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Specialty: Neurology
Management: National Institutes of Health (NIH)
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Total 425 results found since Jan 2013.
Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands
Goal: Insufficient data is available about safety and efficacy of endovascular treatment (EVT) in patients with minor stroke symptoms because these patients were excluded from most randomized trials. We aimed to compare characteristics, functional outcome, and complications in patients with minor ischemic stroke National Institutes of Health Stroke Scale score ≤5 (NIHSS score ≤5) and moderate to severe ischemic stroke (NIHSS score ≥6) due to intracranial proximal artery occlusion of the anterior circulation who underwent EVT.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2018 Category: Neurology Authors: R.B. Goldhoorn, Maxim J.H.L. Mulder, Ivo G.H. Jansen, Wim H. van Zwam, Julie Staals, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Jan Albert Vos, Jelis Boiten, Ido R. van den Wijngaard, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Robert J. van Source Type: research
Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke
Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2018 Category: Neurology Authors: Aline Mansueto Mour ão, Laélia Cristina Caseiro Vicente, Mery Natali Silva Abreu, Romeu Vale Sant'Anna, Erica Leandro Marciano Vieira, Leonardo Cruz de Souza, Aline Silva de Miranda, Milene Alvarenga Rachid, Antônio Lucio Teixeira Source Type: research
Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset
Sturge-Weber Syndrome (SWS) is a neurocutaneous disorder caused by a somatic mosaic mutation in GNAQ.1 SWS brain involvement causes seizures, stroke-like episodes and/or neurological deficits such as hemiparesis and intellectual disability. Seventy-five percent of infants with SWS will develop seizures within the first year of life.2 Those with more severe epilepsy experience greater cognitive deficits and intellectual disability.3 There is ictal single-photon emission computed tomography evidence that, in SWS, the seizures themselves may contribute to the brain injury due to an abnormal hemodynamic response.
Source: Pediatric Neurology - November 24, 2018 Category: Neurology Authors: Alyssa M. Day, Adrienne M. Hammill, Csaba Juh ász, Anna L. Pinto, E. Steve Roach, Charles E. McCulloch, Anne M. Comi, National Institutes of Health Sponsor: Rare Diseases Clinical Research Network (RDCRN) Brain and Vascular Malformation Consortium (BVMC) Tags: Perspectives in Pediatric Neurology Source Type: research
Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.
Authors: Lupo A, Cinnera AM, Pucello A, Iosa M, Coiro P, Personeni S, Gimigliano F, Iolascon G, Paolucci S, Morone G
Abstract
Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute str...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research
Clinical outcomes depending on acute blood pressure after cerebral hemorrhage
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 12, 2018 Category: Neurology Authors: Kazunori Toyoda,
Masatoshi Koga,
Haruko Yamamoto,
Lydia Foster,
Yuko Y Palesch,
Yongjun Wang,
Nobuyuki Sakai,
Takayuki Hara,
Chung Y Hsu,
Ryo Itabashi,
Shoichiro Sato,
Mayumi Fukuda,
Thorsten Steiner,
Byung ‐Woo Yoon,
Daniel F Hanley,
Adn Tags: Research Article Source Type: research
Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
ObjectiveThe present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window.MethodsThis was a prospective, randomized, open ‐label, blinded endpoint clinical trial, enrolling patients with internal carotid artery or middle cerebral artery proximal occlusion within 4.5 to 6 hours from symptom onset. Patients were randomly assigned to receive alteplase alone or alteplase with fingolimod. All patients underwent pretreatme nt and 24‐hour noncontrast computed tomography (CT)/perfusion CT/CT angiography. The coprimary endpoint...
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: De ‐Cai Tian,
Kaibin Shi,
Zilong Zhu,
Jia Yao,
Xiaoxia Yang,
Lei Su,
Sheng Zhang,
Meixia Zhang,
Rayna J. Gonzales,
Qiang Liu,
DeRen Huang,
Michael F. Waters,
Kevin N. Sheth,
Andrew F. Ducruet,
Ying Fu,
Min Lou,
Fu‐Dong Shi Tags: Research Article Source Type: research
Neuroimaging and clinical outcomes of oral anticoagulant –associated intracerebral hemorrhage
ObjectiveWhether intracerebral hemorrhage (ICH) associated with non –vitamin K antagonist oral anticoagulants (NOAC‐ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA‐ICH) is uncertain.MethodsWe performed a systematic review and individual patient data meta ‐analysis of cohort studies comparing clinical and radiological outcomes between NOAC‐ICH and VKA‐ICH patients. The primary outcome measure was 30‐day all‐cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricul ar hemorrhage extension.Results...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Georgios Tsivgoulis,
Duncan Wilson,
Aristeidis H. Katsanos,
Jo ão Sargento‐Freitas,
Cláudia Marques‐Matos,
Elsa Azevedo,
Tomohide Adachi,
Christian Brelie,
Yoshifusa Aizawa,
Hiroshi Abe,
Hirofumi Tomita,
Ken Okumura,
Joji Hagii,
David J Tags: Research Article Source Type: research
Lp-PLA2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis.
Authors: Wang Y, Hu S, Ren L, Lei Z, Lan T, Cai J, Li C
Abstract
INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is still unclear. The aim of this study is to identify the relationship between Lp-PLA2 levels and early neurological deterioration (END) in acute ischemic stroke patients with Trial of Org 10 172 in Acute Stroke Treatment (TOAST) subtype of large arterial atherosclerosis (LAA).
