History of dietary treatment: Guelpa & Marie first report of intermittent fasting for epilepsy in 1911
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Sophie Höhn, Blandine Dozières-Puyravel, Stéphane AuvinAbstractWe analyzed the article of Guelpa & Marie, published in 1911 and often quoted in the history of dietary treatment, as the basis for the use of ketogenic diet to mimic fasting. In this paper, the authors treated 21 patients with a diet consisting of daily administration of 30 g of sodium sulphate for 4 days, with unlimited aqueous beverage and no food, followed by a vegetarian diet restricted to half of the ordinary intake. This is the first report of interm...
Source: Epilepsy and Behavior - April 17, 2019 Category: Neurology Source Type: research

EEG changes in patients on antipsychotic therapy: A systematic review
ConclusionsThis systematic review suggests that, among antipsychotics, clozapine most frequently induces EEG slowing and epileptiform discharges. There remains limited data with respect to other individual antipsychotic agents and covariates including drug dose, plasma levels, dose adjustments, and treatment duration that influence EEG changes. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 17, 2019 Category: Neurology Source Type: research

Quality of life in adults enrolled in an open-label study of cannabidiol (CBD) for treatment-resistant epilepsy
Publication date: June 2019Source: Epilepsy & Behavior, Volume 95Author(s): Tyler E. Gaston, Magdalena Szaflarski, Barbara Hansen, E. Martina Bebin, Jerzy P. Szaflarski, for the UAB CBD ProgramAbstractTreatment-resistant epilepsy (TRE) is associated with low quality of life (QOL). Cannabidiol (CBD) may improve QOL, but it is unclear if such improvements are independent of improvements in seizure control. Our aim was to compare QOL at baseline and after 1 year of treatment with CBD. We hypothesized that QOL would improve independent of changes in seizure frequency (SF) or severity, mood, or adverse events. We assessed...
Source: Epilepsy and Behavior - April 17, 2019 Category: Neurology Source Type: research

Methodological concerns on retinal and choroidal thickness variations measured by optical coherence tomography in patients with epilepsy
Publication date: Available online 11 April 2019Source: Epilepsy & BehaviorAuthor(s): Lorenzo Ferro Desideri, Fabio Barra, Simone Ferrero (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 12, 2019 Category: Neurology Source Type: research

Emotional asymmetries in refractory medial temporal and frontal lobe epilepsy: Their impact on predicting lateralization and localization of seizures
ConclusionsWe provide evidence for an anterior-frontal versus a posterior-medial temporal cerebral functional asymmetry with regard to the manifestation of manic and depressive emotional traits in FLE and MTLE, respectively. Our results are mainly discussed within the frame of their contribution in localizing and to a lesser extent in lateralizing seizures foci in epilepsy surgery candidates. We suggest that this is of great importance in the context of preoperative monitoring of epilepsy surgery, especially when neuropsychologists are called upon to provide anatomical information in defining the functional deficit zone. (...
Source: Epilepsy and Behavior - April 12, 2019 Category: Neurology Source Type: research

Evolving dynamic networks: An underlying mechanism of drug resistance in epilepsy?
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Wessel Woldman, Mark J. Cook, John R. TerryAbstractAt least one-third of all people with epilepsy have seizures that remain poorly controlled despite an increasing number of available anti-epileptic drugs (AEDs). Often, there is an initial good response to a newly introduced AED, which may last up to months, eventually followed by the return of seizures thought to be due to the development of tolerance. We introduce a framework within which the interplay between AED response and brain networks can be explored to understand the development of tol...
Source: Epilepsy and Behavior - April 12, 2019 Category: Neurology Source Type: research

Who is driving and who is prone to have traffic accidents? A systematic review and meta-analysis among people with seizures
DiscussionStable multivariate models to predict driving or traffic accidents among people with seizures have not yet been developed. Current evidence shows that the likelihood of driving is associated with demographic and epilepsy-related factors, while the risk of traffic accidents is associated with seizure frequency. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

Can short-term video-EEG substitute long-term video-EEG monitoring in psychogenic nonepileptic seizures? A prospective observational study
The objective of this study was to evaluate effectiveness of STVEEG in PNES and to look into their clinical profile and outcome.Design/MethodsConsecutive cases of PNES diagnosed with STVEEG or LTVEEG during 2015–16 (two years) were enrolled. All cases were followed for 12 months or more. Detailed clinical evaluation was done including demography, semiology, coexisting anxiety/depressive disorders, and seizure frequency at time of first diagnosis and follow-up. The PNES were classified as Type I hypermotor, type II hypomotor, and type III unclassified/mixed. Favorable outcome was defined as seizure freedom or>&nb...
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

