Filtered By:
Drug: Aspirin
This page shows you your search results in order of date. This is page number 11.
Order by Relevance | Date
Total 5437 results found since Jan 2013.
Seeing Colchicine in a New Light: Repurposing Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
This article presents a brief overview of colchicine's long history as a medicine, as well as a critical review of safety and efficacy from the results of recent cardiovascular clinical trials.FINDINGS: Long-term continuous colchicine use at doses between 0.6 and 2.4 mg has been used to prevent inflammatory flares in patients with gout and familial Mediterranean fever and less commonly employed in a range of other inflammatory conditions. In these settings, lifelong therapy has been found to be safe and well tolerated. Understanding the central role of inflammation in atherosclerosis has led to the search for effective ant...
Source: Clinical Therapeutics - July 29, 2023 Category: Drugs & Pharmacology Authors: Stefan Mark Nidorf Source Type: research
Aspirin chemoprevention in colorectal cancer: network meta-analysis of low, moderate, and high doses
CONCLUSION: In this network meta-analysis of RCTs, high-dose aspirin was associated with a reduction in colorectal cancer incidence. However, this was based on a limited number of trials. This study did not show a statistically significant risk reduction in colorectal cancer incidence with mid- or low-dose aspirin.PMID:37499126 | DOI:10.1093/bjs/znad231
Source: The British Journal of Surgery - July 27, 2023 Category: Surgery Authors: Devansh Shah Angelina Di Re James W T Toh Source Type: research
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25;382:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity usin...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research
Aspirin chemoprevention in colorectal cancer: network meta-analysis of low, moderate, and high doses
CONCLUSION: In this network meta-analysis of RCTs, high-dose aspirin was associated with a reduction in colorectal cancer incidence. However, this was based on a limited number of trials. This study did not show a statistically significant risk reduction in colorectal cancer incidence with mid- or low-dose aspirin.PMID:37499126 | DOI:10.1093/bjs/znad231
Source: The British Journal of Surgery - July 27, 2023 Category: Surgery Authors: Devansh Shah Angelina Di Re James W T Toh Source Type: research
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity using hu...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research
Correction: Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly
Ann Intern Med. 2023 Jul 25. doi: 10.7326/L23-0274. Online ahead of print.NO ABSTRACTPMID:37487218 | DOI:10.7326/L23-0274
Source: Annals of Internal Medicine - July 24, 2023 Category: Internal Medicine Source Type: research
Eosinophilic Granulomatosis with Polyangiitis Presenting as Aspirin Exacerbated Respiratory Disease
Ann Allergy Asthma Immunol. 2023 Jul 22:S1081-1206(23)00519-7. doi: 10.1016/j.anai.2023.07.014. Online ahead of print.NO ABSTRACTPMID:37487803 | DOI:10.1016/j.anai.2023.07.014
Source: Annals of Allergy, Asthma and Immunology - July 24, 2023 Category: Allergy & Immunology Authors: Sabrina D Herzberg Alyssa M Bosso Neel R Sangal John V Bosso Source Type: research
Correction: Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly
Ann Intern Med. 2023 Jul 25. doi: 10.7326/L23-0274. Online ahead of print.NO ABSTRACTPMID:37487218 | DOI:10.7326/L23-0274
Source: Annals of Internal Medicine - July 24, 2023 Category: Internal Medicine Source Type: research
