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Impaired theory of mind in Chinese children and adolescents with idiopathic generalized epilepsy: Association with behavioral manifestations of executive dysfunction
Conclusions Our results revealed significant impairments in ToM and EF in children and adolescents with IGE compared with healthy controls. We found significant correlations between ToM and two subcomponents of EF (inhibition and working memory) in children with IGE. Additionally, the duration of seizures affected ToM in patients but was a less powerful predictor than the two subcomponents of EF. Even for children with new-onset seizures and without medication, the deficits in ToM and some distinct subscales of EF were apparent. This result has clinical implications for both nonpharmaceutical therapies and cognitive rehabi...
Source: Epilepsy and Behavior - January 6, 2018 Category: Neurology Source Type: research

Facial emotion processing in patients with seizure disorders
This study provides preliminary evidence that patients with PNES exhibit altered facial emotion processing compared with patients with TLE and HCs and increased amygdala functional connectivity compared with TLE. These findings identify potential key differences in facial emotion processing reflective of neurophysiologic markers of neural circuitry alterations that can be used to generate further hypotheses for developing studies that examine the contributions of emotion processing to the development and maintenance of PNES. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 6, 2018 Category: Neurology Source Type: research

Allergy in patients with anti-N-methyl-d-aspartate receptor encephalitis
Conclusions Patients with anti-NMDAR encephalitis show higher allergic rate than those with virus encephalitis. Patients with allergy show higher CSF antibody titers and greater illness severity. However, the final outcome of anti-NMDAR encephalitis was not influenced. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 5, 2018 Category: Neurology Source Type: research

Verbal learning and memory outcome in selective amygdalohippocampectomy versus temporal lobe resection in patients with hippocampal sclerosis
Conclusion In patients with drug-resistant focal MTLE, HS and no magnetic resonance imaging (MRI) signs of dual pathology, selective amygdalohippocampectomy results in sustained seizure freedom and better memory function compared with patients operated with nonselective temporal lobe resection. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 5, 2018 Category: Neurology Source Type: research

Pregestational stress attenuated fertility rate in dams and increased seizure susceptibility in offspring
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Maryam Mahmoodkhani, Ehsan Saboory, Shiva Roshan-Milani, Negar Azizi, Mojtaba Karimipour, Yosef Rasmi, Zafar Gholinejad Many studies have found that stress during pregnancy is linked to an increased incidence of epileptic behaviors and reproductive disorders. However, few works have investigated the effect of pregestational stress on seizure susceptibility in the offspring. We investigated the effect of pregestational stress on epileptic behaviors in the offspring as well as fertility rate in dams. The male and female rats were random...
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Jawad Laadraoui, Kenza Bezza, Zineb El Gabbas, Fatimazahra Marhoume, El Mehdi Wakrim, Hind Ferehan, Rachida Aboufatima, Zahra Sokar, Najib Kissani, Abderrahman Chait Tobacco smoking is considered the greatest risk factor for early death caused by noncommunicable diseases. Currently, there are more than one billion tobacco smokers in the world predisposed to many diseases including heart attack, stroke, cancer, and premature birth or birth defects related to the consumption of cigarettes. However, studies on the association between tob...
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Phenotype variability of GLUT1 deficiency syndrome: Description of a case series with novel SLC2A1 gene mutations
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Lidia Di Vito, Laura Licchetta, Tommaso Pippucci, Sara Baldassari, Carlotta Stipa, Barbara Mostacci, Lara Alvisi, Paolo Tinuper, Francesca Bisulli (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Patients' perspectives on management and barriers of regular antiepileptic drug intake
Conclusion Patients treated by neurologists specialized in epileptology did not report less problems with adherence than patients surveyed in pharmacies. Since barriers for a regular intake are diverse, the use of a short questionnaire on management of drug intake may lead to an individually tailored counseling of patients to improve adherence. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Symptoms of anxiety and depression and family's quality of life in children and adolescents with epilepsy
Conclusions Anxiety and depression in CAWE are independent from the characteristics of the disease but are correlated to the lower well-being of the family. A search of these emotional problems is recommended for better care of the patients and their families. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Association of white matter diffusion characteristics and cognitive deficits in temporal lobe epilepsy
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Raúl Rodríguez-Cruces, Leticia Velázquez-Pérez, Ildefonso Rodríguez-Leyva, Ana Luisa Velasco, David Trejo-Martínez, Héctor Manuel Barragán-Campos, Vicente Camacho-Téllez, Luis Concha Objective The purpose of this study was to evaluate the relation between cognitive performance and white matter (WM) integrity in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS). Methods We included 26 patients with TLE (10 right, 16 left onset) as well as 24 he...
Source: Epilepsy and Behavior - January 4, 2018 Category: Neurology Source Type: research

