Association between seizure freedom and default mode network reorganization in patients with unilateral temporal lobe epilepsy
ConclusionSeizure freedom seems to be associated with hub redistributions that may underlie longer paths and (in trend) reduced local efficiency of the network. An associated slower system response might reduce the probability of a rapid spread of epileptic discharges over the whole network and may help to prevent hypersynchronous neuronal activity in brain networks that may result in epileptic seizures. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 9, 2018 Category: Neurology Source Type: research

Executive functioning phenotypes in youth with epilepsy
The objectives of this study were to identify executive functioning (EF) phenotypes in youth with epilepsy and to examine whether phenotypes differ on psychosocial and medical outcomes (i.e., absence/presence of seizures in the past three months), health-related quality of life (HRQOL), and emotional and behavioral functioning.MethodsYouth 5–18 years with diagnosed epilepsy and caregivers completed a battery of questionnaires as part of a larger national validation of the Pediatric Quality of Life (PedsQL) Epilepsy Module. The primary measure of interest was the Behavior Rating Inventory of Executive Function&mdash...
Source: Epilepsy and Behavior - December 8, 2018 Category: Neurology Source Type: research

What information about sudden unexpected death in epilepsy (SUDEP) is available on YouTube?
ConclusionSubstantial information is available regarding SUDEP on YouTube; however, the viewer engagement remains limited. Individual user-created videos about SUDEP are the most popular and viewer engaging. Incorporating personal/anecdotal experiences in addition to scientific information in the video content might further improve the viewer engagement. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 7, 2018 Category: Neurology Source Type: research

The 4th International Lafora Epilepsy Workshop: Shifting paradigms, paths to treatment, and hope for patients
Publication date: Available online 6 December 2018Source: Epilepsy & BehaviorAuthor(s): M. Kathryn Brewer, Tamar R. Grossman, Tracy R. McKnight, Y. Paul Goldberg, Hal Landy, Matthew S. Gentry (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 6, 2018 Category: Neurology Source Type: research

Outcomes and comorbidities of SCN1A-related seizure disorders
ConclusionsSevere behavioral problems and walking disabilities are common in patients with Dravet syndrome and should receive specific attention during clinical management. Although the epilepsy course of patients with non-Dravet syndromes is much more favorable, milder comorbidities frequently occur in this group as well. Our results may be of great value for clinical care and informing newly diagnosed patients and their parents about prognosis. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 5, 2018 Category: Neurology Source Type: research

Incidence of epilepsy and associated factors in elderly patients in Germany
ConclusionsThe incidence of epilepsy was high and increased with age in elderly patients followed in general practices in Germany. Addressing identified risk factors may help reduce the risk of developing epilepsy. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 5, 2018 Category: Neurology Source Type: research

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood
ConclusionsThere is currently insufficient evidence to determine the etiology of pediatric SUDEP. Current best practice to prevent pediatric SUDEP is to optimize the management of epilepsy. A national SUDEP registry would provide invaluable high-quality data and insights into modifiable risk factors, genetic predispositions, and novel prevention strategies. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 4, 2018 Category: Neurology Source Type: research

Long-term seizure outcome in frontal lobe epilepsy surgery
ConclusionSurgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 4, 2018 Category: Neurology Source Type: research

Online behavior of people visiting a scientific website on epilepsy
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Francesco Brigo, Simona Lattanzi, Michael O. Kinney, Nicola Luigi Bragazzi, Laura Tassi, Raffaele Nardone, Oriano MecarelliAbstractWe investigated the online behavior of Internet users consulting the website of the Italian Chapter of the International League Against Epilepsy (Lega Italiana Contro l'Epilessia [LICE]). We obtained the visualization statistics of the LICE website using AWStats (https://awstats.sourceforge.io/) and Google Trends (https://trends.google.com/trends/), and compared the statistics of years 2010, 2014, and 2017. The f...
Source: Epilepsy and Behavior - December 4, 2018 Category: Neurology Source Type: research

Psychogenic nonepileptic seizures in children and adolescents: An international cross-cultural study
ConclusionYoung patients with PNES across borders and between cultures share more similarities than differences with regard to their demographic and clinical characteristics. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 3, 2018 Category: Neurology Source Type: research