The epileptic experience in the works of Dostoyevsky and Machado de Assis
This article is part of the Special Issue “NEWroscience 2018”. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

Signs and symptoms of the postictal period in epilepsy: A systematic review and meta-analysis
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Ann Subota, Sundus Khan, Colin B. Josephson, Sofiya Manji, Sara Lukmanji, Pamela Roach, Samuel Wiebe, Jeffrey Buchhalter, Paolo Federico, G. Campbell Teskey, Diane L. Lorenzetti, Nathalie JettéAbstractObjectiveThe postictal period has many physical, behavioral, and cognitive manifestations associated with it. These signs and symptoms are common, can be quite debilitating, and can have a continued impact long after the seizure has ended. The purpose of this systematic review was to quantify the occurrence of postictal signs and symptoms, a...
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

Evaluation of sleep quality in spouses of people with epilepsy
The objective of this study was to evaluate the spouses of people with epilepsy with and without a history of seizures during sleep in terms of depression, anxiety, and sleep quality.Methods and materialsThis prospective, cross-sectional study was conducted in three groups of 18–55 year olds, who were at least primary school graduates.The 1st group consisted of healthy spouses of 30 healthy volunteers with age and sex matched with the other groups.The 2nd group comprised spouses of 30 people with epilepsy who had been married for at least one year and had no history of seizures during sleep.The 3rd group consisted ...
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

Parental stress in pediatric epilepsy after therapy withdrawal
ConclusionsResults suggested that parents of children with epilepsy were not reassured about the child's condition, even after clinical improvement. Parental stress levels remained higher than expected, even 2 years after the discontinuation of therapy and freedom from seizures. This was probably due to concerns with the reappearance of new seizures or a more severe type of epilepsy with the discontinuation of drug(s), and feelings of inadequacy with their parental role(s). (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 11, 2019 Category: Neurology Source Type: research

Depression and quality of life among African Americans with epilepsy: Findings from the Managing Epilepsy Well (MEW) Network integrated database
This study sought to describe the prevalence of depression among African Americans with epilepsy participating in self-management studies and to examine the relationship between depression and QOL. Using data from the Managing Epilepsy Well (MEW) research network, a subgroup of African Americans with epilepsy were selected for the analytic sample. Descriptive statistics indicated the prevalence of depression (Patient Health Questionnaire-9 [PHQ-9]) and reports of epilepsy-specific QOL (Quality of Life in Epilepsy-10 [QOLIE-10]) in the sample. Multiple linear regression examined the relationship between depression and QOL w...
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

Seizure characteristics, treatment, and outcome in autoimmune synaptic encephalitis: A long-term study
ConclusionsA complex of clinical and subclinical seizures, and nonepileptic events characterize ASE. Patients with anti-LGI1 or anti-GABABR antibodies have a higher risk of developing persistent seizures; AEDs are suitable for achieving additional seizure freedom, but not for patients with serious conditions. A few patients present with super-refractory epilepsy despite multiple treatments. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

An evaluation of the psychosocial impact of epilepsy on marriage in the United Kingdom
ConclusionAlthough severe seizures in this sample of couples were correlated with a smaller discrepancy in perceived seizure burden, gender-specific differences in perception of epilepsy-related psychosocial burden exist. This is true for both PWE and their spouses. Irrespective of gender, onset of epilepsy within matrimony was correlated with higher levels of anxiety and stigma. These factors need to be considered during efforts to reduce epilepsy-related stigmatization, as well as in tailoring therapies that aim to support the spouse as well as the PWE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

Cognitive functioning after epilepsy surgery in children with mild malformation of cortical development and focal cortical dysplasia
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Tim J. Veersema, Monique M.J. van Schooneveld, Cyrille H. Ferrier, Pieter van Eijsden, Peter H. Gosselaar, Peter C. van Rijen, Wim G.M. Spliet, Angelika Mühlebner, Eleonora Aronica, Kees P.J. BraunAbstractMild malformation of cortical development (mMCD) and focal cortical dysplasia (FCD) subtypes combined are by far the most common histological diagnoses in children who undergo surgery as treatment for refractory epilepsy. In patients with refractory epilepsy, a substantial burden of disease is due to cognitive impairment. We studied intell...
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

