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Total 585 results found since Jan 2013.

Clinical and radiographic phenotypes of patients with multifocal subcortical versus cortical cerebral infarcts
Infarct topology is a key determinant in classification of a stroke as potentially embolic, with cortical and multifocal lesions being presumed embolic. Whether isolated subcortical multifocal infarcts are likely embolic has not been well studied.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2022 Category: Neurology Authors: Emma Frost, Scott Kamen, Solomon Oak, Christopher Higham, Lauren Thau, Nicholas Vigilante, Jared Wolfe, Jesse M. Thon, H. Christian Schumacher, James E. Siegler Source Type: research

Intracranial artery stenosis is associated with cortical thinning in stroke-free individuals of two longitudinal cohorts
CONCLUSION: We found both radiographically and neuropathologically determined aICAS to be associated with global cortical thinning. Interestingly, posterior circulation stenoses appeared to drive this association with global cortical thinning, raising the possibility of pathophysiologic mechanisms for cortical thinning other than impaired hemodynamics.PMID:36577280 | DOI:10.1016/j.jns.2022.120533
Source: Atherosclerosis - December 28, 2022 Category: Cardiology Authors: Dixon Yang Arjun V Masurkar Farid Khasiyev Tatjana Rundek Clinton B Wright Mitchell S V Elkind Ralph L Sacco Jose Gutierrez Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Publication date: Available online 12 February 2015 Source:The Lancet Neurology Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods W...
Source: The Lancet Neurology - February 13, 2015 Category: Neurology Source Type: research

Vertigo and Dizziness in Anterior Circulation Cerebrovascular Disease: A Systematic Review (P3.092)
CONCLUSIONS: Vertigo and dizziness are not rare manifestations of carotid territory ischemia, particularly in the temporo-parietal regions. Although dizziness is generally more prevalent in women, anterior circulation stroke causing dizziness appears to be more prevalent in men. Clinicians should carefully consider a search for anterior circulation vascular disease in patients presenting with vestibular symptoms.Disclosure: Dr. Zhou has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Mantokoudis has nothing to disclose. Dr. Saber Tehrani has nothing to disclose. Dr. Ying has nothing to disclose. Dr. Kerber has re...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Zhou, Y., Lee, S.-H., Mantokoudis, G., Saber Tehrani, A., Ying, S., Kerber, K., Hsieh, Y.-H., Robinson, K., Hanley, D., Zee, D., Newman-Toker, D. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical Management Source Type: research

Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
Publication date: Available online 31 October 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Michael R McClung, Michelle L O'Donoghue, Socrates E Papapoulos, Henry Bone, Bente Langdahl, Kenneth G Saag, Ian R Reid, Douglas P Kiel, Ilaria Cavallari, Marc P Bonaca, Stephen D Wiviott, Tobias de Villiers, Xu Ling, Kurt Lippuner, Toshitaka Nakamura, Jean-Yves Reginster, Jose Adolfo Rodriguez-Portales, Christian Roux, José Zanchetta, Cristiano A F ZerbiniSummaryBackgroundOdanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone...
Source: The Lancet Diabetes and Endocrinology - November 2, 2019 Category: Endocrinology Source Type: research

Comparison of risk factors, treatment, and outcome in patients with symptomatic intracranial atherosclerotic disease in India and the United States
Conclusion: Compared to patients in US with symptomatic ICAD, Indian patients were younger and had more severe strokes. However, Indian patients had lower rates of recurrent stroke, perhaps due to greater use of dual antiplatelet therapy.
Source: Annals of Indian Academy of Neurology - June 9, 2020 Category: Neurology Authors: Udit Saraf Shyam Prabhakaran K Arun Ahmed Babiker Adithyan Rajendran Chandrasekharan Kesavadas PN Sylaja Source Type: research

E-019 tcar
ConclusionsOur analysis of a single-center cohort demonstrates that TCAR is a safe and effective treatment for symptomatic carotid stenosis, with a low perioperative stroke risk. The present study’s findings concur with the combined adverse outcome rate of 3.5% reported in the ROADSTER trial.Disclosures A. Bajaj: None. S. Monje: None. C. Ayala: None. J. Poggi: None. E. Shaaya: None. J. Feler: None. K. Moldovan: None. C. Doberstein: None. R. McTaggart: None. R. Torabi: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Bajaj, A., Monje, S., Ayala, C., Poggi, J., Shaaya, E., Feler, J., Moldovan, K., Doberstein, C., McTaggart, R., Torabi, R. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-124 Timing surgery and hemorrhagic complications in endocarditis with concomitant cerebral complications
ConclusionsPatients with radiographic evidence of ischemic stroke from septic emboli can safely undergo valvular surgery for IE without increased risk of symptomatic hemorrhage. We advocate for baseline CTA screening to evaluate for IIA in patients who present with a primary diagnosis of IE and propose a management algorithm.Disclosures B. Lucke-Wold: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lucke-Wold, B. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