Cortical excitability affects mood state in patients with idiopathic generalized epilepsies (IGEs)
This study aimed to investigate the influences of cortical excitability and seizure control on mood state in patients with IGEs. Single and paired-pulse transcranial magnetic stimulation (TMS) was applied to 30 patients with IGEs (16 controlled IGEs [cIGEs], 14 with treatment-resistant IGEs [trIGEs]), and 22 healthy controls (HCs) to assess cortical excitability with LICI. The Profile of Mood Sates (POMS) questionnaire was used to assess total mood disturbance (TMD), as well as, six mood domains: Depression, Confusion, Anger, Anxiety, Fatigue, and Vigor. To assess the effects of seizure control (HC vs. cIGEs vs. trIGEs) an...
Source: Epilepsy and Behavior - December 3, 2018 Category: Neurology Source Type: research

Clinical presentations of onchocerciasis-associated epilepsy (OAE) in Cameroon
ConclusionPeople with epilepsy in onchocerciasis-endemic villages in Cameroon present with a wide clinical spectrum including nodding seizures and Nakalanga features. A great majority of participants met the diagnostic criteria for OAE, suggesting that better onchocerciasis control could prevent new cases. Epilepsy management algorithms in these areas must be adjusted to reflect the varied seizure types. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 2, 2018 Category: Neurology Source Type: research

Level of awareness and attitudes toward epilepsy in Qassim, Saudi Arabia: A cross-sectional study
ConclusionInsufficient knowledge about epilepsy, which is a very common disorder, has a great and negative impact on people with epilepsy, their families and communities, and the healthcare systems. In our study, we found that good knowledge was associated with being a young adult, male, unmarried, and being a university student. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 2, 2018 Category: Neurology Source Type: research

Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy
ConclusionsCognitive impairment in CWEOE can be detected with sensitivity at 85% (in identifying mild/moderate or severe CI) and specificity of 84%, by network analysis.SignificanceThis study outlines a data-driven methodology for identifying candidate biomarkers of CI in CWEOE from network features. Following additional replication, the proposed method and its use of routinely acquired EEG forms an attractive proposition for supporting clinical assessment of CI. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - December 2, 2018 Category: Neurology Source Type: research

Negative, but not positive, religious coping strategies are associated with psychological distress, independent of religiosity, in Korean adults with epilepsy
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Sang-Ahm Lee, Eun-Ju Choi, Han Uk RyuAbstractPurposeReligion can be important in the everyday lives of persons with epilepsy (PWE). However, there is little research on religion, as it relates to individuals with epilepsy. We determined a relationship between religious coping strategies and psychological distress in Korean adults with epilepsy who had a religious affiliation.MethodsThis cross-sectional study was conducted in outpatient clinics. Religiosity and religious coping strategies were assessed using the Duke University Religion Index...
Source: Epilepsy and Behavior - December 2, 2018 Category: Neurology Source Type: research

Factors contributing to excessive daytime sleepiness in Korean adults with epilepsy: A sleep questionnaire-based study
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Sang-Ahm Lee, Young-Joo No, Kwang-Deog Jo, Jee-Hyun Kwon, Jeong Yeon Kim, Dong-Jin ShinAbstractObjectivesWe determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE).MethodsA total of 147 AWE who had been treated for> 1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Subjective sleep disturbances were assessed with the Sleep Apnea of Sleep Disorder Questionnaire (SA-SDQ) and questionnaires about insomnia and restless legs syndrome (RLS). ...
Source: Epilepsy and Behavior - December 2, 2018 Category: Neurology Source Type: research

