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Multifunctional Polymer Vesicles for Synergistic Antibiotic-Antioxidant Treatment of Bacterial Keratitis
Biomacromolecules. 2023 Sep 21. doi: 10.1021/acs.biomac.3c00754. Online ahead of print.ABSTRACTAs an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity, such as corneal perforation, intraocular infection, and permanent corneal opacity, if rapid and effective treatments are not available. In addition to eradicating pathogenic bacteria, protecting corneal tissue from oxidative damage and promoting wound healing by relieving inflammation are equally critical for the efficient treatment of BK. Besides, it is very necessary to improve the bioavailability of drugs by enhancing the ocular sur...
Source: Biomacromolecules - September 21, 2023 Category: Biochemistry Authors: Qiumeng Chen Xiaopeng Han Lu Liu Yong Duan Yifei Chen Linqi Shi Quankui Lin Liangliang Shen Source Type: research
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
We report herein the design, synthesis and biological evaluation of series of 7-substituted fluoroquinolones with pyridoxine derivatives. In vitro screening of antibacterial activity and toxicity of 39 synthesized fluoroquinolones defined compounds 7 and 28 as lead compounds for further investigations. On various clinical isolates lead compounds 7 and 28 exhibited antibacterial activity comparable with reference fluoroqinolones. Mutagenic effects haven't been observed for these compounds in SOS-chromotest. Compound 7 are non-toxic in vivo on mice (LD50 > 2000 mg/kg, oral) and rats (LD50 > 2000 mg/kg, oral). Compound ...
Source: European Journal of Medicinal Chemistry - September 20, 2023 Category: Chemistry Authors: Nikita V Shtyrlin Airat R Kayumov Maria N Agafonova Marsel R Garipov Alina E Gatina Mikhail V Pugachev Elena S Bulatova Denis Y Grishaev Alfiya G Iksanova Rail M Khaziev Ilnur M Ganiev Aleksandr M Aimaletdinov Oleg I Gnezdilov Yurii G Shtyrlin Source Type: research
Virulence Factors and Antimicrobial Resistance of Uropathogenic < em > Escherichia coli < /em > EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan
Biomed Res Int. 2023 Sep 11;2023:7278070. doi: 10.1155/2023/7278070. eCollection 2023.ABSTRACTInfectious diseases have been tremendously increasing as the organisms of even normal flora become opportunistic and cause an infection, and Escherichia coli (E. coli EQ101) is one of them. Urinary tract infections are caused by various microorganisms, but Escherichia coli is the primary cause of almost 70%-90% of all UTIs. It has multiple strains, possessing diverse virulence factors, contributing to its pathogenicity. Furthermore, these virulent strains also can cause overlapping pathogenesis by sharing resistance and virulence ...
Source: Biomed Res - September 20, 2023 Category: Research Authors: Sareen Fatima Ali Akbar Muhammad Irfan Muhammad Shafee Amjad Ali Zaara Ishaq Syed Kashif Raza Abdul Samad Mohammad Y Alshahrani Syed Shah Hassan Source Type: research
Expression of concern: Solar-driven photodegradation of 17- β-estradiol and ciprofloxacin from waste water and CO2 conversion using sustainable coal-char/polymeric-g-C3N4/RGO metal-free nano-hybrids
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Amit Kumar, Ajay Kumar, Gaurav Sharma, Mu. Naushad, Renato Cataluna Veses, Ayman A. Ghfar, Florian J. Stadler, Mohammad Rizwan Khan To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 19, 2023 Category: Chemistry Authors: Amit Kumar Source Type: research
Genomic Characterization of Salmonella enterica Resistant to Cephalosporin, Quinolones, And Macrolides
This study focused on determining the antimicrobial resistance of 373 Salmonella isolates, collected from various foods, humans, and animals, as well as the environmental sludge between 2005 and 2020 in Türkiye. Phenotypic analysis of the resistance was determined by disk diffusion method. Isolates resistant to any of the following: ciprofloxacin, pefloxacin, azithromycin, and ceftriaxone were tested for the presence of quinolone, beta-lactamase, and/or macrolide resistance genes by PCR and gel electrophoresis. Five multi-drug-resistant isolates were then further whole genome sequenced and analyzed. More than 32% (n = 120...
