Filtered By:
Specialty: Neurology
Management: National Institutes of Health (NIH)

This page shows you your search results in order of date. This is page number 20.

Order by Relevance | Date

Total 425 results found since Jan 2013.

Scientists manipulate consciousness in rats
Scientists showed that they could alter brain activity of rats and either wake them up or put them in an unconscious state by changing the firing rates of neurons in the central thalamus, a region known to regulate arousal. The study, published in eLIFE, was partially funded by the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 18, 2015 Category: Neurology Source Type: news

Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction
Abstract Evidence of the appropriate amount of fluid intake during the first few days after acute stroke was scarce. Concerns were raised in patients with acute malignant middle cerebral infarction, who tended to have malignant brain edema later. The purpose of the study was to evaluate the effect of fluid intake on the occurrence of malignant brain edema in patients with acute middle cerebral artery infarction. Patients with acute middle cerebral artery infarction who had National Institute of Health Stroke Scale (NIHSS) score of at least 15 were included. Baseline characteristics and amount of fluid intake durin...
Source: Translational Stroke Research - December 15, 2015 Category: Neurology Source Type: research

Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry
In this study, we aimed to identify which factors were associated with adverse outcomes of a minor stroke. Methods: The China National Stroke Registry (CNSR) is a nationwide prospective registry for patients presented to hospitals with acute cerebrovascular events between September 2007 and August 2008. The 3-month follow-up was completed in 4669 patients with a minor stroke defined as the initial neurological severity lower than 4 in the National Institutes of Health Stroke Scale (NIHSS). Multivariate model was used to determine the association between risk factors and clinical outcomes. Results: Of 4669 patients with a m...
Source: BMC Neurology - December 9, 2015 Category: Neurology Authors: Lingyun WuAnxin WangXianwei WangXingquan ZhaoChunxue WangLiping LiuHuaguang ZhengYongjun WangYibin CaoYilong Wangon behalf of the China National Stroke Registry investigators Source Type: research

Neurologic Complications of Human Immunodeficiency Virus Infection
This article reviews the neurologic complications caused by HIV infection, associated comorbidities, or antiretroviral drugs that are commonly encountered by neurologists. DISCLAIMER: This article was written by Dr Avindra Nath in his personal capacity. The views expressed are his own and do not necessarily represent the views of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
Source: CONTINUUM - December 1, 2015 Category: Neurology Tags: Review Articles Source Type: research

DNA repair factor linked to breast cancer may also play a role in Alzheimer’s disease
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia. The study was funded by the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - November 30, 2015 Category: Neurology Source Type: news

Development and Assessment of a Computer Algorithm for Stroke Vascular Localization Using Components of the National Institutes of Health Stroke Scale
The National Institutes of Health Stroke Scale (NIHSS) was not intended to be used to determine the stroke's vascular distribution. The aim of this study was to develop, assess the reliability, and validate a computer algorithm based on the NIHSS for this purpose.
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2015 Category: Neurology Authors: David P. Lerner, Bertrand P. Tseng, Larry B. Goldstein Source Type: research

Scientists identify main component of brain repair after stroke
Looking at brain tissue from mice, monkeys and humans, scientists have found that a molecule known as growth and differentiation factor 10 (GDF10) is a key player in repair mechanisms following stroke. The findings suggest that GDF10 may be a potential therapy for recovery after stroke. The study, published in Nature Neuroscience, was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 28, 2015 Category: Neurology Source Type: news

Study in mice shows how brain ignores distractions
In a study of mice, scientists discovered that a brain region called the thalamus may be critical for filtering out distractions. The study, published in Nature and partially funded by the National Institutes of Health, paves the way to understanding how defects in the thalamus might underlie symptoms seen in patients with autism, attention deficit hyperactivity disorder (ADHD), and schizophrenia.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 21, 2015 Category: Neurology Source Type: news

Nuclear transport problems linked to ALS and FTD
Three teams of scientists supported by the National Institutes of Health showed that a genetic mutation linked to some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) may destroy neurons by disrupting the movement of materials in and out of the cell’s nucleus, or command center where most of its DNA is stored.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 16, 2015 Category: Neurology Source Type: news

Treatment of Rivaroxaban versus Aspirin for Non-disabling Cerebrovascular Events (TRACE): study protocol for a randomized controlled trial
DiscussionEven though the new oral anticoagulants seem to be both safe and effective, few clinical trials have been carried out to test their effect on non-disabling cerebrovascular events. Treatment with rivaroxaban may prevent more cerebrovascular events with an acceptable risk profile after TIA or minor stroke, compared with aspirin, thus helping to improve the outcome of the disease.Trial registrationNo. NCT01923818
Source: BMC Neurology - October 12, 2015 Category: Neurology Authors: Fang YangWenrui JiangYa BaiJunliang HanXuedong LiuGuangyun ZhangGang Zhao Source Type: research

Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study
Background: The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development. Methods: Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanali...
Source: BMC Neurology - October 7, 2015 Category: Neurology Authors: David WangLeonid ChurilovRichard DowlingPeter MitchellBernard Yan Source Type: research

Current trends in the management of acute ischemic stroke
Srinivasan ParamasivamNeurology India 2015 63(5):665-672Stroke is the leading cause of disability and most of the cases are those of ischemic stroke. Management strategies especially for large vessel occlusive stroke have undergone a significant change in the recent years that include widespread use of thrombolytic medications followed by endovascular clot removal. For successful treatment by endovascular thrombectomy, the important factors are patient selection based on clinical criterion including age, time of onset, premorbid clinical condition, co-morbidities, National Institute of Health Stroke Scale, and imaging crit...
Source: Neurology India - October 6, 2015 Category: Neurology Authors: Srinivasan Paramasivam Source Type: research

NIH invests $85 million for BRAIN Initiative research
The National Institutes of Health announced its second wave of grants to support the goals of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, bringing the NIH investment to $85 million in fiscal year 2015.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 1, 2015 Category: Neurology Source Type: news

Dormant viral genes may awaken to cause ALS
Scientists at the National Institutes of Health (NIH) discovered that reactivation of ancient viral genes embedded in the human genome may cause the destruction of neurons in some forms of amyotrophic lateral sclerosis (ALS).
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 30, 2015 Category: Neurology Source Type: news

MicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke
Abstract The aim of this study is to determine the expression levels and clinical significance of circulating microRNAs (miRNAs), let-7e and miR-338 at different stages following ischemic stroke (IS). Seventy-two patients with IS at the acute stage were enrolled and monitored at different stages, and 51 healthy volunteers were served as the normal controls. Expression of let-7e and miR-338 in serum and cerebral spinal fluid (CSF) samples was analyzed by real-time quantitative PCR. The relationship between expression levels of let-7e and miR-338, National Institutes of Health Stroke Scale (NIHSS) scores, and the le...
Source: Translational Stroke Research - September 29, 2015 Category: Neurology Source Type: research