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Specialty: Neurology
Drug: Insulin

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Total 327 results found since Jan 2013.

Role of Adiponectin in Central Nervous System Disorders.
Abstract Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation of glucose and lipid metabolism. Adiponectin also possesses insulin-sensitizing, anti-inflammatory, angiogenic, and vasodilatory properties which may influence central nervous system (CNS) disorders. Although initially not thought to cross the blood-brain barrier, adiponectin enters the brain through peripheral circulation. In the brain, adiponectin signaling through its receptors, AdipoR1 and AdipoR2, directly influences important brain functions such as energy homeostasis, hippocampal neurogenesis, and synaptic pl...
Source: Neural Plasticity - August 30, 2018 Category: Neurology Authors: Bloemer J, Pinky PD, Govindarajulu M, Hong H, Judd R, Amin RH, Moore T, Dhanasekaran M, Reed MN, Suppiramaniam V Tags: Neural Plast Source Type: research

Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational study
Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS). However, in patients who have suffered IS, various associations between the levels of serum IGF-I (s-IGF-I...
Source: BMC Neurology - August 6, 2018 Category: Neurology Authors: N. David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, H. Georg Kuhn, Johan Svensson, Christina Jern and Jörgen Isgaard Tags: Research article Source Type: research

Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice Basic Sciences
Conclusions—miR-141-3p is increased with poststroke isolation. Inhibition of miR-141-3p improved mortality, neurological deficits, and decreased infarct volumes. Importantly, these therapeutic effects occurred in aged animals, the population most at risk for stroke and poststroke isolation.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Rajkumar Verma, Rodney M. Ritzel, Nia M. Harris, Juneyoung Lee, TaeHee Kim, Gopal Pandi, Raghu Vemuganti, Louise D. McCullough Tags: Basic Science Research, Ischemia, Translational Studies Original Contributions Source Type: research

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease Clinical Sciences
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice.
In this study, we confirmed the ameliorative effects of KY-226 on ischemia/reperfusion (I/R) injury using a murine model of middle cerebral artery occlusion (MCAO). ICR mice were subjected to MCAO for 2 h followed by reperfusion. Although KY-226 permeability was poor through the blood-brain barrier (BBB) of normal mice, it could penetrate through the BBB of mice after I/R insult. Intraperitoneal KY-226 administration elicited dose-dependent reductions in infarcted brain areas and improved neurological deficits. The neuroprotective effects of KY-266 were obtained when administered within 0.5 h after reperfusion. KY-226 (10 ...
Source: Brain Research - April 26, 2018 Category: Neurology Authors: Sun M, Izumi H, Shinoda Y, Fukunaga K Tags: Brain Res Source Type: research

Growth Hormone Improves Cognitive Function After Experimental Stroke Basic Sciences
Conclusions—These findings provide compelling preclinical evidence for the usage of GH as a potential therapeutic tool in the recovery phase of patients after stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lin Kooi Ong, Wei Zhen Chow, Clifford TeBay, Murielle Kluge, Giovanni Pietrogrande, Katarzyna Zalewska, Patricia Crock, N. David Aberg, Andrew Bivard, Sarah J. Johnson, Frederick R. Walker, Michael Nilsson, Jorgen Isgaard Tags: Angiogenesis, Basic Science Research, Growth Factors/Cytokines, Cognitive Impairment, Neurogenesis Original Contributions Source Type: research

Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Diabetic Rats via Enhanced Post-Ischemic Mitochondrial Dysfunction
AbstractDiabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function has been implicated as a central player in the development of cerebral ischemic damage. Hypoglycemia is also known to affect mitochondrial functioning. The present study tested the hypothesis that prior exposure of insulin-treated diabetic (ITD) rats to RH exacerbates brain damage via enhanced post-is...
Source: Translational Stroke Research - March 22, 2018 Category: Neurology Source Type: research

