Filtered By:
Specialty: Neurology
Management: National Institutes of Health (NIH)

This page shows you your search results in order of date.

Order by Relevance | Date

Total 425 results found since Jan 2013.

Prognostic Value of Venous Outflow Profiles on Multiphase CT Angiography for the Patients with Acute Ischemic Stroke After Endovascular Thrombectomy
This study supports that favorable peak venous VO profiles on mCTA might be a promising biomarker in predicting the good outcome in patients with AIS after EVT.
Source: Translational Stroke Research - September 5, 2023 Category: Neurology Source Type: research

Death and ADL Dependency After Scoring Zero on the NIHSS: A Swedish Retrospective Registry-Based Study
Discussion One of 17 patients has either died or become ADL-dependent 3 months after a 0-NIHSS stroke, stressing that these strokes are not always benign. Older and physically inactive patients are at greater risk of an adverse outcome.
Source: Neurology Clinical Practice - September 1, 2023 Category: Neurology Authors: Darehed, D., Reinholdsson, M., Viktorisson, A., Abzhandadze, T., Sunnerhagen, K. S. Tags: Outcome research, All Cerebrovascular disease/Stroke, Cohort studies Research Article Source Type: research

Ipsilateral and contralateral carotid stenosis contribute to the outcome of reperfusion treatment for ischemic stroke
DiscussionAccording to our findings, ICS and CCS negatively influence AIS patients' outcome treated by interventional therapies. ICS might exert an unfavorable effect both by cerebral hypoperfusion and by continuous microembolization toward ischemic area, while CCS is probable involved in reducing the collateral circles effectiveness. The importance of early carotid stenosis detection and treatment should then be reevaluated not only to manage the prevention approaches but also to obtain insights about post-stroke treatment strategies efficacy.
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research

Endovascular Treatment for Acute Ischemic Stroke in China: a study protocol for a prospective, national, multi-center, registry study
This study plans to enroll a total of 3,000 consecutive patients who received EVT for LVO. All eligible patients are adults aged 18 years or older with acute LVO who received EVT and standard medical treatment according to the Chinese stroke guidelines and local practice.OutcomeThe primary outcome is functional independence (modified Rankin Scale score, mRS ≤ 2) at 90 days. The secondary outcomes include (1) the proportion of patients with mRS scores of 0–1 at 90 days, (2) distribution of mRS at 90 days, (3) changes in National Institutes of Health stroke scale (NIHSS) at 24 h, 48 h, and 12 days or discharge (whichever...
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research

Case report: Mechanical thrombectomy for acute basilar artery occlusion via persistent hypoglossal artery
Persistent hypoglossal artery (PHA) is a rare carotid-vertebrobasilar anastomosis in adults. Here, we report a case of mechanical thrombectomy for acute basilar artery occlusion via the PHA. A 44-year-old man was admitted to our stroke unit with an unstable gait and aphasia for 2 h. The baseline National Institutes of Health Stroke Scale (NIHSS) score was 4, but the clinical symptoms continued to worsen. Computed tomography angiography showed the absence of the basilar artery and an abnormal anastomosis between the anterior and posterior circulation. Clinical symptoms continued to worsen, and endovascular treatment was sch...
Source: Frontiers in Neurology - July 27, 2023 Category: Neurology Source Type: research

Case report: Flow changes in routes of collateral circulation in patients with LVO and low NIHSS: a point favor to treat
In this study, we present the case of a 62-year-old individual, with left internal carotid occlusion stroke and low NIHSS, who had compensatory collateral flow from Willis polygon via the anterior communicating artery. The patient subsequently exhibited neurological deterioration and collateral flow failure from Willis polygon, indicating the need for urgent intervention. The study of collaterals in patients with large vessel occlusion stroke has garnered considerable attention, with research suggesting that individuals with low NIHSS scores and poor collateral profiles may be at a heightened risk of early neurological det...
Source: Frontiers in Neurology - June 8, 2023 Category: Neurology Source Type: research

Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5
AbstractAnalysis of a National Institutes of Health (NIH) trial shows that cigarette smoking protected tissue plasminogen activator (tPA)-treated patients from hemorrhage transformation (HT); however, the underlying mechanism is not clear. Damage to the integrity of the blood-brain barrier (BBB) is the pathological basis of HT. Here, we investigated the molecular events of BBB damage after acute ischemic stroke (AIS) usingin vitro oxygen-glucose deprivation (OGD) andin vivo mice middle cerebral artery occlusion (MCAO) models. Our results showed that the permeability of bEND.3 monolayer endothelial cells was significantly i...
Source: Translational Stroke Research - May 26, 2023 Category: Neurology Source Type: research

