as a mode of transportation. In Mongolia, yaks are frequently raised alongside other livestock animals such as cattle, Bactrian camels, sheep, goats, and horses. Recently, we demonstrated that Babesia bovis, Babesia bigemina, and Babesia naoakii-parasites with the potential to cause clinical bovine babesiosis-infect not only cattle but also Bactrian camels in Mongolia. However, yaks have neve...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Davaajav Otgonsuren Punsantsogvoo Myagmarsuren Myagmar Zoljargal Believe Ahedor Thillaiampalam Sivakumar Banzragch Battur Badgar Battsetseg Naoaki Yokoyama Source Type: research
Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913165219. Online ahead of print.ABSTRACTMalaria is a devastating infectious disease that affects large swathes of human populations across the planet's tropical regions. It is caused by parasites of the genus Plasmodium, with Plasmodium falciparum being responsible for the most lethal form of the disease. During the intraerythrocytic stage in the human hosts, malaria parasites multiply and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine proteases, falcipains 2 and 3 (FP-2 and FP-3). Due to their role as major hemoglobinases, FP-2 and...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Jorge Enrique Hern ández González Emir Salas-Sarduy Lilian Hern ández Alvarez Pedro A Valiente Raghuvir K Arni Pedro G Pascutti Source Type: research
Tapeworms (cestoda: ophiotaenia) from the northern cottonmouth (agkistrodon piscivorus)
J Parasitol. 2023 Oct 1;109(5):464-479. doi: 10.1645/23-32.ABSTRACTThe northern cottonmouth, Agkistrodon piscivorus (Lacépède, 1789) (Viperidae: Crotalinae), occurs in the southeastern United States and is one of the few semiaquatic vipers in the world. Three proteocephalid tapeworms of the genus OphiotaeniaLa Rue, 1911 (Cestoda), have been described from this venomous snake. A critical evaluation of type specimens and tapeworms recently collected from A. piscivorus has revealed that only 2 species, Ophiotaenia marenzelleri (Barrois, 1898) and Ophiotaenia grandisLa Rue, 1911 (new synonym Ophiotaenia agkistrodontis [Harwo...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Tom áš Scholz Alain de Chambrier Chris T McAllister Vasyl V Tkach Roman Kuchta Source Type: research
The first survey of bovine babesia species infecting yaks (bos grunniens) in mongolia
J Parasitol. 2023 Oct 1;109(5):480-485. doi: 10.1645/22-93.ABSTRACTYak (Bos grunniens) farming is an important part of Mongolia's livestock industry. Yaks survive in harsh mountain environments; provide meat, milk, and wool; and serve as a mode of transportation. In Mongolia, yaks are frequently raised alongside other livestock animals such as cattle, Bactrian camels, sheep, goats, and horses. Recently, we demonstrated that Babesia bovis, Babesia bigemina, and Babesia naoakii-parasites with the potential to cause clinical bovine babesiosis-infect not only cattle but also Bactrian camels in Mongolia. However, yaks have neve...
Source: The Journal of Parasitology - September 15, 2023 Category: Parasitology Authors: Davaajav Otgonsuren Punsantsogvoo Myagmarsuren Myagmar Zoljargal Believe Ahedor Thillaiampalam Sivakumar Banzragch Battur Badgar Battsetseg Naoaki Yokoyama Source Type: research
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Infect Genet Evol. 2023 Sep 12:105501. doi: 10.1016/j.meegid.2023.105501. Online ahead of print.ABSTRACTThe primary vector of the trypanosome parasite causing human and animal African trypanosomiasis in Uganda is the riverine tsetse fly Glossina fuscipes fuscipes (Gff). Our study improved the Gff genome assembly with whole genome 10× Chromium sequencing of a lab reared pupae, identified autosomal versus sex-chromosomal regions of the genome with ddRAD-seq data from 627 field caught Gff, and identified SNPs associated with trypanosome infection with genome-wide association (GWA) analysis in a subset of 351 flies. Results f...
