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How Can You Mend a Broken Brain - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 13, 2014 Category: Neurology Source Type: research

Application of 68Ga-PRGD2 PET/CT for αvβ3-integrin Imaging of Myocardial Infarction and Stroke
Conclusions: 68Ga-PRGD2 uptake was observed around the ischemic region in both MI and stroke patients, which was correlated with the disease phase and severity. The different image patterns and uptake levels in MI and stroke patients warrant further investigations.
Source: Theranostics - November 15, 2014 Category: Molecular Biology Authors: Yi Sun, Yong Zeng, Yicheng Zhu, Feng Feng, Weihai Xu, Chenxi Wu, Bing Xing, Weihong Zhang, Peiling Wu, Liying Cui, Renzhi Wang, Fang Li, Xiaoyuan Chen, Zhaohui Zhu Tags: Research Paper Source Type: research

Peripheral to central: organ interactions in stroke pathophysiology.
Abstract Stroke is associated with a high risk of disability and mortality, and with the exception of recombinant tissue-type plasminogen activator for acute stroke, most treatments have proven ineffective. Clinical translation of promising experimental therapeutics is limited by inadequate stroke models and a lack of understanding of the mechanisms underlying acute stroke and how they affect outcome. Bidirectional communication between the ischemic brain and peripheral immune system modulates stroke progression and tissue repair, while epidemiological studies have provided evidence of an association between organ...
Source: Experimental Neurology - June 5, 2015 Category: Neurology Authors: Ma S, Zhao H, Ji X, Luo Y Tags: Exp Neurol Source Type: research

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative
Abstract Stroke not only causes initial cell death, but also a limited process of repair and recovery. As an overall biological process, stroke has been most often considered from the perspective of early phases of ischemia, how these inter-relate and lead to expansion of the infarct. However, just as the biology of later stages of stroke becomes better understood, the clinical realities of stroke indicate that it is now more a chronic disease than an acute killer. As an overall biological process, it is now more important to understand how early cell death leads to the later, limited recovery so as develop an int...
Source: Neurotherapeutics - November 24, 2015 Category: Neurology Source Type: research

Incidence of Stroke Following Thoracic Endovascular Aortic Repair for Descending Aortic Aneurysm: A Systematic Review of the Literature with Meta-analysis.
CONCLUSION: Stroke incidence is an important morbidity after TEVAR, and probably increases if the LSA is covered during the procedure, particularly in those without revascularisation. PMID: 27993454 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - December 15, 2016 Category: Surgery Authors: von Allmen RS, Gahl B, Powell JT Tags: Eur J Vasc Endovasc Surg Source Type: research

Immunomodulatory Therapeutic Strategies in Stroke
The role of immunity in all stages of stroke is increasingly being recognised, from the pathogenesis of risk factors to tissue repair, leading to the investigation of a range of immunomodulatory therapies. In the acute phase of stroke, proposed therapies include drugs targeting pro-inflammatory cytokines, matrix metalloproteinases, and leukocyte infiltration, with a key objective to reduce initial brain cell toxicity. Systemically, the early stages of stroke are also characterised by stroke-induced immunosuppression, where downregulation of host defences predisposes patients to infection. Therefore, strategies to modulate ...
Source: Frontiers in Pharmacology - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Hemorrhagic Transformation and Stroke Recurrence in Children with Cardiac Disease Receiving Antithrombotic Therapy for Secondary Stroke Prevention
CONCLUSIONS: In spite of the 24% hemorrhagic transformation rate, antithrombotic therapy has a positive risk-balance in certain cardioembolic stroke subgroups, particularly in those with single-ventricle physiology, when accounting for stroke volume.PMID:34152075 | DOI:10.1111/jth.15428
Source: Thrombosis and Haemostasis - June 21, 2021 Category: Hematology Authors: Elizabeth Pulcine Mike Seed Leonardo R Brand ão Mahmoud Slim Sunitha Palasamudram Manohar Shroff Mahendranath Moharir Gabrielle deVeber Nomazulu Dlamini Source Type: research

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice
This study aims to evaluate the potential effects of rFGF21 on cerebrovascular remodeling after T2DM stroke. Permanent distal middle cerebral artery occlusion was performed in heterozygous non-diabetic db/ + and homozygous diabetic db/db mice. Daily rFGF21 administration was initiated 1 week after stroke induction and maintained for up to 2 weeks thereafter. Multiple markers associated with post-stroke recovery, including angiogenesis, oligodendrogenesis, white matter integrity, and neurogenesis, were assessed up to 3 weeks after stroke. Our results showed an impairment in post-stroke vascular remodeling under T2DM conditi...
Source: Cell Research - September 15, 2021 Category: Cytology Authors: Yinghua Jiang Jinrui Han Yadan Li Yinga Wu Ning Liu Samuel X Shi Li Lin Jing Yuan Shusheng Wang Ming-Ming Ning Aaron S Dumont Xiaoying Wang Source Type: research

ERCC1 polymorphism and its expression associated with ischemic stroke in Chinese population
ConclusionIt was suggested that the ERCC1 rs3212986 polymorphism was associated with ischemic stroke susceptibility in a Chinese Han population and that an A allele of rs3212986 was related to increased ischemic stroke risk. The altered ERCC1 expression level caused by the rs3212986 polymorphism might participate in the pathophysiological process of ischemic stroke.
Source: Frontiers in Neurology - January 12, 2023 Category: Neurology Source Type: research

Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research

The Relationship of Astrocytes and Microglia with Different Stages of Ischemic Stroke
CONCLUSION: Understanding the details of astrocyte-microglia interaction processes will contribute to a better understanding of the mechanisms underlying ischemic stroke, contributing to the identification of new therapeutic interventions.PMID:37464832 | DOI:10.2174/1570159X21666230718104634
Source: Current Neuropharmacology - July 19, 2023 Category: Drugs & Pharmacology Authors: Zhen Liang Yingyue Lou Yulei Hao Hui Li Jiachun Feng Songyan Liu Source Type: research