Electrode placement accuracy in robot-assisted epilepsy surgery: A comparison of different referencing techniques including frame-based CT versus facial laser scan based on CT or MRI
ConclusionRobot-guided sEEG electrode implantation using CT-frame referencing and CT-laser-based referencing is most accurate and can serve for high precision placement of electrodes. In contrast, 3.0-T MRI-laser-based referencing is less accurate, but saves radiation. Most trajectories can be reached if alternative routes over less vascularized brain areas are used.This article is part of the Special Issue "Individualized Epilepsy Management: Medicines, Surgery and Beyond". (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Changes in self-perception in patients treated with neurostimulating devices
ConclusionsProperly designed questionnaires – like the FST-questionnaire as standardized assessment tool – can detect changes in self-perception in patients during neurostimulatory treatment in a wide spectrum of brain stimulation techniques. This may provide a strategy to systematically identify the subgroup of patients liable to experience such problems during treatment already prior to treatment decisions. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Citing Hippocrates on depression in epilepsy
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Christian HoppeAbstractObjectivesWhen writing about the bidirectional etiological relationship between depression and epilepsy, neuropsychiatrists often cite Lewis (1934) [Lewis AJ. Melancholia: a historical review. Journal of Mental Science 1934; 80: 1–42] who cited Hippocrates — namely, “melancholics ordinarily become epileptics, and epileptics, melancholics”. In this paper, the complicated reference for this citation from Lewis (1934) was critically reappraised.MethodsThe Greek–Latin edition of Hippocratic wr...
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Lipid and thyroid hormone levels in children with epilepsy treated with levetiracetam or carbamazepine: A prospective observational study
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Masahiro Nishiyama, Yuichi Takami, Yusuke Ishida, Kazumi Tomioka, Tsukasa Tanaka, Hiroaki Nagase, Taku Nakagawa, Shoichi Tokumoto, Hiroshi Yamaguchi, Daisaku Toyoshima, Azusa Maruyama, Kandai Nozu, Noriyuki Nishimura, Kazumoto IijimaAbstractAlthough previous studies have investigated the influence of antiepileptic drugs (AEDs) on lipid profiles and thyroid hormone levels, there is little evidence regarding the effects of levetiracetam (LEV). Therefore, we conducted a prospective longitudinal study to evaluate the effects of LEV and carbamaze...
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Prevalence of psychiatric disorders in Thai patients with epilepsy
ConclusionsThe prevalence of psychiatric disorders among Thai PWE was higher than that in general population. Screening for psychiatric disorders in PWE is recommended, especially among those who have EEG abnormalities in the temporal lobe. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Experiences and needs of parents of young children with active epilepsy: A population-based study
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Chloe Jones, Patricia Atkinson, Ayesha Memon, Lyvia Dabydeen, Krishna B. Das, J. Helen Cross, Christopher Gillberg, Brian G.R. Neville, Rod C. Scott, Colin ReillyAbstractThe aim of the study was to gain a comprehensive understanding of the experiences and needs of parents of young children with epilepsy from a total population sample. The parents (mothers (n = 38), fathers (n = 9)) of 40/53 (75% of total population) young children (1–7 years; 23 males, 17 females) with ‘active’ epilepsy (had a seizure in the last ...
Source: Epilepsy and Behavior - November 29, 2018 Category: Neurology Source Type: research

Epilepsy surgery for children with severe developmental delay: An ethical double jeopardy
Publication date: Available online 23 November 2018Source: Epilepsy & BehaviorAuthor(s): Han Yan, Carter Snead, George M. Ibrahim (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 24, 2018 Category: Neurology Source Type: research

Determining the cost of first-ever seizures: A narrative review and future directions
Publication date: Available online 23 November 2018Source: Epilepsy & BehaviorAuthor(s): Emma Foster, Zanfina Ademi, Nicholas Lawn, Zhibin Chen, Patrick Carney, Danny Liew, Terence John O'Brien, Patrick Kwan (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 24, 2018 Category: Neurology Source Type: research

Experiences of self-conscious emotions in temporal lobe epilepsy
In conclusion, experiences of SCEs can be dysregulated in patients with TLE. This dysregulation is linked to the patients' clinical and psychological symptoms and quality of life. In this context, SCEs might be a target of interest in the management of epilepsy. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 24, 2018 Category: Neurology Source Type: research

Analysis of tissue Doppler parameters and 24-hour heart rate variations in children with newly diagnosed untreated idiopathic epilepsy in interictal period
ConclusionWe found that patients with untreated newly diagnosed epilepsy have a significant subclinical deterioration of left ventricular functions, and they also showed changes in heart rate variability (HRV) regarding the sympathovagal imbalance in interictal period. These findings can be related with increased cardiac mortality. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 24, 2018 Category: Neurology Source Type: research

Coronary vasodilation impairment in pilocarpine model of epilepsy
Publication date: January 2019Source: Epilepsy & Behavior, Volume 90Author(s): Paula R. Vitorino, Karina P. Gomes, Poliana P. Ghazale, Marielly da Silva, Elizabeth P. Mendes, Fernanda C.A. dos Santos, Aline P. Pansani, Carlos H. de Castro, Fulvio A. Scorza, Diego B. ColugnatiAbstractWe investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine. To do so, male Wistar rats weighing between 250 g and 300 g were used. Status epilepticus (SE) was induced in rats using 385 mg/kg (i.p.) of pilocarpine. After 60 days from the first spontaneous seizure, rats were submitted to ...
Source: Epilepsy and Behavior - November 24, 2018 Category: Neurology Source Type: research