Favorable adverse effect profile of brivaracetam vs levetiracetam in a preclinical model
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Nathalie T. Sanon, Jonathan Gagné, Daniele C. Wolf, Soumia Aboulamer, Ciprian M. Bosoi, Alexe Simard, Estelle Messiet, Sébastien Desgent, Lionel Carmant Levetiracetam (LEV), and its newer selective analog brivaracetam (BRV), are two seizure medications that share an innovative mechanism of action targeting the Synaptic Vesicle Protein 2A (SV2A), altering neurotransmitter release and decreasing seizure frequency. Behavioral changes are the most significant adverse effects reported by patients taking LEV. We hypothesize th...
Source: Epilepsy and Behavior - December 26, 2017 Category: Neurology Source Type: research

The effectiveness and safety of lacosamide in children with epilepsy in a clinical practice setting
Conclusions Lacosamide use in children with refractory focal epilepsy can result in a reduction in seizure rate that improves progressively over time with few adverse effects, making lacosamide a promising option in these patients. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 26, 2017 Category: Neurology Source Type: research

Impact of vagus nerve stimulation on sleep-related breathing disorders in adults with epilepsy
Conclusion Despite the relatively modest clinical impact on epilepsy, in view of the associated cardiovascular risk factor development, easy treatment, and the relatively high SAS prevalence, routine screening for SAS before and after VNS implantation may represent a reasonable practice. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 26, 2017 Category: Neurology Source Type: research

How to assess physical activity in people with epilepsy?
Publication date: Available online 23 December 2017 Source:Epilepsy & Behavior Author(s): Rodrigo Luiz Vancini, Marília Santos Andrade, Hudson Renato de Paula Oliveira, Claudio Andre Barbosa de Lira (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 24, 2017 Category: Neurology Source Type: research

Clinical correlates of negative health events in a research sample with epilepsy
Conclusions Consistent with previous literature, more frequent seizures were associated with worse depression severity and quality of life. A finding that is less established is that higher seizure frequency is also associated with worse epilepsy-related stigma. Epilepsy self-management approaches need to address depression and stigma as well as seizure control. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 24, 2017 Category: Neurology Source Type: research

