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Specialty: Neurology
Management: National Institutes of Health (NIH)

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Total 425 results found since Jan 2013.

New members selected for National Advisory Neurological Disorders and Stroke Council
Six esteemed individuals have been selected to serve on the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - February 4, 2016 Category: Neurology Source Type: news

Higher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
Abstract Insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke. We investigated whether there is a relationship between insulin resistance and clinical findings and outcomes of acute ischemic stroke patients treated with intravenous thrombolysis. In our study, 180 acute ischemic stroke non-diabetic patients treated with intravenous recombinant tissue-type plasminogen activator (iv rt-PA) were evaluated for insulin resistance assessed by homeostasis model assessment insulin resistance (HOMA-IR). The threshold for HOMA-IR was determined as 2.7. Patients were grouped as HOMA-IR > 2...
Source: Translational Stroke Research - January 30, 2016 Category: Neurology Source Type: research

Acute Ischemic Stroke with Very Early Clinical Improvement: A National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trials Exploratory Analysis
A high proportion of patients excluded from recombinant tissue plasminogen activator (rt-PA) treatment because of rapid improvement occurring before treatment decision had incomplete recovery. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Trials dataset allows for systematic analyses of very early postrandomization improvement (VEPRIM) in stroke severity as a National Institutes of Health Stroke Scale (NIHSS) score was available for all subjects enrolled in the study at baseline (NIHSSB) and at 2 hours after randomization (NIHSS2H).
Source: Journal of Stroke and Cerebrovascular Diseases - January 26, 2016 Category: Neurology Authors: Clotilde Balucani, Steven R. Levine, Jane C. Khoury, Pooja Khatri, Jeffrey L. Saver, Joseph P. Broderick Source Type: research

The National Institutes of Health StrokeNet: A Users Guide Editorials
Source: Stroke - January 25, 2016 Category: Neurology Authors: Broderick, J. P., Palesch, Y. Y., Janis, L. S., for the National Institutes of Health StrokeNet Investigators Tags: Cerebrovascular Disease/Stroke Editorials Source Type: research

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health St...
Source: Journal of Neuroinflammation - January 20, 2016 Category: Neurology Authors: R. ZangariE. ZanierG. TorganoA. BersanoS. BerettaE. BeghiB. CasollaN. CheccarelliS. LanfranconiA. MainoC. MandelliG. MicieliF. OrziE. PicettiM. SilvestriniN. StocchettiB. ZeccaP. GarredM. De Simonithe LEPAS group Source Type: research

Dynamic thiol–disulfide homeostasis in acute ischemic stroke patients
In this study, 54 patients and 53 healthy controls were included. The mean of the native thiol levels in the stroke group was 356.572 ± 61.659 μmol/L (min/max 228.00/546.40), while it was 415.453 ± 39.436 μmol/L (min/max 323.50/488.70) in the control group (p < 0.001). A negative, significant correlation was observed between the infarct volumes and native thiol levels (ρ = −0.378; p = 0.005), and the disulfide levels were similar between the groups (Z = 0.774; p = 0.439). Significant difference was found between the thiol levels of the mild and moderate-severe NIHSS groups (p = 0.026). The chang...
Source: Acta Neurologica Belgica - January 18, 2016 Category: Neurology Source Type: research

Stroke Severity and Comorbidity Index for Prediction of Mortality after Ischemic Stroke from the Virtual International Stroke Trials Archive–Acute Collaboration
There is increasing interest in the use of administrative data (incorporating comorbidity index) and stroke severity score to predict ischemic stroke mortality. The aim of this study was to determine the optimal timing for the collection of stroke severity data and the minimum clinical dataset to be included in models of stroke mortality. To address these issues, we chose the Virtual International Stroke Trials Archive (VISTA), which contains National Institutes of Health Stroke Scale (NIHSS) on admission and at 24 hours, as well as outcome at 90 days.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2016 Category: Neurology Authors: Thanh G. Phan, Benjamin Clissold, John Ly, Henry Ma, Chris Moran, Velandai Srikanth, VISTA–Acute Collaboration Source Type: research

