Non ‐alcoholic Fatty Liver Disease is associated with stroke severity and progression of brainstem infarctions

Abstract BackgroundNon‐alcoholic fatty liver disease (NAFLD) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance, and type 2 diabetes mellitus (T2DM). We sought to assess the association between a specific stroke subgroup, brainstem infarctions (BSIs), and NAFLD. Furthermore, we evaluated whether NAFLD is an independent risk factor in patients with BSIs. MethodsNAFLD was assessed in 306 radiologically confirmed BSIs patients via liver ultrasound. Differences between patients with and without NAFLD were compared. Data associated with stroke severity and progression after admission was collected. ResultsNAFLD was found in 130 (42.5%) patients with acute BSIs; 58 (19.0%) had National Institutes of Health Stroke Scale (NIHSS) scores>7, and 57 (18.6%) had progression after admission. Initial NIHSS scores, incidence of progression and stroke severity, and modified Rankin Scale (mRS) scores at discharge were significantly higher in patients with NAFLD than those without NAFLD. NAFLD was associated with stroke severity (Cox Regression, HR 2.243, CI 1.254–4.013, p
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research

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