Modulation of the anticonvulsant effect of swim stress by agmatine
In this study, we investigated the interaction of agmatine with the anticonvulsant effect of swim stress in mice on pentylenetetrazole (PTZ)-induced seizure threshold. Then we studied the involvement of nitric oxide (NO) pathway and endogenous opioid system in that interaction. Swim stress induced an anticonvulsant effect on PTZ seizures which was opioid-independent in shorter than 1-min swim durations and opioid-dependent with longer swims, as it was completely reversed by pretreatment with naltrexone (NTX) (10mg/kg), an opioid receptor antagonist. Agmatine significantly enhanced the anticonvulsant effect of opioid-indepe...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors
Publication date: January 2018 Source:Epilepsy & Behavior, Volume 78 Author(s): Andrew Hooper, Rumzah Paracha, Jamie Maguire Our laboratory recently demonstrated that seizures activate the hypothalamic-pituitary-adrenal (HPA) axis, increasing circulating levels of corticosterone (O'Toole et al., 2013). Given the well-established proconvulsant actions of corticosterone, we hypothesized that seizure-induced activation of the HPA axis may contribute to future seizure susceptibility. Further, since hypercortisolism is associated with depression, we propose that seizure-induced activation of the HPA axis may contribute...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis
Publication date: January 2018 Source:Epilepsy & Behavior, Volume 78 Author(s): Clarissa Vasconcelos de Oliveira, Jéssica Grigoletto, Julia Marion Canzian, Marta Maria Medeiros Frescura Duarte, Thiago Duarte, Ana Flávia Furian, Mauro Schneider Oliveira Temporal lobe epilepsy (TLE) is the most frequent and medically refractory type of epilepsy in humans. In addition to seizures, patients with TLE suffer from behavioral alterations and cognitive deficits. Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, o...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Concordance between the Wada test and neuroimaging lateralization: Influence of imaging modality (fMRI and MEG) and patient experience
We present these discordant findings in support of the position that functional imaging and the Wada test are distinctive procedures, with little in the way of overlapping mechanisms, and that patient's experience should be taken into account when procedures are selected and offered to them. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Optimizing clobazam treatment in patients with Lennox –Gastaut syndrome
Publication date: January 2018 Source:Epilepsy & Behavior, Volume 78 Author(s): Jouko Isojarvi, Barry E. Gidal, Steve Chung, Robert T. Wechsler Given the complexities managing Lennox–Gastaut syndrome (LGS)—comorbid conditions, multiple associated seizure types that tend to be refractory to treatment—dosage optimization of antiepileptic drug (AED) treatment is a challenge. In the absence of clinical trial data on optimization of AED dosage in patients with LGS, dose titration is guided by personal experience, anecdotal evidence, and specific patient factors (age, comorbid conditions and medication...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Efficacy and safety of vigabatrin in Japanese patients with infantile spasms: Primary short-term study and extension study
This study evaluated the efficacy and safety of vigabatrin for Japanese patients with infantile spasms. Of 15 patients (aged ≥4weeks and <2years) enrolled, with the exception of two patients who did not receive vigabatrin, 13 were treated with a titrated dosage of vigabatrin (50–150mg/kg/day; limited to 3000mg/day). Twelve out of 13 patients receiving vigabatrin had spasms that were treatment refractory; these patients were concurrently treated with at least one other antiepileptic drug. One patient received vigabatrin monotherapy. Eight of the 13 patients (61.5% [95% CI: 31.6–86.1%]) had a ≥50% re...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Mozart's music in children with drug-refractory epileptic encephalopathies: Comparison of two protocols
In conclusion, the present study seems to confirm that music therapy may be an additional, nonpharmacological, effective treatment for patients with refractory epileptic seizures in childhood. The Mozart's set of different compositions can be better accepted and effective than the K448. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

IDH1 and IDH2 mutations in postoperative diffuse glioma-associated epilepsy
Publication date: January 2018 Source:Epilepsy & Behavior, Volume 78 Author(s): Andrew Neal, Patrick Kwan, Terence John O'Brien, Michael E. Buckland, Michael Gonzales, Andrew Morokoff Objective Isocitrate dehydrogenase 1 and 2 mutations (IDH1/2) have an established association with preoperative seizures in patients with grades II–IV diffuse gliomas. Here, we examined if IDH1/2 mutations are a biomarker of postoperative seizure frequency. Methods This was a retrospective study. Patients with grades II–IV supratentorial diffuse glioma, immunohistochemistry results of IDH1-R132H, and antiepileptic drug (A...
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Perceived epilepsy stigma mediates relationships between personality and social well-being in a diverse epilepsy population
Conclusion Higher neuroticism and lower extraversion covaried with stigma beliefs, and these may be markers of poor social outcomes in PWE. Mediation models suggest that targeting epilepsy stigma beliefs may be a particularly useful component to incorporate when developing interventions aimed at promoting social well-being in diverse PWE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Stigma accounts for depression in patients with epilepsy
Conclusion This study shows that stigmatization of the patients with epilepsy leads to depression in those patients. Therefore, protection of the patients with epilepsy against stigmatization may also help to protect them from a concomitant disabling condition. On the other hand, detection for depressive symptoms in already stigmatized patients with epilepsy may unearth a treatable condition. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 23, 2017 Category: Neurology Source Type: research

