Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection

Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this technique could lead to improved prevention. However, TCD embolic signal (ES) detection is particularly labour intensive in asymptomatic individuals due to relatively low ES detection rates. Approximately 10% of individuals have at least 1–2 ES detected within 1–2 h of TCD monitoring, with median hourly ES rates among ES-positive arteries of 1–2 (1–3). In the Asymptomatic Stenosis Embolus Detection (ASED) Study, on average one ES was detected for every 6.25 h of TCD monitoring (1). The efficiency of TCD monitoring to identify microembolism could be improved if factors influencing shedding rates, including time of day, were better identified. It is unknown if time of day has a significant influence on detecting microembolism associated with asymptomatic carotid stenosis. However, preliminary data from a cohort of seven symptomatic persons wit...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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In this study, we present the first molecular phylogeny of Pyrgomorphidae that includes the members of all four New World tribes and representative genera from the Old World based on entire mitochondrial genome and four nuclear genes to investigate the biogeography of this fascinating lineage. Our results recover Pyrgomorphidae as monophyletic and the New World Pyrgomorphidae as a paraphyletic group comprising three clades, consisting of: 1) The Caribbean Jaragua + the South American Algete; 2) The Mexican and Central American Sphenarium + Prosphena; and 3) The Mexican lineages Ichthiacridini + Ichthyotettigini. The diverg...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
ConclusionsThus, galectin-3 might be a useful prognostic marker in the population with prediabetes and diabetes. Moreover, it can be a marker showing the condition of developing complications in diabetic patients.
Source: Life Sciences - Category: Biology Source Type: research
ConclusionWe present a comprehensive mRNA expression profile of chromogranin A positive enteroendocrine cells following RYGB in rats. The data provides a region-specific characterization of all regulated preprohormone encoding genes in the rat GI tract including 16 not hitherto known. The comprehensive catalogue of preprohormone expression changes may support our understanding of hormone mediated effects of RYGB on diabetes remission and body weight reduction.Graphical abstract
Source: Peptides - Category: Biochemistry Source Type: research
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): David Limón, Kirian Talló Domínguez, María Luisa Garduño-Ramírez, Berenice Andrade, Ana C. Calpena, Lluïsa Pérez-GarcíaAbstractSupramolecular hydrogels were synthesized using a bis-imidazolium based amphiphile, and incorporating chemically diverse drugs, such as the cytostatics gemcitabine hydrochloride and methotrexate sodium salt, the immunosuppressive drug tacrolimus, as well as the corticoid drugs betamethasone 17-valerate and triamcinolone acetonide, and th...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study, we employed an efficient strategy by the combinations of chain-growth condensation polymerization (CGCP), styrenics-assisted atom transfer radical coupling (SA ATRC), and ring-opening polymerization (ROP) to synthesize novel miktoarm (μ) star copolymers. Accordingly, poly(N-octyl benzamide) (PBA) and poly(ε-caprolactone) (PCL) arms were conjugated to form μ-(PBA)2(PCL)m star (m = ca. 4; Mn = ca. 13400; Đ = 1.17; abbr.: μ-(PBA)(PCL)). Thermal properties of homopolymers and μ-(PBA)(PCL) were examined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: 15 September 2019Source: Journal of Alloys and Compounds, Volume 801Author(s): Tong Wei, Fengming Yang, Qingshen Jing, Chuanzhen Zhao, Mingchao Wang, Mingrun Du, Yanyan Guo, Qingjun Zhou, Zepeng LiAbstractMulti-functional up-conversion (UC) phosphors are highly desirable for many potentially technological applications. Here, Er3+- and Yb3+-doped SrBi4Ti4O15 (SBT:xEr3+/yYb3+) UC nanoparticles (NPs) have been successfully synthesized for the first time by a convenient EDTA-citrate approach. The structures and morphologies were characterized by powder X-ray diffraction, Fourier transform infrared reflectivit...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Alloys and CompoundsAuthor(s): N'driDieudonné Diby, Yueqin Duan, Patrick Atheba Grah, Fengshi Cai, Zhihao YuanAbstractIn the photoelectrochemical (PEC) water splitting for the hydrogen production, the fabrication of a stable and efficient photocatalyst semiconductor remains a challenge. CdS, which is one of most used chalcogenide materials, coupled with metal oxide semiconductor exhibit a generally low durability. TiO2 nanorods arrays (TNR) sensitized with CdS were synthesized via hydrothermal method and denoted as TNR-CdS. CdS deposition on TNR surfa...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: Available online 13 June 2019Source: Journal of Alloys and CompoundsAuthor(s): Yong Wang, Luyao Wang, Qianfen ZhuangAbstractA ratiometric electrochemical sensor is developed for dopamine detection based on hierarchical manganese dioxide (MnO2) nanoflower/multiwalled carbon nanotube (MWCNT) nanocomposite modified glassy carbon electrode (GCE). The hierarchical MnO2 nanoflower was electrodeposited onto the electrochemically pretreated GCE modified with MWCNT (MWCNT/EPGCE) to prepare an inner reference electrochemical probe. The fabrication process of the MnO2/MWCNT/EPGCE electrode was characterized by scann...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: 1 November 2019Source: Chemical Engineering Journal, Volume 375Author(s): Xiao-Hong Yi, Si-Qi Ma, Xue-Dong Du, Chen Zhao, Huifen Fu, Peng Wang, Chong-Chen WangAbstractZ-scheme g-C3N4/UiO-66 (BGxUy) heterojunctions constructed from 3D UiO-66 and 2D g-C3N4 sheets were facilely fabricated using ball-milling method, which were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), N2 adsorption-d...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
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