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Nutrition: Calcium

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Total 132 results found since Jan 2013.

Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients.
CONCLUSIONS: The plasma FGF23 may be a potential biomarker for cerebral atherosclerosis, particularly the presence and burden of ICAS in stroke patients. PMID: 31942755 [PubMed]
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Human Milk Oligosaccharide 2 ′-Fucosyllactose Reduces Neurodegeneration in Stroke Brain
In conclusion, our data suggest that 2’-FL has neuroprotective action through inhibition of Ca++i, inflammation, and apoptosis. Posttreatment with 2 ’-FL facilitates neural repair in stroke brain.
Source: Translational Stroke Research - January 1, 2020 Category: Neurology Source Type: research

Anti-hypertensive agents in Alzheimer's disease: beyond vascular protection.
Authors: Lebouvier T, Chen Y, Duriez P, Pasquier F, Bordet R Abstract INTRODUCTIONMidlife hypertension has been consistently linked with increased risk of cognitive decline and Alzheimer's disease (AD). Observational studies and randomized trials show that the use of antihypertensive therapy is associated with a lesser incidence or prevalence of cognitive impairment and dementia. However, whether anti-hypertensive agents specifically target the pathological process of AD remains elusive.AREAS COVEREDThis review of literature provides an update on the clinical and preclinical arguments supporting anti-AD properties of ...
Source: Expert Review of Neurotherapeutics - December 24, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The Relation of Calcium Volume Score and Stenosis of Carotid Artery
The aim of this study was to investigate the value of extracranial carotid artery calcium score in predicting severity of carotid arterial stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2019 Category: Neurology Authors: Maryam Moradi, Mohammad Mehdi Baradaran Mahdavi, Mehdi Karami Nogourani Source Type: research

Continuous theta burst stimulation provides neuroprotection by accelerating local cerebral blood flow and inhibiting inflammation in a mouse model of acute ischemic stroke.
Abstract Acute ischemic stroke is a leading cause of disability with limited therapeutic options. Continuous theta burst stimulation (cTBS) has recently been shown to be a promising noninvasive therapeutic strategy for neuroprotection in ischemic stroke patients. Here, we investigated the protective effects of cTBS following acute infarction using a photothrombotic stroke (PTS) model in the right posterior parietal cortex (PPC) of C57BL/6 mice. Treatment with cTBS resulted in a reduction in the volume of the infarct region and significantly increased vascular diameter and blood flow velocity in peri-infarct region...
Source: Brain Research - October 2, 2019 Category: Neurology Authors: Wu C, Li MN, Feng YW, He XF, Li WQ, Liang FY, Li X, Li G, Pei Z, Lan Y, Xu GQ Tags: Brain Res Source Type: research

Acute symptomatic seizures and epilepsy after mechanical thrombectomy
ConclusionsThe incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further.This article is part of the Special Issue "Seizures & Stroke".
Source: Epilepsy and Behavior - September 14, 2019 Category: Neurology Source Type: research

Acute symptomatic seizures and epilepsy after mechanical thrombectomy.
CONCLUSIONS: The incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further. This article is part of the Special Issue "Seizures & Stroke". PMID: 31526644 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - September 12, 2019 Category: Neurology Authors: Eriksson H, Löwhagen Hendén P, Rentzos A, Pujol-Calderón F, Karlsson JE, Höglund K, Blennow K, Zetterberg H, Rosengren L, Zelano J Tags: Epilepsy Behav Source Type: research

Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke
This study aimed to investigate whether PKA signaling mediated by 5-HT1A receptors was involved in the electroacupuncture (EA)-mediated learning and memory in a rat model of middle cerebral artery occlusion-induced cognitive deficit (MICD). Compared to no treatment or non-acupoint EA treatment, EA at DU20 and DU24 acupoints improved the neurological deficit of scores, shortened escape latency and increased the frequency of crossing the platform in the Morris water maze test. T2-weighted imaging demonstrated that the MICD rat brain lesions were mainly located in the cortex and hippocampus, and injured volumes were reduced a...
Source: Metabolic Brain Disease - September 11, 2019 Category: Neurology Source Type: research

KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3 β pathway.
KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway. Neurobiol Dis. 2019 Aug 27;:104588 Authors: Wei T, Wang Y, Xu W, Yan L, Chen H, Yu Z Abstract Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active in the phenotypic switch that occurs during astrogliosis in Alzheimer's disease and ischemic stroke. Here, transcriptome sequencing (RNA-Seq), immunohistochemistry, western blotting, pharmacological blockade, and calcium...
Source: Neurobiology of Disease - August 26, 2019 Category: Neurology Authors: Wei T, Wang Y, Xu W, Yan L, Chen H, Yu Z Tags: Neurobiol Dis Source Type: research

Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke
Conclusion: Our findings indicate a relationship between coronary atherosclerotic burden measured by the CAC score and the severity of sleep apnea. Performing polysomnography could be useful for investigating the severity of hidden coronary artery disease among these patients.
Source: Frontiers in Neurology - July 30, 2019 Category: Neurology Source Type: research

An unusual combination of neurological manifestations and sudden vision loss in a child with familial hyperphosphatemic tumoral calcinosis
We report a child with hyperphosphatemia who presented with multiple episodes of neurologic dysfunction involving lower motor neuron facial nerve palsy along with sequential visual loss. He also had an episode of stroke. There was an extensive metastatic calcification of soft tissue and vasculature. Hyperphosphatemia with normal serum alkaline phosphatase, calcium, parathyroid hormone, and renal function was noted. He was managed with hemodialysis and sevelamer (3 months) without much success in reducing serum phosphate level, requiring continuous ambulatory peritoneal dialysis (3 years). Intact fibroblast growth factor 23...
Source: Annals of Indian Academy of Neurology - June 30, 2019 Category: Neurology Authors: Lokesh Lingappa Shoji Ichikawa Amie K Gray Dena Acton Michael J Evans Rajsekara Chakravarthi Madarasu Ramesh Kekunnaya Sirisharani Siddaiahagari Source Type: research

Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels
AbstractHippocampal injury and cognitive impairments are common after cardiac arrest and stroke and do not have an effective intervention despite much effort. Therefore, we developed a new approach aimed at reversing synaptic dysfunction by targeting TRPM2 channels. Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in mice was used to investigate cognitive deficits and the role of the calcium-permeable ion channel transient receptor potential-M2 (TRPM2) in ischemia-induced synaptic dysfunction. Our data indicates that absence (TRPM2−/−) or acute inhibition of TRPM2 channels with tatM2NX reduced hippocampal cell dea...
Source: Translational Stroke Research - June 27, 2019 Category: Neurology Source Type: research

Intracranial Artery Calcium Burden Predicts Recurrent Cerebrovascular Events in Transient Ischaemic Attack Patients
Background: Patients with initial transient ischaemic attack (TIA) subsequently have a higher risk of recurrent TIA or acute ischemic stroke (AIS). The role of scoring intracranial arterial calcification (IAC) in predicting the prevalence of stroke remains unclear. We aim to evaluate if radiological CT calcium score measuring IAC burden could predict future ischemic events in a cohort of TIA patients. Methods: We studied consecutive patients from July 2014 to December 2015 who presented with first episode of TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2019 Category: Neurology Authors: Wan Yee Kong, Benjamin YQ Tan, Eide Sterling Ellis, Nicholas JH Ngiam, Wilson GW Goh, Vijay K Sharma, Bernard PL Chan, Leonard LL Yeo Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research