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Therapy: Stem Cell Therapy
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Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
