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Infectious Disease: Parasitic Diseases
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Total 27724 results found since Jan 2013.
< em > Plasmodium falciparum < /em > GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Antimicrob Agents Chemother. 2023 Sep 13:e0057723. doi: 10.1128/aac.00577-23. Online ahead of print.ABSTRACTPlasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological stresses in the human host. Given that GCN5 plays a critical role in regulating stress responses in model organisms, we aimed to elucidate PfGCN5's function in stress responses in P. falciparum. The protein level of PfGCN5 was substantially induced under three stress conditions [heat shock, low glucose starvation, and dihydroartemisinin, the active metabolite of artemisinin (ART)]. With a TetR-DOZI condition...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Amuza Byaruhanga Lucky Chengqi Wang Ahmad Rushdi Shakri Mohammad Kalamuddin Anongruk Chim-Ong Xiaolian Li Jun Miao Source Type: research
Detection of < em > Leishmania < /em > DNA in Phlebotomine Sand Flies in Tsatee, a Community in the Volta Region, Ghana
This study focused on the Tsatee community, in the South Dayi District of the Volta Region, and is aimed at identifying the sand fly fauna and detecting the presence of Leishmania DNA by the use of primers that target the conserved region of Leishmania spp. minicircle DNA of the parasite kinetoplast. The miniature light traps and hand aspirators provided by the Centers for Disease Control and Prevention (CDC) were used to collect outdoor and indoor sand flies for five months in a guinea woodland and semideciduous forest area. From the collections, 4,580 phlebotomine sand flies were obtained and identified, and females were...
Source: Biomed Res - September 13, 2023 Category: Research Authors: Seth Offei Addo Emmanuel Kwame Amoako Ronald Essah Bentil Bright Agbodzi Mba-Tihssommah Mosore Clara Yeboah Naiki Attram John Asiedu Larbi Godwin Kwakye-Nuako Dziedzom K de Souza Michael David Wilson Daniel Adjei Boakye Source Type: research
< em > Plasmodium falciparum < /em > GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Antimicrob Agents Chemother. 2023 Sep 13:e0057723. doi: 10.1128/aac.00577-23. Online ahead of print.ABSTRACTPlasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological stresses in the human host. Given that GCN5 plays a critical role in regulating stress responses in model organisms, we aimed to elucidate PfGCN5's function in stress responses in P. falciparum. The protein level of PfGCN5 was substantially induced under three stress conditions [heat shock, low glucose starvation, and dihydroartemisinin, the active metabolite of artemisinin (ART)]. With a TetR-DOZI condition...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Amuza Byaruhanga Lucky Chengqi Wang Ahmad Rushdi Shakri Mohammad Kalamuddin Anongruk Chim-Ong Xiaolian Li Jun Miao Source Type: research
Chromosome-level Dinobdella ferox genome provided a molecular model for its specific parasitism
CONCLUSIONS: Our study represents the first-ever attempt to propose a molecular model for specific parasitism. This molecular model may serve as a practical reference for parasitism models of other species and a theoretical foundation for a molecular process of parasitism.PMID:37697397 | PMC:PMC10494388 | DOI:10.1186/s13071-023-05837-7
Source: Genomics Proteomics ... - September 12, 2023 Category: Genetics & Stem Cells Authors: Jiang-Wei Gao Jian-Wei Sun Xiang-Rong Tong Hao Wang Qing-Mei Hu Yan-Ru Cao Zhan-Han Zhou Zi-Chao Liu Source Type: research
Induction of TLR5, IRAK1, and NF- κB expression by Trichomonas vaginalis in cervical cancer cell (HeLa) and normal human vaginal epithelial cell (HVECs) lines
CONCLUSIONS: These findings provide insight into the host-parasite interaction, and the results indicated that T. vaginalis could stimulate TLR5 and activate related pathways.PMID:37699101 | DOI:10.3855/jidc.18066
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Soraya Mohammadi Esfanjani Leili Aghebati Maleki Sanam Nami Mina Ebrahimi Amir Baghbanzadeh Gregorio Perez-Cordon Sonia M Rodrigues Oliveira Maria De Lourdes Pereira Aleksandra Bara ć Ehsan Ahmadpour Jelena Mici ć Source Type: research
Head louse paleoepidemiology in the osmore river valley, southern peru
J Parasitol. 2023 Oct 1;109(5):450-463. doi: 10.1645/23-4.ABSTRACTRecent studies of louse ectoparasites from mummies have developed robust data sets that allow a true epidemiological approach to the prehistory of louse parasitism. One epidemiological principle is that the binomial of overdispersion is normally negative, meaning that in a host population, parasites are aggregated in a few individuals. We demonstrate the overdispersion of lice in 3 different prehistoric communities that differ along 3 axes or variables: environmental setting, socioeconomic status, and cultural affiliation. Distinct cultural practices could h...
Source: The Journal of Parasitology - September 12, 2023 Category: Parasitology Authors: Karl Reinhard Nicole Searcey Elisa Pucu Bernardo Arriaza Jane Buikstra Bruce Owen Source Type: research
Anguillid eels
Curr Biol. 2023 Sep 11;33(17):R888-R893. doi: 10.1016/j.cub.2023.07.044.ABSTRACTAnguillid eels have fascinated humans for centuries, but our knowledge of these mysterious fish is still scant. There are 19 species or subspecies in the genus Anguilla, which are found globally, except in the eastern Pacific and southern Atlantic. Their common label 'freshwater eels' is a misnomer - all anguillids are facultatively catadromous, born in marine environments, developing in continental waters, with a proportion never entering freshwater at all. Anguillid eels have several life history traits that have allowed them to exploit a bro...
Source: Current Biology - September 12, 2023 Category: Biology Authors: Michael J Williamson Charlotte Pike Matthew Gollock David M P Jacoby Adam T Piper Source Type: research
Genomic associations with antibody response to an oral cholera vaccine
Vaccine. 2023 Sep 10:S0264-410X(23)01084-8. doi: 10.1016/j.vaccine.2023.09.016. Online ahead of print.ABSTRACTOral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Vijay Laxmi Roy Partha P Majumder Source Type: research
microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research