Validation of the Neurological Disorders Depression Inventory for Epilepsy (NDDIE) as a rapid suicidality screening tool in Chinese people with epilepsy
ConclusionItem 4 of the NDDIE is a valuable tool for screening suicidality in Chinese PWE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

Maternal epilepsy and behavioral development of the child: Family factors do matter
DiscussionIncluding family factors in research regarding children of mothers with epilepsy is important as they can have a contribution additional to the teratogenic risks of prenatal exposure to antiepileptic drugs (AEDs). Family factors, in particular distal and proximal family factors, can weaken or strengthen child development and may provide starting points for interventions. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 9, 2019 Category: Neurology Source Type: research

Visuospatial learning and memory in children pre- and posttemporal lobe resection: Patterns of localization and lateralization
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Elizabeth Stewart, Mary Lou SmithAbstractIn children with epilepsy, the impact of surgery including or sparing the mesial temporal lobes (TLs) on visuospatial memory has not been thoroughly investigated, and a clear pattern of hemispheric lateralization has not been observed. The primary aim of this study was to examine visuospatial learning and memory outcomes in children with epilepsy prior to and one year after surgical excision, to determine whether outcomes differed as a function of the localization and lateralization of surgical excisions....
Source: Epilepsy and Behavior - April 8, 2019 Category: Neurology Source Type: research

Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy
ConclusionsHigh-dose oral Vitamin D3, 5000 IU/day was safe and well tolerated in subjects with epilepsy. Vitamin D levels increased significantly at 6 and 12 weeks but never exceeded potentially toxic levels, defined as> 100 ng/ml. To reduce variability, we will now recruit subjects who only have three or more seizures per month. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 8, 2019 Category: Neurology Source Type: research

Coping with stress: A pilot study of a self-help stress management intervention for patients with epileptic or psychogenic nonepileptic seizures
ConclusionThe intervention was perceived to be acceptable, safe, and helpful by participants. It could be a useful complementary treatment option for reducing stress experienced by patients living with seizure disorders. Further evaluation in a larger trial is warranted. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 8, 2019 Category: Neurology Source Type: research

Long-term outcome in a sample of underprivileged patients with psychogenic nonepileptic seizures (PNES) living in Argentina
ConclusionsArgentinian patients from economically disadvantaged backgrounds, diagnosed as having PNES reported improvements in seizure frequency and occupational status during long-term follow-up. Future studies will need to focus on what (e.g., communication of diagnosis, psychotherapy, alternative treatments) may have contributed to these changes. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 8, 2019 Category: Neurology Source Type: research

Long-term efficacy and safety of lacosamide and levetiracetam monotherapy in elderly patients with focal epilepsy: A retrospective study
This study is aimed at assessing the efficacy and the tolerability of LCM as monotherapy in elderly patients affected by focal onset epilepsy compared with those receiving LEV.MethodsA retrospective chart review of patients aged ≥ 65 years suffering from focal onset seizures, with or without secondary generalization on LCM monotherapy or LEV monotherapy, was performed. Data regarding demographic characteristics, seizure type and etiology, LCM and LEV daily dose, number of lifetime AEDs, seizure frequency at baseline and at 12 months of follow-up, and seizure freedom rates were reported.ResultsIn this observatio...
Source: Epilepsy and Behavior - April 8, 2019 Category: Neurology Source Type: research

Parental consanguinity in patients with psychogenic nonepileptic seizures
ConclusionsIn this study, we observed that more than one-third of the patients with PNES had parental consanguinity. This rate is very similar to the rate of consanguinity in the general population in Iran. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 6, 2019 Category: Neurology Source Type: research

Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration
Publication date: Available online 1 April 2019Source: Epilepsy & BehaviorAuthor(s): Ali Zeynal Abidin Tak, Yıldızhan Şengül, Burcu Ekmekçi, Ayşe Sevgi Karadağ (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - April 1, 2019 Category: Neurology Source Type: research

Can behavioral strategies increase physical activity and influence depressive symptoms and quality of life among children with epilepsy? Results of a randomized controlled trial
This study examined whether increasing physical activity (PA) through 6 months of behavioral counseling positively influenced depressive symptoms and quality of life (QoL) over 12 months among children with epilepsy (CWE).MethodsA longitudinal multisite randomized controlled trial (RCT) was conducted with 8–14-year-old children with active epilepsy. Participants wore a pedometer to track daily PA and completed 3 measures at 4 time points to examine depressive symptoms and QoL. Stratified by site and activity level, participants were randomized to an intervention or control group. The 6-month intervention included...
Source: Epilepsy and Behavior - March 31, 2019 Category: Neurology Source Type: research