METHODS: We enrolled Chinese patients with first ever acute ischemic stroke admitt...
Source: Neurological Research - October 10, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Epidemiology and Outcomes of Ischemic Stroke and Transient Ischemic Attack in the Adult and Geriatric Population
Background: Rate of ischemic strokes and transient ischemic attacks (TIAs) increases with age. There is lack of evidence on how age affects treatment strategies and outcomes. Our aim is to compare epidemiology of ischemic strokes and TIAs in adult and geriatric populations including risk factors, treatment delivered, and outcomes. Design: We designed a retrospective cross-sectional review of patients admitted to neurology with diagnosis of stroke or TIA from 2010 to 2015. Obtained variables were: age, sex, risk factors, acute therapy, National Institutes of Health Stroke Scale on admission and discharge, and disposition.
Source: Journal of Stroke and Cerebrovascular Diseases - October 6, 2018 Category: Neurology Authors: Allison Navis, Rocio Garcia-Santibanez, Maryna Skliut Source Type: research
Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Luis San Román, Bijoy K Menon, Jordi Blasco, María Hernández-Pérez, Antoni Dávalos, Charles B L M Majoie, Bruce C V Campbell, Francis Guillemin, Hester Lingsma, René Anxionnat, Jonathan Epstein, Jeffrey L Saver, Henk Marquering, John H Wong, Demetrius Lopes, Gernot Reimann, Hubert Desal, Diederik W J Dippel, Shelagh Coutts, Richard du Mesnil de RochemontSummaryBackgroundEvidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the associat...
Source: The Lancet Neurology - September 19, 2018 Category: Neurology Source Type: research
Congenital muscular dystrophies
To determine the minimal clinically important difference (MCID) for the motor function measure (MFM-32) in congenital muscular dystrophy and congenital myopathy patient an observational, retrospective, multicentric study was conducted on 85 congenital muscular dystrophy or congenital myopathy patients, aged 5 to 22 years at the national institute of neurological disorders and stroke of the national institutes of health and 2 French departments of paediatric physical medicine and rehabilitation. Data were collected if at least 2 MFMs were performed (MFM1 and MFM2) within 8 to 36 months of each other and if during MFM2 paren...
Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: L. Le Goff, M. Fink, G. Norato, P. Rippert, K. Meilleur, A.R. Foley, M. Jain, M. Waite, S. Donkervoort, C. B önnemann, C. Vuillerot Source Type: research
Complement Complex C5b-9 Levels Are Associated with the Clinical Outcomes of Acute Ischemic Stroke and Carotid Plaque Stability
AbstractThe terminal complement complex C5b-9 plays an important role in acute ischemic stroke (AIS) and carotid atherosclerosis. However, the associations between serum C5b-9, the severity and outcome of AIS, and the stability of carotid plaques have not been well investigated. In this clinical study, 70 patients with AIS and 70 healthy controls were enrolled. Serum C5b-9 levels at 72 h after stroke onset were measured by enzyme-linked immunosorbent assay (ELISA). Infarct size, the National Institutes of Health Stroke Scale (NIHSS), the 90-day modified Rankin Scale (mRS), and carotid plaque and stenosis were evaluated. ...
Source: Translational Stroke Research - September 1, 2018 Category: Neurology Source Type: research
Race is a Predictor of Withdrawal of Life Support in Patients with Intracerebral Hemorrhage
Introduction: Medical and socioeconomic factors may impact decisions to change the goals of care for patients with intracerebral hemorrhage (ICH) to comfort measures only. Methods: We reviewed prospectively collected data on patients with ICH, including baseline patient demographics, Glasgow Coma Scale (GCS), National Institute of Health Stroke Scale (NIHSS), and ICH score. We conducted multivariable logistic regression analysis to identify predictors of change to comfort measures only status. Results: Of 198 patients included in the analysis, 39 (19.7%) were made comfort measures only.
Source: Journal of Stroke and Cerebrovascular Diseases - August 16, 2018 Category: Neurology Authors: Stuart M. Fraser, Glenda L. Torres, Chunyan Cai, H. Alex Choi, Anjail Sharrief, Tiffany R. Chang Source Type: research
Laterality is an Independent Predictor of Endovascular Thrombectomy in Patients With Low National Institute of Health Stroke Scale
Endovascular thrombectomy (ET) for acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) is offered to select patients meeting strict criteria. One of the criteria is stroke severity as indicated by the National Institute of Health Stroke Scale (NIHSS). Inherently, NIHSS is biased towards left hemisphere strokes (LHS) with median NIHSS score 4 points higher than right hemisphere strokes (RHS). This may potentially affect clinical decision making and thrombectomy eligibility. We sought to test this hypothesis.
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2018 Category: Neurology Authors: Shashvat M. Desai, Marcelo Rocha, Matthew Starr, Bradley J. Molyneaux, Cynthia L. Kenmuir, Bradley A. Gross, Brian T. Jankowitz, Tudor G. Jovin, Ashutosh P. Jadhav Source Type: research
Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke
In this study, we investigated the short-term prognostic value of early measurement of irisin concentration in 1530 Han Chinese patients with acute ischemic stroke (AIS) from three stroke centers. The subjects were the first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Clinical information and stroke severity were collected at admission. Neurological evaluations were conducted at the 6-month follow-up. Serum levels of irisin, National Institutes of Health Stroke Scale (NIHSS), and conventional risk factors were evaluated to determine their value to pr...
Source: Neurotherapeutics - July 20, 2018 Category: Neurology Source Type: research