Should adult neurologists play a role in the management of the most common psychiatric comorbidities? Practical considerations
This article is part of the Special Issue “Obstacles of Treatment of Psychiatric Comorbidities in Epilepsy”. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 23, 2018 Category: Neurology Source Type: research

Alcohol-related seizures may be associated with more severe depression, alcohol dependence syndrome, and more pronounced alcohol-related problems
This article is part of the Special Issue "Individualized Epilepsy Management: Medicines, Surgery and Beyond". (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 21, 2018 Category: Neurology Source Type: research

Corrigendum to “SPECT perfusion changes during ictal automatisms with preserved responsiveness in patients with right temporal lobe epilepsy” [Epilepsy Behav 80C (2018) 11–14]
Publication date: November 2018Source: Epilepsy & Behavior, Volume 88Author(s): Hea Ree Park, Min Jae Seong, Young-Min Shon, Eun Yeon Joo, Dae-Won Seo, Seung Bong Hong (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 14, 2018 Category: Neurology Source Type: research

The Single Word Auditory Comprehension (SWAC) test: A simple method to identify receptive language areas with electrical stimulation
Conclusion/significanceThe SWAC test is reliable, simple and fast to implement, and suitable for intraoperating mapping. It could be used as a simple initial test to identify receptive language areas where more complex additional tests can be performed. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 14, 2018 Category: Neurology Source Type: research

Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy
This study aimed to prospectively assess the following: (i) the prevalence of specific and nonspecific interictal psychiatric comorbidities in a population of patients with drug-resistant focal epilepsy and (ii) the influence of epilepsy lateralization and localization on these psychiatric comorbidities.In this prospective monocentric study, we collected demographic data, characteristics of the epilepsy, interictal psychiatric comorbidities, mood, anxiety, and alexithymia dimensions. We used criteria from Diagnostic and Statistical Manual of Mental Disorders IV ( DSM IV) (Mini International Mental Interview (MINI)), diagno...
Source: Epilepsy and Behavior - November 12, 2018 Category: Neurology Source Type: research

Current value of intraoperative electrocorticography (iopECoG)
ConclusionAfter a period of scepticism, iopECoG seems back in the focus of interest for intraoperative guidance of resecting epileptogenic tissue to raise postoperative favorable seizure outcome. In temporal and extratemporal lesional epilepsies, especially in cases of focal cortical dysplasia, tuberous sclerosis, or cavernous malformations, an excellent correlation between iopECoG-guided resection and postoperative seizure relief was found. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 11, 2018 Category: Neurology Source Type: research

What Saudi teachers know about epilepsy: A cross-sectional study of Tabuk City
This study was conducted to evaluate awareness, knowledge, and attitudes of teachers toward the disease in Tabuk City in north Saudi Arabia and identify areas in which training and education are required.MethodData were collected from 349 school teachers using a structured 28-item questionnaire. Data were collected between December 2017 and May 2018 in Tabuk City.ResultsIn general, the study shows a negative trend in knowledge and attitude toward epilepsy. The majority of the participants (84%) have read or heard about epilepsy, and more than half (67%) had witnessed a seizure. Epilepsy was considered contagious and psycho...
Source: Epilepsy and Behavior - November 11, 2018 Category: Neurology Source Type: research

Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats
The objective of the present study was to investigate the effect of the combined treatment of naringin (40 mg/kg and 80 mg/kg) and phenytoin on prevention of seizure attacks, development of kindling, oxidative stress, cognitive impairment, and neurochemicals in the frontal cortex, temporal cortex, and hippocampus, and morphological changes in the hippocampus. Treatment with the high dose of naringin (80 mg/kg) along with phenytoin has shown to offer protection against seizures, development of kindling, and cognition enhancement through Y-maze test and improved % conditioned avoidance response (% CAR) through pole cli...
Source: Epilepsy and Behavior - November 11, 2018 Category: Neurology Source Type: research

