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Therapy: Stem Cell Therapy
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Total 1233 results found since Jan 2013.
Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling
This study aimed to investigate whether dental pulp stem cell conditioned medium (DPSC-CM) ameliorates SAH-induced microcirculation impairment and the underlying mechanisms. SAH was induced via intrathecal injection of fresh autologous blood in Wistar male adult rat. DPSC-CM or DPSC-CM + insulin growth factor-1 (IGF-1) antibody was randomly administered by intrathecal route 5 min after SAH induction. To evaluate the underlying mechanisms of DPSC-CM in the treatment of SAH, primary rat astrocyte and microglia co-cultures were challenged with hemolysate or SAH-patient CSF in t he presence or absence of DPSC-CM. The res...
Source: Translational Stroke Research - October 1, 2022 Category: Neurology Source Type: research
Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by inhibiting microRNA-15a-5p
ConclusionsConclusively, BMSC-released exosomes might carry long noncoding RNA ZFAS1 to curb oxidative stress and inflammation related to ischemic stroke, which was possibly realized through miR-15a-5p inhibition.
Source: Metabolic Brain Disease - October 1, 2022 Category: Neurology Source Type: research
Combination of EPC-EXs and NPC-EXs with miR-126 and miR-210 overexpression produces better therapeutic effects on ischemic stroke by protecting neurons through the Nox2/ROS and BDNF/TrkB pathways
CONCLUSION: EPC-EXsmiR-126 combined NPC-EXsmiR-210 further orchestrate the combinative protective effects of EPC-EXs and NPC-EXs on IS, possibly by protecting H/R-injured neurons through the Nox2/ ROS and BDNF/TrkB pathways.PMID:36174747 | DOI:10.1016/j.expneurol.2022.114235
Source: Experimental Neurology - September 29, 2022 Category: Neurology Authors: Xiaobing Xu Huiting Zhang Jiahui Li Yanyu Chen Wangtao Zhong Yanfang Chen Xiaotang Ma Source Type: research
Genes, Vol. 13, Pages 1664: Expression Profile of New Gene Markers Involved in Differentiation of Canine Adipose-Derived Stem Cells into Chondrocytes
artosz Kempisty
The interest in stem cell research continuously increased over the last decades, becoming one of the most important trends in the 21st century medicine. Stem cell-based therapies have a potential to become a solution for a range of currently untreatable diseases, such as spinal cord injuries, type I diabetes, Parkinson’s disease, heart disease, stroke, and osteoarthritis. Hence, this study, based on canine material, aims to investigate the molecular basis of adipose-derived stem cell (ASC) differentiation into chondrocytes, to serve as a transcriptomic reference for further research aiming...
Source: Genes - September 16, 2022 Category: Genetics & Stem Cells Authors: Maurycy Jankowski Mariusz Kaczmarek Grzegorz W ąsiatycz Aneta Konwerska Claudia Dompe Dorota Bukowska Pawe ł Antosik Paul Mozdziak Bartosz Kempisty Tags: Article Source Type: research
Cerebral dopamine neurotrophic factor increases proliferation, Migration and differentiation of subventricular zone neuroblasts in photothrombotic stroke model of mouse
Cerebral ischemic stroke can induce the proliferation of subventricular zone (SVZ) neural stem cells (NSCs) in the adult brain. However, this reparative process is restricted because of NSCs ’ death shortly after injury or disability of them to reach the infarct boundary. In the present study, we investigated the ability of cerebral dopamine neurotrophic factor (CDNF) on the attraction of SVZ-resident NSCs toward the lesioned area and neurological recovery in a photothrombotic (PT) st roke model of mice
Source: Journal of Stroke and Cerebrovascular Diseases - September 15, 2022 Category: Neurology Authors: Zahra Shabani, Hamid Soltani Zangbar, Ava Nasrolahi Source Type: research
Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents
In this study we compared the cell composition of COs at different culture time and explored the cell types, cell ratios and volume size of COs at 85 days (85 d-CO). The 85 d-CO with diameter more than 2 mm was chosen for establishing humanized ischemic stroke model of OGD. By determining the time-injury relationship of the model, we observed aggravated ischemic injury of COs with OGD exposure time, obtaining first-hand evidence for the damage degree of COs under different OGD condition. The sensitivity of the model to ischemic injury and related treatment was validated by the proven pan-Caspase inhibitor Z-VAD-FMK (20 μM...