Knowledge about epilepsy in university health students: A multicenter study
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Priscila Souza, Leslie A. Portes, Robert K. Thomas, Jorge R. Bonito, Marilia Rua, Fabio J. Pacheco, Phillip Plaatjes, Natalia C. Oliveira Even with economic development and improvements in health care around the world, it is estimated that nowadays, 50 million people have epilepsy. It is one of the most prevalent neurological diseases, yet it is still surrounded by prejudice, stigma, lack of awareness, and wrong attitudes of the population towards the disease. The aim of this study was to evaluate and compare the knowledge about epile...
Source: Epilepsy and Behavior - December 22, 2017 Category: Neurology Source Type: research

Antidepressants in people with epilepsy: A double-edge sword!
Publication date: Available online 21 December 2017 Source:Epilepsy & Behavior Author(s): Rocco Salvatore Calabrò, Alfredo Manuli, Simona Portaro, Antonino Naro, Fabrizio Quattrini (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 21, 2017 Category: Neurology Source Type: research

Interictal cardiac repolarization abnormalities in people with epilepsy
Conclusions Corrected QT interval prolongation (both severe and borderline) was more prevalent among patients with epilepsy, especially if uncontrolled or elderly. Electrocardiogram should be established as a part of the diagnostic workup of epilepsy in order to identify such electrocardiographic abnormality. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 21, 2017 Category: Neurology Source Type: research

A clinical social worker's epilepsy treatment perspective
Publication date: Available online 20 December 2017 Source:Epilepsy & Behavior Author(s): Susan Vosburgh, Steven Owens (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 20, 2017 Category: Neurology Source Type: research

Evaluation of the "non-epileptic" patient in a tertiary center epilepsy clinic
Conclusions A significant proportion of patients seen in our tertiary care epilepsy clinic is in fact, not patients with epilepsy. Enhanced knowledge of these differential diagnosis and important anamnesis components to rule out seizures will help improve guidelines for referral to Epilepsy clinic and cost-effectively optimize the use of paraclinical investigations. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 19, 2017 Category: Neurology Source Type: research

Seizure activity and individual vulnerability on first-episode interictal psychosis in epilepsy
Conclusions The accumulation of seizure-related damages and family history of psychosis is associated with the onset of IIP episodes, particularly in the patients with PE. Seizure activity and individual vulnerability to psychosis are likely to be interacted for as the development of IIP in patients with epilepsy. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

People with epilepsy are diagnosed most often with unspecified epilepsy, followed by focal epilepsy, generalized convulsive epilepsy, and generalized nonconvulsive epilepsy —US MarketScan data, 2010–2015
Publication date: Available online 15 December 2017 Source:Epilepsy & Behavior Author(s): Sanjeeb Sapkota, Rosemarie Kobau, Daniel M. Pastula, Matthew M. Zack The distribution of epilepsy types varies by age, etiology, provider diagnostic capabilities, and assessment criteria. No recent US study has examined the distribution of epilepsy types in a large, population-based sample of people with epilepsy. We used MarketScan data from January 1, 2010 through September 30, 2015, to estimate the proportion of epilepsy types among all (N=370,570) individuals diagnosed with epilepsy. We identified cases of epilepsy as ind...
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

