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Specialty: Neurology
Management: National Institutes of Health (NIH)

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Total 425 results found since Jan 2013.

Clinical prediction of large vessel occlusion in anterior circulation stroke: mission impossible?
Abstract Simple clinical scores to predict large vessel occlusion (LVO) in acute ischemic stroke would be helpful to triage patients in the prehospital phase. We assessed the ability of various combinations of National Institutes of Health Stroke Scale (NIHSS) subitems and published stroke scales (i.e., RACE scale, 3I-SS, sNIHSS-8, sNIHSS-5, sNIHSS-1, mNIHSS, a-NIHSS items profiles A–E, CPSS1, CPSS2, and CPSSS) to predict LVO on CT or MR arteriography in 1085 consecutive patients (39.4 % women, mean age 67.7 years) with anterior circulation strokes within 6 h of symptom onset. 657 patients (61 %) had an occl...
Source: Journal of Neurology - June 5, 2016 Category: Neurology Source Type: research

Patients with Low National Institutes of Health Stroke Scale Scores Have Longer Door-to-Needle Times: Analysis of a Telestroke Network
The benefits of intravenous tissue-type plasminogen activator (IV-tPA) in acute ischemic stroke (AIS) are time dependent. Because emergency rooms quickly initiate a stroke alert with more severe symptoms, we hypothesized that patients with lower National Institutes of Health Stroke Scale (NIHSS) scores, indicating a less severe stroke, would have longer door-to-needle (DTN) times compared to patients with higher NIHSS scores.
Source: Journal of Stroke and Cerebrovascular Diseases - June 2, 2016 Category: Neurology Authors: Archit Bhatt, Alexandra Lesko, Lindsay Lucas, Amit Kansara, Elizabeth Baraban Source Type: research

Mean Platelet Volume During Ischemic Stroke Is A Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome.
Abstract The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and in large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting, Studies are not currently available on the association between MPV and stroke recovery after neurorehabilitation. The relationship between MPV and clinical and functional outcome measures was assessed in twenty-four patients in the acute phase of first-ever ischemic stroke, and before and after 8-week intensive multifunctional neurorehabilitation. Neurorehabilitation was associated with improve...
Source: Current Neurovascular Research - May 16, 2016 Category: Neurology Authors: Ciancarelli I, De Amicis D, Di Massimo C, Pistarini C, Ciancarelli MG Tags: Curr Neurovasc Res Source Type: research

Association of post stroke depression with social factors, insomnia, and neurological status in Chinese elderly population
Abstract The purpose of this study was to investigate the association of post stroke depression (PSD) with social factors, insomnia, and neurological status among elderly Chinese patients with ischemic stroke. Six hundred and eight patients over 60 years of age, who had suffered from a first episode of ischemic stroke within 7 days, were enrolled into the study. They were divided into PSD and non-PSD groups according to the Self-rating Depression Scale (SDS) scores. The association of PSD with social factors, insomnia, and neurological status was analyzed using multivariable logistic regression analysis. Compare...
Source: Neurological Sciences - April 26, 2016 Category: Neurology Source Type: research

New role identified for scars at the site of injured spinal cord
For decades, it was thought that scar-forming cells called astrocytes were responsible for blocking neuronal regrowth across the level of spinal cord injury, but recent findings challenge this idea. According to a new mouse study, astrocyte scars may actually be required for repair and regrowth following spinal cord injury. The research was funded by the National Institutes of Health, and published in Nature.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - April 8, 2016 Category: Neurology Source Type: news

Infections Present on Admission and Stroke in the Young (P3.230)
Discussion: IPOA in young stroke patients are closely associated with NIHSS and subsequent poor outcomes at discharge. Further studies are needed to understand the role of infection and whether infections moderate the effect of stroke severity on stroke outcomes in young patients.Disclosure: Dr. Boehme has nothing to disclose. Dr. Hazan has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Rostanski has nothing to disclose. Dr. Willey has received personal compensation for activities with Heartier Incorporated. Dr. Marshall has received personal compensation in an editorial cap...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boehme, A., Hazan, R., Miller, E., Yaghi, S., Rostanski, S., Willey, J., Marshall, R., Elkind, M. Tags: Stroke in the Young Source Type: research

