Relationship of antiepileptic drugs to generic brittleness in patients with epilepsy
ConclusionsTaking lamotrigine IR tablets was associated with a greater probability of being GB and tended to cause more frequent switch problems than other AEDs in this cohort of patients. Six AEDs were associated with a reduced probability of being GB. The lower number of different generics for these six drugs may result in greater patient certainty in medication identity, due to greater consistency in medication color, shape, and size, and hence less generic skepticism or generic brittleness. Also, patients taking more AEDs showed increased odds of a switch problem.Graphical abstract (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy
Publication date: April 2020Source: Epilepsy & Behavior, Volume 105Author(s): Kristine Lossius, Anne de Saint Martin, Sverre Myren-Svelstad, Marit Bjørnvold, Guro Minken, Caroline Seegmuller, Maria Paola Valenti Hirsch, Jamel Chelly, Ortrud Steinlein, Fabienne Picard, Eylert BrodtkorbAbstractObjectiveAutosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by hypermotor seizures and may be caused by gain-of-function mutations affecting the nicotinic acetylcholine receptor (nAChR). Benefit from nicotine consumption has been reported in adult patients with this disorder. For the first time, th...
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

Seizure detection devices and health-related quality of life: A patient- and caregiver-centered evaluation
ConclusionsSeizure detection devices provide moderate or greater anxiety reduction among the majority of people with epilepsy and their caregivers, but current translatability into improvements in overall HR-QOL may be limited. Affordability and technological support are potential barriers to maximizing benefit equally among the epilepsy community. These considerations may be useful to help guide future device development and inform patient–clinician discussions on device usage and HR-QOL. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

The coexistence of psychogenic nonepileptic and epileptic seizures in the same patient is more frequent than expected: Is there any clinical feature for defining these patients?
This study aimed to investigate the prevalence of psychogenic nonepileptic seizures (PNES) and PNES-epilepsy coexistence within all video-electroencephalography (EEG) monitoring unit (VEMU) referrals and to identify semiological and electrophysiological features to differentiate patients with PNES-epilepsy coexistence from PNES-only.MethodsWe retrospectively reviewed medical files, VEMU reports, and videos of 1983 adult patients. Demographical, historical, clinical, neuroimaging, and electrophysiological parameters of all patients were recorded. We classified patients into five groups as definite PNES-only, definite PNES-e...
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine
Publication date: April 2020Source: Epilepsy & Behavior, Volume 105Author(s): Vivek Sabharwal, Mugilan Poongkunran, Murad Talahma, Ifeanyi O. Iwuchukwu, Eugene Ramsay, Fawad Khan, Uma Menon, Giuseppe Ciccotto, Namir Khandker, Harold McGradeAbstractBackgroundTherapeutic hypothermia as a potent nonpharmacologic antiseizure therapy has been investigated experimentally in animal models and humans. Although induced hypothermia has been shown to be neuroprotective in acute convulsive status epilepticus, whether its use will translate into improved outcomes for patients with super-refractory nonconvulsive status epilepticus (...
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

ACTON PROLONGATUM® suppresses spasms head to head with Acthar® Gel in the model of infantile spasms
In this study, we determined the efficacy of ACTON PROLONGATUM® (AP; Ferring Pharmaceuticals) in comparison with Acthar® Gel (Mallinckrodt) and full 39 amino-acid rat ACTH molecule (Genscript) in the rodent model of IS consisting of prenatal priming with betamethasone and repeated postnatal trigger of spasms with N-methyl-d-aspartate. Treatment with these ACTH varieties was given on postnatal days (P)12, P13, and P14 in a prospective test (treatment onset on P12 AFTER induction of spasms). Two independent arms were investigated: subcutaneous (SC) and intramuscular (IM) deliveries that were evaluated separately. In ...
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

Anatomoelectroclinical features of SEEG-confirmed pure insular-onset epilepsy
ConclusionsSeizure semiology is heterogeneous in pure insular-onset epilepsy. Differences between the anterior and posterior insular seizures reflect the functional organization of the insula. Particularly, the different types of motor symptoms may help to distinguish anterior from posterior insular seizure onset. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 22, 2020 Category: Neurology Source Type: research

