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Specialty: Neurology
Drug: Insulin
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Total 327 results found since Jan 2013.
MiR-125a-5p silencing inhibits cerebral ischemia-induced injury through targeting IGFBP3
This study conducted a series of experiments that were designed to elucidate the regulatory action of miR-125a-5p in ischemic brain injury and its underlying mechanisms. The results of this study found that the expression of miR-125a-5p was increased in BV2 microglial cells under oxygen-glucose deprivation/reoxygenation (OGD/R) setting, as well as in rat brain tissue after middle cerebral artery occlusion (MCAO). OGD/R triggered BV2 microglial cell apoptosis, whereas downregulation of miRNA-125a-5p suppressed the apoptosis rate in OGD/R-induced BV2 microglial cells. Subsequently, insulin-like growth factor binding protein ...
Source: Folia Neuropathologica - July 21, 2021 Category: Neurology Authors: Bo Song Jing Xu Ping Zhong Lei Fang Source Type: research
High Triglyceride Glucose Index Is Associated with Poor Outcomes in Ischemic Stroke Patients after Reperfusion Therapy
Conclusions: IR, represented by a high TyG index, may predict poor 3-month functional outcomes in patients with AIS who undergo reperfusion therapy.Cerebrovasc Dis
Source: Cerebrovascular Diseases - July 6, 2021 Category: Neurology Source Type: research
Stroke Prevention: Little-Known and Neglected Aspects
Combining available therapies has the potential to reduce the risk of stroke by 80% or more. A comprehensive review of all aspects of stroke prevention would be very lengthy; in this narrative review, we focus on some aspects of stroke prevention that are little-known and/or neglected. These include the following: (1) implementation of a Mediterranean diet; (2) B vitamins to lower homocysteine; (3) coordinated approaches to smoking cessation; (4) intensive lipid-lowering therapy; (5) lipid lowering in the elderly; (6) physiologically individualized therapy for hypertension based on renin/aldosterone phenotyping; (7) avoidi...
Source: Cerebrovascular Diseases - May 27, 2021 Category: Neurology Source Type: research
Mild traumatic brain injury increases vulnerability to cerebral ischemia in mice
Exp Neurol. 2021 May 13:113765. doi: 10.1016/j.expneurol.2021.113765. Online ahead of print.ABSTRACTRecent studies have reported that TBI is an independent risk factor for subsequent stroke. Here, we tested the hypothesis that TBI would exacerbate experimental stroke outcomes via alternations in neuroimmune and neurometabolic function. We performed a mild closed-head TBI and then one week later induced an experimental stroke in adult male mice. Mice that had previously experienced TBI exhibited larger infarcts, greater functional deficits, and more pronounced neuroinflammatory responses to stroke. We hypothesized that impa...
Source: Experimental Neurology - May 16, 2021 Category: Neurology Authors: Zachary M Weil Kate Karelina Bailey Whitehead Ruth Velazquez-Cruz Robin Oliverio Mark Pinti Divine C Nwafor Samuel Nicholson Julie A Fitzgerald John Hollander Candice M Brown Ning Zhang A Courtney DeVries Source Type: research
An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
Conclusion: Overweight/obese patients with ischemic stroke have better survival than patients with low/normal weight. The association of BMI and stroke outcome is not changed by TYG index.
Source: Frontiers in Neurology - April 22, 2021 Category: Neurology Source Type: research
Positive Association Between Serum Insulin-Like Growth Factor-1 and Cognition in Patients with Cerebral Small Vessel Disease
Cognitive impairment is one of the main complications of cerebral small vessel disease (CSVD). Serum insulin-like growth factor-1 (IGF-1) might serve as a marker for the risk of cognitive decline in patients with CSVD. We investigated the association of IGF-1 with the development of cognitive impairment in patients with CSVD. We included 216 patients with CVSD (mean age, 67.57 ± 8.53 years; 31.9% female). We compared 117 (54.2%) patients who developed cognitive impairment with 99 (45.8%) patients without cognitive impairment.
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Jingwen Kang, Wenqiu Luo, Cuiwei Zhang, Yi Ren, Liping Cao, Jian Wu, Huajie Li Source Type: research