A Survey of Functional Movement Disorders at the National Institutes of Health (P1.073)
OBJECTIVE: To better characterize the clinical presentation of functional movement disorders. BACKGROUND: Functional (psychogenic) movement disorders are receiving greater attention as valid and treatable neurologic disorders. Unfortunately, the often long list of complaints with variable presentations may hamper timely diagnosis and treatment. METHODS: We reviewed 113 charts retrospectively of patients presenting to the National Institutes of Health. Patients were referred from 44 states and the District of Columbia, with the majority presenting from the local Washington D.C. metropolitan area. Most patients were diagnose...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ahmad, O., Maurer, C., Villegas, M. A. F., Lungu, C., Hallett, M. Tags: Movement Disorders: Miscellaneous Source Type: research

Infections Present on Admission and Stroke in the Young (I2.004)
Discussion: IPOA in young stroke patients are closely associated with NIHSS and subsequent poor outcomes at discharge. Further studies are needed to understand the role of infection and whether infections moderate the effect of stroke severity on stroke outcomes in young patients.Disclosure: Dr. Boehme has nothing to disclose. Dr. Hazan has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Rostanski has nothing to disclose. Dr. Willey has received personal compensation for activities with Heartier Incorporated. Dr. Marshall has received personal compensation in an editorial cap...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boehme, A., Hazan, R., Miller, E., Yaghi, S., Rostanski, S., Willey, J., Marshall, R., Elkind, M. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Data Blitz Presentations Source Type: research

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference
On March 10 to March 12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland, to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis (http://www.ninds.nih.gov/about_ninds/plans/tscler_research_plan.htm). In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the Nationa...
Source: Pediatric Neurology - April 1, 2016 Category: Neurology Authors: Mustafa Sahin, Elizabeth P. Henske, Brendan D. Manning, Kevin C. Ess, John J. Bissler, Eric Klann, David J. Kwiatkowski, Steven L. Roberds, Alcino J. Silva, Coryse St. Hillaire-Clarke, Lisa R. Young, Mark Zervas, Laura A. Mamounas, Tuberous Sclerosis Comp Tags: Topical Review Source Type: research

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations from the 2015 Strategic Planning Conference
On March 10-12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis (http://www.ninds.nih.gov/about_ninds/plans/tscler_research_plan.htm). In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the National Institut...
Source: Pediatric Neurology - April 1, 2016 Category: Neurology Authors: Mustafa Sahin, Elizabeth P. Henske, Brendan D. Manning, Kevin C. Ess, John J. Bissler, Eric Klann, David J. Kwiatkowski, Steven L. Roberds, Alcino Silva, Coryse St. Hillaire-Clarke, Lisa R. Young, Mark Zervas, Laura A. Mamounas, Tuberous Sclerosis Complex Tags: Topical Review Source Type: research

Imaging and Recurrent Cerebrovascular Events in Patients After Stroke
This cohort study seeks to determine predictors of early recurrent cerebrovascular events among patients with transient ischemic attacks and minor strokes and National Institutes of Health Stroke Scale scores of 0 to 3.
Source: JAMA Neurology - March 21, 2016 Category: Neurology Source Type: research

Eye cells may use math to detect motion
Our eyes constantly send bits of information about the world around us to our brains where the information is assembled into objects we recognize. Along the way, a series of neurons in the eye use electrical and chemical signals to relay the information. In a study of mice, National Institutes of Health (NIH) scientists showed how one type of neuron may do this to distinguish moving objects.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - March 7, 2016 Category: Neurology Source Type: news

National Institutes of Health Stroke Scale–Time Score Predicts Outcome after Endovascular Therapy in Acute Ischemic Stroke: A Retrospective Single-Center Study
In this study, we assessed whether a similar combination of the ORT and the NIHSS score can be applied to predict the outcomes after endovascular therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2016 Category: Neurology Authors: Kenichi Todo, Nobuyuki Sakai, Tomoyuki Kono, Taku Hoshi, Hirotoshi Imamura, Hidemitsu Adachi, Nobuo Kohara Source Type: research

Systolic Blood Pressure Variability is Associated with Severe Hemorrhagic Transformation in the Early Stage After Thrombolysis
Abstract The present study investigates the association between hour-to-hour blood pressure (BP) variability and severe hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) during hyperacute stage. We analyzed hour-to-hour BP measurement within 24 h after IVT in patients with acute ischemic stroke. We calculated the maximum, minimum, and average (mean) of 24-h BP values, and BP variability profiles including standard deviation (SD), average squared difference between successive measurements (SV), average squared difference between rise and drop successive measurements (SV rise and SV drop), and ma...
Source: Translational Stroke Research - February 19, 2016 Category: Neurology Source Type: research