Development of the transition-age program (TAP): Review of a pilot psychosocial multidisciplinary transition program in a Level 4 epilepsy center
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Katie L. Reger, Abigail Hughes-Scalise, Maureen A. O'ConnorAbstractApproximately 50% of patients diagnosed with epilepsy in childhood will need treatment in adulthood. Transition from pediatric to adult epilepsy care is challenging, and an unsuccessful transition can have detrimental effects. Researchers emphasize the importance of addressing possible barriers to transition in a multidisciplinary setting. In this paper, we describe a transition program implemented in a Level 4 epilepsy center in the Midwest. This program involves a psychoso...
Source: Epilepsy and Behavior - November 9, 2018 Category: Neurology Source Type: research

Validation of the Chinese version of the Hamilton Rating Scale for Depression in adults with epilepsy
ConclusionThe C-HRSD-17 proved to be a valid and reliable assessment tool, with a cutoff score of 9 for screening of current MDD in Chinese adult PWE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 9, 2018 Category: Neurology Source Type: research

Semiological characteristics of patients with psychogenic nonepileptic seizures: Gender-related differences
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Meltem Korucuk, Sibel Gazioglu, Ahmet Yildirim, Evrim Ozkorumak Karaguzel, Sibel K. VeliogluAbstractPsychogenic nonepileptic seizures (PNES) are more prevalent among women, and diagnosis may sometimes be delayed by as much as seven years. Understanding the effect of gender on the presentation of a PNES may assist with diagnosis based on semiological details in the clinical setting. Although video-EEG monitoring (VEM) is the gold standard for diagnosing PNES, determining gender-related seizure semiology through careful history may prevent di...
Source: Epilepsy and Behavior - November 9, 2018 Category: Neurology Source Type: research

Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs)
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Lauren B. Bolden, Joseph C. Griffis, Rodolphe Nenert, Jane B. Allendorfer, Jerzy P. SzaflarskiAbstractWe recently found that higher cortical excitability is associated with poorer attention performance in healthy adults. While patients with idiopathic generalized epilepsies (IGEs), previously termed genetic generalized epilepsies, are known to demonstrate increased cortical excitability and cognitive deficits, a relationship between these variables in IGEs has not been investigated. Therefore, we aimed to characterize the effects of cortica...
Source: Epilepsy and Behavior - November 9, 2018 Category: Neurology Source Type: research

Revisiting the public awareness, attitudes, and understanding towards epilepsy among Singapore residents
ConclusionThe awareness, attitudes, and understanding towards epilepsy does not seem to show any significant difference when compared with that in 1999. Reluctance to marry and employ a person with epilepsy persists. The awareness about first aid of a patient having a seizure, attitudes towards marrying a person with epilepsy, and the understanding of cause of epilepsy have shown some positive changes over 17 years. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 9, 2018 Category: Neurology Source Type: research

The intentional brain: Motion, emotion, and the development of modern neuropsychiatry, Michael R. Trimble. John Hopkins University Press, Baltimore (2016), [Hardcover. Pages: 328 ISBN 10: 1421419491 Price $ 29.95]
Publication date: Available online 7 November 2018Source: Epilepsy & BehaviorAuthor(s): Marco Mula (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 8, 2018 Category: Neurology Source Type: research

Making epilepsy a national priority in African countries:
Publication date: Available online 8 November 2018Source: Epilepsy & BehaviorAuthor(s): Ann Little, Mary Secco, Jacob Mugumbate (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - November 8, 2018 Category: Neurology Source Type: research

Cesarean section in Australian women with epilepsy
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Frank John Emery Vajda, Terence John O'Brien, Janet Elizabeth Graham, Alison Anne Hitchcock, Raphael John Paul Kuhn, Cecilie Margaret Lander, Mervyn John EadieAbstractThe literature suggests that cesarean delivery or birth is carried out more often in pregnant women with epilepsy (WWE) than in pregnant women in the general population. Data were utilized from the Australian Pregnancy Register (APR) for Women on Antiepileptic Medication to investigate this issue in Australia.Over almost two decades, the mean CS rate in 1900 APR women was 39.2...
Source: Epilepsy and Behavior - November 8, 2018 Category: Neurology Source Type: research

Predicting drug-resistant epilepsy — A machine learning approach based on administrative claims data
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Sungtae An, Kunal Malhotra, Cynthia Dilley, Edward Han-Burgess, Jeffrey N. Valdez, Joseph Robertson, Chris Clark, M. Brandon Westover, Jimeng SunAbstractPatients with drug-resistant epilepsy (DRE) are at high risk of morbidity and mortality, yet their referral to specialist care is frequently delayed. The ability to identify patients at high risk of DRE at the time of treatment initiation, and to subsequently steer their treatment pathway toward more personalized interventions, has high clinical utility. Here, we aim to demonstrate the feas...
Source: Epilepsy and Behavior - November 8, 2018 Category: Neurology Source Type: research