Comparative neuropsychological effects of carbamazepine and eslicarbazepine acetate
In this study, we compared the neuropsychological effects of eslicarbazepine acetate (ESL) and carbamazepine immediate-release (CBZ) using a randomized, double-blind, crossover design in healthy volunteers with a 2-week titration and 4-week maintenance phase in each treatment arm (CBZ = 400 mg BID and ESL = 800 mg qAM). Neuropsychological testing was performed at the initial visit, repeated at 1st baseline nondrug condition, end treatment #1, 2nd nondrug condition one month after treatment #1, end treatment #2, and 3rd nondrug condition one month after treatment #2. Neuropsychological testing was conducted 2 ...
Source: Epilepsy and Behavior - March 31, 2019 Category: Neurology Source Type: research

Gender and psychiatric disorders in children with epilepsy. A meta-analysis
ConclusionCompared with girls in the general population, girls with epilepsy seem to be at a higher risk of being diagnosed with ADHD/ASD as the gender ratio is more equal. This could be related to differences in the assessment of CWE and/or a shared pathogenesis between psychiatric conditions and epilepsy. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 24, 2019 Category: Neurology Source Type: research

The voices of patients and families must be heard
Publication date: Available online 22 March 2019Source: Epilepsy & BehaviorAuthor(s): Steven C. Schachter (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 23, 2019 Category: Neurology Source Type: research

The neuropsychological profile of parietal and occipital lobe epilepsy
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Aikaterini Traianou, Panayiotis Patrikelis, Mary H. Kosmidis, Vasilios Κ. Kimiskidis, Stylianos GatzonisAbstractDespite the extensive body of research in clinical neurology on the functional organization of posterior cortices, parietal and occipital lobe epilepsy (PLE and OLE) have not as yet received the attention afforded frontal and temporal lobe epilepsy (FLE and TLE), perhaps due to their low prevalence. Posterior epilepsies however, represent a challenge for epileptology in general and neuropsychological differential diagnosis in par...
Source: Epilepsy and Behavior - March 23, 2019 Category: Neurology Source Type: research

Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests
ConclusionsChildren with TLE exhibit executive dysfunction which correlates with DMN alterations. These findings suggest that the level of deactivation of specific functional networks may contribute to cognitive impairment in children with TLE. The findings also indicate that children with TLE have network alterations in extratemporal lobe brain regions. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 23, 2019 Category: Neurology Source Type: research

BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy
The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) ε4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy.MethodsOne hundred forty-eight adults (Mage = 38 years; 53% female) with refractory epilepsy completed self-report measures of mood, anxiety, and/or personality/psychopathology. Mann–Whitney U, t-tests, and Fisher's exact tests were used to determine if APOE4, ...
Source: Epilepsy and Behavior - March 23, 2019 Category: Neurology Source Type: research

REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Victor Navarrete-Modesto, Sandra Orozco-Suárez, Mario Alonso-Vanegas, Iris A. Feria-Romero, Luisa RochaAbstractThe Repressor Element-1 Silencing Transcription factor or Neuron-Restrictive Silencer Factor (REST/NRSF) is a zinc finger repressor transcription factor of the Kruppel family. Several studies in experimental models have shown that overexpression of REST/NRSF occurs after the induction of seizures. In the present study, the expression of REST/NRSF (messenger ribonucleic acid (mRNA) and protein) was evaluated in the hippocampus of ...
Source: Epilepsy and Behavior - March 23, 2019 Category: Neurology Source Type: research

Re-examining the crowding hypothesis in pediatric epilepsy
The objective of this study was to investigate the crowding hypothesis using a heterogeneous sample of children with intractable epilepsy and typical (left) language dominance or atypical (right or bilateral) language dominance. We examined the relative contributions of seizure onset (before or after age 5), handedness (right versus left), seizure localization (temporal versus extratemporal), as well as language dominance on verbal versus visual cognitive skills.MethodWe retrospectively analyzed neuropsychology assessment results from a sample of 91 children who completed presurgical evaluation at the Hospital for Sick Chi...
Source: Epilepsy and Behavior - March 22, 2019 Category: Neurology Source Type: research

