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Total 5437 results found since Jan 2013.
CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research
Serotonin secretion by blood platelets: accuracy of high-performance liquid chromatography-electrochemical technique compared with the isotopic test and use in a clinical laboratory
CONCLUSION: HPLC-ECD assay for platelet serotonin secretion is highly accurate, has advantages over the reference 3H-5-HT test, and is suitable as a clinical laboratory technique.PMID:37601022 | PMC:PMC10439442 | DOI:10.1016/j.rpth.2023.102156
Source: Thrombosis and Haemostasis - August 21, 2023 Category: Hematology Authors: Eduardo Aranda Seiki Iha Sandra Solari David Rodr íguez Viviana Romero Luis Villarroel Jaime Pereira Olga Panes Diego Mezzano Source Type: research
Prenatal Care: An Evidence-Based Approach
Am Fam Physician. 2023 Aug;108(2):139-150.ABSTRACTWell-coordinated prenatal care that follows an evidence-based, informed process results in fewer hospital admissions, improved education, greater satisfaction, and lower pregnancy-associated morbidity and mortality. Care initiated at 10 weeks or earlier improves outcomes. Identification and treatment of periodontal disease decreases preterm delivery risk. A prepregnancy body mass index greater than 25 kg per m2 is associated with gestational diabetes mellitus, hypertension, miscarriage, and stillbirth. Advanced maternal and paternal age (35 years or older) is associated wit...
Source: American Family Physician - August 17, 2023 Category: Primary Care Authors: Sarah In és Ramírez Source Type: research
Prophylactic anticoagulants for non-hospitalised people with COVID-19
CONCLUSIONS: We found low- to moderate-certainty evidence from five RCTs that prophylactic anticoagulants result in little or no difference in major bleeding, DVT, need for hospitalisation, or adverse events when compared with placebo or no treatment in non-hospitalised people with COVID-19. Low-certainty evidence indicates that prophylactic anticoagulants may result in little or no difference in all-cause mortality when compared with placebo or no treatment, but moderate-certainty evidence indicates that prophylactic anticoagulants probably reduce the incidence of VTE and PE. Low-certainty evidence suggests that comparing...
Source: Cochrane Database of Systematic Reviews - August 17, 2023 Category: General Medicine Authors: Brena C Santos Ronald Lg Flumignan Vinicius T Civile Álvaro N Atallah Luis Cu Nakano Source Type: research
Prenatal Care: An Evidence-Based Approach
Am Fam Physician. 2023 Aug;108(2):139-150.ABSTRACTWell-coordinated prenatal care that follows an evidence-based, informed process results in fewer hospital admissions, improved education, greater satisfaction, and lower pregnancy-associated morbidity and mortality. Care initiated at 10 weeks or earlier improves outcomes. Identification and treatment of periodontal disease decreases preterm delivery risk. A prepregnancy body mass index greater than 25 kg per m2 is associated with gestational diabetes mellitus, hypertension, miscarriage, and stillbirth. Advanced maternal and paternal age (35 years or older) is associated wit...
Source: American Family Physician - August 17, 2023 Category: Primary Care Authors: Sarah In és Ramírez Source Type: research