Parental report of quality of life in children with epilepsy: A Spanish/French comparison
ConclusionsThis questionnaire made it possible to detect comorbidities and daily life difficulties in children with epilepsy and their families. The type of epilepsy had the same influence on Spanish and French families' ratings of QoL. Families shared the same comorbidities in terms of hyperactivity/attention/sociability problems. Nevertheless, the intensity of reported difficulties varied in both countries, possibly because of differences in cultural and educational environments. This aspect should be further explored in future research. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 21, 2020 Category: Neurology Source Type: research

The global burden of epilepsy report: Implications for low- and middle-income countries
Publication date: April 2020Source: Epilepsy & Behavior, Volume 105Author(s): Gagandeep Singh, Josemir W. SanderAbstractThe Global Burden of Epilepsy Report estimates that there are 13 million disability adjusted life years due to epilepsy each year. Estimates of years lived with disability attributed to uncontrolled and untreated epilepsies are particularly raised in comparison to controlled epilepsies in countries with low sociodemographic indices. There are 50 million people with epilepsy in the world and of these, 125,000 die each year, and over 80% of these deaths occur in low- and middle-income countries. Overall...
Source: Epilepsy and Behavior - February 21, 2020 Category: Neurology Source Type: research

The experiences of therapists providing cognitive behavioral therapy (CBT) for dissociative seizures in the CODES randomized controlled trial: A qualitative study
ConclusionsThis study demonstrated that the DS-specific CBT intervention met with general approval from therapists who also highlighted some practical challenges. Because of the nature of the condition, the need for experience of working with complex patients should be considered when applying the intervention to individual cases. Setting the CBT intervention in the context of a structured care pathway involving neurology and psychiatry may facilitate the therapeutic process. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 19, 2020 Category: Neurology Source Type: research

Management of epileptic seizures in school-age children: Educational project dedicated to school staff
ConclusionsResults of this project documented an increase in knowledge of epilepsy, a better knowledge on management of acute seizures in the school settings, a reduction in anxiety, and an increase in willingness to administer rescue medications. Further studies should be planned in order to document the changes in the real-world management of seizures, to evaluate if a reduction in hospital admittances might be reached, and to extend the project by assessing, through a questionnaire, the stigma and prejudices against the children affected by epilepsy by their classmates. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 19, 2020 Category: Neurology Source Type: research

Hospital service utilization trajectories of individuals living with epilepsy in New South Wales, Australia, 2012–2016: A population-based study
ConclusionIt is important to gain a better understanding of hospital service utilization among individuals living with epilepsy. This research has identified trajectory groups of hospital service utilization profiles of individuals living with epilepsy. Identification of predictors of trajectory group membership allows targeting of strategies to reduce hospital admissions, inform healthcare service delivery, and improve the health and wellbeing of individuals living with epilepsy. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 15, 2020 Category: Neurology Source Type: research

EEF1A2 mutations in epileptic encephalopathy/intellectual disability: Understanding the potential mechanism of phenotypic variation
This study highlights the potential genotype–phenotype relationship in EEF1A2 and facilitates the evaluation of the pathogenicity of EEF1A2 mutations in clinical practice. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 15, 2020 Category: Neurology Source Type: research

Metabolic correlates of cognitive impairment in mesial temporal lobe epilepsy
Publication date: April 2020Source: Epilepsy & Behavior, Volume 105Author(s): Agathe Laurent, Eric Artiges, Charles Mellerio, Magali Boutin-Watine, Elisabeth Landré, Franck Semah, Francine ChassouxAbstractPurposeThe purpose of the study was to determine the correlations between brain metabolism and cognitive impairment in patients with drug-resistant mesial temporal lobe epilepsy (MTLE).Methods[18F]-FluoroDeoxyGlucose positron emission tomography ([18F]-FDG-PET) and neuropsychological assessment were performed in 97 patients with MTLE (53 females, 15–56 years old, mean: 31.6 years, standard deviation (...
Source: Epilepsy and Behavior - February 15, 2020 Category: Neurology Source Type: research

Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole
Publication date: April 2020Source: Epilepsy & Behavior, Volume 105Author(s): Azadeh Yazdi, Mohammadmahdi Doostmohammadi, Farshid Pourhossein Majarshin, Siamak BeheshtiAbstractA seizure may occur because of the imbalance between glutamate and gamma-aminobutyric acid (GABA). Recurrent seizures induce some cognitive problems, such as, depression, learning and memory deficits, and neurodegeneration. Histamine is an appropriate therapeutic target for epilepsy via its effect on regulating neurotransmitter release. Also, evidence indicates the effect of histamine on neuroprotection and alleviating cognitive disorders. An ide...
Source: Epilepsy and Behavior - February 15, 2020 Category: Neurology Source Type: research