LB-008 Treatment outcomes for ARUBA eligible brain arteriovenous malformations: a comparison of real-world data from the NVQI-QOD AVM registry to the ARUBA trial
ConclusionOur results suggest that intervention for unruptured brain AVMs at specialized centers across the United States is safe and effective.DisclosuresA. Alrohimi: None. R. Achey: None. R. Abdalla: None. T. Patterson: None. Y. Moazeni: None. P. Rasmussen: None. G. Toth: None. M. Bain: None. S. Ansari: None. S. Hussain: None. N. Moore: None.
Source: Journal of NeuroInterventional Surgery - August 3, 2023 Category: Neurosurgery Authors: Alrohimi, A., Achey, R., Abdalla, R., Patterson, T., Moazeni, Y., Rasmussen, P., Toth, G., Bain, M., Ansari, S., Hussain, S., Moore, N. Tags: SNIS 20th annual meeting late-breaking oral abstracts Source Type: research

Is There an Increased Risk of Intracranial Hemorrhage When Treating Patients Who Are Currently on Dual Anti-Platelets with IV tPA? (P01.233)
CONCLUSIONS: In our cohort, there was no additional risk of hemorrhagic complications in patients on dual antiplatelet therapy who received IVtPA, prospective studies are needed to confirm this finding.Disclosure: Dr. Kung has nothing to disclose. Dr. Korsnack has nothing to disclose. Dr. Zaidi has nothing to disclose. Dr. Jumaa has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kung, V., Korsnack, A., Zaidi, S., Jumaa, M. Tags: P01 Cerebrovascular Disease I Source Type: research

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Conclusions Data from the current study indicate that an H2-enriched intravenous solution is safe for patients with acute cerebral infarction, including patients treated with t-PA.
Source: Medical Gas Research - June 25, 2013 Category: Biomedical Science Source Type: research

Cn-20 * bevacizumab causing recurrent cerebral infarction in a patient with glioblastoma: a previously undocumented phenomenon
CONCLUSIONS: Here we describe a case of an ischemic stroke with radiographic correlate while on bevacizumab, with clinical improvement arrested by the development of a recurrent stroke when bevacizumab was restarted. Interestingly, the distal arteries within the stroke bed appeared somewhat attentuated, suggestive of radiation vasculopathy. This case, describing a previously undocumented phenomenon, raises the possibility of a synergistic effect of bevacizumab and radiation vasculopathy. It may be that radiation vasculoapthy alone is typically insufficient to cause ischemia, but the addition of bevacizumab may precipitate ...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Winkel, D., Voloschin, A. Tags: COMPLICATIONS OF THERAPY AND NEUROTOXICITY Source Type: research

P-001 Permanent Implantation of the Solitaire Device as a Bailout Technique for Large Vessel Intracranial Occlusions
ConclusionWith the recent over-whelming evidence demonstrating the effectiveness endovascular therapy in acute ischemic stroke, the expansion of stroke therapy requires that a variety of techniques be available to the operators. Permanent implantation of the Solitaire stent achieves adequate distal flow and good clinical outcomes in the setting of AIS. This case series suggests this technique provides a safe alternative for difficult cases refractory to other revascularization techniques.Key Wordsstroke, revascularization, stentDisclosuresJ. Houde: None. E. Barber: None. M. Kelly: 2; C; Medtronic. 4; C; Blockade. 6; C; Pen...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Houde, J., Barber, E., Kelly, M., Peeling, L. Tags: Oral poster abstracts Source Type: research

To Treat or Not to Treat M2 Occlusions? The Question (and Answer) From a Single Institution
CONCLUSION: The results of our single-institution experience suggest that endovascular therapy for M2 occlusions is safe and effective. Additional evaluation with randomized, controlled studies is warranted. ABBREVIATIONS: ADAPT, direct aspiration first-pass technique ECASS, European-Australasian Cooperative Acute Stroke Study ICH, intracranial hemorrhage IMS, Interventional Management of Stroke MERCI, Mechanical Embolus Removal in Cerebral Ischemia mRS, modified Rankin Scale NIHSS, National Institutes of Health Stroke Scale PROACT, Prolyse in Acute Cerebral Thromboembolism TICI, Thrombolysis in Cerebral Infarctio...
Source: Neurosurgery - September 1, 2016 Category: Neurosurgery Tags: Research-Human-Clinical Studies Source Type: research