Source: Current Microbiology - September 19, 2023 Category: Microbiology Authors: Diala Konyali Mustafa Guzel Ye şim Soyer Source Type: research
The characterization and correlation between the phenotypic and genotypic resistance of < em > Campylobacter < /em > spp < em > . < /em > isolates from commercial broilers and native chickens in the south of Thailand
Avian Pathol. 2023 Sep 18:1-49. doi: 10.1080/03079457.2023.2260322. Online ahead of print.ABSTRACTAbstractChicken is a major reservoir and source of human infections from zoonotic Campylobacter. In southern Thailand, chicken is the most popular meat consumed; however, little is known about the antimicrobial resistance (AMR) of Campylobacter spp. in chicken production systems. We aimed to investigate the prevalence and characteristics of AMR in Campylobacter isolates from commercial broiler and native chicken farms in southern Thailand. A total of 286 Campylobacter isolates (adjusted prevalence: 60.3%, SE ±0.01) were recov...
Source: Avian Pathology - September 18, 2023 Category: Pathology Authors: Doan Hoang Phu Ruethai Narinthorn Nguyen Thi Nhung Niwat Chansiripornchai Patrick J Blackall Conny Turni Juan Carrique-Mas Thotsapol Thomrongsuwannakij Source Type: research
Bacterial isolates and their antimicrobial susceptibility profile of superficial and deep-seated skin and soft tissue infections
CONCLUSIONS: The predominant etiology of SSTIs is GNR. Currently, there is very high resistance against oral antibiotics. Antimicrobial resistance against carbapenem has also increased. Moreover, there is a high frequency of MRSA. MDR E. coli and Klebsiella spp. isolates are frequently involved in dSSTIs.PMID:37719324 | PMC:PMC10505063 | DOI:10.2478/abm-2023-0045
Source: Biomed Res - September 18, 2023 Category: Research Authors: Rao Muhammad Abid Khan Sunil Kumar Dodani Ali Nadeem Sana Jamil Mirza Naqi Zafar Source Type: research
Prevalence of mutations associated with macrolide and fluoroquinolone resistance in Neisseria gonorrhoeae with Allplex NG-DR Assay (Seegene) in a tertiary hospital from Madrid, Spain
CONCLUSIONS: We report a low-prevalence of mutations A2059G/C2611T to macrolides and a high-prevalence to S91F in NG infections. Molecular methods for the detection of NG resistance could be useful in direct non-culturable samples.PMID:37721708 | DOI:10.37201/req/058.2023
Source: Revista Espanola de Quimioterapia - September 18, 2023 Category: Drugs & Pharmacology Authors: A Maldonado-Barrueco C Sanz-Gonz ález I Falces-Romero P Garc ía-Clemente J Cacho-Calvo I Quiles-Melero Source Type: research
Terbium-based dual-ligand metal organic framework by diffusion method for selective and sensitive detection of danofloxacin in aqueous medium
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29895-7. Online ahead of print.ABSTRACTA water-dispersible Tb(III)-based metal organic framework (TBP) was produced by diffusion technique using benzene-1,3,5-tricarboxylic acid (BTC) and pyridine as easily accessible ligands at low cost. The as-synthesized TBP with a crystalline structure and rod-shaped morphology has exhibited thermal stability up to 465 °C. Elemental analysis confirmed the presence of carbon, oxygen, nitrogen, and terbium in the synthesized MOF. TBP was used as a fluorescent probe for detection of danofloxacin (DANO) in an aqueous medium ...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Gurdeep Singh Deepika Garg Sanjay Kumar Rajpal Verma Ashok Kumar Malik Source Type: research
Cuprous-mediated peroxymonosulfate activation for Fenton-like removal of micropollutants: The function of co-catalyst and the accelerated degradation mechanism
This study provides a basis for enhancing cuprous-mediated PMS activation for wastewater treatment.PMID:37722303 | DOI:10.1016/j.ecoenv.2023.115435
Source: Ecotoxicology and Environmental Safety - September 18, 2023 Category: Environmental Health Authors: Miao Li Juan Li Chencheng Qin Xiaoai Guo Hou Wang Zhuotong Zeng Xingzhong Yuan Source Type: research