The cerebellum and epilepsy
This article is part of the Special Issue “NEWroscience 2018 (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 6, 2020 Category: Neurology Source Type: research

GABAergic interneurons in epilepsy: More than a simple change in inhibition
This article is part of the Special Issue “NEWroscience 2018 (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 6, 2020 Category: Neurology Source Type: research

“Stop playing ping-pong! Epi-Psy, an effective discipline to promote” Comment on “Psychiatric comorbidities go unrecognized in patients with epilepsy: ‘You see what you know’”
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): C. Hingray, Louis Maillard, Aileen McGonigal, Raymund Schwan, Wissam El-Hage, Bertrand De Toffol (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 5, 2020 Category: Neurology Source Type: research

Postoperative outcomes following pediatric intracranial electrode monitoring: A case for stereoelectroencephalography (SEEG)
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Lily H. Kim, Jonathon J. Parker, Allen L. Ho, Arjun V. Pendharkar, Eric S. Sussman, Casey H. Halpern, Brenda Porter, Gerald A. GrantAbstractBackgroundFor patients with medically refractory epilepsy, intracranial electrode monitoring can help identify epileptogenic foci. Despite the increasing utilization of stereoelectroencephalography (SEEG), the relative risks or benefits associated with the technique when compared with the traditional subdural electrode monitoring (SDE) remain unclear, especially in the pediatric population. Our ai...
Source: Epilepsy and Behavior - February 5, 2020 Category: Neurology Source Type: research

Genetic and molecular basis of epilepsy-related cognitive dysfunction
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Lin Zhu, Lu Chen, Puying Xu, Di Lu, Shujuan Dai, Lianmei Zhong, Yanbing Han, Mengqi Zhang, Bo Xiao, Lvhua Chang, Qian WuAbstractEpilepsy is a common neurological disease characterized by recurrent seizures. About 70 million people were affected by epilepsy or epileptic seizures. Epilepsy is a complicated complex or symptomatic syndromes induced by structural, functional, and genetic causes. Meanwhile, several comorbidities are accompanied by epileptic seizures. Cognitive dysfunction is a long-standing complication associated with epil...
Source: Epilepsy and Behavior - February 5, 2020 Category: Neurology Source Type: research

Transition of patients with childhood onset epilepsy: Perspectives from pediatric and adult neurologists
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Rima Nabbout, Theo Teng, Nicole Chemaly, Delphine Breuillard, Mathieu KuchenbuchAbstractTransition from pediatric to adult care systems is a major challenge in the management of adolescents with epilepsy. The comparison of pediatric and adult physicians' points of view on this issue is scarcely described. The aim of this study was to understand pediatric and adult neurologists' experience and opinions on transition in epilepsy in France. We investigate the age at which they usually transfer patients, their opinion on the factors that ...
Source: Epilepsy and Behavior - February 5, 2020 Category: Neurology Source Type: research

Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats
ConclusionProbiotic and NS supplementation have some protection against seizure, seizure-induced cognitive impairment, and hippocampal LTP in kindled rats. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - February 5, 2020 Category: Neurology Source Type: research

Experience of epilepsy: Coping strategies and health outcomes among Ghanaians living with epilepsy
ConclusionThe consultation of spiritualists and herbalists for treatment was a reflection of their beliefs about the causes of epilepsy among the participants. There is a need for increased education on epilepsy in Ghana. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 30, 2020 Category: Neurology Source Type: research

Antiepileptic drug effects on subjective and objective cognition
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Robert J. Quon, Morgan T. Mazanec, Samantha S. Schmidt, Angeline S. Andrew, Robert M. Roth, Todd A. MacKenzie, Martha Sajatovic, Tanya Spruill, Barbara C. JobstAbstractRationaleCognitive impairment is one of the most common complaints for persons with epilepsy (PWE). These impairments are not only associated with seizures, but are also regularly reported as adverse effects of antiepileptic drugs (AEDs). Previous studies have examined cognitive effects of both AED monotherapy and polytherapy, yet there is limited research on these diff...
Source: Epilepsy and Behavior - January 30, 2020 Category: Neurology Source Type: research