Source: Acta Pharmacologica Sinica - September 13, 2022 Category: Drugs & Pharmacology Authors: Shu-Na Wang Zhi Wang Xi-Yuan Wang Xiu-Ping Zhang Tian-Ying Xu Chao-Yu Miao Source Type: research
Optimal therapeutic conditions for the neural stem cell-based management of ischemic stroke: a systematic review and network meta-analysis based on animal studies
This study aimed ...
Source: BMC Neurology - September 13, 2022 Category: Neurology Authors: Yongna Yang, Xurui Hu, Qijie Qin, Fanling Kong, Xiaolan Peng, Jing Zhao, Jianghua Si, Zhilong Yang and Shoupin Xie Tags: Research Source Type: research
EndMT-derived mesenchymal stem cells: a new therapeutic target to atherosclerosis treatment
Mol Cell Biochem. 2022 Sep 9. doi: 10.1007/s11010-022-04544-8. Online ahead of print.ABSTRACTCardiovascular diseases, such as coronary artery disease and stroke, are the main threats to human health worldwide. Atherosclerosis, a chronic inflammatory disorder, plays a role as an initiator of all of the above-mentioned diseases. Cell therapy for diseases has attracted widespread attention. Mesenchymal stem cells (MSCs) are a type of stem cell that still exist in adults and have the characteristics of self-renewal ability, pluripotent differentiation potential, immunomodulation, tissue regeneration, anti-inflammation and low ...
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Xiaofan Zhang Zhong Ren Zhisheng Jiang Source Type: research
Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke
Ischemic stroke is becoming one of the most common causes of death and disability in developed countries. Since current therapeutic options are quite limited, focused on acute reperfusion therapies that are hampered by a very narrow therapeutic time window, it is essential to discover novel treatments that not only stop the progression of the ischemic cascade during the acute phase, but also improve the recovery of stroke patients during the sub-acute or chronic phase. In this regard, several studies have shown that endothelial progenitor cells (EPCs) can repair damaged vessels as well as generate new ones following cerebr...
Source: Frontiers in Neurology - September 8, 2022 Category: Neurology Source Type: research
Bone marrow-derived mesenchymal stem cells overexpressed with miR-182-5p protects against brain injury in a mouse model of cerebral ischemia
This study investigates whether overexpressing miR-182-5p in bone marrow-derived mesenchymal stem cells (BM-MSCs) could potentiate the neuroprotective effects of BM-MSCs in a mouse model of ischemic brain injury.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2022 Category: Neurology Authors: Mingyang Deng, Jianyang Liu, Jialin He, Ziwei Lan, Shuangxi Cheng, Zhiping Hu, Han Xiao Source Type: research
Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia
Intravenous transplantation of mesenchymal stem (stromal) cells (MSC) is a promising approach to the treatment of ischemic stroke. In the published reports of the already completed preclinical and clinical studies the dosages of transplanted MSC greatly vary. However, the optimal dosage has not been determined. The dose-dependent effect of intravenous MSC transplantation was studied, in rats with experimental cerebral infarction. To this end, 5 ×105 and 2 ×106 MSC were intravenously administered 24 h after modeling of acute focal ischemia followed by complex assessment of the therapeutic efficacy over 60 days. The rate a...
Source: Bulletin of Experimental Biology and Medicine - September 5, 2022 Category: Biology Source Type: research