Neurogenic pulmonary edema following seizures: A retrospective computed tomography study
ConclusionsThe highly selected and biased patient group warrants caution in the interpretation of the study results. Our data, however, confirm that signs of NPE appear to be rather frequent in patients with GCS. Its clinical significance as regards morbidity and sudden death in epilepsy is discussed. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 22, 2019 Category: Neurology Source Type: research

Seizure-alerting behavior in dogs owned by people experiencing seizures
ConclusionThis study collected a large group of dog owners with seizures reporting behavioral changes in their dogs before their seizures occurred. This was associated with the presence of preictal symptoms. The seizure-alerting behavior of the dog may have a positive influence on the bond between the owner and the dog. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 20, 2019 Category: Neurology Source Type: research

Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES)
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Ann Hempel, Michael Frost, Nitin AgarwalAbstractFew studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patient...
Source: Epilepsy and Behavior - March 20, 2019 Category: Neurology Source Type: research

Assessing recent suicidal ideation and behavior in the adult epilepsy monitoring unit
ConclusionsThe rate of suicidal ideation and behavior in this sample of EMU patients was higher compared with other inpatient populations. The presence of a psychiatric disorder was independently associated with a higher risk. There was no statistically significant difference in the risk between those with ES and PNES. Screening for suicide risk, suicidal ideation, and behavior is recommended for all patients admitted to the EMU. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 20, 2019 Category: Neurology Source Type: research

Serious psychological distress among adults with active epilepsy in all racial/ethnic groups and among adults with inactive epilepsy in non-Hispanic whites is significantly higher than among adults without epilepsy—U.S. National Health Interview Survey, 2010, 2013, 2015, and 2017
Publication date: Available online 18 March 2019Source: Epilepsy & BehaviorAuthor(s): Rosemarie Kobau, Sanjeeb Sapkota, Matthew M. ZackAbstractSerious psychological distress (SPD) includes mental health problems severe enough to cause moderate-to-serious impairment in daily activities and to require treatment. Serious psychological distress is based on answers to six survey questions from the Kessler-6 scale used internationally in public health surveillance systems to assess recent feelings of sadness, restlessness, hopelessness, nervousness, worthlessness, and the sense that everything is an effort. We combined natio...
Source: Epilepsy and Behavior - March 19, 2019 Category: Neurology Source Type: research

New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy
Publication date: Available online 18 March 2019Source: Epilepsy & BehaviorAuthor(s): Gia Melikishvili, Nino Epitashvili, Nazi Tabatadze, Gocha Chikvinidze, Olivier Dulac, Thierry Bienvenu, Svetlana GataullinaAbstractEight patients, seven girls and one boy, had CDKL5 gene mutation, duplication, or deletion. Epileptic spasms started at a mean age of 3.5 months (range = 4 weeks–8 months). In five cases, tonic seizures preceded spasms at a median age of 6 weeks. In one patient who started at 8 months, spasms had a component of terror on awakening, reminding sleep terror. In two patients, electroencepha...
Source: Epilepsy and Behavior - March 19, 2019 Category: Neurology Source Type: research

Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy
ConclusionsPerampanel is effective against various types of seizures, including ES, in pediatric patients with refractory epilepsy. Furthermore, PER has good tolerability when the dose is adjusted based on serum concentrations. The PER CD ratio was lower in pediatric patients than in adolescents and adults; therefore, clinicians must consider the CD ratio when treating children with PER. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 19, 2019 Category: Neurology Source Type: research

The rhetoric and reality of integrated patient-centered care for healthcare providers: An ethnographic exploration of epilepsy care in Ireland
This study explored the perceptions of healthcare providers in the Irish epilepsy care ecosystem to understand their level of readiness to realize the benefits of an integrated PCC model. Ethnographic fieldwork including observations of different clinical settings across three regions in Ireland and one-to-one interviews with consultant epileptologists (n = 3), epilepsy specialist nurses (n = 5), general practitioners (n = 4), and senior healthcare managers (n = 3) were conducted. While there is a person-centered ambiance and a disposition toward advancing integrated PCC, there are limits to the readiness o...
Source: Epilepsy and Behavior - March 19, 2019 Category: Neurology Source Type: research

Patterns of impaired social cognition in children and adolescents with epilepsy: The borders between different epilepsy phenotypes
In conclusion, findings suggest that social cognitive impairments represent a shared feature of epilepsy in childhood. The results support a neural network account of epilepsy, in which a shared neural network of dysfunction may be underlying social cognitive deficits in this group. Further research is needed to examine the functional correlates of social cognitive impairments, as well as to evaluate screening tools and treatment methods to identify and address significant social and emotional difficulties in this patient group.This article is part of the Special Issue "Epilepsy and social cognition across the lifespa...
Source: Epilepsy and Behavior - March 18, 2019 Category: Neurology Source Type: research