“By working together and caring for one another we can win this fight”: A qualitative exploration of a traditional healer's perspectives of care of people with epilepsy in a South African urban township in Cape Town
Publication date: Available online 15 December 2017 Source:Epilepsy & Behavior Author(s): Mpoe Johannah Keikelame, Leslie Swartz There is a gap in knowledge about the construction of care in the Global South where biomedical care remains largely inaccessible to many people, resulting in people seeking health care from the indigenous sector of health care. As part of a larger study, in this, article we present findings from a single individual interview with an indigenous healer using a semi-structured interview guide that was based on Kleinman's Explanatory Model Framework. Key themes that emerged from the themati...
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

Impact of the modified Atkins diet on cardiovascular health in adults with epilepsy
Conclusion Our results provide clinical evidence demonstrating the cardiovascular safety of a high-fat, low-carbohydrate diet used in adults with epilepsy for at least 12months. It also highlights potential markers of cardiovascular risk – small dense LDL particles – that should be closely monitored in adults treated with diet therapy long-term. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy
Conclusions While memory demonstrated some decline in the long run, what is most important is that a progressive decline in memory is seldom found after sAH in patients with LE. Moreover, the dynamics in performance and MRI before and after surgery reveal disease dynamics independent of surgery. Selective amygdalohippocampectomy can lead to seizure freedom, but should be considered as a last resort treatment option for drug-resistant patients with temporal lobe epilepsy due to LE. Particular caution is recommended in patients with GAD65-LE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

Effect of lacosamide on depression and anxiety symptoms in patients with focal refractory epilepsy: A prospective multicenter study
Conclusion Lacosamide seems to have a positive effect on depressive and anxiety symptoms. Although the efficacy of LCM in seizure control was demonstrated, the antidepressant and anxiolytic effect on mood and anxiety seems to be an independent factor. Graphical abstract (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

The influence of EEG-detected nocturnal centrotemporal discharges on the expression of core symptoms of ADHD in children with benign childhood epilepsy with centrotemporal spikes (BCECTS): A prospective study in a tertiary referral center
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Pavlína Danhofer, Jana Pejčochová, Ladislav Dušek, Ivan Rektor, Hana Ošlejšková Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most frequent benign focal epilepsy in childhood. Although it is described as a benign epilepsy syndrome, many studies have revealed that a significant number of patients have some degree of neuropsychological impairment. Thirty-two patients with BCECTS aged 6–11years were included in the study. All patients (without any antiepileptic or ps...
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

Internalizing and externalizing symptoms in preschool and school-aged children with epilepsy: Focus on clinical and EEG features
Conclusions Several clinical and EEG features are associated with an increased risk for emotional and behavioral comorbidities in children with epilepsy. Their identification may foster an early diagnosis and appropriate care, limiting the worsening of psychiatric symptoms and their impact on quality of life and health status. A better understanding of the underlying clinical and molecular mechanisms is needed to further improve prevention and treatment interventions. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

The electroclinical spectrum, etiologies, treatment and outcome of nonconvulsive status epilepticus in the elderly
Conclusion In the elderly, NCSE has heterogeneous electroclinical phenotypes and etiologies. In spite of the treatment limitations conditioned by the comorbidities, more aggressive treatments could be justified to reduce mortality in patients with high STESS scores. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

A discrete-choice experiment to elicit preferences of patients with epilepsy for self-management programs
Conclusion Given the heterogeneity of the epilepsies, preferences, and dispreferences across subgroups, our study highlights that if full account is not taken of different segmentation strategies when designing a self-management program, a large proportion of the population may not be attracted to it. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

The clinical impact of integration of magnetoencephalography in the presurgical workup for refractory nonlesional epilepsy
Conclusion In this single center retrospective study, MEG would have changed patient management, icEEG planning, and surgical outcome in a significant percentage of patients with NLRFE and should be considered in the presurgical workup in those patients. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 16, 2017 Category: Neurology Source Type: research