Blood microRNA-15a correlates with IL-6, IGF-1 and acute cerebral ischemia.
CONCLUSIONS: Blood miR-15a was associated with IL-6,IGF-1 and acute cerebral ischemia. It could serve as a potential diagnostic biomarker and therapeutic target for stroke. PMID: 29557747 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - March 19, 2018 Category: Neurology Authors: Lu W, Wang Y, Zhang Y, Liang H, Tu X, He J, Yang G, Zeng L Tags: Curr Neurovasc Res Source Type: research

Insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in Chinese subjects from ischemic stroke
Previous studies suggested that insulin resistance (IR) may be a significant causal risk factor for cardiovascular events and depression independent of other risk factors. In this prospective, we assess the value of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) at admission to predict post-stroke depression (PSD) later developed at 3 months follow-up.
Source: Journal of Affective Disorders - February 2, 2018 Category: Neurology Authors: Han-Cheng Qiu, Hui-Zhen Liu, Xuemei Li, Xianwei Zeng, Ji-Zong Zhao Tags: Research paper Source Type: research

Association between β‐cell function estimated by HOMA‐β and prognosis of non‐diabetic patients with ischaemic stroke
ConclusionsOur study shows that lower HOMA‐β level is associated with poor outcomes at 1 year in non‐diabetic patients with ischaemic stroke.
Source: European Journal of Neurology - January 15, 2018 Category: Neurology Authors: M. Zhou, Y. Pan, J. Jing, Y. Wang, X. Zhao, L. Liu, H. Li, Y. Wang Tags: Original Article Source Type: research

European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre ‐hospital management of stroke
ConclusionsThese guidelines inform on the contemporary approach to patients with suspected stroke in the pre‐hospital setting. Further studies, preferably randomized controlled trials, are required to examine the impact of particular interventions on quality parameters and outcome.
Source: European Journal of Neurology - January 12, 2018 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G. A. Ford, A. C. Fonseca, G. J. Luijckx, J. Korv, N. P érez Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guideline Source Type: research

Non ‐alcoholic Fatty Liver Disease is associated with stroke severity and progression of brainstem infarctions
ConclusionThese results suggest that NAFLD is a potential risk factor when evaluating the severity and progression of acute BSIs. This relationship is independent of classic risk factors and metabolic syndrome features.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Haiyan Li, Biao Hu, Wei Lei, Li Zhou, Lei Zhang, Yinyao Lin, Bing Qin, Yongqiang Dai, Zhengqi Lu Tags: Original Article Source Type: research

European Academy of Neurology – European Stroke Organisation consensus statement and practical guidance for pre‐hospital management of stroke
This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 7, 2017 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G.A. Ford, A.C. Fonseca, G.J. Luijckx, J. Korv, N. P érez de la Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guidelines Source Type: research

Association between β‐cell function estimated by HOMA‐β and prognosis of nondiabetic patients with ischaemic stroke
ConclusionsOur study shows that lower HOMA‐β level is associated with poor outcomes at one year in nondiabetic patients with ischaemic stroke.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 1, 2017 Category: Neurology Authors: Mengyuan Zhou, Yuesong Pan, Jing Jing, Yongjun Wang, Xingquan Zhao, Liping Liu, Hao Li, Yilong Wang Tags: Original Article Source Type: research

Which Patients With Ischemic Stroke and Insulin Resistance May Benefit From Pioglitazone?
The Insulin Resistance Intervention After Stroke (IRIS) trial has reported that treating insulin resistance with the peroxisome proliferator –activated receptor γ agonist pioglitazone hydrochloride reduced recurrent stroke or myocardial infarction (MI) by about one-fourth compared with placebo (pioglitazone, 9.0% vs placebo, 11.8%; hazard ratio [HR], 0.76; 95% CI, 0.62-0.93) in 3876 patients with recent (<6 months) ischemic stroke or transient ischemic attack and insulin resistance but without diabetes, heart failure, or bladder cancer. Pioglitazone was also associated with less incident diabetes vs placebo (3.8% vs ...
Source: JAMA Neurology - November 1, 2017 Category: Neurology Source Type: research