Impact of Mechanical Thrombectomy on the Organization of the Management of Acute Ischemic Stroke
Background: Several trials and meta-analyses have recently demonstrated the superiority of endovascular therapy over standard medical treatment in patients presenting with acute ischemic stroke. In order to offer the best possible treatment to a maximum number of patients, many stroke care networks probably have to be reorganized. After analyzing the reliability of data in the literature, an algorithm is suggested for a pre-hospital and in-hospital alert system to improve the timeliness of subsequent treatment: a drip-and-ship approach. Summary: Five recent well-designed randomized studies have demonstrated the benefit of ...
Source: European Neurology - January 16, 2016 Category: Neurology Source Type: research

Elevated Serum Levels of CXC Chemokine Ligand-12 Are Associated with Unfavorable Functional Outcome and Mortality at 6-Month Follow-up in Chinese Patients with Acute Ischemic Stroke
Abstract The aim of this study was to examine whether the circulating CXC chemokine ligand-12 (CXCL12) level can predict a 6-month outcome in Chinese patients with acute ischemic stroke (AIS). In a prospective study, CXCL12 levels were measured on admission in the serum of 304 consecutive patients with AIS. The prognostic value of CXCL12 to predict the functional outcome and mortality within 1 year was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors. A receiver operating characteristic (ROC) curve was used to evaluate the accuracy of serum CXCL12 in predi...
Source: Molecular Neurobiology - January 16, 2016 Category: Neurology Source Type: research

Using Radiological Data to Estimate Ischemic Stroke Severity
Risk-adjusted poststroke mortality has been proposed for use as a measure of stroke care quality. Although valid measures of stroke severity (e.g., the National Institutes of Health Stroke Scale [NIHSS]) are not typically available in administrative datasets, radiology reports are often available within electronic health records. We sought to examine whether admission head computed tomography data could be used to estimate stroke severity.
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2016 Category: Neurology Authors: Jason J. Sico, Michael S. Phipps, John Concato, Cynthia Brandt, Carolyn K. Wells, Albert C. Lo, Stephen E. Nadeau, Linda S. Williams, Mark Gorman, John L. Boice, Dawn M. Bravata Source Type: research

Thrombolysis in Stroke Patients with Isolated Aphasia
Background: Data about evolution of aphasia following stroke are rare and controversial especially following fibrinolysis. The aim of this study was to describe the early clinical patterns of isolated aphasia in consecutive stroke patients with or without thrombolysis. Methods: Clinical and radiological data of consecutive stroke patients were routinely entered in prospective registry. Patients were considered aphasic when NIHSS (National Institutes of Health Stroke Scale) item 9>0. ‘Isolated aphasia' was defined by aphasic patients without motor limb deficit. We created a ‘composite language score' obtained by summing...
Source: Cerebrovascular Diseases - January 12, 2016 Category: Neurology Source Type: research

Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients
Abstract Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified consecutive adult CVT patients treated at the Helsinki University Hospital (1987–2013) and invited them to a follow-up visit. Each clinical examination was combined with interview. We also recorded recurrent venous thromboembolism (VTE) and hemorrhagic events during follow-up and antithrombo...
Source: Journal of Neurology - January 2, 2016 Category: Neurology Source Type: research

Speeding up brain ’s waste disposal may slow down neurodegenerative diseases
A study of mice shows how proteasomes, a cell ’s waste disposal system, may break down during Alzheimer’s disease (AD), creating a cycle in which increased levels of damaged proteins become toxic, clog proteasomes, and kill neurons. The study, published in Nature Medicine and supported by the National Institutes of Health, suggests that enh ancing proteasome activity with drugs during the early stages of AD may prevent dementia and reduce damage to the brain.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 21, 2015 Category: Neurology Source Type: news

Speeding up brain’s waste disposal may slow down neurodegenerative diseases
A study of mice shows how proteasomes, a cell’s waste disposal system, may break down during Alzheimer’s disease (AD), creating a cycle in which increased levels of damaged proteins become toxic, clog proteasomes, and kill neurons. The study, published in Nature Medicine and supported by the National Institutes of Health, suggests that enhancing proteasome activity with drugs during the early stages of AD may prevent dementia and reduce damage to the brain.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 21, 2015 Category: Neurology Source Type: news

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
Publication date: Available online 19 December 2015 Source:The Lancet Neurology Author(s): NINDS Stroke Genetics Network (SiGN)International Stroke Genetics Consortium (ISGC) Background The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. ...
Source: The Lancet Neurology - December 19, 2015 Category: Neurology Source Type: research