The effect of left and right long-term amygdala kindling on interictal emotionality and Fos expression
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Neil M. Fournier, Lianne E. Brandt, Lisa E. KalynchukAbstractClinical observations have often reported that patients with seizures arising from limbic structures on the right side of the brain have a higher incidence of emotional disturbances, such as fear and anxiety, than those who have seizures lateralized to limbic structures on the left side. However, there have been some inconsistent reports regarding the presence of these laterality effects. The use of animal models of epilepsy can help circumvent many of the methodological and...
Source: Epilepsy and Behavior - January 30, 2020 Category: Neurology Source Type: research

Corrigendum to “Effectiveness and safety of perampanel as early add-on treatment in patients with epilepsy and focal seizures in the routine clinical practice: Spain prospective study (PERADON)” [Epilepsy Behav 102 (2020) 106655]
Publication date: Available online 28 January 2020Source: Epilepsy & BehaviorAuthor(s): Javier Abril Jaramillo, José Carlos Estévez María, Juan Miguel Girón Úbeda, Óscar Vega López, María Elena Calzado Rivas, Hernando Pérez Díaz, Guillermina García Martín, Elena Vila Herrero, María Isabel Chamorro Muñoz, Fernando Vázquez Gutiérrez, Cristina de la Fuente Cañete, Luis Redondo Verge, Nazaret Peláez Viña, Patricia Santágueda, Juan Jesús Rodríguez Uranga (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 30, 2020 Category: Neurology Source Type: research

Risk and protective factors related to stigma among people with epilepsy: An integrative review
ConclusionsThe impression of and beliefs about epilepsy among the general population as well as among PWE were the primary factors affecting stigma. Thus, there is a need for the provision of accurate information about epilepsy to both these groups. Additional studies on epilepsy-associated stigma employing various methodological approaches are required. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 28, 2020 Category: Neurology Source Type: research

Validation of the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55 and QOLCE-16) for use by parents of young adults with childhood-onset epilepsy
The objective of the study was to validate the parent-proxy reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) in a sample of young adults with a history of childhood-onset epilepsy, allowing for the utilization of a consistent informant (the parent) across the youths' stages of development. The 55-item (QOLCE-55) and 16-item versions (QOLCE-16) were evaluated.MethodsData came from 134 young adults (aged 18.0 to 28.5 years) with childhood-onset epilepsy, recruited through community and tertiary care centers across Canada. Confirmatory factor analysis (CFA) was used to assess the higher-order factor stru...
Source: Epilepsy and Behavior - January 28, 2020 Category: Neurology Source Type: research

Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic
The objective of this study was to assess factors associated with research participation among epilepsy clinic patients who screened positive for anxiety or depression. This was accomplished by characterizing clinical and psychiatric factors among patients seen in an epilepsy clinic and evaluating which factors were associated with consent for potential research participation, via a combined clinical and research screening model.MethodsIn a pragmatic trial of anxiety and depression treatment in epilepsy, individuals with a positive screen for anxiety and/or depression at a routine epilepsy clinic visit were invited to opt-...
Source: Epilepsy and Behavior - January 28, 2020 Category: Neurology Source Type: research

Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats
In conclusion, the current study shed light on the potential neuroprotective role of metformin and trimetazidine in the amelioration of cognitive function via hindering inflammatory processes in diabetic epileptic rats.Graphical abstractDiagram illustrating alterations in the hippocampus induced in diabetic epileptic rats. DAP, death-associated protein; ATP/ADP, ratio of adenosine triphosphate and adenosine diphosphate; mTOR, mammalian target of rapamycin; Casp-3, caspase-3; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB, nuclear factor-κB; IGF-1, insulin growth factor 1. (So...
Source: Epilepsy and Behavior - January 28, 2020 Category: Neurology Source Type: research

Interictal spike quantification in continuous spike–wave of sleep (CSWS): Clinical usefulness of a wearable EEG device
ConclusionsA wearable EEG device with 2 bipolar channels simplifies the process of obtaining repeated SI quantification allowing a more accurate follow-up of spike activity in the clinical setting. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 27, 2020 Category: Neurology Source Type: research

Group-based cognitive behavioral therapy program for improving poor sleep quality and quality of life in people with epilepsy: A pilot study
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Diana Paardekooper, Zoe Thayer, Laurie Miller, Armin Nikpour, Michael B GascoigneAbstractSleep difficulties are commonly reported by patients with epilepsy and can have a detrimental impact on overall quality of life. The purpose of this pilot study was to assess the efficacy of a psychotherapeutic approach, namely Cognitive Behavioral Therapy for Insomnia (CBT-I), in improving sleep quality in patients with epilepsy. Twenty outpatients with epilepsy who reported poor sleep quality were randomized to either a control or CBT-I treatmen...
Source: Epilepsy and Behavior - January 25, 2020 Category: Neurology Source Type: research