Association between clinician reported outcome and patient reported outcome measures one year after stroke
In evaluating the burden of stroke and the effect of stroke treatment, several clinicians ’ outcome measures regarding physical functioning are used, such as National Institutes of Health Stroke Scale (NIHSS),1 Barthel index,2 and modified Rankin Scale (mRS).3
Source: Journal of Stroke and Cerebrovascular Diseases - May 11, 2023 Category: Neurology Authors: Astrid Glimmerveen, Suzanne Holewijn, Sarah Vermeer Source Type: research

Intravenous thrombolysis for mild stroke: NIHSS 3 –5 Versus NIHSS 0–2
Studies have shown that mild stroke patients with National Institutes of Health Stroke Scale (NIHSS) score 3 –5 but not 0–2 may benefit from the intravenous thrombolysis when compared with antiplatelet therapy. We aimed to compare the safety and effectiveness of thrombolysis in mild stroke with NIHSS score of 0–2 vs. 3–5 and identify the predictors of an excellent functional outcome in a real world longitudinal registry.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2023 Category: Neurology Authors: Liyuan Wang, Guangshuo Li, Yahui Hao, Manjun Hao, Yunyun Xiong Source Type: research

Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke —A prospective single-center study
DiscussionOlder age, higher NIHSS, large vessel occlusion, and intra-arterial thrombolysis may correlate with ICH. The unfavorable outcome is more common in patients with ICH. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patient's prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA.
Source: Frontiers in Neurology - February 1, 2023 Category: Neurology Source Type: research

Case Report: Successful Anterior Circulation Thrombectomy After 24 Hours in An Adolescent
Arterial ischemic stroke (AIS) in children comes with the potential for morbidity and mortality and can result in a high cost of care and decreased quality of life among survivors.Children with AIS are increasingly being treated with mechanical thrombectomy (MT), but little is known about the risks and benefits 24 hours after a patient ’s last known well (LKW) time. A 16-year-old female presented with acute onset of dysarthria and right hemiparesis with LKW time 22 hours prior. Pediatric National Institutes of Health Stroke Scale (PedNIHSS) was 12.
Source: Pediatric Neurology - January 27, 2023 Category: Neurology Authors: Victoria Vinarsky, Lisa R. Sun, Vivek S. Yedavalli, Lindsay Schleifer, Karissa Arthur, Ferdinand Hui, Dana B. Harrar Tags: Research Paper Source Type: research

Corrigendum to ‘Self-Reported Race as a Social Determinant of Stroke Risk in Observational Versus Clinical Trial Datasets’
The authors regret omitting the funding support for Dr. Karen C. Johnston's effort on the project, National Center for Advancing Translational Science of the National Institutes of Health Award UL1TR003015/ KL2TR003016. The authors would like to apologize for any inconvenience caused.
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2022 Category: Neurology Authors: Alison L. Herman, Kevin N. Sheth, Olajide A. Williams, Karen C. Johnston, Shyam Prabhakaran, Adamde Havenon Tags: Corrigendum Source Type: research

Low NIHSS score large vessel occlusion caused by infective endocarditis treated with thrombectomy
A 24-year-old woman had undergone dental treatment 3 weeks before and had a mild fever for a week. She presented to the emergency department with the chief complaint of weakness in the right upper limb after waking up. She had mild paralysis of the right upper limb (National Institutes of Health Stroke Scale [NIHSS] score 1). Head magnetic resonance imaging (MRI) showed scattered infarcts in the left frontal and parietal lobes and left internal cerebral artery (ICA) occlusion (Fig. 1A, B). Cerebral angiography showed that the left ICA was occluded immediately after its origin (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2022 Category: Neurology Authors: So Matsukawa, Kohichi Go, Tao Yang, Takahisa Katsuki, Yohei Takenobu, Kenji Hashimoto Tags: Case Report Source Type: research

Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes —Where is the data: A systematic review
Women continue to face a greater lifetime morbidity and mortality from stroke and have been shown to respond differently to stroke treatments compared to men. Since 2016, updated National Institutes of Health (NIH) policies require research studies to consider sex as a biological variable. However, the way in which this policy affects study design, analysis, and reporting is variable, with few studies performing and reporting a subgroup analysis based on biological sex. In acute ischemic stroke, the underlying biological explanation for sex-based differences in patient outcomes and response to treatments remains understudi...
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research

The acute-to-chronic glycemic ratio correlates with the severity of illness at admission in patients with diabetes experiencing acute ischemic stroke
Acute hyperglycemia is a powerful indicator of the severity of acute ischemic stroke (AIS); however, the relationship between these two factors is not very clear in patients with diabetes. We aimed to retrospectively evaluate data from 335 consecutive patients who experienced AIS from November 2015 to November 2016 to investigate whether a comprehensive assessment of blood glucose levels is a more valuable indicator of the severity of AIS or the presence of acute hyperglycemia in patients with diabetes. We collected demographic data, clinical manifestation information, clinical scores, and laboratory data [including fastin...
Source: Frontiers in Neurology - November 7, 2022 Category: Neurology Source Type: research