Health-related quality of life in Veterans with epileptic and psychogenic nonepileptic seizures
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Martin Salinsky, Paul Rutecki, Karen Parko, Elizabeth Goy, Daniel Storzbach, Sheila Markwardt, Laurence Binder, Sandra JoosAbstractRationaleHealth-related quality of life (HRQoL) is compromised in civilians with epileptic seizures (ES) or psychogenic nonepileptic seizures (PNES). U.S. Veterans are a distinct patient group with regard to gender, age, and background. We studied HRQoL in Veterans and asked the following: (1) Is there a difference in HRQoL in Veterans with ES vs. PNES?; (2) What factors influence HRQoL in each group?; (3) What facto...
Source: Epilepsy and Behavior - March 18, 2019 Category: Neurology Source Type: research

Understanding the patient perspective of epilepsy treatment through text mining of online patient support groups
This study showed the feasibility of learning about concerns of patients with epilepsy, especially treatment issues, through text mining methods. However, some manual selection and filtering were necessary to ensure quality results for the treatment analysis. Providers should be aware of online discussions and use analyses of such discussions to help guide effective patient engagement during care. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 18, 2019 Category: Neurology Source Type: research

Performance of the International Index of Erectile Function tool in men with epilepsy
ConclusionThe IIEF can be administered to men with epilepsy. The addition of specific targeted questions in this patient population may also provide better understanding and facilitate an open dialog about how male sexual function relates to epilepsy and/or treatment thereof. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 18, 2019 Category: Neurology Source Type: research

Improving awareness, knowledge, and attitude among Malaysian parents of children with epilepsy using an Interactive Animated Epilepsy Education Programme (IAEEP)
ConclusionThe IAEEP is an effective epilepsy educational tool to increase the levels of AKA among parents of CWE. Following the use of the IAEEP, parents of CWE also reported an improvement of their child's quality of life in the interpersonal/social and epilepsy secrecy CHEQOL-25 domains. There was no impact on parental mental health following exposure to the IAEEP. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 17, 2019 Category: Neurology Source Type: research

Qualitative insights into the feelings, knowledge, and impact of SUDEP: A narrative synthesis
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Sarah S. Collard, Pramod RegmiAbstractPeople with epilepsy (PWE) have a two- to threefold increased chance of premature death due to the condition. Interested in exploring the first-person perspective on this topic, we conducted a narrative synthesis to present the qualitative insight of PWE, their family, friends, and healthcare providers (HCPs) in relation to epilepsy-related death. A comprehensive electronic search of all peer-reviewed qualitative studies was conducted through databases using relevant keywords and Medical Subject Headings (Me...
Source: Epilepsy and Behavior - March 17, 2019 Category: Neurology Source Type: research

Parent-reported symptoms of ADHD in young people with epilepsy before and two years after epilepsy surgery
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Colin Reilly, Tove Hallböök, Gerd Viggedal, Bertil Rydenhag, Paul Uvebrant, Ingrid OlssonAbstractThe aim was to compare parent-reported symptoms of attention-deficit/hyperactivity disorder (ADHD) before (baseline) and two years after pediatric epilepsy surgery (follow-up). The parents of 107 children who underwent epilepsy surgery completed surveys including the Conners 10-item scale at baseline and follow-up. Changes in scores between baseline and follow-up were compared using paired sample t-test. Factors associated with changes in s...
Source: Epilepsy and Behavior - March 17, 2019 Category: Neurology Source Type: research

Asymmetric gelastic seizure as a lateralizing sign in patients with hypothalamic hamartoma
Publication date: May 2019Source: Epilepsy & Behavior, Volume 94Author(s): Shigeki Kameyama, Hiroshi Shirozu, Hiroshi MasudaAbstractGelastic seizure (GS) is a cardinal symptom of hypothalamic hamartoma (HH), which is intractable but surgically remediable. Although facial asymmetry with GS has not been extensively discussed, asymmetric GS has been frequently recognized in our large series. We hypothesized that asymmetric GS represents a lateralizing sign caused by the epileptic propagation from the attachment of the HH. To examine this hypothesis, the positive predictive value (PPV) and diagnostic odds ratio (DOR) of as...
Source: Epilepsy and Behavior - March 17, 2019 Category: Neurology Source Type: research