Children and adolescents with epilepsy in rehabilitation centers: A French prospective transversal study
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Delphine Coste-Zeitoun, Mathieu Kuchenbuch, Daniela Pennaroli, Clémence Castaignède, Sylvia Napuri, Christine Satre, Jean-Luc Schaff, Sylvie Sukno, Marie Hélias, Nathalie de Grissac-Moriez, Georges Delattolas, Dominique Olive, Christine Bulteau, Guy Zeitoun, Anna KaminskaAbstractIntroductionThe reason why some children and adolescent with epilepsy (CAWE) still challenge the “inclusive” educative policy needs to be explored.Methods/patientsWe conducted a transversal study in French medical, social, and ...
Source: Epilepsy and Behavior - January 25, 2020 Category: Neurology Source Type: research

Sexual and reproductive healthcare for adolescent and young adult women with epilepsy: A qualitative study of pediatric neurologists and epileptologists
ConclusionThis is the first study to assess attitudes and practices of pediatric neurologists and epileptologists regarding sexual and reproductive healthcare for adolescent and young adult WWE. Our findings suggest that there is a need for development of improved systems for sexual and reproductive healthcare delivery and comanagement for adolescent and young adult WWE. Providers identified many barriers and facilitators that might serve as the basis for interventions to improve care. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 25, 2020 Category: Neurology Source Type: research

Self-reported antiepilepsy medication adherence and its connection to perception of medication error
This study found that 41% of respondents reported suboptimal adherence to AED therapy, while 28.5% of respondents self-reported that they unintentionally do not take their AED medication on an occasional, regular, or frequent basis. A 5.9% of respondents self-reported that they intentionally do not take their medication as prescribed. A 6% of respondents self-reported that they are both unintentionally and intentionally nonadherent to their AED therapy. No significant associations were demonstrated between age, sex, perceived effectiveness of medication, feelings of stigma/embarrassment, adverse effects or additional neuro...
Source: Epilepsy and Behavior - January 25, 2020 Category: Neurology Source Type: research

Terminology for psychogenic nonepileptic seizures: Making the case for “functional seizures”
ConclusionFrom the available evidence, FS meets more of the criteria proposed for an acceptable label than other popular terms in the field. While the term FS is neutral with regard to etiology and pathology (particularly regarding whether psychological or not), other terms such as “dissociative”, “conversion”, or “psychogenic” seizures are not. In addition, FS can potentially facilitate multidisciplinary (physical and psychological) management more than other terms. Adopting a universally accepted terminology to describe this disorder could standardize our approach to the illness and fa...
Source: Epilepsy and Behavior - January 25, 2020 Category: Neurology Source Type: research

Emergency room diagnoses of psychogenic nonepileptic seizures with psychogenic status and functional (psychogenic) symptoms: Whopping
Publication date: March 2020Source: Epilepsy & Behavior, Volume 104, Part AAuthor(s): Helene Kholi, Laurent VercueilAbstractCollecting 130 electronic medical records and diagnoses from emergency room stays of eleven patients with confirmed psychogenic nonepileptic seizure (PNES) over a 17-year period (2001–2018), 48 different diagnostic terms were retrieved. This emphasized the need for a consensual terminology encompassing not only PNES but also all functional transient (paroxysmal) events, including episodes of motor or sensory deficits, and cognitive symptoms. Rather than defining what it is not (PNES, stroke ...
Source: Epilepsy and Behavior - January 24, 2020 Category: Neurology Source Type: research

Reply to the article “Management of status epilepticus in adults. Position paper of the Italian League against Epilepsy”
Publication date: Available online 23 January 2020Source: Epilepsy & BehaviorAuthor(s): Giuseppe Capovilla, Robert Nistico, Armando Magrelli (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 24, 2020 Category: Neurology Source Type: research

Incidence of seizure exacerbation and injury related to football participation in people with epilepsy
ConclusionThe risk of injury and seizure exacerbation due to participation in football for patients with epilepsy is low. Clinicians should use their best judgment in deciding whether contact sports increase risks for a particular patient based on individual seizure frequency, concurrent neurological and medical issues, and medication adverse effects. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

