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Therapy: Stem Cell Therapy
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Total 1233 results found since Jan 2013.
Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1
CONCLUSION: Collectively, exosomal miR-145-derived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1. These studies may serve as a potential approach for treating of cerebral I/R injury.PMID:36206599 | DOI:10.1016/j.bbrc.2022.09.089
Source: Cell Research - October 7, 2022 Category: Cytology Authors: Hai Zhou Jing Zhou Hongwei Teng Hua Yang Jinsong Qiu Xiangdong Li Source Type: research
Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling
This study aimed to investigate whether dental pulp stem cell conditioned medium (DPSC-CM) ameliorates SAH-induced microcirculation impairment and the underlying mechanisms. SAH was induced via intrathecal injection of fresh autologous blood in Wistar male adult rat. DPSC-CM or DPSC-CM + insulin growth factor-1 (IGF-1) antibody was randomly administered by intrathecal route 5 min after SAH induction. To evaluate the underlying mechanisms of DPSC-CM in the treatment of SAH, primary rat astrocyte and microglia co-cultures were challenged with hemolysate or SAH-patient CSF in the presence or absence of DPSC-CM. The results sh...
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Ling-Yu Yang Yong-Ren Chen Jing-Er Lee Kuo-Wei Chen Hui-Tzung Luh Yi-Tzu Chen Kuo-Chuan Wang Sung-Tsang Hsieh Source Type: research