Predictors of outcomes and refractoriness in status epilepticus: A prospective study; Methodological issues
Publication date: Available online 13 December 2017 Source:Epilepsy & Behavior Author(s): Mostafa Qorbani, Saeid Safiri (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 13, 2017 Category: Neurology Source Type: research

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis
Conclusion Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 13, 2017 Category: Neurology Source Type: research

Intraindividual variability in attentional vigilance in children with epilepsy
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Kyle Srnka, Michael Seidenberg, Bruce Hermann, Jana Jones Attentional vigilance, the ability to maintain focus over time, is frequently impaired in childhood epilepsy. Typically, indices of Omissions (failure to detect a target) and Commissions (responding to a nontarget) are considered primary indices of attentional vigilance. Recently, the concept of intraindividual variability (IIV) has been identified as an important measure of attentional vigilance in several pediatric and adult clinical populations, but has not yet been systemat...
Source: Epilepsy and Behavior - December 13, 2017 Category: Neurology Source Type: research

Community-based rehabilitation offers cost-effective epilepsy treatment in rural Guinea-Bissau
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Eric van Diessen, Frank van der Maas, Vladimir Cabral, Willem M. Otte Treatment of epilepsy in low-income countries is a challenge considering the lack of resources, availability of antiepileptic drugs, and cultural beliefs. We used a community-based rehabilitation (CBR) service for the detection, monitoring, and treatment of epilepsy. A local network of trained community volunteers provided education, good quality antiepileptic drugs, and clinical follow-up for people with epilepsy (PWE). In a period of 2years, approximately 22,500 p...
Source: Epilepsy and Behavior - December 13, 2017 Category: Neurology Source Type: research

ECoG high-gamma modulation versus electrical stimulation for presurgical language mapping
Conclusion Electrocorticographic high-γ modulation is a specific but not sensitive method for language localization compared with gold-standard ESM. Given the pooled DOR of 6.44 and AUC of 0.77, ECoG HGM can fairly reliably ascertain electrodes overlying ESM cortical language sites. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 13, 2017 Category: Neurology Source Type: research

Prevalence of anxiety disorders in epilepsy
Conclusions Panic disorder and other forms of AD are common among PWE. Age and age of seizure onset are important factors associated with AD among PWE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 8, 2017 Category: Neurology Source Type: research

The different patterns of seizure-induced aphasia in temporal lobe epilepsies
This study investigated the different facets of ictal aphasia in intracerebrally recorded TLE. Methods Video-stereoelectroencephalography (SEEG) recordings of 37 seizures in 17 right-handed patients with drug-resistant TLE were analyzed; SEEG electroclinical correlations between language disturbance and involvement of temporal lobe structures were assessed. In the clinical analysis, we separated speech disturbance from loss of consciousness. Results According to the region involved, different patterns of ictal aphasia in TLE were identified. Impaired speech comprehension was associated with posterior lateral involvement, a...
Source: Epilepsy and Behavior - December 7, 2017 Category: Neurology Source Type: research

Juvenile myoclonic epilepsy – An insider's guide
Publication date: Available online 7 December 2017 Source:Epilepsy & Behavior Author(s): Timothy J. Counihan (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 7, 2017 Category: Neurology Source Type: research

Pregnancy-related knowledge of women with epilepsy — An internet-based survey in German-speaking countries
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Carolin Dierking, Thomas Porschen, Uwe Walter, Johannes Rösche There are several issues, which have to be acknowledged, when treating women with epilepsy (WWE). The need for counseling WWE in Germany with epilepsy on pregnancy-related matters was stressed in several papers and medical guidelines. Physicians treating WWE in Germany therefore should be aware of the information needs of their patients. We aimed to determine the level of pregnancy-related knowledge of WWE and their informational needs concerning pregnancy and childbi...
Source: Epilepsy and Behavior - December 7, 2017 Category: Neurology Source Type: research