The other side of the leaf: Seizures associated with synthetic cannabinoid use
In conclusion, smoking of some synthetic cannabinoids is associated with seizures, and this may relate to an intrinsic proconvulsant effect. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Prevalence of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy from western China: A cross-sectional survey
ConclusionsMedication adherence is not high in children with epilepsy from western China. Medication adherence is affected by many factors, and we suggest that efforts are focused on tailored approaches to epilepsy education and behavioral interventions for better adherence. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

No improvement in quality of life in children with epilepsy treated with the low glycemic index diet
ConclusionsThe lack of improvement in patient-reported QoL points towards an overall negative impact of the LGIT on patient well-being, despite positive effects on seizure control. Our preliminary results indicate that the benefits of seizure control may subjectively be outweighed by adverse social effects of the LGIT. Families should be made aware of psychosocial risks of the diet. Whenever possible, children should be part of the therapeutic decision-making process. Larger prospective studies are required to fully assess the overall impact of the LGIT. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Knowledge and current practices of physiotherapists on the physical activity and exercise in the rehabilitation of children with epileptic seizures
ConclusionsIt was concluded that physiotherapists had sufficient knowledge about epilepsy and were using current skills/physical activity in the rehabilitation of children with epileptic seizures. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Patients' attitude toward AED withdrawal: A survey among individuals who had been seizure-free for over 2 years
ConclusionsMore than half of the patients with epilepsy preferred to continue their AED after 2 years of seizure freedom. Male gender, being single, and somewhat younger age were associated preferences to withdraw AED. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Painting epilepsy – The essence of disease by participants of the Latin American Summer School on Epilepsy (LASSE XIII)
ConclusionParticipants of LASSE XIII demonstrated an ability to empathize with their patients in retrospect by portraying the inner feelings of division and imprisonment of those having seizures. Epilepsy specialists visualize the disease as a composite phenomenon both in terms of its neural origin and of multidisciplinary requirements to implement its care. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Who is more important in stigmatization, family or friends?
In this study, it was aimed to investigate which of the current social support resources of the patients are related to stigmatization, whether the support received from family or friends and a special person.Materials and methodsA total of 60 patients with epilepsy (30 males and 30 females) were included in the study. Sociodemographic data form, stigma scale of epilepsy, and multidimensional scale of perceived social support were administered to all participants.ResultsDuration of education from sociodemographic variables and duration of epilepsy from clinical variables were associated with stigma scores (for each other, p 
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Social impairment and stigma in genetic generalized epilepsies
DiscussionWe found an impairment in every social domain assessed (except in level of education) when compared with general population. Most of the social outcome parameters were unexpectedly close or similar to MTLE-HS or even worse as it was the prevalence of homelessness among GGE. Social impairment is underdiagnosed and might be considered in clinical practice even in syndromes for some time considered benign such as GGE. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Improving neuropsychological seizure lateralization in Spanish-speaking people with epilepsy in the US: The need to account for education and demographic differences
ConclusionThis study demonstrated the clinical utility of the NeSBHIS in seizure lateralization in a large cohort of Spanish-speaking PWE by analyzing standardized scores based on refined, education-based normative samples. These results also highlight that demographic variables, in particular, education, which varies greatly across Spanish-speaking nations in terms of compulsory educational opportunity and quality, must be accounted for more carefully in clinical and research practice. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Quality of life and its association with comorbidities and adverse events from antiepileptic medications: Online survey of patients with epilepsy in Australia
This study aimed to explore the quality of life (QoL) of adult patients with epilepsy (PwE) in Australia and its relationship with comorbidities and adverse events (AEs) from antiepileptic drugs (AEDs).MethodsCross-sectional surveys were completed by PwE, or carer proxies, recruited via the online pharmacy application MedAdvisor and Australian PwE Facebook groups from May to August 2018. Data were collected on demographics, epilepsy severity and management, AEs, comorbidities, and QoL (using the Patient-Weighted Quality of Life in Epilepsy Inventory [QOLIE-10-P] total score). Two linear regression models were constructed t...
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research

Forced conceptual thought induced by electrical stimulation of the left prefrontal gyrus involves widespread neural networks
ConclusionsWe illustrate the neural networks involved in conceptual thought through a unique patient population and argue that PFC supports this function through activation of a widespread network. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - January 22, 2020 Category: Neurology Source Type: research