Source: Infection, Genetics and Evolution - September 14, 2023 Category: Genetics & Stem Cells Authors: Norah P Saarman Jae Hak Son Hongyu Zhao Luciano V Cosme Yong Kong Mo Li Shiyu Wang Brian L Weiss Richard Echodu Robert Opiro Serap Aksoy Adalgisa Caccone Source Type: research
Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector
Cell Host Microbe. 2023 Sep 13;31(9):1539-1551.e6. doi: 10.1016/j.chom.2023.08.010.ABSTRACTMalaria remains one of the most devastating infectious diseases. Reverse genetic screens offer a powerful approach to identify genes and molecular processes governing malaria parasite biology. However, the complex regulation of gene expression and genotype-phenotype associations in the mosquito vector, along with sexual reproduction, have hindered the development of screens in this critical part of the parasite life cycle. To address this, we developed a genetic approach in the rodent parasite Plasmodium berghei that, in combination ...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Chiamaka Valerie Ukegbu Ana Rita Gomes Maria Giorgalli Melina Campos Alexander J Bailey Tanguy Rene Balthazar Besson Oliver Billker Dina Vlachou George K Christophides Source Type: research
Sex determination and transmission: Leveraging genetic screens to reveal Plasmodium's secrets
Cell Host Microbe. 2023 Sep 13;31(9):1430-1432. doi: 10.1016/j.chom.2023.08.007.ABSTRACTGenes and regulatory mechanisms governing malaria parasite transmission and development in mosquitoes are incompletely understood. Recently, Russell and colleagues identified genes required for parasite sexual development. In this issue of Cell Host & Microbe, Ukegbu and colleagues report a genetic approach to study genes enabling parasite survival in mosquito stages.PMID:37708851 | DOI:10.1016/j.chom.2023.08.007
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Thomas Hollin Karine G Le Roch Source Type: research
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Infect Genet Evol. 2023 Sep 12:105501. doi: 10.1016/j.meegid.2023.105501. Online ahead of print.ABSTRACTThe primary vector of the trypanosome parasite causing human and animal African trypanosomiasis in Uganda is the riverine tsetse fly Glossina fuscipes fuscipes (Gff). Our study improved the Gff genome assembly with whole genome 10× Chromium sequencing of a lab reared pupae, identified autosomal versus sex-chromosomal regions of the genome with ddRAD-seq data from 627 field caught Gff, and identified SNPs associated with trypanosome infection with genome-wide association (GWA) analysis in a subset of 351 flies. Results f...
Source: Infection, Genetics and Evolution - September 14, 2023 Category: Genetics & Stem Cells Authors: Norah P Saarman Jae Hak Son Hongyu Zhao Luciano V Cosme Yong Kong Mo Li Shiyu Wang Brian L Weiss Richard Echodu Robert Opiro Serap Aksoy Adalgisa Caccone Source Type: research
Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector
Cell Host Microbe. 2023 Sep 13;31(9):1539-1551.e6. doi: 10.1016/j.chom.2023.08.010.ABSTRACTMalaria remains one of the most devastating infectious diseases. Reverse genetic screens offer a powerful approach to identify genes and molecular processes governing malaria parasite biology. However, the complex regulation of gene expression and genotype-phenotype associations in the mosquito vector, along with sexual reproduction, have hindered the development of screens in this critical part of the parasite life cycle. To address this, we developed a genetic approach in the rodent parasite Plasmodium berghei that, in combination ...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Chiamaka Valerie Ukegbu Ana Rita Gomes Maria Giorgalli Melina Campos Alexander J Bailey Tanguy Rene Balthazar Besson Oliver Billker Dina Vlachou George K Christophides Source Type: research
Sex determination and transmission: Leveraging genetic screens to reveal Plasmodium's secrets
Cell Host Microbe. 2023 Sep 13;31(9):1430-1432. doi: 10.1016/j.chom.2023.08.007.ABSTRACTGenes and regulatory mechanisms governing malaria parasite transmission and development in mosquitoes are incompletely understood. Recently, Russell and colleagues identified genes required for parasite sexual development. In this issue of Cell Host & Microbe, Ukegbu and colleagues report a genetic approach to study genes enabling parasite survival in mosquito stages.PMID:37708851 | DOI:10.1016/j.chom.2023.08.007
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Thomas Hollin Karine G Le Roch Source Type: research
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Infect Genet Evol. 2023 Sep 12:105501. doi: 10.1016/j.meegid.2023.105501. Online ahead of print.ABSTRACTThe primary vector of the trypanosome parasite causing human and animal African trypanosomiasis in Uganda is the riverine tsetse fly Glossina fuscipes fuscipes (Gff). Our study improved the Gff genome assembly with whole genome 10× Chromium sequencing of a lab reared pupae, identified autosomal versus sex-chromosomal regions of the genome with ddRAD-seq data from 627 field caught Gff, and identified SNPs associated with trypanosome infection with genome-wide association (GWA) analysis in a subset of 351 flies. Results f...
Source: Infection, Genetics and Evolution - September 14, 2023 Category: Genetics & Stem Cells Authors: Norah P Saarman Jae Hak Son Hongyu Zhao Luciano V Cosme Yong Kong Mo Li Shiyu Wang Brian L Weiss Richard Echodu Robert Opiro Serap Aksoy Adalgisa Caccone Source Type: research