Parenting stress and perceived stigma in mothers of young children with epilepsy: A case–control study
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Colin Reilly, Patricia Atkinson, Ayesha Memon, Chloe Jones, Lyvia Dabydeen, Krishna B. Das, J. Helen Cross, Brian G.R. Neville, Christopher Gillberg, Rod C. ScottAbstractThe aim was to provide data on parenting stress and perceived stigma in mothers (n = 47) of young children with epilepsy, and to compare findings with those of mothers (n = 48) of developmental, age- and gender-matched children with nonepilepsy-related neurodisability (neurological and/or neurodevelopmental concerns). The mothers of young children (1–7 years...
Source: Epilepsy and Behavior - November 7, 2018 Category: Neurology Source Type: research

Cancer frequency detected by positron emission tomography-computed tomography in limbic encephalitis
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Niels Hansen, Guido Widman, Svenja Stuff, Albert J. Becker, Juri-Alexander Witt, Hojjat Ahmadzadehfar, Christoph Helmstaedter, Christian E. ElgerAbstractObjectiveParaneoplastic limbic encephalitis (LE) occurs frequently with considerable variability according to literature reports. We thus determined the cancer frequency in mixed LE subtypes sharing the diagnosis of temporal lobe epilepsy (TLE).MethodsAll patients underwent magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG) recordings, neuropsychological testing, im...
Source: Epilepsy and Behavior - November 7, 2018 Category: Neurology Source Type: research

The cognitive phenotype of idiopathic generalized epilepsy
We describe the neuropsychological profile of a group of patients with different syndromes of IGE including simultaneous video electroencephalography (EEG).MethodsWe performed a comprehensive cognitive and neuropsychiatric evaluation with video-EEG on 61 adults with IGE (JME 19; IGE with generalized tonic–clonic seizures [GTCS] alone [IGE-GTCS] 22; childhood absence epilepsy [CAE] or juvenile absences epilepsy [JAE] persisting in adulthood 20). We compared results between patients (globally and by syndrome) and a control group of 21 individuals (similar age, educational level); p-values were adjusted for multiple tes...
Source: Epilepsy and Behavior - November 7, 2018 Category: Neurology Source Type: research

Electrographic spikes are common in wildtype mice
Publication date: December 2018Source: Epilepsy & Behavior, Volume 89Author(s): Hannah Purtell, Sameer C. Dhamne, Sarika Gurnani, Elizabeth Bainbridge, Meera E. Modi, Stephen H.T. Lammers, Chloe E. Super, Mustafa Q. Hameed, Ervin L. Johnson, Mustafa Sahin, Alexander RotenbergAbstractHigh-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is kno...
Source: Epilepsy and Behavior - November 4, 2018 Category: Neurology Source Type: research

Innovative approaches reaching underserved and rural communities to improve epilepsy care: A review of the methodology of the Connectors Project
ConclusionLocal Epilepsy Foundation offices successfully connected healthcare providers in rural and underserved areas to epilepsy education designed to enhance quality care in epilepsy. Educational opportunities for people with epilepsy and their families addressed critical gaps in accessing quality epilepsy care and self-management. Tailored and innovative educational approaches can be used to increase awareness levels and to overcome geographic challenges in reaching underserved populations. Relationship building and repeated, consistent engagement with healthcare providers and patients can assist in improving communica...
Source: Epilepsy and Behavior - November 1, 2018 Category: Neurology Source Type: research

Time to response and patient visibility during tonic–clonic seizures in the epilepsy monitoring unit
This study considers potential quality measures in EMUs for generalized tonic–clonic (GTC) seizures: types of safety signals, response time, and visibility of patient's limbs for semiology. These quality measures have been summarized across 12 EMUs to estimate response times to GTC seizures and the quality of video data that is captured during admissions.MethodsVideo electroencephalographies (vEEGs) from two prospective regulatory studies for the Brain Sentinel device were reviewed. A total of 232 subjects with a history of GTC seizures underwent routine clinical EMU stays. Fifty-four of the study subjects had 96 GTC...
Source: Epilepsy and Behavior - November 1, 2018 Category: Neurology Source Type: research