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Therapy: Stem Cell Therapy
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Total 1233 results found since Jan 2013.
ASA: Stem Cell Transplant Improves Vasculopathy in Sickle Cell Patients
THURSDAY, Feb. 9, 2023 -- For adults with sickle cell disease (SCD), hematopoietic stem cell transplantation (HSCT) seems to improve or prevent development of vasculopathies, according to a study presented at the American Stroke Association...
Source: Drugs.com - Pharma News - February 9, 2023 Category: Pharmaceuticals Source Type: news
Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia
CONCLUSIONS: Fibrinogen deposition inhibits remyelination after ischemic damage and NSC-derived exosomal miR-128-3p promotes OPC differentiation into OLs by suppressing BMP signaling, indicating that NSC-derived exosomal miR-128-3p represents a potential therapeutic target for ischemic stroke.PMID:36756722 | DOI:10.1111/cns.14113
Source: CNS Neuroscience and Therapeutics - February 9, 2023 Category: Neuroscience Authors: Huiqing Hou Yafei Wang Lan Yang Yongjun Wang Source Type: research
An overview of hyperbaric oxygen preconditioning against ischemic stroke
This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observe...
Source: Metabolic Brain Disease - February 2, 2023 Category: Neurology Source Type: research
Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF- κB Axis
Neurochem Res. 2023 Jan 30. doi: 10.1007/s11064-023-03866-3. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke and the second leading cause of death overall. Neural stem cells play protective roles in IS, but the underlying mechanism remains to be determined. Neural stem cells (NSC) were obtained from the fetal brain tissue of C57BL/6J mice. NSC-derived exosomes (NSC-Exos) were identified in the conditioned medium. Internalization of NSC-Exos was analyzed by fluorescence microscopy. In vitro microglia ischemic stroke injury model was induced using oxygen glucose deprivation/re-oxygenation...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Jun Peng Zhengtao Yu Rongjun Xiao Xiqi Hu Ying Xia Source Type: research
Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
CONCLUSIONS: This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF.PMID:36691091 | DOI:10.1186/s13287-023-03236-4
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Satoru Yabuno Takao Yasuhara Takayuki Nagase Satoshi Kawauchi Chiaki Sugahara Yosuke Okazaki Kakeru Hosomoto Susumu Sasada Tatsuya Sasaki Naoki Tajiri Cesar V Borlongan Isao Date Source Type: research
Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling
Cell Stress Chaperones. 2023 Jan 9. doi: 10.1007/s12192-022-01319-4. Online ahead of print.ABSTRACTApoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion injury (I/R injury). Previous in vitro and in vivo studies have suggested that following I/R injury, ER stress is vital for mediating CCAT-enhancer-binding protein homologous protein (CHOP) and caspase-12-dependent apoptosis. However, its modulation in the presence of stem cells and the underlying mechanism of cytoprotection remains elusive. In vivo studies from our lab have reported ...
Source: Cell Stress and Chaperones - January 9, 2023 Category: Cytology Authors: Harpreet Kaur Deepaneeta Sarmah Aishika Datta Anupom Borah Dileep R Yavagal Pallab Bhattacharya Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
