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Drug: Aspirin
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Total 5437 results found since Jan 2013.
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy
CONCLUSIONS: Addition of glenzocimab to aspirin and ticagrelor enhances platelet inhibition via multiple mechanisms of atherothrombosis. Compared to a GPIIb/IIIa inhibitor, glenzocimab shares multiple antithrombotic effects, with less inhibition of mechanisms involved in general haemostasis.PMID:37541591 | DOI:10.1016/j.jtha.2023.07.018
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Fawaz O Alenazy Maan H Harbi Dean P Kavanagh Joshua Price Paul Brady Oscar Hargreaves Paul Harrison Alexandre Slater Alok Tiwari Phillip L R Nicolson Derek L Connolly Paulus Kirchhof Neena Kalia Martine Jandrot-Perrus Pierre H Mangin Steve P Watson Mark R Source Type: research
The great obstetrical syndromes and the placenta
BJOG. 2023 Aug 2. doi: 10.1111/1471-0528.17613. Online ahead of print.ABSTRACTAlthough historically pre-eclampsia, preterm birth, abruption, fetal growth restriction and stillbirth have been viewed as clinically distinct entities, a growing body of literature has demonstrated that the placenta and its development is the root cause of many cases of these conditions. This has led to the term 'the great obstetrical syndromes' being coined to reflect this common origin. Although these conditions mostly manifest in the second half of pregnancy, a failure to complete deep placentation (the transition from histiotrophic placentat...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 2, 2023 Category: OBGYN Authors: Matthew K Hoffman Source Type: research
Associations between prediagnostic aspirin use and ovarian tumor gene expression
CONCLUSION: Our results suggest low and regular-dose aspirin may impair ovarian tumorigenesis in part via enhancing adaptive immune response and decreasing metastatic potential supporting the likely differential effects on ovarian carcinogenesis and progression by dose of aspirin.PMID:37525619 | DOI:10.1002/cam4.6386
Source: Cancer Control - August 1, 2023 Category: Cancer & Oncology Authors: Naoko Sasamoto Paul A Stewart Tianyi Wang Zachary J Thompson Sean J Yoder Jonathan L Hecht John L Cleveland Jose Conejo-Garcia Brooke L Fridley Kathryn L Terry Shelley S Tworoger Source Type: research
Remediation of water tainted with noxious aspirin and fluoride ion using UiO-66-NH < sub > 2 < /sub > loaded peanut shell
Environ Sci Pollut Res Int. 2023 Jul 31. doi: 10.1007/s11356-023-28906-x. Online ahead of print.ABSTRACTOne green adsorbent, UiO-66-NH2 modified peanut shell (c-PS-MOF), was prepared in a green synthetic route for improving the capture level of aspirin (ASP) and fluoride ion (F-). The adsorption properties of c-PS-MOF were evaluated by batch experiments and its physicochemical properties were explored by various characterization methods. The results showed that c-PS-MOF exhibited a wide range of pH applications (ASP: 2-10; F-: 3-12) and high salt resistance in the capturing processes of ASP and F-. The unit adsorption capa...
Source: Environmental Science and Pollution Research International - July 31, 2023 Category: Environmental Health Authors: Xiaoting Zhang Xiaoyu Han Yang Liu Runping Han Rong Wang Lingbo Qu Source Type: research
A genome-wide association study identifies 41 loci associated with eicosanoid levels
We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 loci associated with 92 eicosanoids and related metabolites. These findings highlight loci required for eicosanoid biosynthesis, including FADS1-3, ELOVL2, and numerous CYP450 loci. In addition, significant associations implicate a range of non-oxidative lipid metabolic processes in eicosanoid regulation, including at PKD2L1/SCD and several loci involved in fatty acyl-CoA metabolism. Further, our findings highlight select clearance mechanisms, for example, through the hepatic transporter encoded b...
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Eugene P Rhee Aditya L Surapaneni Pascal Schlosser Mona Alotaibi Yueh-Ning Yang Josef Coresh Mohit Jain Susan Cheng Bing Yu Morgan E Grams Source Type: research
Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients
CONCLUSIONS: Our findings have demonstrated that the use of DPP-4 inhibitors may be associated with a reduced incidence of first cardiovascular events in Japanese diabetic patients. The results require confirmation in randomized controlled trials.PMID:37522902 | DOI:10.1007/s00380-023-02291-4
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Hirofumi Soejima Hisao Ogawa Takeshi Morimoto Sadanori Okada Chisa Matsumoto Masafumi Nakayama Izuru Masuda Hideaki Jinnouchi Masako Waki Yoshihiko Saito JPAD Trial Investigators Source Type: research
Small-diameter PCL/PU vascular graft modified with heparin-aspirin compound for preventing the occurrence of acute thrombosis
Int J Biol Macromol. 2023 Jul 29:126058. doi: 10.1016/j.ijbiomac.2023.126058. Online ahead of print.ABSTRACTThe occurrence of acute thrombosis, directly related to platelet aggregation and coagulant system, is a considerable reason for the failure of small-diameter vascular grafts. Heparin is commonly used as a functional molecule for graft modification due to the strong anticoagulant effect. Unfortunately, heparin cannot directly resist the adhesion and aggregation of platelets. Therefore, we have prepared a heparin-aspirin compound by coupling heparin with aspirin, an antiplatelet drug, and covalently grafted it onto the...
Source: International Journal of Biological Macromolecules - July 31, 2023 Category: Biochemistry Authors: Si-Yuan Zhou Lei Li Enzehua Xie Mei-Xi Li Jian-Hua Cao Xiu-Bin Yang Da-Yong Wu Source Type: research
Preparation of drug-loaded chitosan microspheres repair materials
CONCLUSIONS: The research shows that the kaolin/chitosan drug-loaded microspheres prepared by the emulsification and cross-linking method are excellent drug-loading materials.PMID:37522660 | DOI:10.26355/eurrev_202307_33119
Source: Pharmacological Reviews - July 31, 2023 Category: Drugs & Pharmacology Authors: X Luo K-Y Tang Y-Y Wang Source Type: research
Aspirin 15cH has Different Effects on Morphology and Function of Lipopolysaccharide-Challenged RAW 264.7 Macrophages In Vitro Compared to a Pharmacological Dose of Aspirin
CONCLUSION: Aspirin 15cH, aspirin 200 µg/mL, LPS and succussed water appear to act as independent stimuli able to induce different patterns of macrophage response. Aspirin 15cH induced changes suggestive of M2 polarization of the macrophages (i.e., toward a wound healing or tissue repair, rather than inflammatory, phenotype). These preliminary findings need to be confirmed in further specific studies.PMID:37517405 | DOI:10.1055/s-0043-1769105
Source: Homeopathy - July 30, 2023 Category: Complementary Medicine Authors: Adalberto C von Ancken Nathalia Salles S de Medeiros Sandra Kalil Perdomo Mario Costa Cruz Anuska M Alvares-Saraiva Elizabeth C Perez Rodrigo Augusto da Silva Francisco Xavier Eizayaga Leoni Villano Bonamin Source Type: research
